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Karlah L. R. Mansauda
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Journal : PHARMACON

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PENGARUH VARIASI TRIETANOLAMIN DAN ASAM STEARAT TERHADAP STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.) Asticha Opod; Paulina V. Y. Yamlean; Karlah L. R. Mansauda
PHARMACON Vol. 13 No. 1 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49566

Abstract

Kestabilan suatu sediaan emulsi dipengaruhi oleh beberapa faktor yaitu emulgator, suhu serta waktu. Pembuatan krim membutuhkan penambahan emulsifier atau massa pengemulsi, karena dapat mempengaruhi kualitas dan stabilitas produk krim, misalnya triethanolamine dan asam stearat digunakan sebagai emulsifier. Tujuan dari penelitian ini yaitu untuk melihat efek dari variasi trietanolamin dan asam stearat terhadap stabilitas fisik dari formula sediaan krim ekstrak etanol daun sirsak yang mempunyai perbandingan trietanolamin dan asam stearat 2%: 16%, 2,5%:15,5%, 3%:15%, dan 3,5%:14,5%. Daun sirsak diekstrak dengan pelarut etanol 96% kemudian dibuat krim M/A. Dilakukan pengujian stabilitas sediaan krim dengan cara menyimpan sediaan krim pada suhu kamar (25º±2C) selama 4 minggu. Pengujian fisik seperti uji daya lekat, uji daya sebar, uji pH, uji homogenitas dan uji organoleptik dilaksanakan tiap minggunya. Hasilnya, variasi konsentrasi trietanolamin dan asam stearat tidak memiliki dampak pada pengujian homogenitas, tetapi variasi konsentrasi trietanolamin dan asam stearat memiliki dampak pada pengujian daya lekat, pengujian daya sebar, pengujian pH, dan pengujian organoleptic darri sediaan krim ekstrak etanol daun sirsak. Kesimpulannya F1 (asam stearat 16% : trietanolamin 2%) merupakan formulasi yang paling stabil secara fisik. Kata Kunci: Krim, Trietanolamin, Asam Stearat, Emulgator, Stabilitas Fisik
Karakterisasi Fisik Gel Asam Salisilat Berbasis Pati Sagu Terasetilasi Mansauda, Karlah Lifie
PHARMACON Vol. 14 No. 3 (2025): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.14.2025.66264

Abstract

Salicylic acid gel formulations require a gelling agent that can provide optimal physical stability during storage. This study aimed to characterize the physical properties of salicylic acid gel based on acetylated sago starch as a natural alternative gelling agent. Sago starch was extracted from sago flour with a yield of 87.05%,  and subsequently acetylated, producing modified starch with an acetyl content of 9.46 ± 0.30% and a degree of substitution of 0.39 ± 0.01. Three gel formulations (F1, F2, F3) contained 2% salicylic acid and 6%, 8%, or 10% acetylated starch. Organoleptic properties, homogeneity, pH, adhesiveness, and syneresis were evaluated on days 0 and 30. All formulations exhibited transparent orange color, characteristic salicylic acid odor, semisolid consistency, and stable homogeneity. The pH (5.36–5.91) met topical requirements, adhesiveness increased with starch concentration (≈4.2–5.6 seconds), and syneresis remained low and stable. Acetylated sago starch shows potential as a stable and biocompatible gelling agent for salicylic acid gel.
Co-Authors Abbas, Syahruni Ramdhani Adelaida Joroh Adithya Yudistira Admia Terkasih Mokoginta Adriyan Warokka Apitalau, Etserlisa A. Apriliani Margaret Marista Lourina Rarung Arief Perdana Kumaat Asticha Opod Datu, Ronald Joy Defny Silvia Wewengkang Desinta, Ni Wayan Dita Wulan Cahyani Susanto Ekadelania Buyung Elly Suoth ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Gayatri Citraningtyas Gloria Sefania Maukar Gratia, Berta Herny E.I. Simbala Hosea Edy Hosea Jaya Edy I Gede Para Atmaja Jayanto, Imam Julianri Sari Lebang, Julianri Sari Korengkeng, Nathania Anabel Kumakauw, Vanesa Vebiola Langi, Priski Leony Ariesta Wenno Lolowang, Sheren N. Makalew, Mario Y. Mallaka, Indriyani Marhaba, Fera Anelia Maureen Langie Meldha, Meldha meliska debora saibaka Mende, Rivaldo Mokoginta, Rizkah V. Mumu, Britney Stevani Nathania Anabel Korengkeng Nurbayasanti, Ni Luh Paulina V. Y. Yamlean Paulina yamlean Precylia Ribka Rambing Rante, Trian Rizki Kala’ Rondonuwu, Arnold R. Ryan Irwanto Tunggal Siampa, Jainer Pasca Simanjuntak, Christopel Hamonangan Siwi, Herotje Stanley B. Dodie Stieven N. Rumokoy Sumerah, Marsella Sumerah, Marsella E. Surya Sumantri Abdullah Tunggal, Ryan Irwanto Veren Naftalia Mamangkey Vinny Valentina Kaitu Widya Astuty Lolo Widya Lolo