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All Journal MEDISAINS CHEMPUBLISH JOURNAL Acta Pharmaciae Indonesia : Acta Pharm Indo JFL : Jurnal Farmasi Lampung PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM PROFESI (Profesional Islam): Media Publikasi Penelitian Jurnal Mandala Pengabdian Masyarakat Archive: Jurnal Pengabdian Kepada Masyarakat Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Panacea Jurnal Ilmiah Kesehatan Keperawatan Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Global Health Research
Wahyu Rahmatulloh
Universitas Muhammadiyah Gombong
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Optimalisasi Potensi Lokal melalui Pelatihan Pengolahan Ikan Lele menjadi Abon bagi KWT untuk Meningkatkan Kemandirian Ekonomi Perempuan Desa Bogangin, Kacamatan Sumpiuh, Kabupaten Banyumas Qomar, Umi Laelatul; Rahmatullah, Wahyu; Pratama, Wilson Candra Teguh; Sujono, Tanti Azizah; Muhtadi, Muhtadi; Putro, Sartono; Rahmadhani, Wulan; Dewi, Adinda Putri Sari
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 12 (2025): Volume 8 No 12 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i12.23253

Abstract

ABSTRAK Pemanfaatan potensi lokal menjadi salah satu upaya strategis dalam meningkatkan kemandirian ekonomi masyarakat pedesaan. Desa Bogangin, Kecamatan Sumpiuh, memiliki potensi besar di sektor perikanan air tawar, khususnya budidaya ikan lele. Namun, keterbatasan pengetahuan dan keterampilan masyarakat, terutama kelompok wanita tani (KWT), dalam mengolah hasil perikanan menjadi produk bernilai ekonomi tinggi masih menjadi kendala. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan kemampuan anggota KWT dalam mengolah ikan lele menjadi abon sebagai produk olahan yang memiliki daya jual tinggi dan daya simpan panjang. Metode kegiatan meliputi penyuluhan, pelatihan praktis pembuatan abon lele, pendampingan manajemen usaha, dan strategi pemasaran digital. Hasil kegiatan menunjukkan peningkatan pengetahuan dan keterampilan peserta sebesar 85%, serta munculnya inisiatif KWT untuk membentuk usaha bersama dalam skala rumah tangga. Kegiatan ini berkontribusi nyata terhadap pemberdayaan ekonomi perempuan dan penguatan potensi lokal berbasis sumber daya desa. Kata Kunci: KWT, Abon Lele, Pemberdayaan Perempuan, Potensi Lokal, Ekonomi Desa.  ABSTRACT Utilizing local potential is one of the strategic efforts to enhance the economic independence of rural communities. Bogangin Village, located in Sumpiuh Subdistrict, has great potential in the freshwater fisheries sector, particularly in catfish farming. However, the limited knowledge and skills of the community—especially the Women Farmers Group (KWT)—in processing fishery products into high-value economic commodities remain a challenge. This community service activity aims to improve the ability of KWT members to process catfish into shredded fish (abon) as a value-added product with high market potential and long shelf life. The methods used include counseling, hands-on training in making shredded catfish, business management assistance, and digital marketing strategies.The results show an 85% increase in participants’ knowledge and skills, as well as the emergence of an initiative from the KWT to establish a joint household-scale business. This activity has made a tangible contribution to women’s economic empowerment and the strengthening of local potential based on village resources. Keywords: Women Farmers Group (KWT), Shredded Catfish, Women’s Empowerment, Local Potential, Village Economy.
Hubungan Tingkat Distress Terhadap Luaran Terapi Pada Pasien Diabetes Melitus Tipe 2 di RSUD dr. Soedirman kebumen Nugroho, Fani Alan; Rahmatulloh, Wahyu; Khuluq, Muh Husnul
Jurnal Ilmiah Kesehatan Keperawatan Vol 21, No 2 (2025): JURNAL ILMIAH KESEHATAN KEPERAWATAN
Publisher : LPPM UNIVERSITAS MUHAMMADIYAH GOMBONG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jikk.v21i2.1746

Abstract

Latar Belakang: Diabetes merupakan penyakit yang masih menjadi masalah besar dalam kesehatan global, dimana tidak hanya mempengaruhi aspek fisik tetapi juga berdampak besar pada kesehatan psikologis pasien. Pasien dengan diabetes melitus tipe 2 memiliki resiko lebih tinggi mengalami diabetes distress.Tujuan Penelitian: Mengetahui hubungan antara tingkat distress terhadap luaran terapi pada pasien diabetes melitus tipe 2 di RSUD Dr. Soedirman Kebumen.Metode Penelitian: Metode kuantitatif dengan desain analisis korelasional dengan pendekatan cross sectional. Instrumen yang digunakan adalah kuesioner Diabetes Distress Scale (DDS). Subjek penelitian 100 pasien diabetes melitus tipe 2 di RSUD Dr. Soedirman Kebumen. Analisis data menggunakan uji statistik Spearman’s rho.Hasil Penelitian: Uji statistik Spearman’s rho diperoleh nilai p-value 0,000 hal ini menunjukkan terdapat hubungan antara tingkat distress terhadap luaran terapi pada pasien diabetes melitus tipe 2 di RSUD Dr. Soedirman Kebumen. Nilai koefisien korelasi 0,494 menunjukkan adanya tingkat kekuatan hubungan yang sedang dan nilainya positif.Kesimpulan: Terdapat hubungan antara tingkat distress terhadap luaran terapi pada pasien diabetes melitus tipe 2 di RSUD Dr. Soedirman Kebumen dengan tingkat kekuatan hubungan sedang, semakin berat tingkat distress maka semakin buruk luaran terapi.Rekomendasi: Diharapkan dapat untuk melakukan penelitian lebih lanjut dengan desain yang lebih kuat, seperti studi longitudinal atau intervensi, serta cakupan yang lebih luas.
The relationship between medication compliance and therapy outcome in outpatients patient with type 2 diabetes mellitus at PKU Muhammadiyah Gombong Hospital: The Relationship Between Medication Compliance And Therapy Outcome In Outpatients Patient With Type 2 Diabetes Mellitus At PKU Muhammadiyah Gombong Hospital Sarwoko, Sarwoko; Widiastuti, Tri Cahyani; Rahmatulloh, Wahyu; Sodik, Anwar
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/qzb9ep23

Abstract

Diabetes is a metabolic condition characterized by chronic hyperglycemia due to decreased insulin synthesis or insulin resistance. The prevalence of type 2 diabetes mellitus in Central Java has increased by 0.5%. The aim of this study was to determine the relationship between medication adherence and therapeutic outcomes in outpatients with type 2 diabetes mellitus at PKU Muhammadiyah Gombong Hospital. The study used a non-experimental method with an analytical and descriptive cross-sectional design and a prospective approach (observing respondent adherence) for 3 months of treatment. The level of adherence to drug therapy in type 2 diabetes mellitus patients at the Outpatient Installation of PKU Muhammadiyah Gombong Hospital was dominated by the category of moderately adherent (70 patients) , non-adherent (28 patients) , and adherent (2 patients) . The results of the Spearman rho statistical test indicated a p-value of 0.000 (p<0.05) for both outcome parameters (HbA1c and GDS). The correlation between adherence scores and HbA1c was -0.830 (a very strong correlation), while the correlation with GDS was -0.463 (a moderately strong correlation). There was a significant correlation between medication adherence and therapeutic outcomes in patients with type 2 diabetes mellitus at the Outpatient Unit of PKU Muhammadiyah Gombong Hospital.
Exploration of Belitung Taro Stems (Xanthosoma sagittifolium) as an Antidiabetic Candidate: An In Silico and In Vitro Approach Rahmatulloh, Wahyu; Supriyanto, Sugeng; Saputra, Aditya Mahe; Rahma, Nabila Aulia
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.48655

Abstract

Diabetes mellitus is a global metabolic disorder characterized by chronic hyperglycemia. While conventional oral antidiabetics are effective, their long-term use is associated with adverse side effects, necessitating the search for safer alternatives from natural sources. Belitung taro (Xanthosoma sagittifolium) is a locally abundant tuber crop in Indonesia, but its stems are typically discarded as agricultural by-products despite their potential bioactive content. This study evaluated the antidiabetic potential of X. sagittifolium stem extract by investigating its α-amylase inhibitory activity through an integrative in silico and in vitro approach. In silico screening was performed on eight secondary metabolites from the CMAUP database, filtered based on Lipinski's Rule of Five and ADMET profiles using the pkCSM server. The lead compound, NPC141921, was docked into human pancreatic α-amylase (PDB ID: 2QV4) using AutoDock, validated by redocking acarbose. The ethanol extract was subjected to phytochemical screening and tested for α-amylase inhibition using the iodine-starch assay. NPC141921 showed a binding free energy of -6.13 kcal/mol, comparable to acarbose (-6.66 kcal/mol), forming stable hydrogen bonds with catalytic residues (ASP197, GLU233, ASP300) and substrate-binding residues (ARG195, HIS305). Phytochemical screening confirmed flavonoids, tannins, saponins, and steroids, supporting the in silico predictions. In vitro assays revealed an IC₅₀ of 5028 ppm for the stem extract versus 1953 ppm for acarbose. Although the crude extract showed lower potency due to matrix dilution effects, the findings confirm that X. sagittifolium stems contain bioactive metabolites capable of α-amylase inhibition, highlighting their potential as a natural ingredient for hyperglycemia management.
Antidiabetic Potential of Combined Extracts of Ageratum Conyzoides and Cyperus Rotundus: in Vivo Study Wahyu Rahmatulloh; Laeli Fitriyati; Tri Cahyani Widiastuti; Dwiana Rahmi Nur Rofiqoh; Aryadi Suryanata Kusuma; Muh Fathurrahman
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.808

Abstract

Long-term use of synthetic antidiabetic drugs often causes side effects, prompting the search for safer herbal alternatives. Ageratum conyzoides and Cyperus rotundus are known for their antihyperglycemic properties, but studies on their combination remain limited. To evaluate the antihyperglycemic effect of combined ethanol extracts of A. conyzoides leaves and C. rotundus rhizomes in streptozotocin (STZ)-induced diabetic rats. Male white rats were divided into nine groups: control, single extract, and combination treatments (100:200 and 150:500 mg/kg BW). Treatments were given orally for 15 days, and blood glucose levels were measured periodically. Data were analyzed using one-way ANOVA and Tukey's post hoc test. The combination of A. conyzoides and C. rotundus (150:500 mg/kg BW) significantly reduced blood glucose levels, comparable to glimepiride (p < 0.05 vs. negative control; p > 0.05 vs. positive control). Single extracts showed moderate effects in a dose-dependent manner. The combination of A. conyzoides and C. rotundus extracts exhibited synergistic antihyperglycemic activity, suggesting potential as a safe phytotherapeutic alternative for diabetes management.
Co-Authors Abrori, Fadhil Agustina, Resti Ainni, Ayu Nissa Anwar Sodik, Anwar Ari Purnomo Aji Aryadi Suryanata Kusuma Ayu, Ayu Ainni Dewi, Adinda Putri Sari Diah Kurniasih Dwiana Rahmi Nur Rofiqoh Dwiki Fitri Dyah Aryani Perwitasari Fitriyati, Laeli Haafizah Dania Imaniar Noor Faridah Khuluq, Muh Husnul Kiromah, Naelaz Zukhruf Wakhidatul Kusumaningsih, Wiji Sri Laeli Fitriyati Lalu Muhammad Irham Menit Ardhiani Miyarso, Chondrosuro Muh Fathurrahman Muhtadi Muhtadi Naelaz Zukhruf Wakhidatul Kiromah Nugroho, Fani Alan Nurhawa, Rosmadianti Hujjatun Pratama, Wilson Candra Teguh Qubro, Khodijah Karimatul Al Rahayu, Titi Pudji Rahma, Nabila Aulia Ristiyorini, Iin Saputra, Aditya Mahe Sartono Putro Sarwoko Sarwoko Sinta Wahyu Septiani Supartiningsih, Sinta Supriyanto, Sugeng Tanti Azizah Sujono Tiara, Hayyu Listina Martha TITI PUDJI RAHAYU Tri Cahyani Widiastuti umi laelatul qomar Widiastuti, Tri Cahyani Winarno, Tunjung Wulan Rahmadhani, Wulan Zakhroh, Siti Aminatun