Article Per Year (5 Year)
p-Index From 2021 - 2026
2.405
P-Index
This Author published in this journals
All Journal Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Jurnal Kreativitas PKM Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Pharmacoscript Cendekia : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Farmako Bahari Jurnal Abdimas Kartika Wijayakusuma Jurnal Farmasi Galenika
Fajarwati, Kania
Fakultas Farmasi, Universitas Bhakti Kencana
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Network Pharmacology-Guided Identification of Antiaging Targets of Lavandula Flower Bioactives Using LC–MS/MS and Molecular Simulation Approaches Syafnir, Livia; Fajarwati, Kania; Faizal, Ibnu Dharsono; Fakih, Taufik Muhammad
MPI (Media Pharmaceutica Indonesiana) Vol. 8 No. 1 (2026): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v8i1.8597

Abstract

Lavandula flowers are widely used in cosmetic and dermatological formulations, yet the molecular basis of their antiaging activity remains incompletely understood. This study aimed to elucidate the antiaging potential of lavandula flower bioactives through LC–MS/MS-based metabolite profiling integrated with network pharmacology and molecular docking analysis. Metabolites were characterized using LC–MS/MS and annotated based on accurate mass and fragmentation patterns. Predicted targets of selected metabolites were obtained using in silico target prediction and intersected with antiaging-related genes to construct protein–protein interaction networks and identify key regulatory pathways. Molecular docking was performed to evaluate binding affinity and interaction modes between prioritized metabolites against JAK2. LC–MS/MS analysis revealed a diverse chemical profile dominated by carveol (16.12%), methylumbelliferone (8.77%), camphor (3.97%), and two late-eluting high-molecular-weight metabolites contributing 29.86% and 35.36% of the total peak area. Network pharmacology highlighted convergence on kinase-driven signaling, extracellular matrix regulation, inflammatory response, and oxidative stress pathways relevant to skin aging. The docking results against JAK2 showed that the substituted pyridin-4-ol derivative exhibited the strongest affinity among Lavandula metabolites (ΔG = −8.81 kcal/mol), followed by the piperidinyl-substituted trienone (ΔG = −7.92 kcal/mol), while methylumbelliferone (ΔG = −5.93 kcal/ mol) and ferulic acid (ΔG = −5.53 kcal/mol) displayed moderate binding. Lavandula flower bioactives exhibit antiaging potential through multitarget modulation of signaling and matrix-associated proteins, supported by quantitative metabolite profiling and docking-validated target engagement.
Co-Authors Amida Sriwianti Sarbini Andriansyah, Ivan Aris Suhardiman Budiana, Wempi Daryanti, Eneng Denni Fransiska Eki Pratidina Emma Emawati, Emma Faizal, Ibnu Dharsono Fauza, M. Reda Helena Marpaung Ika Kurnia Sukmawati M. Reda Fauza Mardiana, Neng Dian Marlina, Yani Nazarul Mastura Nova Riani Nurfazri, Aulia Pratama, Reza Purwaniati, Purwaniati - Reni Nurdianti Rizki Muliani Roni, Asep Salsha Rosilopya Saputro, M. Ramadhan Selifiana, Nita Sutrisno, Entris Syafnir, Livia Taufik Muhammad Fakih Yakobus L Sinaga Yani Mulyani