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Evaluasi Penggunaan Antibiotika Pada Pengobatan Sepsis Neonatal Dengan Metoda Gyssens di RSAD Salak Bogor Tahun 2018 Patminingsih, Nanik; Ratih Laksmitawati, Dian; Utami Ramadaniati, Hesty
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (723.942 KB) | DOI: 10.36418/syntax-literate.v5i7.1468

Abstract

Sepsis merupakan disfungsi organ yang mengancam kehidupan yang diakibatkan oleh disregulasi imun terhadap infeksi. Pemberian antibiotika yang sesuai merupakan salah satu kriteria dalam tata laksana sepsis. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotika pada pasien sepsis neonatal. Penelitian dilakukan secara obsevasi analitik dengan alur prospektif. Sebanyak 34 sampel pasien sepsis neonatal dilakukan pemantauan terapi obat. Karakteristik dominan bayi yang mengalami sepsis adalah bayi laki-laki dengan prosentase 59%, terdapat 62% Berat Badan Bayi Cukup (BBLC), 59% jenis sepsis Early Onset Sepsis (EOS), kehamilan cukup bulan 79% dan riwayat persalinan normal 62%. Penggunaan antibiotika terbanyak adalah kombinasi seftriakson-gentamisin sebanyak 50%, kombinasi ampisilin-gentamisin sebagai lini pertama sebanyak 35%, ceftriakson tunggal 9% serta ceftazidim tunggal dan kombinasi seftazidim-gentamisin masing-masing 3%. Hasil evaluasi Gyssens menunjukkan hasil kerasionalan antibiotika 18%, ketidakrasionalan 82%. Hasil statistic menunjukkan bahwa nilai sig yang didapat sebesar 0.912 > alpha 0.05. Hal ini menunjukkan H0 diterima atau tidak adanya hubungan rasionalitas dengan lama hari sembuh. Penggunaan rasional atau tidaknya tidak ada hubungannya dengan seorang pasien lebih cepat atau lebih lama dalam penyembuhan. Kata kunci : Penggunaan antibiotika; sepsis neonatal; metoda Gyssens
E-Health Literacy and Adherence to Health Protocols Among Self-Quarantined Patients with COVID-19 in a Sub-district in West Java Hesty Utami Ramadaniati; Sondang Khairani; Nurul Azizah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004176

Abstract

During the Coronavirus Disease-2019 (COVID-19) pandemic, valid information was crucial and electronic health literacy (EHL) plays a significant role in public adherence to health protocols. This study aimed to evaluate the pattern of COVID-19 information-seeking, and the association between EHL, COVID-19 knowledge, and health protocol adherence among patients with COVID-19 during self-quarantine. Data were collected through an online survey sent to self-quarantined COVID-19 patients during March – December 2020 in a sub-district in West Java. Spearman tests were used to evaluate the relationship between EHL with COVID-19 knowledge, and EHL with health protocol adherence. There were 56 respondents with more than half being female (58.9%), university graduates (64.3%) and having good health status level (57.1%). Social media were the commonest online sources. During self-isolation, the frequency of Internet use increased (i.e., every day) with information on vitamins and supplements as the most commonly searched. Respondents had high scores on EHL (mean= 20.0), knowledge (mean = 8.89/10, SD = 1.796), and adherence (mean = 26.98/30, SD = 3.066). This study found significant relationships between EHL and knowledge (p-value = 0.001, r = 0.436), and the adherence (p-value = 0.011, r = 0.339). In conclusion, EHL had a modest influence on COVID-19 knowledge and minor relationship with adherence to health protocols among self-quarantined patients with COVID-19.
Evaluasi Pelaksanaan Pengendalian Resistensi Antimikroba Dalam Meningkatkan Kualitas Penggunaan Antibiotik Pada Pasien Rawat Inap Pneumonia Anak Vera Mulyawantie; Hesty Utami Ramadaniati; Prih Sarnianto; Taufik Hidayat
Jurnal Keperawatan Profesional (KEPO) Vol. 4 No. 2 (2023): Volume 4 Nomor 2 November 2023
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/kepo.v4i2.825

Abstract

Resistensi antibiotik menyebabkan kurangnya efektivitas terapi yang berdampak pada peningkatan morbiditas dan mortalitas serta pengeluaran perawatan kesehatan. Tujuan penelitian mengevaluasi pelaksanaan pengendalian resistensi antimikroba dalam meningkatkan kualitas penggunaan antibiotik pada pasien rawat inap pneumonia anak di RSD Gunung Jati Cirebon. Penelitian ini menggunakan pendekatan deskriptif-evallualtif dengan pengambilan data rekam medik secara retrospektif tahun 2017 - 2022. Hasil penelitian yaitu Penggunaan antibiotik pasien pneumonia anak mengalami perubahan yang cukup besar. Penggunaan antibiotik sebelum PPRA total DDD 65,17 gram menjadi DDD 46,02 gram sesudah PPRA. Hasil evaluasi metode Gyssens jumlah kasus yang rasional meningkat dari 6 kasus pada sebelum PPRA menjadi 15 kasus pada sesudah PPRA, sedangkan kasus yang tidak rasional mengalami penurunan dari 47 kasus menjadi 32 kasus pada sesudah PPRA dan implementasi PPRA di RSD Gunung Jati Cirebon masih memiliki kekurangan, yakni sosialisasi belum optimal dari KPRA untuk lebih menekankan lagi akan kesadaran dokter menulis resep antibiotik secara rasional, dan ada dukungan dari pihak manajemen rumah sakit.
Analisis Drug Related Problems dan Pengaruhnya terhadap Pengendalian Glukosa Darah pada Pasien Covid-19 dengan Komorbiditas Diabetes Melitus Tipe 2 Yoppy Mayrosa; Hesty Utami Ramadaniati; Dian Ratih Laksmitawati; Ivans Panduwiguna
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v8i11.13955

Abstract

This study aims to anayze the effect of drug related problems (DRPs) on glycemic control in COVID-19 patients with comorbid diabetes mellitus type 2. This research is a cross-sectiona study using retrospective data obtained from secondary data from the medica records of Covid-19 patients. with type 2 diabetes mellitus. The research location was at Jati Padang Hospita. The sample consisted of 76 medica records with total sampling method. Data collected using PCNE V9.00 were then tested using the Wilcoxon test comparing initia GDS in hospita with GDS at the end of patient discharge, the Chisquare test which correlated changes in GDS with patient clinica outcomes and the Spearman test which linked changes in GDS with DRPs, characteristics of Covid-19 patients with diabetes mellitus predominant age 46-55 years (30.3%), predominant sex mae (51.3%), length of stay 6-10 days (64.5%), profile of drug use that is often used antivira, antibiotics, vitamins and supplements, symptomatic and antidiabetic (100%). The most common comorbidities were hypertension (60.4%), the incidence of DRPs (92.1%), the most common fina GDS was hyperglycemia (≥ 200 mg/dL) (65.8%). 58 patients were discharged with a negative sample (76.3%). The results of the Wilcoxon test on blood glucose showed differences in blood glucose at the beginning and at the end. The results of the Chi-square test between changes in blood glucose and the patient's clinica outcome (p>0.05) showed that there was no significant relationship between changes in blood glucose levels and the patient's clinica outcome. Spearmen's correlation test results (p>0.05) showed a significant relationship between DRPs and changes in patient's blood glucose. The correlation between the incidence of DRPS and blood glucose (0.169) shows a weak relationship. It can be interpreted that DRPs do not realy affect changes in blood glucose in patients at Jati Padang Hospital.
Pengaruh Penerapan Clinical Pathway pada Peresepan Antibiotik Pasien Tifoid Anak di Rumah Sakit Swasta X Kota Bogor: Effect of Clinical Pathway on Antibiotic Prescribing for Children Typhoid Patients at Hospital X Bogor Oriza Safrini; Dian Ratih Laksmitawati; Hesty Utami Ramadaniati
Jurnal Sains dan Kesehatan Vol. 5 No. 4 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i4.1581

Abstract

Typhus occurs almost all over the world. To reduce the variation of antibiotics in hospitals, especially for inpatients, a Clinical Pathway was created. This study aims to determine the effect of the application of a clinical pathway on antibiotic prescribing in pediatric typhus patients in the inpatient room of X Private Hospital, Bogor. This research is a comparative observational study that compares the prescribing of antibiotics before the implementation of the clinical pathway and after the application of the clinical pathway. The Chi-square test was used to compare the rationality of antibiotic use, length of stay, and solubility of antibiotic choices with guidelines. A sample of 81 people was obtained before the application of the clinical pathway and 78 people after the application of the clinical pathway. Before the implementation of the clinical pathway, the rational use of antibiotics was 48.88% and after the application of the clinical pathway, it increased to 67.05%. (p = 0.016). Based on the results of statistical tests, there were 52 patients (64.19%) who had a length of stay ? 5 days before the implementation of the clinical pathway and 68 patients (87.17%) before the implementation of the clinical pathway (p=0.001). As much as 68.89% of the selection of antibiotics before the application of clinical pathways according to management guidelines and after the application of clinical pathways increased to 88.64%. (p = 0.001). The conclusion from this study is that the application of a clinical pathway at Hospital X Bogor City has increased the rationality of using antibiotics Keywords: Antibiotic, Clinical pathways, Gyssen, Typhoid Abstrak Tifoid terjadi hampir di seluruh dunia. Untuk mengurangi variasi antibiotik di rumah sakit khususnya pada pasien rawat inapmaka dibuatlah Clinical pathway. Adapun tyjuan penelitian ini adalah untuk mengetahui pengaruh implementasi clinical pathway terhadap peresepan antibiotik untuk pasien Tifoid anak di ruang rawat inap Rumah Sakit Swasta X di Bogor. Penelitian ini bersifat observasional comparative study membandingkan peresepan antibiotik sebelum penerapan clinical pathway dan setelah penerapan clinical pathway. Uji Chi square digunakan untuk membandingkan rasionalitas penggunaan antibiotik, lama rawat dan kesesuaian pilihan antibiotik dengan pedoman. Diperoleh sampel sebanyak 81 orang sebelum penerapan clinical pathway dan 78 orang setelah penerapan clinical pathway. Sebelum penerapan clinical pathway penggunaan antibiotik rasional sebanyak 48.88% dan setelah penerapan clinical pathway meningkat menjadi 67.05%. (p = 0,016). Berdasarkan hasil uji statistik menujukkan pasien yang memiliki lama rawat ? 5 hari sebelum penerapan clinical pathway sebanyak 52 pasien (64.19%) dan sebelum penerapan clinical pathway sebanyak 68 pasien (87.17%) (p = 0,001). Sebanyak 68,89% pemilihan antibiotik sebelum penerapan clinical pathway telah sesuai dengan pedoman tata laksana dan setelah penerapan clinical pathway meningkat menjadi 88.64%. (p = 0,001). Adapun kesimpulan dari penelitian ini adalah implementasi clinical pathway di Rumah Sakit X di kota Bogor telah meningkatkan rasionalitas penggunaan antibiotik. Kata Kunci: Antibiotik, Clinical pathway, Gyssen, Tifoid
Home Care Improves Knowledge, Attitude, Practice and Blood Pressure Control in Hypertensive Patients: Exploring the Expanded Role of Community Pharmacists Ramadaniati, Hesty Utami; Anggriani, Yusi; Saragi, Sahat; Yazid, Ricky Chaerul
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 3 (2020): J Sains Farm Klin 7(3), Desember 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.3.236-243.2020

Abstract

Hypertension remains a leading cause of morbidity and mortality.This study aimed to evaluate the impact of community pharmacists-provided home care on knowledge, attitude, practice (KAP) and blood pressure (BP) control of hypertensive patients. A quasi-experimental study was conducted in two pharmacies in Banten involving hypertensive patients regularly refilling prescriptions. Patients in Pharmacy A were assigned in the intervention group (IG), whilst those in Pharmacy B in the control group (CG). IG received home care in addition to standard care. Questionnaires to assess KAP were distributed at the initiation and end of the study. BP was measured monthly. A total of 110 patients (60 in IG vs 50 in CG) were enrolled. At baseline there was no significant difference in demographic and clinical characteristics. Post-intervention, proportion of patients with ‘good’ knowledge was considerably higher in IG (100%) vs 2.0% in CG, IG demonstrated ‘very ideal’ attitude compared to ‘less ideal’ in CG, IG performed ‘good’ practice as opposed to ‘fair’ practice in CG. The decrease of systolic BP in IG was significantly greater (14.8 mmHg) vs 1.8 mmHg in CG. In conclusion, expanded role of community pharmacists in providing home care improves KAP and BP control in hypertensive patients.
Pengaruh Ketersediaan Obat Hipertensi Terhadap Rujukan Pasien Hipertensi Ringan Dan Sedang Di Puskesmas Oktiano, Dwi; Sarnianto, Prih; Utami Ramadaniati, Hesty
Journals of Ners Community Vol 13 No 6 (2022): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i6.2284

Abstract

DKI Jakarta masuk dalam 10 besar Provinsi dengan tingkat prevalensi hipertensi tertinggi di Indonesia. Tinggi nya prevalensi penyakit hipertensi diiringi dengan meningkatnya ketidak terkendalian hipertensi. Obat sebagai salah satu komponen dalam pelayanan kesehatan memiliki fungsi sosial. Permasalahan terkait akses obat adalah belum optimalnya pengelolaan obat pada fasilitas kesehatan , yang ditandai dengan tingkat ketersediaan obat yang masih rendah. Ketidaktersediaan obat dapat memperburuk kesehatan pasien, membuat rancu pelayanan kesehatan di fasilitas kesehatan dan menyebabkan pemindahan pasien ke fasilitas kesehatan lain. Tujuan penelitian yaitu untuk mengetahui hubungan antara ketersediaan obat hipertensi terhadap rujukan pasien hipertensi ringan dan sedang di Puskesmas Kecamatan Provinsi DKI Jakarta tahun 2019. Penelitian dilakukan selama 3 bulan, dari Oktober sampai Desember 2020, menggunakan desain penelitian deskriptif kuantitatif melalui pengambilan data kuantitatif dan kualitatif, dengan lokasi penelitian di 20 puskesmas. Data kuantitatif dalam penelitian ini terdiri atas data primer dan data sekunder. Data primer berupa data ketersediaan obat, data kunjungan hipertensi, data rujukan hipertensi. Data sekunder berupa hasil wawancara mendalam. Sampel penelitian adalah 20 Puskesmas Kecamatan dengan pembagian dari masing masing wilayah kota administrasi sebanyak 4 Puskesmas Kecamatan, Hasil Penelitian menunjukan pada tahun 2019 sebanyak 10 Puskesmas memiliki ketersediaan obat hipertensi ≥1 bulan (kriteria “aman”), 8 Puskesmas memiliki ketersediaan obat ≤0,5 - <1 bulan (kriteria “kurang aman”), dan 2 Puskesmas memiliki ketersediaan < 0,5 bulan (kriteria “bahaya”, dimana pada puskesmas dengan kriteria “aman” memiliki persentase rujukan rata-rata sebesar 6,03%, sedangkan puskesmas dengan kriteria “kurang aman” memiliki persentase rujukan rata -rata sebesar 8,68%, dan puskesmas dengan kriteria “bahaya” memiliki persentase rujukan rata-rata sebesar 12,06 %. Puskesmas Taman Sari dengan kriteria ketersediaan obat “kurang aman” pada amlodipin 10 mg berdampak meningkatkan rujukan hipertensi sebesar 0,49 %-0,69% dari rata- rata rujukan perbulan sebesar 0,88 %, dan peningkatan kunjungan hipertensi sebesar 0,66 % - 5,22% dari rata-rata kunjungan perbulan sebesar 12,05%. Puskesmas Makasar dengan kriteria ketersediaan obat “bahaya” pada amlodipin 10 mg berdampak meningkatkan rujukan hipertensi sebesar 0,8% dari rata- rata rujukan perbulan sebesar 1,05 %, dan peningkatan kunjungan hipertensi sebesar 6,83 % dari rata-rata kunjungan perbulan sebesar 28,38 % . Penelitian ini menyimpulkan bahwa ketidaktersediaan obat hipertensi di Puskesmas Kecamatan Provinsi DKI Jakarta masih terjadi dengan hambatan terbesar disebabkan ketidak mampuan suplai oleh penyedia, berdampak pada ketidaktersediaan obat dan meningkatkan persentase rujukan dan kunjungan hipertensi
The ANALYSIS OF PHARMACEUTICAL SERVICES IN COMMUNITY PHARMACIES IN DKI DURING COVID-19 PANDEMIC: ANALYSIS OF PHARMACEUTICAL SERVICES IN COMMUNITY PHARMACIES IN DKI DURING COVID-19 PANDEMIC Karlina, Lina; Sumiyati, Yati; Utami Ramadaniati, Hesty; S. Mardiko, Etty
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2307

Abstract

The COVID-19 pandemic has caused changes to pharmaceutical services activities in community pharmacies, due to various adjustments that must be made. To analyze the impact of COVID-19 pandemic on pharmaceutical service activities in community pharmacies. Cross-sectional approach involving community pharmacist in DKI Jakarta. The quantitative data were collected through distributing online questionnaires in November 2022, while qualitative data were obtained through online in-depth interviews. The quantitative data was analyzed descriptively whereas qualitative data was analyzed using content analysis. Research revealed an increase of 29.4% of pharmacies experiencing out of stock in pharmaceutical supplies compared to before the pandemic. There was a 42.1% decrease indirect Drug Information Services (DIS) compared to before the pandemic. Meanwhile, during the pandmeic a 42.1% increase in online DIS. There were various innovations and strategies done by pharmacies including maximizing the use of digitalization both in the implementation of pharmaceutical services, as well as in promotional activities and online sales of pharmacy productsand. It can be concluded that there are considerable differences in managerial activities and clinical pharmacy services before and during the COVID-19 pandemic, with more digital-based technology involvement in managerial activities and clinical pharmacy services during the pandemic. Keywords: Pharmaceutical services, Pharmacy, COVID-19, Innovations, Strategic
ANALISIS KUALITATIF DAN KUANTITATIF PENGGUNAAN ANTIBIOTIK PADA PASIEN PASCA OPERASI LAPAROTOMI DI RUANG ICU RSUD JENDERAL AHMAD YANI METRO LAMPUNG TAHUN 2023: ANALISIS KUALITATIF DAN KUANTITATIF PENGGUNAAN ANTIBIOTIK PADA PASIEN PASCA OPERASI LAPAROTOMI DI RUANG ICU RSUD JENDERAL AHMAD YANI METRO LAMPUNG TAHUN 2023 Kurniati, Rizki; Sumiyati, Yati; Ramadaniati, Hesty Utami; Syahputri, Devina Harti
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2522

Abstract

Laparotomy is a surgery performed to open the abdomen, a form of major surgery by cutting the layers of the abdominal wall, risking causing infection of the surgical wound where antibiotics are given as treatment. Antibiotic resistance can lead to increased morbidity, mortality and health costs, therefore there needs to be an analysis for the use of antibiotics. The analysis of the use of antibiotics was carried out in the ICU room of the General Ahmad Yani Metro Lampung Hospital with the aim of analyzing how to use antibiotics qualitatively and quantitatively. The method used is descriptive with retrospective data collection from the period of January 1 to December 31, 2023. The qualitative analysis of the use of antibiotics used the Gyssens method and quantitatively with the ATC/DDD du 90% method. The sample of this study consisted of 52 patients after laparotomy surgery in the ICU room of General Ahmad Yani Metro Hospital Lampung, where based on the inclusion and exclusion criteria determined. Based on the results of the analysis of antibiotic use with the Gyssens method, 83.8% used antibiotics non-adherence (category 0) and 16.2% used antibiotics adherence (categories VIA and V). Analysis of the use of antibiotics using the ATC/DDD method obtained that Seftriaxone had the highest DDD with DDD/100 patients – 76.4 DDD per day and those in the DU segment of 90% were Seftriaxone and Metronidazole.    Keywords: ATC/DDD du 90%, Gyssens, Laparotomy, Quantitative, Qualitative
Evaluasi Penggunaan Antibiotik dengan Metode Kuantitatif pada Pasien Pneumonia Rawat Inap di Rumah Sakit Nusa Tenggara Barat Khairani, Sondang; Ramadaniati, Hesty Utami; Sarnianto, Prih; Kristin, Erna; Anggriani, Yusi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1449

Abstract

Abstract Overuse of antibiotics is a public health challenge that can lead to antimicrobial resistance. To reduce the occurrence of antibiotic resistance, it is necessary to evaluate the use of antibiotics to determine the rational use of drugs using quantitative methods, namely the ATC /DD method. The purpose of the study was to determine the use of antibiotics and describe the pattern of antibiotic use in inpatients at West Nusa Tenggara Hospital using the ATC /DD method and DU90%. The research method is a cross-sectional study design with retrospective data collection on adult pneumonia patients hospitalized in the period Januari-December 2019 and 2022, data obtained from medical records. The results of the study met the inclusion criteria of 218 patients with the majority being male 117 (53.67%) and the most age > 65, namely 66 (30.28%). Antibiotic use has a total DDD value of 185.56 DDD/100 days of care with the highest antibiotic DDD value being ceftriaxone which is 104.00 DDD/100 days of hospitalization while antibiotics that are included in the DU 90% are ceftriaxone, levofloxacin, cefoperazon and meropenem. Conclusion the most antibiotics used were ceftriaxone 104.00 DDD/100 days of length of stay.