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All Journal International Journal of Public Health Science (IJPHS) E-Jurnal Medika Udayana Jurnal Mahasiswa PSPD FK Universitas Tanjungpura Microbiology Indonesia Health Science Journal of Indonesia Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Andalas Jurnal Farmasi Sains dan Komunitas Jurnal Pendidikan Informatika dan Sains Jurnal Fitofarmaka Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Pharmacology and Clinical Pharmacy Research Majalah Kedokteran Andalas Healthcare Nursing Journal Muhammadiyah Medical Journal Cermin Dunia Kedokteran Berita Kedokteran Masyarakat Mutiara: Multidiciplinary Scientifict Journal Jurnal Penelitian Keperawatan Cermin Dunia Kedokteran Jurnal Veteriner Jurnal Abdimas Kedokteran dan Kesehatan (JARAS)
Mardhia Mardhia
Departemen Mikrobiologi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianak
Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Enhancing Leptospirosis Awareness: A Study on Knowledge among Health Undergraduate Students in Pontianak, West Kalimantan Auliya Az Zahra; Mardhia Mardhia; Mahyarudin Mahyarudin; Delima Fajar Liana
Jurnal Veteriner Vol. 26 No. 4 (2025)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/

Abstract

Leptospirosis is a zoonotic infectious disease caused by the spirochete bacteria Leptospira, with a high risk of transmission in flood-prone areas such as Pontianak, West Kalimantan. Health undergraduate students play a critical role in preventing and managing infectious diseases, including leptospirosis. Hence, sufficient knowledge is necessary. This study aimed to describe the knowledge of health undergraduate students in Pontianak regarding leptospirosis. A descriptive study with a cross-sectional approach was conducted involving 172 respondents selected through proportionate stratified random sampling. Data were collected using an 18-question questionnaire covering definitions, etiology, epidemiology, clinical manifestations, transmission mechanisms and pathogenesis, diagnosis, prevention, and management. The results show that most health undergraduate students at Universitas Tanjungpura, Pontianak had poor knowledge (57.5%), while 35.5% had moderate knowledge, and only 7% demonstrated good knowledge. Electronic media or the internet was the most frequently used source of information (51.74%), followed by lecture materials (44.18%), journals (22.67%), textbooks (14.53%), and printed media (11.04%). This study concludes that the majority of students lack knowledge of leptospirosis. Improving health literacy and access to accurate information, particularly through electronic media, is essential to enhance their understanding of the disease.
The Relationship Between Knowledge and Behavior Toward Antibiotic Stewardship Among Healthcare Workers at Referral Hospital, West Borneo Fahira Amanda Fitaloka; Mardhia Mardhia; Delima Fajar Liana; Mahyarudin Mahyarudin; Hariyanto IH
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009974

Abstract

Irrational use of antibiotics is currently still a major health problem in the world. Worldwide around 50% of medicines are sold, distributed, and given to patients inappropriately. Irrational use of antibiotics can trigger antibiotic resistance. Knowledge and behavior regarding antibiotic stewardship are important in preventing antibiotic resistance. This cross-sectional research was conducted to determine the relationship between knowledge and behavior regarding antibiotic stewardship among healthcare workers. This study's 58 respondents were general practitioners/dentists, specialist doctors/dentists, and pharmacists. The instrument used in this study was a valid and reliable questionnaire. The data analysis used was univariate analysis and Spearman analysis with IBM SPSS Statistics 26 and significance set as p0.05. In this study, the results showed that the majority of respondents worked as specialist doctors/dentists (53.44%), aged in the range 26-35 years (36.20%), of the type female (58.62%), have work experience for more than 10 years (39.65%) and all of the surveyed respondents have good knowledge and behavior (100%). Spearman’s rank analysis showed no significant relationship between knowledge and antibiotic stewardship behavior (p0.05). The high level of expertise of respondents does not significantly affect the level of behavior because it can influence several factors, both internal and external. Further study is needed to identify other factors influencing antibiotic stewardship and rational use of medicine.
Antibacterial activity of fermented single-bulb garlic (Allium sativum L.) ethanol extract against ESBL-producing Escherichia coli Mahyarudin Mahyarudin; Mardhia Mardhia; Delima Fajar Liana; Rangga Putra Nugraha; Ambar Rialita; Muhammad Syifa Irvandy
Jurnal Pendidikan Informatika dan Sains Vol. 14 No. 2 (2025): Jurnal Pendidikan Informatika dan Sains
Publisher : Universitas PGRI Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31571/saintek.v14i2.8606

Abstract

Extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli is a major cause of multidrug-resistant infections, posing significant challenges to antibiotic therapy. The search for natural antibacterial alternatives has led to growing interest in fermented single bulb Allium sativum (FSBAS), a thermally processed form of garlic with enhanced bioactive properties. This study aimed to evaluate the antibacterial activity of ethanol extracts of FSBAS against ESBL-producing E. coli isolates. FSBAS was produced by fermentation at 70°C for 35 days. FSBAS was extracted using maceration with 96% ethanol. Antibacterial activity was assessed using the disc diffusion method. This experiment consisted of four treatment groups i.e. extract concentrations of 25%, 50%, 75%, and 100%; and two control groups, namely the negative control (1% DMSO) and the positive control (amoxicillin–clavulanate, 30 µg/disc). The ethanol extract of FSBAS showed measurable antibacterial activity against ESBL-producing E. coli. The diameter of the inhibition zone increased proportionally with the extract concentration, with the strongest effect observed at 100%. Statistical analysis confirmed treatment groups with concentrations of 50%, 75%, and 100% showing no significant differences with positive control (p > 0.05). The FSBAS extract shows promising antibacterial potential against multidrug-resistant E. coli.
Updated Resistensi Antibiotik: Dari Pre Klinik Hingga Aplikasi Klinik Tenaga Kesehatan Rike Syahniar; Audia Nizhma Nabila; Desy Januarrifianto; Mardhia Mardhia; Nurmalia Lusida; Inas Farida
Jurnal Abdimas Kedokteran dan Kesehatan Vol. 2 No. 1 (2024): Jurnal Abdimas Kedokteran dan Kesehatan (JARAS)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/jaras.2.1.13-18

Abstract

Penyalahgunaan dan penggunaan antibiotik yang berlebihan menyebabkan meningkatnya prevalensi resistensi antibiotik. Dokter, perawat, bidan, dan tenaga kefarmasian berperan penting dalam memberikan informasi dan edukasi penggunaan antibiotik kepada masyarakat. Tujuan kegiatan ini adalah untuk memberikan edukasi mengenai penggunaan dan resistensi antibiotik. Kegiatan dimulai dengan memberikan pre-test kepada partisipan, dilanjutkan dengan penyampaian materi mengenai update resistensi antibiotik oleh narasumber dan kemudian diberikan post-test. Hasil uji wilcoxon, diketahui p-value = 0,000 < 0,05, serta ada kenaikan nilai mean pre test sebesar 68.44 menjadi 82.34 pada post test. Dapat disimpulkan bahwa ada pengaruh edukasi terhadap peningkatan pengetahuan peserta mengenai resistensi antibiotik.
mrkA, mrkD, AND fimH BIOFILM GENES DETECTION: A STUDY ON Klebsiella pneumoniae CLINICAL ISOLATES Intan ‘Ariqah ‘Azizah; Mardhia Mardhia; Delima Fajar Liana; Mahyarudin Mahyarudin
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 19 No 1 (2025): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan (In Press)
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v19i1.10331

Abstract

Biofilm formation is a virulence factor contributing to the pathogenicity and antibiotic resistance of Klebsiella pneumoniae. This process occurs due to biofilm genes in clinical isolates, especially the mrkA, mrkD, and fimH genes. These three genes are related the quality of biofilms formed, which lead to chronic and prolonged infections. This study was conducted to determine the presence of mrkA, mrkD, and fimH genes as biofilm formers in Klebsiella pneumoniaeclinical isolates. The study used a descriptive in vitro laboratory study, with total of 24 Klebsiella pneumoniae clinical isolates from the collection of the Department of Microbiology, Faculty of Medicine, Universitas Tanjungpura. Isolates were subculture in MacConkey Agar, Gram staining, followed by DNA extraction and gene detection using PCR. The results showed the presence of the mrkA gene in 91.6% of the isolates, while the mrkD and fimH genes were each in 87.5% of the isolates. The high percentage of biofilm gene detected, should increase health workers and stakeholder awarness about the impact.
PENDIDIKAN KESEHATAN BERBASIS KELUARGA TERHADAP PENGETAHUAN DAN SIKAP MASYARAKAT TENTANG VAKSIN COVID-19 M. Ali Maulana; Yoga Pramana; Mardhia Mardhia
HealthCare Nursing Journal Vol. 4 No. 1 (2022): HealthCare Nursing Journal
Publisher : LP3M Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/healthcare.v4i1.1821

Abstract

Penderita penyakit Covid-19 terus bertambah di seluruh dunia hingga saat ini. Tercatat pada Oktober 2020 terlaporkan sekitar 20.369.778 kasus dan 948.795 kasus meninggal dunia. Kejadian di Indonesia hingga saat ini penderita yang terkonfirmasi positif pada oktober 2020 tercatat 344.749 orang. Pada kondisi memburuk seperti ini, WHO telah mendorong negara-negara untuk mengembangkan vaksin untuk menangani penyakit covid-19 ini. Keresahan masyarakat mengenai informasi vaksin yang diterima dapat mempengaruhi persepsinya terhadap vaksin covid-19, Pendekatan promosi Kesehatan berbasis keluarga bisa menjadi solusi untuk memberikan informasi terbaik tentang vaksin covid-19 di masyarakat, khususnya pada lingkup kecil di tiap keluarga. Adapun tujuan yang ingin dicapai dalam penelitian yaitu menganalisis pengaruh Pendidikan Kesehatan berbasis keluarga terhadap pengetahuan dan sikap masyarakat tentang vaksin covid-19. Penelitian ini adalah penelitian kuantitatif menggunakan desain quasi experimental dengan pendekatan Pre and Post Test dengan metode nonequivalent control group design melibatkan 100 responden dari masyarakat di wilayah kecamatan pontianak barat – kalimantan barat, menggunakan instrumen materi edukasi dan kuesioner pengetahuan dan sikap tentang vaksin covid-19. Hasil penelitian membuktikan bahwa edukasi berbasis keluarga berpengaruh lebih efektif terhadap peningkatan pengetahuan dan sikap masyarakat terhadap vaksinasi Covid-19 dibandingkan dengan edukasi yang diberikan secara publik atau menggunakan media massa
Co-Authors Abror Irsan Ade Dharmawan Amany, Hana Amirah Ambar Rialita Ambar Rialita Ambar Rialita Ambar Rialita Andriani Andriani Andriani Andriani Armyanti, Ita Asseggaf, Syarifah Nurul Yanti Rizki Syahab Audia Nizhma Nabila Auliya Az Zahra Delima Fajar Liana Delima Fajar Liana Delima Fajar Liana Delima Fajar Liana Delima Fajar Liana Desy Januarrifianto Dewinta Putri Utami Diana Natalia Eka Ardiani Putri Fahira Amanda Fitaloka Farsida, Farsida Hariyanto IH Heri Setiyo Bekti Heru Fajar Trianto Husna, Ismalia Hutahaean, Olifer Jannes Inas Farida Indriyani Indriyani Intan ‘Ariqah ‘Azizah Irvandy, Muhammad Syifa Khairunnisa Khairunnisa Khairunnisa Kosasih, Audia Nizhma Nabila Kurniawan, Prayoga Liana, Delima F. M. Ali Maulana Mahyarudin Mahyarudin Mahyarudin Mahyarudin Mahyarudin, Mahyarudin Marpaung, Nurasi Lidya E. Meika Meidina Yuanita Mira Miftahul Jannah Mistika Zakiah Mitra Handini Muhammad I. llrniawan Muhammad In&#039;am Ilmiawan Muhammad In’am Ilmiawan Muhammad In’am Ilmiawan Muhammad Syifa Irvandy Musfiroh Musfiroh Nur - Atirah Nur Al Huda Nur Atirah Nurani Takwim Nurmalia Lusida popy Puspidawati Rangga Putra Nugraha Restika, Risma A. Rialita, Ambar Rifdah, Dzuria Adhana Rike Syahniar Rike Syahniar Shafira Kurnia Warianti Teguh Rinjaya Vanesa, Vanesa Veren Evelyn Chandra Vinny Vania Parinding Virhan Novianry Yoga Pramana Zaitin Nur Zulfikar Dwi Kiswahyu Nindo