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All Journal Jurnal Ilmu Pertanian VALENSI Indonesia Chimica Acta Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry Jurnal Pengabdian Magister Pendidikan IPA jurnal Ilmu Pertanian (Agricultural Science) Acta Chimica Asiana Jurnal Ilmiah Abdi Mas TPB Unram Jurnal Warta Desa (JWD) Jurnal Pendidikan dan Pengabdian Masyarakat Jurnal Pengabdian Inovasi Masyarakat Indonesia Molekul: Jurnal Ilmiah Kimia Jurnal Ilmiah Multidisiplin
Tri Dharmayani, Ni Komang
Universitas Mataram
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Materials Science & Nanotechnology Physics Social Sciences Other

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Isolasi Metabolit Sekunder dan Uji Aktivitas Antibakteri Pada Ekstrak Metanol Temu Kunci (Boesembergia Pandurata) Wahidatun, Wahidatun; Dharmayani, Ni Komang Tri; Ulfa, Maria; Yuanita, Emmy; Hermawati, Elvira
Jurnal Ilmiah Multidisipin Vol. 2 No. 12 (2024): Jurnal Ilmiah Multidisiplin, Desember 2024
Publisher : Lumbung Pare Cendekia

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Abstract

Temu kunci merupakan salah satu tanaman yang banyak dijumpai di beberapa daerah di Indonesia dan memiliki berbagai macam potensi dalam bidang farmakologi. Pada penelitian ini telah dilakukan isolasi dan uji aktivitas antibakteri dari temu kunci (Boesembergia pandurata) asal Dompu. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder pada temu kunci dan aktivitasnya sebagai antibakteri. Proses isolasi dilakukan dalam beberapa tahapan yaitu ekstraksi, pemisahan dan pemurnian. Metode ekstraksi yang digunakan yaitu maserasi dengan pelarut metanol. Ekstrak metanol yang diperoleh selanjutnya dilakukan pemisahan dan pemurnian dengan menggunakan berbagai teknik kromatografi, seperti Kromatografi Lapis Tipis (KLT), Kromatografi Vakum Cair (KVC) dan Kromatografi Kolom Gravitasi (KKG) serta diidentifikasi menggunakan spektroskopi Nuclear Magnetic Resonance (NMR) satu dimensi (1H-NMR dan 13C-NMR). Berdasarkan hasil analisis spektroskopinya senyawa hasil isolasi yang diperoleh yaitu bis-(2-etilheksil) ftalat dan merupakan turunan dari asam ftalat. Selanjutnya dilakukan uji aktivitas antibakteri terhadap bakteri Gram positif (Staphylococcus aureus ATCC 25923) dan bakteri Gram negatif (Escherichia coli ATCC 25922) menggunakan metode difusi sumuran dengan konsentrasi ekstrak metanol 600 ppm dan senyawa bis-(2-etilheksil) ftalat menggunakan tiga variasi konsentrasi yaitu 50, 100, 150 ppm. Hasil pengujian antibakteri menunjukkan zona hambat terhadap bakteri S.aureus berturut-turut 12,33; 13; 15,33; dan 16,66 mm sedangkan terhadap bakteri E. coli berturut-turut 11,67; 13,33; 14,67; dan 15,33. Hasil uji tersebut menunjukkan bahwa ekstrak metanol dan senyawa hasil isolasi memiliki aktivitas antibakteri terhadap bakteri S.aureus dan E. coli.
Enhanced Methods for Synthesizing Hydroxyxanthone Using Eaton and ZnCl2 Catalyst with Microwave Irradiation Yuanita, Emmy; Eryani, Farica; Septiyana, Maulida; Lestarini, Ima Arum; Dharmayani, Ni Komang Tri; Sugara, Taufan Hari
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.753-758

Abstract

The methods for synthesizing hydroxyxanthone compounds are continually advancing. Among these, microwave-assisted organic synthesis (MAOS) has emerged as a particularly advantageous technique due to its reduced reaction times, improved yields, and enhanced selectivity. This study reports the efficient synthesis of 3,7 dihydroxyxanthone through the reaction of 2,5-dihydroxybenzoate and resorcinol, using Eaton’s reagent and zinc chloride (ZnCl2) as catalyst under MAOS conditions. The structures of the resulting compounds were analyzed using Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR). The efficiency of the catalytic systems was evaluated based on the product yields. The Eaton reagent catalysis resulted in a 9.38% yield of a red solid, while the ZnCl2-catalyzed reaction produced a significantly higher yield of 23.07%, with the product appearing as an orange solid. These results demonstrate that Zn
Hydrophilic Surfaces Turning of Graphene Nano Platelets by 1,3,6-Trihydroxyxanthone: π–π Stacking Interaction Affair in 2-D Yuanita, Emmy; Sirojuttolibin, Sirojuttolibin; Dharmayani, Ni Komang Tri; Ulfa, Maria; Septiyana, Maulida; Sudirman, Sudirman
Indonesian Journal of Chemistry Vol 25, No 3 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.89894

Abstract

Graphene nanoplatelet (GNP) has a good potential to be developed as a drug carrier material. In this study, the interaction of GNP with one type of drug, namely 1,3,6-trihydroxyxanthone (THX), has been studied. The results of XRD analysis and FTIR uptake show an excellent interaction between THX and GNP through the π–π stacking channel. This interaction makes the GNP surface more polar and soluble in the aqueous media. THX-graphene shows physical and chemical stabilities, where THX can be released under specific and controlled conditions. The results of this study show the potential of utilizing graphene as a drug carrier material for more specific disease targets with a longer drug release time.
Co-Authors Anjartikasari, Nurul Ari Jamhari Pratama Baiq Nila Sariningsih Baiq Nurmayana Cahyani, Ni Wayan Chyntia Pramesti Devy Febriana Dewi Fitri Nur’afuddin Dhoni Hermanto DIAN LESTARI Emmy Yuani Emmy Yuanita Emmy Yuanita Emmy Yuanita Emmy Yuanita Emmy Yuanita Emmy Yuanita Ernidasari Rohmati Erwin Jayadi Putra Eryani, Farica Haviz, Nur Vinna Hayani, Hafiyatul Hermawati, Elvira I MADE SUDARMA Ima Arum Lestarini Inda Noviani Inggit Garnasih Ira Agustina Isnaini Iwan Sumarlan Jufrizal Syahri Kadek Yefta Christian Lalu Dimas Pratama Atmaja Made Ganesh Darmayanti Maria Ulfa Maria Ulfa Maria Ulfa Maria Ulfa Maria Ulfa Maulida Septiyana Muhammad Suprodi Suprodi Ni Ketut Santi Rahayu Ningsih, Baiq Nila Sari Nur Indrianingsih M.G Indrianingsih Nurlely Shabna Syundari Ratnasari, Baiq Desy Ridho Abdi Saputra RINA KURNIANINGSIH Rizkyani, Azizah Rohmana, Ainni Romel Hidayat Saprizal Hadisaputra Septiari, Wayan Uni Sirojuttolibin, Sirojuttolibin Siti Raudhatul Kamali Sri Seno Handayani Sudewianingsih, Ni Made Sudirman Sudirman Sudirman Sudirman Sudirman Sudirman Sudirman Sudirman Sudirman Sudirman Surya Hadi Surya Hadi Surya Hadi Tamara, Cynthia Claudia Taufan Hari Sugara Wahidatun, Wahidatun