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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Adi Widya : Jurnal Pengabdian Masyarakat Cendekia Journal of Pharmacy Madani : Indonesian Journal of Civil Society Empiricism Journal Pharmaqueous Indonesian Journal of Pharmacy and Natural Product Jurnal Tumbuhan Obat Indonesia Jurnal Ilmiah Nusantara
Tajudin, Tatang
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Potensi Squalen dalam Anti-aging: Tinjauan Literatur Review Arumsari, Putri; Tajudin, Tatang; Indratmoko, Septiana; Issusilaningtyas, Elisa
Empiricism Journal Vol. 7 No. 1: March 2026
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/skqxqk05

Abstract

Penuaan kulit semakin mendapat perhatian, namun pemahaman tentang peran senyawa alami sebagai agen anti-aging masih perlu diperdalam. Squalene, senyawa triterpen hidrokarbon alami (C30H50) yang ditemukan dalam minyak hati ikan hiu, minyak zaitun, amaranth, dedak padi, serta mikroba rekayasa genetik, menarik perhatian sebagai bahan aktif anti-aging alami. Kajian ini bertujuan menganalisis kandungan aktif, mekanisme kerja, bentuk konsumsi, dan bukti ilmiah squalene dalam potensi anti-aging melalui pendekatan systematic literature review. Penelitian ini menganalisis 14 artikel dari bidang kosmetologi, dermatologi, dan bioteknologi farmasi (2016-2025), yang sebagian besar merupakan penelitian eksperimental (in vitro, ex vivo, dan in vivo) serta beberapa studi klinis awal. Hasil menunjukkan bahwa squalene bekerja melalui empat mekanisme utama: aktivitas antioksidan (menetralkan ROS, menekan MMP-1, mengaktifkan jalur Nrf2/ARE), antiinflamasi (menghambat NF-KB dan sitokin proinflamasi), fotoprotektif (mencegah peroksidasi lipid akibat UV), dan regeneratif (menstimulasi TGF-B untuk pembentukan kolagen). Formulasi nanoemulsi dan oleogel berbasis squalene efektif meningkatkan kondisi kulit. Squalene nabati, seperti dari minyak zaitun dan amaranth, menunjukkan efektivitas setara dengan sumber hewani, mendukung keberlanjutan dan etika produksi kosmetik. Squalene berpotensi sebagai bahan aktif anti-aging generasi baru yang aman, efektif, dan ramah lingkungan, namun kajian lebih lanjut diperlukan untuk menilai efektivitas jangka panjang dan dosis optimalnya. The Potential of Squalene in Anti-aging: A Literature Review Abstract Skin aging is becoming an increasingly recognized issue, but understanding the role of natural compounds as anti-aging agents still requires further exploration. Squalene, a natural triterpene hydrocarbon (C30H50) found in shark liver oil, olive oil, amaranth, rice bran, and genetically engineered microbes, has gained attention as a natural anti-aging active ingredient. This review aims to analyze the active content, mechanisms of action, consumption forms, and scientific evidence supporting the anti-aging potential of squalene through a systematic literature review approach. The study analyzes 14 articles from the fields of cosmetology, dermatology, and pharmaceutical biotechnology (2016-2025), mostly experimental research (in vitro, ex vivo, and in vivo) supported by some early clinical studies. The results show that squalene works through four main mechanisms: antioxidant activity (neutralizing ROS, inhibiting MMP-1, activating Nrf2/ARE pathway), anti-inflammatory (inhibiting NF-KB and pro-inflammatory cytokines), photoprotective (preventing lipid peroxidation due to UV), and regenerative (stimulating TGF-B for collagen formation). Squalene-based nanoemulsion and oleogel formulations effectively improve skin conditions. Plant-based squalene, such as from olive oil and amaranth, shows comparable effectiveness to animal sources, supporting sustainability and ethical considerations in modern cosmetic production. Overall, squalene has great potential as a new generation of safe, effective, and environmentally friendly anti-aging active ingredients, though further studies are needed to assess long-term effectiveness and optimal dosages.
Pengaruh Minyak Sacha Inchi (Plukenetia volubilis L.) terhadap Kadar MDA Plasma Tikus Wistar Diinduksi Klorpirifos Rahayu, Putri; Tajudin, Tatang; Pertiwi, Yuniariana
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 13 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v13i1.20756

Abstract

The use of chlorpyrifos remains prevalent in Indonesia, and excessive exposure can trigger oxidative stress, as indicated by increased Malondialdehyde (MDA) levels. Sacha inchi oil (Plukenetia volubilis L.) contains antioxidant compounds that may mitigate oxidative stress. This study investigated the effect of sacha inchi oil on plasma MDA concentrations, Body Weight (BW), and clinical parameters in male Wistar rats exposed to chlorpyrifos. Thirty rats were allocated to five groups (n=6 per group): a normal control, a negative control (chlorpyrifos 10 mg/kg BW/day), and three treatment groups receiving sacha inchi oil orally at doses of 1, 2, and 4 mL/kg BW/day for 28 days. Plasma MDA levels were measured using the TBARS method with spectrophotometric detection at 532 nm, and data were analysed by One-Way ANOVA followed by Tukey’s HSD test. Chlorpyrifos exposure increased MDA levels (18.83 nmol/mL) compared with the normal control, whereas sacha inchi oil reduced MDA levels in a dose-dependent manner to 11.32, 8.98, and 3.90 nmol/mL (p<0.05). Supplementation promoted BW gain and ameliorated clinical manifestations, including lethargy, alopecia, and increased respiratory rate, with no mortality observed in treated groups. Sacha inchi oil exhibited protective effects against chlorpyrifos-induced oxidative stress, demonstrating maximal efficacy at 4 mL/kg BW/day.
Co-Authors Ajeng Puspo Aji Ananta, Sella Dwi Anggaraksa, Wiman Arumsari, Putri Aryani, Feby Putri Dede Yusuf, Dede Dewi, Dian Mustika Elisa Issusilaningtyas Erniawati Fadilah, Ilham Farabi, Meka Faizal Faradiba, Velya Iis Wahyuningsih INDRA RACHMAWATI Indratmoko , Septiana Kencana Dwi Pangesti, Nanda Kurniawati, Marina Lufi, Afi Himawan Mika Tri Kumala Swandari, Mika Tri Kumala Mubarak, Zulfikar Yusya Natasya Sefiani, Herlin Nugroho, Ikhwan Dwi Wahyu Nur Triwibowo, Rony Nurrahman, Asep Nurwibowo, Fajar Nuswantari, Ervina Laely Pertiwi, Yuniariana Prawatya, Adecya Nur Puspoaji, Ajeng Rahayu, Putri Reja Rafli, Afan Rini Susanti Rochmah, Nikmah Nur Setiyabudi , Lulu Susanti , Susanti Tofik Hidayat Tri Yuwono, Tri Trikumalaswandari, Mika Utami, Tri Fitri Yana Wahyu Widyaningsih Wahyuningtyas, Adika Wardani, Tri Kusuma Yulianto, Asep Nurrahman Yuliartanti, Yesi