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All Journal Community Development Journal: Jurnal Pengabdian Masyarakat Makara Journal of Science Jurnal Sains dan Kesehatan
MARTHA, RAHMA DIYAN
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Pemberian Terapi Komplementer Jinten Hitam (Nigella sativa) terhadap Kadar SGPT Pada Pasien Hipertensi di Desa Sodo Kecamatan Pakel: Effect of Black Cumin Compementary (Nigella sativa) on SGPT Levels Hypertensive Patiens at Sodo Village, Pakel District Khakim, Lukmanul; Santoso, Arif; Martha, Rahma Diyan; Huda, Choirul; Muadhifah, Afidatul
Jurnal Sains dan Kesehatan Vol. 6 No. 3 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i3.2174

Abstract

Hypertension is a disease that requires long-term medical therapy. Among the complications caused by hypertension is fatty liver. The aim of this research was to determine the effect of complementary administration of black cumin (nigella sativa) on SGPT levels. The experimental research method uses Randomized Controlled Trial (RCT). Randomization of samples used a random sampling method and patients with a diagnosis of hypertension were divided into two groups. The control group was given placebo therapy 2x2 capsules a day, while the treatment group was given black cumin capsule therapy 2x2 capsules a day. This research was carried out for 30 days by measuring SGPT levels on days 0 and 31. The results of sociodemographic data analysis show that hypertension sufferers are more likely to be in the age range 55-65 years, female gender, primary school education, work as a housewife, suffering < 2 years, the most common comorbidity is hypercholesterolemia, more often have no history of hypertension, more people consume medication but not routinely. Changes in SGPT levels in hypertensive patients in the control group showed an average decrease of 0.60 U/L P-value 0.280 and the treatment group showed an average decrease of 0.65 U/L P-value 0.719. The independent T-test between the control group and the treatment group showed that there was no significant difference in the effect of using black cumin with a P-value of 0.600. This shows that giving black cumin capsules is safe for use in the liver of hypertensive patients. Keywords:          Hypertension, SGPT levels, Black Cumin, Hepatoprotector   Abstrak Hipertensi penyakit yang membutuhkan terapi pengobatan dalam jangka panjang. Diantara komplikasi yang disebabkan oleh penyakit hipertensi adalah perlemakan hati. Tujuan dari penelitian ini untuk mengetahui bagaimana pengaruh pemberian  komplementer  jinten hitam (nigella sativa ) terhadap  kadar SGPT. Metode penelitian eksperimetal menggunakan Randomized Controlled Trial (RCT). Pengacakan sampel menggunakan metode sample random sampling dan pasien dengan diagnosis hipertensi dibagi mejadi dua kelompok. Kelompok kontrol diberi terapi plasebo 2x2 kapsul sehari, sedangkan kelompok perlakuan diberi terapi kapsul  jinten hitam 2x2 kapsul sehari. Penelitian ini dilakukan selama 30-hari  dengan mengukur kadar SGPT pada hari ke-0 dan dan ke-31. Hasil analisis data sosiodemografi penderita hipertensi lebih banyak pada rentang usia 55-65 tahun, jenis kelamin perempuan, pendidikan terakhir SD, pekerjaan sebagai IRT, lama menderita < 2 tahun, penyakit penyerta terbanyak hiperkolesterolemia, lebih banyak tidak terdapat riwayat hipertensi, lebih banyak mengkonsumsi obat namun tidak rutin. Perubahan kadar SGPT pasien hipertensi kelompok kontrol menunjukan nilai rata-rata penurunan 0,60 U/L P-value 0,280 dan kelompok perlakuan menunjukan nilai rata-rata penurunan 0,65 U/L  P-value 0,719. Independent T-test antara kelompok kontrol dan kelompok perlakuan menunjukan tidak ada perbedaan pengaruh penggunaan jinten hitam signifikan dengan nilai P-value 0,600. Hal ini menunjukan bahwa pemberian kapsul jinten hitam aman digunakan terhadap hati pasien hipertensi. Kata Kunci:         Hipertensi, kadar SGPT, Jinten Hitam, Hepatoprotetektor
UPAYA PENINGKATAN PERILAKU PENCEGAHAN DAN PENGENDALIAN PENYAKIT DHF UNTUK MENDUKUNG PROGRAM KESMAS DI DESA TANGGUNGGUNUNG Nurjanah, Mutia Hariani; Kumalasari, Nurul Chamidah; Safitri, Yunita Diyah; Martha, Rahma Diyan; Santoso, Arif; Muadifah, Afidatul; Imanez, Ketzia Adrian
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 5 (2024): Vol. 5 No. 5 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i5.34405

Abstract

Dengue haemoragic fever (DHF) nama lain demam berdarah merupakan infeksi virus yang ditularkan melalui gigitan nyamuk Aedes albopictus dan Aedes aegypti. Demam berdarah telah meningkat secara signifikan dalam dekade terakhir seiring dengan pergerakan manusia, peningkatan populasi, dan terjadinya perubahan iklim. Di Indonesia, penyakit DHF mendapat perhatian serius dari seorang pakar kesehatan masyarakat, dimana beliau menjelaskan cara mencegah penularan dengan pendekatan yang efektif dan efisien. Tujuan diadakannya kegiatan kesehatan masyarakat ini ialah memberikan edukasi kepada masyarakat terkait pencegahan penyakit DHF yang disebabkan oleh gigitan nyamuk yang mengandung virus dengue. Hasil yang diperoleh dari kegitan ini adalah dengan cara menjaga lingkungan, menjaga imunitas, perilaku preventif dan pengendalian vector demam berdarah. Kesimpulan dari pengmas ini adalah adanya peningkatan pengetahuan dan pemahaman masyarakat desa Tanggunggunung yang baik dalam upaya mencegah penyakit DHF.
In Silico and Toxicological Evaluation of Crescentia Cujete Aqueous Extract: Potential Anticancer Activity Against Breast Cancer Martha, Rahma Diyan; Fatimah, Fatimah; Wibowo, Syahputra; Kusuma Wardhani, Bantari Wisynu; Siregar, Josephine Elizabeth; Novita Coutrier, Elisabeth Farah; Fitrianita, Alfia; Pramono, Andri Pramesyanti; Nainggolan, Ita Margaretha; Nugraha, Yudhi; Danar, Danar; Abiyyu, Naufal; Unsunnidhal, Lalu; Khairullah, Aswin Rafif; Ansori, Arif Nur Muhammad; Parbuntari, Hesty; Widodo, Wimbuh Tri
Makara Journal of Science Vol. 30, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Majapahit plant (Crescentia cujete), commonly found in Indonesia, has not been extensively explored for its medicinal properties. Given that many cancer treatments are derived from plants, this study aimed to examine the effects of plants on cancer chemical composition of the C. cujete fruit pulp extract, identify its primary compounds, and assess its potential as an antioxidant, anticancer agent, particularly for breast cancer. An insilico approach was used to evaluate the toxicity and interactions, of the compounds with cancer biomarker proteins, in addition to an in vivo Brine Shrimp Lethality Test (BSLT) for BSLT, toxicity screening using six concentrations of the extract (100, 200, 300, 400, and 600 ppm). The extract was obtained by boiling the fruit pulp in distilled water. Compound analysis using liquid chromatography-mass spectrometry (LC-MS) identified approximately 110 compounds, with kaempferol-3-O-rhamnoside (3.29%) and hesperidin (3.19%) being the most abundant. Toxicity analysis using ProTox 3.0 revealed that kaempferol-3-O-rhamnoside exhibited toxicity to the kidney, heart, and lungs, with probabilities of 0.68, 0.82, and 0.51, respectively. Hesperidin was toxic to the kidney and lungs, with probabilities of 0.76 and 0.66. Molecular docking studies with the X-ray spectrometer BRCA1 (P38398 - BRCA1_HUMAN) and BRCA2 (P51587–BRCA2_HUMAN) proteins showed that kaempferol-3- O-rhamnoside formed stable interactions with both proteins, with binding affinities of −7.0 kcal/mol for BRCA1 and -8.1 kcal/mol for BRCA2. Similarly, hesperidin demonstrated stable binding interactions with BRCA1 (binding affinity) of −7.7 kcal/mol) and BRCA2 (binding affinity of −9.0 kcal/mol). The LC50 value for the C. cujete fruit pulp extract was calculated as follows: determined to be 546 ppm (95% CI: 498.3–592.1 ppm), indicating that the extract is toxic and holds potential as an anticancer agent. While individual compounds exhibited organ-specific toxicity, the overall extract was nontoxic, suggesting its potential for further anticancer research. Future studies should focus on additional toxicity testing using cell cultures and mammalian models.
Co-Authors ABIYYU, NAUFAL Adi Sofyan Ansori, Muhammad Andri Pramesyanti Pramono Arif Santoso Danar, Danar fatimah Fatimah Fitrianita, Alfia Imanez, Ketzia Adrian Khairullah, Aswin Rafif Kumalasari, Nurul Chamidah Kusuma Wardhani, Bantari Wisynu Lukmanul Khakim Muadhifah, Afidatul Muadifah, Afidatul Nainggolan, Ita Margaretha Novita Coutrier, Elisabeth Farah Nugraha, Yudhi Nurjanah, Mutia Hariani Parbuntari, Hesty Safitri, Yunita Diyah Siregar, Josephine Elizabeth Unsunnidhal, Lalu Wibowo, Syahputra Wimbuh Tri Widodo