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All Journal Jurnal Ilmu Pertanian VALENSI Jurnal Riset Kimia Indonesia Chimica Acta Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry Jurnal Pengabdian Magister Pendidikan IPA jurnal Ilmu Pertanian (Agricultural Science) EIGEN MATHEMATICS JOURNAL Acta Chimica Asiana Jurnal Ilmiah Abdi Mas TPB Unram Jurnal Diferensial Jurnal Warta Desa (JWD) Journal of Fundamental Mathematics and Applications (JFMA) Jurnal Pendidikan dan Pengabdian Masyarakat Jurnal Pengabdian Inovasi Masyarakat Indonesia Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu-Ilmu Pertanian
Tri Dharmayani, Ni Komang
Universitas Mataram
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Materials Science & Nanotechnology Mathematics Physics Public Health Social Sciences Other

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Modified Bacterial Cellulose-Based Composite Profile for Drug Release of Tetracycline Hydrochloride Cahyani, Ni Wayan Chyntia Pramesti; Yuanita, Emmy; Dharmayani, Ni Komang Tri; Sudirman, Sudirman; Sudewianingsih, Ni Made; Ulfa, Maria
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.37663

Abstract

Bacterial cellulose (BC) is a biodegradable natural polymer with high mechanical strength and non-toxicity. This biopolymer is widely used as a candidate in biomedical fields, such as drug delivery, wound healing, and filtration systems. However, BC lacks antibacterial activity which limits its use in biomedical applications. So, modification of BC-based composite is required. This study aims to examine the effects of modifying BC-based composites with fillers such as graphite (G) and polyvinyl alcohol (PVA) on the release of tetracycline hydrochloride (TCH) drugs. Adding fillers to BC can alter its physical and mechanical properties, reducing its porosity and swelling rate in acidic and alkaline mediums. The drug release of TCH from modified BC-based composites follows the Korsmeyer-Peppas and Hixson-Crowell kinetics models. Adding filler and TCH antibiotic to the composite enhances its antibacterial activity against Staphylococcus aureus with a significant inhibition zone. The results of the inhibition zone show that composites have the potential to be applied in biomedical fields, especially in transdermal patches.
Modified Bacterial Cellulose-Based Composite Profile for Drug Release of Tetracycline Hydrochloride Cahyani, Ni Wayan Chyntia Pramesti; Yuanita, Emmy; Dharmayani, Ni Komang Tri; Sudirman, Sudirman; Sudewianingsih, Ni Made; Ulfa, Maria
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.37663

Abstract

Bacterial cellulose (BC) is a biodegradable natural polymer with high mechanical strength and non-toxicity. This biopolymer is widely used as a candidate in biomedical fields, such as drug delivery, wound healing, and filtration systems. However, BC lacks antibacterial activity which limits its use in biomedical applications. So, modification of BC-based composite is required. This study aims to examine the effects of modifying BC-based composites with fillers such as graphite (G) and polyvinyl alcohol (PVA) on the release of tetracycline hydrochloride (TCH) drugs. Adding fillers to BC can alter its physical and mechanical properties, reducing its porosity and swelling rate in acidic and alkaline mediums. The drug release of TCH from modified BC-based composites follows the Korsmeyer-Peppas and Hixson-Crowell kinetics models. Adding filler and TCH antibiotic to the composite enhances its antibacterial activity against Staphylococcus aureus with a significant inhibition zone. The results of the inhibition zone show that composites have the potential to be applied in biomedical fields, especially in transdermal patches.
Co-Authors Anjartikasari, Nurul Ardana, Alfian Putra Ari Jamhari Pratama Baiq Nurmayana Budiana, Irwan Cahyani, Ni Wayan Chyntia Pramesti Devy Febriana Dewi Fitri Nur’afuddin Dhoni Hermanto DIAN LESTARI Emmy Yuani Emmy Yuanita Emmy Yuanita Emmy Yuanita Emmy Yuanita Emmy Yuanita Ernidasari Rohmati Erwin Jayadi Putra Eryani, Farica Haviz, Nur Vinna Hayani, Hafiyatul Hermanto, Dhoni Hermawati, Elvira Hidayat, Muhammad Ahsan I Gede Adhitya Wisnu Wardhana I MADE SUDARMA Ima Arum Lestarini Inggit Garnasih Ira Agustina Isnaini Iwan Sumarlan Jufrizal Syahri Kadek Yefta Christian Lalu Dimas Pratama Atmaja Lestari, Dia Luzianawati, Luzianawati Made Ganesh Darmayanti Maria Ulfa Maria Ulfa Maria Ulfa Maria Ulfa Maulida Septiyana Miftahurrahman, Miftahurrahman Mufarrihati, Ardelia Muhammad Suprodi Suprodi Ni Ketut Santi Rahayu Ningsih, Apriliya Ningsih, Baiq Nila Sari Noviani, Inda Nur Indrianingsih M.G Indrianingsih Nurlely Shabna Syundari Nursofia, Baiq Ike Pratiwi, Lia Fitta Putri, Baiq Yusmiar Aulia Putri, Syaftirridho Ramdhani, Restu Agung Ridho Abdi Saputra RINA KURNIANINGSIH Rizkyani, Azizah Romel Hidayat Sabil, M. Ibnu Saprizal Hadisaputra Sariningsih, Baiq Nila Septiari, Wayan Uni Sirojuttolibin, Sirojuttolibin Siti Raudhatul Kamali Sri Seno Handayani Sudewianingsih, Ni Made Sudirman Sudirman Sudirman Sudirman Sudirman Sudirman Sudirman Sudirman Sudirman Sukmaningrum, Afif Dwi Surya Hadi Surya Hadi Surya Hadi Tamara, Cynthia Claudia Taufan Hari Sugara Tsani, M. Khairul Wahidatun, Wahidatun