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All Journal International Journal of Public Health Science (IJPHS) E-Jurnal Medika Udayana Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Microbiology Indonesia Health Science Journal of Indonesia Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Andalas Jurnal Fitofarmaka Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Pharmacology and Clinical Pharmacy Research Jurnal Kreativitas PKM Majalah Kedokteran Andalas Healthcare Nursing Journal Muhammadiyah Medical Journal Cermin Dunia Kedokteran eJournal Kedokteran Indonesia Berita Kedokteran Masyarakat Mutiara: Multidiciplinary Scientifict Journal Jurnal Penelitian Keperawatan Cermin Dunia Kedokteran
Mardhia Mardhia
Departemen Mikrobiologi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianak
Arts Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Understanding priorities: cervical cancer prevention in senior high school Dhaifina Putri Windini; Abror Irsan; Mardhia Mardhia
BKM Public Health and Community Medicine Vol 39 No 08 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v39i8.5294

Abstract

Purpose: The study aims to determine the knowledge and priority of prevention issues of health education on senior high school student's knowledge about HPV and cervical cancer. Methods: The research method was quasi-experimental with a one-group pretest-posttest design. The respondents were 42 students from class XI at SMAN 3, Pontianak, Kalimantan Barat. Data analysis used a paired T-test. One of the methods to increase community knowledge, especially adolescents, about HPV and cervical cancer is through health education. Results: Before health education, respondents who had good knowledge were 37 people. After health education, all respondents had good knowledge. The paired T-test showed a significance of p 0,00 (p <0.05). There was an effect of health education on the level of knowledge about cervical cancer before and after intervention. Conclusion: HPV and cervical cancer health education showed effectiveness in increasing knowledge about HPV and cervical cancer in SMAN 3, Pontianak.
UJI AKTIVITAS ANTIBAKTERI AIR PERASAN JERUK SAMBAL (Citrus Microcarpa Bunge) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus Aureus Vanesa, Vanesa; Asseggaf, Syarifah Nurul Yanti Rizki Syahab; Mardhia, Mardhia; Mahyarudin, Mahyarudin
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P16

Abstract

Latar Belakang: Pneumonia dapat diakibatkan oleh infeksi dari salah satu strain bakteri S. aureus, yaitu Methicillin Resistance Staphylococcus aureus (MRSA). Staphylococcus aureus memiliki potensi untuk mengembangkan resistensi terhadap hampir semua kelas antibiotik. Diperlukan pengembangan alternatif agen terapi lain dalam menangani peningkatan kasus resistensi bakteri. Jeruk sambal (Citrus microcarpa Bunge) adalah tanaman yang terdapat di Kalimantan Barat, Indonesia. Air perasan dari buah ini mengandung metabolit sekunder yang memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk mengetahui kemampuan air perasan jeruk sambal sebagai antibakteri terhadap pertumbuhan bakteri Staphylococcus aureus. Metode: Air perasan jeruk sambal dibuat dengan mensterilkan buah, kemudian dipotong menjadi dua, diambil sari buahnya dengan diperas dan disaring menggunakan kertas saring. Metode difusi cakram (Kirby-Bauer) digunakan sebagai metode pengujian aktivitas antibakteri. Kelompok perlakuan dibagi menjadi 4 konsentrasi: 25%, 50%, 75%, dan 100%, kontrol positif (Siprofloksasin 5 ?g/disk) dan kontrol negatif (akuades steril). Hasil: Analisis fitokimia menunjukan terdapat kandungan alkaloid, flavonoid, saponin, tanin, dan fenolik pada air perasan jeruk sambal. Dimana saponin (+++) sebagai kandungan terbanyak. Aktivitas antibakteri didapati pada semua kosentrasi dengan terbentuknya zona hambat disekitar kertas cakram. Kesimpulan: Air perasan jeruk sambal mampu mengambat pertumbuhan bakteri Staphylocaccus aureus secara in vitro, sehingga dapat disimpulkan memiliki aktivitas antibakteri.
Knowledge and attitudes towards antibiotic resistance among health profession students in Indonesia Syahniar, Rike; Farsida, Farsida; Kosasih, Audia Nizhma Nabila; Mardhia, Mardhia; Bekti, Heri Setiyo; Marpaung, Nurasi Lidya E.; Dharmawan, Ade; Indriyani, Indriyani; Husna, Ismalia; Amany, Hana Amirah
International Journal of Public Health Science (IJPHS) Vol 13, No 1: March 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i1.23139

Abstract

Abuse and overuse of antibiotics cause the increasing prevalence of antibiotic resistance. Doctors, nurses, midwives, and pharmacy professionals play an essential role in providing information and education on the use of antibiotics to the public. This study aims to compare and identify the factors that influence the knowledge and attitudes of students’ medicine, midwifery, pharmacy, and nursing toward antimicrobial resistance. An online crosssectional survey involving 530 medical, midwifery, pharmacy, and nursing students who are currently in the clinical or professional study stage. The Mann–Whitney U test and the Kruskal–Wallis test was run to assess differences in the mean scores of knowledges and attitudes. Factors related to knowledge and attitudes regarding antibiotic resistance were analyzed using linear regression. Most (93%) students have a good level of knowledge and have a positive attitude 49.81%, neutral 43.78%, and negative 6.41%. There was a relationship between age (p=0.012), major (p=0.000), source of information (p=0.013), and knowledge and attitudes about antibiotics (p<0.05). We conclude that there are differences in knowledge and attitudes toward antibiotic resistance among clinical-stage students of medicine, midwifery, pharmacy, and nursing. We found that essential knowledge and attitudes should be revised regarding antibiotic resistance.
Potential of Single-Bulb Garlic and Single-Bulb Black Garlic Extracts to Eradicate Uropathogenic Escherichia coli Hutahaean, Olifer Jannes; Liana, Delima Fajar; Mardhia, Mardhia; Mahyarudin , Mahyarudin
eJournal Kedokteran Indonesia Vol. 12 No. 2 (2024): Vol. 12 No. 2 - Agustus 2024
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Uropathogenic Escherichia coli (UPEC) is the main causative organism of urinary tract infections (UTIs). The increasing resistance of UPEC to conventional antibiotics necessitates the exploration of alternative treatments, including the use of herbal remedies such as single-bulb garlic.  This study aimed to evaluate and compare the antibacterial potential of single-bulb garlic extract and single-bulb black garlic extract against clinical isolates of UPEC. The study was conducted at the Microscopic Laboratory, Faculty of Medicine, Universitas Tanjungpura, in June 2023. Ethanol (96%) was used for the extraction process and the antibacterial activity was assessed using the disc diffusion method. The study included  10 treatment groups, comprising single-bulb garlic and single-bulb black garlic extracts at concentrations of 25%, 50%, 75%, and 100%, with nitrofurantoin (300 µg/disc) as the positive control and 1% DMSO as the negative control. The results indicated that the single-bulb garlic extract exhibited no antibacterial activity against UPEC at any concentration. In contrast, the single-bulb black garlic extract demonstrated antibacterial activity at 75% and 100% concentrations, with inhibition zones of 7.28 mm and 7.24 mm, respectively. These findings suggest that single-bulb black garlic extract is more effective than single-bulb garlic extract in inhibiting the growth of UPEC (p = 0.001).
Pelatihan Dokter Cilik Siswa Sekolah Dasar Desa Rasau Jaya Tiga, Kubu Raya Agustina Arundina Triharja Tejoyuwono; Mardhia Mardhia; Sari Eka Pratiwi; Delima Fajar Liana
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 9 (2024): Volume 7 No 9 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i9.14565

Abstract

ABSTRAK Pendidikan dan kesehatan saling berhubungan dan merupakan hal penting bagi anak. Banyak kondisi kesehatan yang dapat dikelola dengan lebih baik atau dicegah jika terdeteksi sejak dini. Lingkungan sekolah dan layanan kesehatan sekolah memberikan peluang untuk intervensi tepat waktu pada berbagai kondisi, termasuk kecemasan dan depresi, perilaku kelainan, kelebihan berat badan, dan kekurangan gizi. UKS merupakan program wajib Kementerian Pendidikan dan Kebudayaan untuk menanamkan hingga melaksanakan prinsip hidup sehat dalam kehidupan sehari-hari, salah satunya melalui peran Dokter Cilik. Metode pelatihan Dokter Cilik yang digunakan adalah ceramah dan praktik. Pelatihan dilakukan pada siswa SD kelas IV dan V dari SD Negeri 2 dan SD Madrasah Ibtidaiyah dengan total peserta berjumlah 30 siswa. Hasil penilaian terhadap pelatihan adalah kemampuan siswa SD mengenai materi yang diajarkan dan kesiapan menjadi kader kesehatan cukup baik, perubahan kemampuan kognitif cukup baik, peningkatan kemampuan afektif baik, psikomotor sangat baik, penilaian praktik semua siswa memiliki kemampuan yang sangat baik. Pelatihan dokter cilik mampu merubah perilaku peserta didik. Kegiatan pelatihan dokter cilik ini sebaiknya dilakukan di tiap sekolah agar penerapan trias UKS di sekolah semakin optimal. Kata Kunci: Dokter Cilik, Kesehatan, Usaha Kesehatan Sekolah  ABSTRACT Education and health are interconnected and important for children. Many health conditions can be better managed or prevented if detected early. The school environment and school health services provide opportunities for timely intervention for a variety of conditions, including anxiety and depression, behavioural disorders, overweight, and malnutrition. The school health unit is a mandatory programme of the Ministry of Education and Culture to instill and implement the principles of healthy living in everyday life, one of which is through the role of Little Doctors. The Little Doctor training methods used are lectures and practice. The training was carried out on elementary school students in grades IV and V from SD Negeri 2 and SD Madrasah Ibtidaiyah, with a total of 30 students. The results of the assessment of the training were that elementary students' abilities regarding the material taught and their readiness to become health cadres were quite good; changes in cognitive abilities were quite good; improvements in affective abilities were good; psychomotor skills were very good; and the practical assessment of all students had very good abilities. Little doctor training is able to change student behavior. The little doctor training should be held in every school, thus the implementation of the UKS triad in schools is optimal. Keywords: Little Doctor, Health, The School Health Unit
Nitrofurantoin Susceptibility Profile on Bacterial Isolates from Urinary Tract Infection in Patients with Diabetes Mellitus Kurniawan, Prayoga; Mardhia, Mardhia; Mahyarudin, Mahyarudin
Muhammadiyah Medical Journal Vol 4, No 2 (2023): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.4.2.79-85

Abstract

Background: Patients with diabetes mellitus have a higher risk of urinary tract infection (UTI) incidence than those without. One of the first-line therapy for UTI is nitrofurantoin. The emergence of drug-resistant UTIs is increasing both in community and healthcare setups. Purposes: Determine the nitrofurantoin susceptibility profile to bacteria causing UTI in diabetic patients. Method: A cross-sectional study was conducted at the Microscopic Laboratory, Faculty of Medicine, Universitas Tanjungpura, Pontianak, from February to November 2019. The antibiotic susceptibility testing was performed by the Kirby-Bauer disk diffusion method on 22 bacterial isolates. The samples were collected on a sterile urine pot, cultured on agar, and identified by biochemistry test, and bacterial isolates were stored at 2-8oC. The bacterial isolates were sub-cultured 24h before the susceptibility test. The susceptibility testing used a 300 µg nitrofurantoin disk. The diameter of zone inhibition was measured and classified based on Clinical and Laboratory Standard Institute guidelines. Result: The results showed that Escherichia coli was 41.67% susceptible (5/12), Shigella sp. was 100% intermediate (1/1), and Enterobacter aerogenes (3/3), Pseudomonas aeruginosa (1/1), Klebsiella sp (1/1) were 100% resistant. Conclusion: The majority of the causative bacteria for UTI in diabetic patients are resistant to nitrofurantoin, suggesting the use of nitrofurantoin should be reconsidered as an empirical antibiotic in Pontianak. Further study using a larger population should be conducted to describe a more extensive antibiotic susceptibility profile of diabetic patients with UTI in Pontianak.
Evaluation of Humoral Response of Emergency Unit Healthcare Workers after Third Dose of COVID-19 Vaccination Irsan, Abror; Mardhia, Mardhia; Rialita, Ambar
Muhammadiyah Medical Journal Vol 3, No 1 (2022): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.3.1.27-32

Abstract

Background:  Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is an emerging disease that has become pandemic. Healthcare workers are vulnerable persons due to SARS-CoV-2 infection. Healthcare workers are a government priority in the COVID-19 vaccine program. Antibody titer evaluation to healthcare workers as the first liner is essential due to the risk of the job. Purposes: The study aims to assess IgG antibody humoral response in healthcare workers in the emergency unit of Anton Soedjarwo Hospital, Pontianak, before and after the third dose of the COVID-19 vaccine. Methods: This study was a descriptive study with a cohort method. Twenty-two healthcare workers in the Emergency Unit in Anton Soedjarwo Hospital, Pontianak, participated in the study. Three ml venous blood samples were collected from the participants in two periods to quantify IgG antibody titer. The first period was before the third dose of the COVID-19 vaccine, and the second period was one month after the third dose of the COVID-19 vaccine. Chemiluminescent Microparticle Immunoassay (CMIA) methods were used to quantification IgG antibodies against spike-receptor binding domain (S-RBD) protein of SARS-CoV-2 Results: One month before the third dose of the COVID-19 vaccine, the majority of IgG antibodies show seropositivity (90.91%), with most on range 50-10,000 AU/ml (54.55%). Two participants (9.09%) show IgG antibodies less than 50 AU/ml (seronegative). One month after the third vaccination dose, all participants (100%) elicit IgG antibodies. Based on the comparison of IgG antibody titer before and after the third dose of the vaccine, the majority (68.18%) showed increasing the IgG antibody titer after the third vaccine.  Conclusion: The third dose vaccine might effectively elevate immune response to SARS-CoV-2 infection.
Knowledge and Behavior Regarding Antibiotic Stewardship in Health Workers at Sultan Syarif Mohammad Alkadrie Hospital, Indonesia Restika, Risma A.; Mardhia, Mardhia; Mahyarudin, Mahyarudin; Liana, Delima F.; IH, Hariyanto
Pharmacology and Clinical Pharmacy Research Vol 9, No 3 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i3.56573

Abstract

Antimicrobial resistance is a global public health concern. The World Health Organization reports that antimicrobial resistance constitutes a serious threat to public health worldwide. One of the risk factors in the development of antimicrobial resistance cases is the irrational use of antibiotics. Knowledge and behavior of health worker about antibiotic stewardship play a role in preventing antibiotic resistance cases. This study aimed to demonstrate knowledge and behavior regarding antibiotic stewardship in health workers at Sultan Syarif Mohamad Alkadrie Hospital, Pontianak. This was a cross-sectional descriptive study using consecutive sampling with total of 39 respondents. Data were collected through questionnaires with total of 45 questions. Knowledge and behavior of respondents were categorized as good, moderate, and low. The data was analyzed using the spearman rank correlation coefficient. The results showed that most health workers had good knowledge 97.44% (38/39) and good behavior 87.18% (34/39) related to antibiotic stewardship with a spearman p-value >0.05. Antibiotic stewardship is important for health workers to prevent an increase in antibiotic resistance cases and their impact on public health worldwide. As we know, increasing antibiotic resistance is a globally major problem as health system depends on effective antibiotics to treat bacterial infections.
Evaluation of Antibiotic Use in the Internal Medicine Ward and ICU at Universitas Tanjungpura Hospital Pontianak with ATC/DDD Rifdah, Dzuria Adhana; Ih, Hariyanto; Liana, Delima Fajar; Mardhia, Mardhia; Mahyarudin, Mahyarudin
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.92330

Abstract

Background: Evaluating the wise use of antibiotics is needed to control antibiotic resistance in hospitals.Objectives: This study aimed to analyze patient characteristics, antibiotic profiles, and quantitative use of antibiotics in inpatients prescribed by internal medicine specialists in the internal medicine ward and Intensive Care Unit (ICU) at Universitas Tanjungpura Hospital Pontianak from August to October 2022.Methods: This study method is descriptive observational, and data collection was done retrospectively using a purposive sampling technique. There were 143 samples that met the inclusion criteria, and then using the Anatomical Therapeutic Chemical (ATC)/Defined Daily Dose (DDD) method, the samples were analyzed quantitatively.Results: Most patient characteristics were female patients (60.14%), patients aged 56-65 (26.57%), and the most common diagnosis was typhoid fever (32.74%). Of the 13 types of antibiotics used, cephalosporin was the most commonly prescribed antibiotic group to patients (58.48%), with the most types of antibiotics in ceftriaxone (42,69%) and intravenous administration of antibiotics was the standard route given to patients. The results of the quantitative analysis of all antibiotic prescriptions obtained a total value of 88.55 DDD/100 patient-days. Antibiotics with the most considerable DDD/100 patient-days value were ceftriaxone (44.71), followed by meropenem (10.46) and levofloxacin (9.28). Furthermore, the value of DDD/100 patient-days is not an indicator in determining the rational use of antibiotics, so further study must be done using the Gyssens method.Conclusion: The value of DDD/100 patient-days is not an indicator in determining the rational use of antibiotics, so further study must be done using the Gyssens method as qualitative evaluation to obtain information regarding the rationality of prescribing antibiotics.
POTENTIAL OF SAMBAS SIAM ORANGE (Citrus nobilis var. microcarpa) LEAVES ETANOL EXTRACT AGAINST Escherichia coli Irvandy, Muhammad Syifa; Zakiah, Mistika; Asseggaf, Syarifah Nurul Yanti Rizki Syahab; Mahyarudin, Mahyarudin; Mardhia, Mardhia
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.549

Abstract

Escherichia coli has virulence factors and is able to avoid host defenses, and is resistant to antibiotics. Increasing resistance requires alternative therapies, including natural ingredients. The potential that comes from West Kalimantan is the Siamese orange (Citrus nobilis var. microcarpa). All parts of this plant contain secondary metabolites that can be utilized, for example the leaves. The compounds contained in secondary metabolites have antibacterial properties. This study was to determine the antibacterial potential of the ethanol extract of Siamese orange leaves on the growth of Escherichia coli bacteria. Method The orange leaves were extracted using 70% ethanol then continued with phytochemical analysis and antibacterial activity testing using the disc diffusion method. The results of the phytochemical analysis showed that the ethanol extract of Siamese orange leaves contained phenolics, alkaloids, saponins, flavonoids, and steroids. Antibacterial activity testing at all concentrations showed no inhibition zone. Conclusion The ethanol extract of Siamese orange leaves did not have antibacterial activity on the growth of Escherichia coli bacteria.
Co-Authors Abror Irsan Ade Dharmawan Agustina Arundina Triharja Tejoyuwono Amany, Hana Amirah Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Andriani Andriani Andriani Andriani Armyanti, Ita Asseggaf, Syarifah Nurul Yanti Rizki Syahab Delima Fajar Liana Dewinta Putri Utami Dhaifina Putri Windini Diana Natalia Eka Ardiani Putri Farsida, Farsida Hariyanto IH Heri Setiyo Bekti Heru Fajar Trianto Husna, Ismalia Hutahaean, Olifer Jannes Indriyani Indriyani Irvandy, Muhammad Syifa Khairunnisa Khairunnisa Khairunnisa Kosasih, Audia Nizhma Nabila Kurniawan, Prayoga Liana, Delima F. M. Ali Maulana Mahyarudin, Mahyarudin Marpaung, Nurasi Lidya E. Meika Meidina Yuanita Mira Miftahul Jannah Mistika Zakiah Mitra Handini Muhammad I. llrniawan Muhammad In&#039;am Ilmiawan Muhammad In’am Ilmiawan Muhammad In’am Ilmiawan Musfiroh Musfiroh Nur - Atirah Nur Al Huda Nur Atirah Nurani Takwim popy Puspidawati Restika, Risma A. Rialita, Ambar Rifdah, Dzuria Adhana Rike Syahniar Sari Eka Pratiwi Shafira Kurnia Warianti Teguh Rinjaya Vanesa, Vanesa Veren Evelyn Chandra Vinny Vania Parinding Virhan Novianry Yoga Pramana Zaitin Nur Zulfikar Dwi Kiswahyu Nindo