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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Adi Widya : Jurnal Pengabdian Masyarakat Cendekia Journal of Pharmacy Madani : Indonesian Journal of Civil Society Empiricism Journal Pharmaqueous Jurnal Tumbuhan Obat Indonesia Jurnal Ilmiah Nusantara
Tajudin, Tatang
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Pengaruh Minyak Sacha Inchi (Plukenetia volubilis L.) terhadap Kadar MDA Plasma Tikus Wistar Diinduksi Klorpirifos Rahayu, Putri; Tajudin, Tatang; Pertiwi, Yuniariana
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 13 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v13i1.20756

Abstract

The use of chlorpyrifos remains prevalent in Indonesia, and excessive exposure can trigger oxidative stress, as indicated by increased Malondialdehyde (MDA) levels. Sacha inchi oil (Plukenetia volubilis L.) contains antioxidant compounds that may mitigate oxidative stress. This study investigated the effect of sacha inchi oil on plasma MDA concentrations, Body Weight (BW), and clinical parameters in male Wistar rats exposed to chlorpyrifos. Thirty rats were allocated to five groups (n=6 per group): a normal control, a negative control (chlorpyrifos 10 mg/kg BW/day), and three treatment groups receiving sacha inchi oil orally at doses of 1, 2, and 4 mL/kg BW/day for 28 days. Plasma MDA levels were measured using the TBARS method with spectrophotometric detection at 532 nm, and data were analysed by One-Way ANOVA followed by Tukey’s HSD test. Chlorpyrifos exposure increased MDA levels (18.83 nmol/mL) compared with the normal control, whereas sacha inchi oil reduced MDA levels in a dose-dependent manner to 11.32, 8.98, and 3.90 nmol/mL (p<0.05). Supplementation promoted BW gain and ameliorated clinical manifestations, including lethargy, alopecia, and increased respiratory rate, with no mortality observed in treated groups. Sacha inchi oil exhibited protective effects against chlorpyrifos-induced oxidative stress, demonstrating maximal efficacy at 4 mL/kg BW/day.
Co-Authors Ajeng Puspo Aji Ananta, Sella Dwi Anggaraksa, Wiman Arumsari, Putri Aryani, Feby Putri Dede Yusuf, Dede Dewi, Dian Mustika Elisa Issusilaningtyas Erniawati Farabi, Meka Faizal Faradiba, Velya INDRA RACHMAWATI Indratmoko , Septiana Kencana Dwi Pangesti, Nanda Kurniawati, Marina Lufi, Afi Himawan Mika Tri Kumala Swandari, Mika Tri Kumala Mubarak, Zulfikar Yusya Natasya Sefiani, Herlin Nugroho, Ikhwan Dwi Wahyu Nur Triwibowo, Rony Nurrahman, Asep Nurwibowo, Fajar Nuswantari, Ervina Laely Pertiwi, Yuniariana Prawatya, Adecya Nur Puspoaji, Ajeng Rahayu, Putri Reja Rafli, Afan Rini Susanti Rochmah, Nikmah Nur Setiyabudi , Lulu Susanti , Susanti Tofik Hidayat Tri Yuwono, Tri Trikumalaswandari, Mika Utami, Tri Fitri Yana Wahyuningtyas, Adika Wardani, Tri Kusuma Yuliartanti, Yesi