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All Journal E-Jurnal Medika Udayana Jurnal Surya Medika Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Medicamento Media Farmasi Indonesia Usadha Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Kefarmasian Indonesia
Suradnyana, I Gede Made
Fakultas Farmasi Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Formulation of Lerak Liquid Extract (Sapindus rarak DC.) as a Biosurfactant for Facial Soap Ariawa, Dewi Cahayani; Suradnyana, I Gede Made; Suena, Ni Made Dharma Shantini
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Sodium lauryl sulfate (SLS) and sodium lauryl ester sulfate (SLES) are components that consumers avoid because they cause skin irritation due to the residue left behind. Lerak (Sapindus rarak DC) is a natural product with potential as a biosurfactant with a saponin content of 28%. The purpose of this study was to determine the suitability of Lerak extract facial liquid soap with the Indonesian National Standard (SNI) and its physical quality compared to soap products containing SLS and SLES, as well as to determine the panelist's acceptance of the Lerak facial soap through a hedonic test. The extract was prepared by ultrasonic-assisted maceration. The facial soap was made into four 100 ml size formulas with extract percentages of 5% (F1), 15% (F2), 25% (F3), and 35% (F4). Aspects studied included organoleptic, pH, specific gravity, foam stability, and total plate number (TPN), compared with SNI provisions. The hedonic test was conducted on 30 panelists aged 19-35. The results showed that the Lerak extract facial liquid soap met the physical quality standards set out in SNI. There are several differences in pH, specific gravity, and foam stability compared to the comparison soap product. Formula F1 gets the best score for color parameters, and F3 gets the best score for shape, smell, and usability parameters. Lerak fruit has the potential to be developed as a cleaning cosmetic product that is safe for the skin and environmentally friendly.
Formulasi serta Evaluasi Aktivitas Antioksidan dan Tabir Surya Secara in Vitro Pada Krim Ekstrak Etanol Daun Sukun (Artocarpus altilis) Suradnyana, I Gede Made; Juli Widiarta, I Made; Yudianti Mendra, Ni Nyoman
Usadha Vol 4 No 2 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i2.12757

Abstract

Ultraviolet (UV) radiation exposure can cause various skin disorders, including sunburn, erythema, premature aging, wrinkles, pigmentation changes, and DNA damage, which may lead to photocarcinogenesis. Sunscreens play an important preventive role against these harmful effects, yet synthetic organic and inorganic agents may cause skin toxicity. Breadfruit (Artocarpus altilis) leaf extract contains phenolic compounds with dual photoprotective properties as antioxidants and UV filters. This study aimed to formulate and evaluate a sunscreen cream containing ethanol extract of breadfruit leaves. The formulation varied the concentrations of stearic acid and triethanolamine as emulsifiers. Physical properties (organoleptic, homogeneity, pH, adhesion, and spreadability) and in vitro activities (antioxidant by DPPH method and SPF by spectrophotometry) were assessed and compared with commercial creams. The results showed that the cream formulation containing 4% stearic acid and 2% triethanolamine exhibited the most ideal physical characteristics compared to commercial products. The breadfruit leaf ethanol extract cream demonstrated weak to moderate antioxidant activity, while at a concentration of 400 ppm, it exhibited sunscreen protection categorized as maximum protection. The ethanol extract of breadfruit leaves has the potential to be developed into a natural sunscreen formulation that is safe and environmentally friendly.
Penggunaan Madu dalam Sediaan Topikal sebagai Pelembap Kulit Ni Kadek Lidia Ayu Aristina; I Gede Made Suradnyana; Ni Made Sukma Sanjiwani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2044

Abstract

Skin is the body's outermost organ, enveloping all parts of the human body. When the water content in the stratum corneum (SC) drops below 10%, the skin can become scaly, rough, and dry. Honey possesses humectant, emollient, and antioxidant properties, making it an effective moisturizer. The humectant properties of honey stem from its high sugar content, particularly glucose and fructose. These  sugars form hydrogen bonds with water, helping to retain moisture in the skin and thus providing a hydrating effect. Additionally, honey contains vitamin C, alpha hydroxy acids, and flavonoids, which contribute to the elasticity and firmness of the skin. Therefore, it is important to conduct a narrative review on the use of honey as a moisturizer in topical preparations, which can serve as a reference for future research. The literature search for this review was conducted using databases such as Google Scholar, Garuda Journal, MDPI, ResearchGate, and Publish or Perish, employing specific inclusion and exclusion criteria. The findings concluded that honey can be used as a moisturizer in various dosage forms, including body scrubs, anti-aging and moisturizing creams, serums, peel-off gel masks, lip moisturizers, and lip scrubs. The concentration of honey used in these formulations depends on the dosage form, its intended function in the formula (whether as an active substance, humectant, or emollient), and the comparison of honey concentration with other ingredients.
Chemical and DPPH Free Radical Scavenging Stability of Avocado Seed Acetone Extract Against pH Changes Suradnyana, I Gede Made; Juliadi, Debby; Mendra, Ni Nyoman Yudianti; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12213

Abstract

Background: Avocado seeds contain phenol, flavonoid, and anthocyanidin compounds that have antioxidant activity. The stability of phenolic compounds depends on the pH of the solution. A decrease in total phenolic levels causes a decrease in antioxidant activity. The chemical stability and DPPH free radical scavenging activity of avocado seed extract against pH are not yet known.Objective: This study aimed to determine the effect of pH on the chemical stability and DPPH free radical scavenging activity of avocado seed extract.Methods: Chemical stability was observed from changes in total phenolic levels, and stability of DPPH free radical scavenging activity was observed from the difference in the percentage of DPPH reduction of the extract solution in phosphate-citrate buffer at pH 3.24, 5.52, and 7.44 before and after being heated at 60°C for 2 hours.Results: The average decrease in total phenolic levels of the extract in buffer pH 3.24, 5.52, and 7.44 before and after being heated was 5.76%, 3.89%, and 22.08%, respectively. The decrease in DPPH free radical scavenging activity of the extract in buffer pH 3.24, 5.52, and 7.44 before and after heating was 24.78%, 1.96%, and 56.09%, respectively. There is a significant difference in the total phenolic content and DPPH free radical scavenging activity of the acetone extract solution in phosphate–citrate buffer at pH 3.24 and 7.44 before and after heating, but there is no significant difference at pH 5.52.Conclusion: Therefore, in the development of formulations containing acetone extract of avocado seeds, buffering at a pH close to 5.22 is required.
Co-Authors Aditya Putra, Aditya Anita Dewi, Ni Luh Kade Arman Antari, Ni Putu Pina Apriliani, Wayan Ariawa, Dewi Cahayani Debby Juliadi Dewi Agustini, Ni Putu Dewi, Ni Luh Samila Erna Cahyaningsih I Kadek Wirata I Komang Gede Mahardika Intansari, Ni Putu Ocha Indira Juli Widiarta, I Made Ketut Agus Adrianta Megawati, Fitria Mendra, Ni Nyoman Yudianti Ni Kadek Lidia Ayu Aristina Ni Made Dharma Shantini Suena Ni Made Dwi Mara Widyani Nayaka Ni Made Puspayanti, Ni Made Ni Made Sukma Sanjiwani Ni Putu Gek Dyah Citra Vitaloka Ni Putu Udayana Antari Nyoman Budiartha Siada Perayanthi, Reni Puspita Wati, Ni Putu Putu Era Sandhi Kusuma Yuda Rahadi , I Wayan Surya RR. Asih Juanita Sugiyanto, Milyadi Sukamto, Ika Sumiyarsi Tiarini, Diah Galuh Vernandes Sasadara, Maria Malida Wardani, I Gusti Agung Ayu Kusuma Wirata, I Kadek Yudianti Mendra, Ni Nyoman