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Handayati, Anik
Department Of Medical Laboratory Technology, Poltekkes Kemenkes Surabaya
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pap Smear Diagnostic Test Towards Gold Standard Histopathology In Cervic Cancer: Uji Diagnostik Pap Smear Terhadap Gold Standard Histopatologi Pada Kanker Serviks Anik Handayati; Putri, Tiara Dewanti; Sri Sulami Endah Astuti
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 2 (2024): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i2.1655

Abstract

Cervical cancer is the second most common cancer in the world. Screening examination plays an important role in early detection of cervical cancer so that it can reduce mortality. Pap smear is an initial examination to detect the presence of abnormal cells in the cervix. This study aims to determine the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of pap smear examination by comparing them to histopathological examination as the gold standard. The design of this study was an observational study with secondary data obtained from the medical records of cervical cancer patients who had performed pap smears as well as histopathological examinations at the Anatomical Pathology Laboratory Installation, RSPAL dr. Ramelan Surabaya for the period January 2020 to March 2022. The data will be sorted based on inclusion and exclusion criteria. Data that pass the inclusion criteria will be tested using crosstabulation and then proceed to the diagnostic test. The sensitivity value is 97%, specificity value is 88%, accuracy value is 96%, positive predictive value is 98%, and negative predictive value is 79%. Pap smears have a fairly good diagnostic value for diagnosing cervical cancer.
Pemberdayaan Kader Kesehatan Dan Keluarga Pasien Tuberkulosis Dalam Pemanfaatan Sambiloto Sebagai Imunomodulator Untuk Keberhasilan Pengobatan Pasien Tuberkulosis Di Wilayah Kerja Puskesmas Gading Kecamatan Tambaksari Kota Surabaya Pestariati, Pestariati; Handayati, Anik; Suhariyadi, Suhariyadi
Sewagati Vol 9 No 3 (2025)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v9i3.2276

Abstract

Indonesia memiliki beban kasus tuberkulosis tertinggi ketiga di dunia. Tahun 2021, jumlah kasus tuberkulosis di Indonesia 824.000 kasus, hanya 402.502 kasus (49%) dari target 85% berhasil ditemukan dan diobati . Indikator keberhasilan pengob- atan di Jawa Timur tahun 2020 sebesar 87,1% (Target renstra Kemenkes 90%). Hal ini disebabkan salah satunya rendahnya pemahaman kader kesehatan, keluarga dan pasien tuberculosis tentang penyakitnya, termasuk bahaya resistensi OAT dan dukun- gan keluarga terhadap kesembuhan pasien. Sambiloto memiliki kandungan senyawa andrografolida, sebagai imunomodulator, meningkatkan keberhasilan pengobatan TB. Kader kesehatan berperan mengedukasi masyarakat tentang TB, memberikan dukungan dan motivasi kepada pasien TB,memfasilitasi kolaborasi antara pasien TB. Setiap Kelurahan Wilayah Puskesmas Gading memiliki Kader Kesehatan yang khusus menangani TB Pada Kelurahan di wilayah Puskesmas Gading, warga memi- liki tanaman Sambiloto baik dilakukan di Pot atau masuk di dalam TOGA RT. Pengabdian memberikan edukasi tentang tuberkulosis dan pemanfaatan sambiloto sebagai imunomodulator kepada kader kesehatan /TB dan keluarga pasien TB. Pen- ingkatan pemahaman kader dan keluarga pasien TB tentang sambiloto (N-Gain > 0,7) berhasil menurunkan angka BTA positif dari 84% menjadi 37,5%, sehingga edukasi (KIE) berkelanjutan sangat diperlukan.
Korelasi Kadar Troponin I dengan Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Low Density Lipoprotein (LDL) Pada Penderita Penyakit Jantung Koroner Di RSUD Haji Provinsi Jawa Timur Amania, Salsabila; Handayati, Anik; Museyaroh
Journal of Indonesian Medical Laboratory and Science Vol 6 No 2: Oktober 2025
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v6i2.279

Abstract

Background: Coronary Heart Disease (CHD) is a condition caused by atherosclerosis, which leads to reduced blood supply to the heart muscle. This condition occurs due to the buildup of plaques resulting form elevated levels of LDL.  Atherosclerosis can trigger myocardial infarction, leading to heart muscle damage and the release of biomarkers such as Troponin I and Serum Glutamic Oxaloacetic Transaminase (SGOT). Objectives: This Study aims to determine the correlation between Troponin I levels and SGOT as well as LDL levels in patients with CHD at Haji General Hospital in East Java Province. Materials and Methods: This study used an analytical observational study with a cross-sectional and purposive sampling. Results: The study results show that the majority of participants were aged 46–65 years (57%) and male (57%). Most patients had high Troponin I levels (70%), normal SGOT levels (63%), and high LDL levels (100%). The correlation analysis using the Spearman test showed a statistically significant correlation between Troponin I and SGOT levels with p value 0.046 and correlation coefficient r= 0.367, but the correlation between Troponin I and LDL levels was not statistically significant with p value 0.330 and correlation coefficient = 0.184. Conclusions:  The study found a correlation between Troponin I and SGOT in patients with CHD and no correlation between Troponin I and LDL in patients with CHD.
Evaluation of the Quality of Commercial Control Materials and Homemade Lyophilized on Clinical Chemistry Parameters with the Sigma Metric Method Maulida Azmi Wimasni Inah; Masdiva Putri Hidayah; Anik Handayati; Museyaroh; Lully Hanni Endarini; Edy Haryanto
Jurnal Teknokes Vol. 18 No. 3 (2025): September
Publisher : Jurusan Teknik Elektromedik, Politeknik Kesehatan Kemenkes Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Control materials are used to maintain the accuracy of testing procedures and the quality of laboratory results. However, commercial control materials are often considered less economical, so an alternative is needed, namely lyophilized human serum. Sigma metric helps improve laboratory operational costs efficiency through control settings and Westgard rule recommendations involving the Total Error Allowable (TEa) value, bias value (d%), and coefficient of variation (CV%). This study aims to determine the quality of commercial control materials and homemade lyophilized materials for blood glucose, uric acid, total cholesterol, and triglyceride parameters based on sigma values. This study used a comparative cross-sectional design. The samples included commercial control materials from one of the primary-level laboratories in Bangkalan District and homemade lyophilized samples from human serum collections. Data Analysis was conducted by statistically comparing the bias value and descriptively comparing the sigma value of commercial control material and homemade lyophilized. The results showed no significant difference in bias value between commercial control material and homemade lyophilized material for all parameters (significance value > α 0,05). The sigma values of commercial control material for blood glucose, uric acid, total cholesterol, and triglyceride parameters were 2.81 (poor), 2.41 (poor), 3.10 (marginal), and 2.14 (poor). The sigma values of the homemade lyophilized were 2.12 (poor), 1.76 (unacceptable), 3.36 (marginal), and 2.08 (poor). Based on the sigma values, the homemade lyophilized material was better for total cholesterol parameters, while the commercial control material was better for blood glucose, uric acid, and triglyceride parameters. It can be concluded that homemade lyophilized can be used as an alternative to commercial control materials, especially for total cholesterol parameters. These findings support the cost efficiency of laboratory operations through the development of more economical homemade lyophilized products that are suitable for use in laboratories.
Efforts to Control Blood Pressure for Prolanis Hypertension Members through the Utilization of Bay Leaf Decoction Handayati, Anik; Suhariyadi; Pestariati
Frontiers in Community Service and Empowerment Vol. 4 No. 3 (2025): September
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ficse.v4i3.104

Abstract

Bay leaves are a type of kitchen spice that is often added to dishes, inexpensive, and easily obtained. Research results have proven that the active compounds in bay leaves are quite effective and safer in lowering blood pressure. Most of the Sreseh residents work as fishermen who tend to consume salty foods, which causes a high incidence of hypertension. Therefore, it is necessary to increase knowledge about healthy lifestyles and the use of herbal medicine made from boiled bay leaves to lower blood pressure among Prolanis hypertension members in the Sreseh Health Center area. The methods used in this community service activity are lecture/presentation and demonstration methods. Lecture activities are carried out by delivering material on the prevention and natural treatment of hypertension using bay leaves, the benefits of bay leaves, and the processing of bay leaves for hypertension treatment. The demonstration method is carried out by showing how to process bay leaves. The target of the activity is Prolanis hypertension patients in Noreh Village, within the working area of the Sreseh Health Center, Sampang, Madura. Members of the Chronic Disease Management Program (PROLANIS), especially those with hypertension, were very enthusiastic and motivated to participate in every stage of the community service activity, from blood pressure checks, Prolanis exercises, to education on the benefits of bay leaves. After consuming boiled bay leaves, blood pressure checks on Prolanis members with hypertension showed a 30% decrease in the number of Prolanis members with hypertension, from the previous 76.67% to 46.67%.
Variance Index Score (Vis) Evaluation Of Homemade And Commercial Control Sera On Ast And Alt Assays Rahmania, Adelia Prisma; Handayati, Anik; Museyaroh, Museyaroh; Haryanto, Edy
Jurnal Riset Kesehatan Vol 13 No 2 (2024): NOVEMBER 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v13i2.11778

Abstract

Control materials are used as indicators of monitoring the performance of laboratory examinations so that the results issued are valid. Method of assessing the implementation of External Quality Assurance (EQAS) used Variance Index Score (VIS). This study aims to determine difference between pooled sera, homemade and commercial lyophilizates on AST and ALT parameters based on VIS. This research used comparative descriptive with quantitative approach in December 2023-May 2024. Homemade lyophilizates performed at UBAYA technobiology laboratory, determination of true value performed at 2 reference laboratories and clinical chemistry laboratory Poltekkes Surabaya, and determination of VIS performed at 10 primary level clinical laboratories in Surabaya Raya which determined by purposive sampling. The statistical analysis results showed no difference between homemade and commercial control materials based on VIS to the true value and all participating laboratories, so it was concluded that homemade control materials could be used as a substitute in implementing EQAS.
Co-Authors ., Pestariati Alizah, Nur Amalia Putri Khurota Ayyun Amania, Salsabila Anggie Banowati Wibiseno Anita Dwi Anggraini Atsania Putri , Puji Lestari Ayu Puspitasari, Ayu Caesaria, Adela Candra Triana Hikma Christ Kartika Rahayuningsih Dewa Ayu Puja Satya Dinarta Diah Titik Mutiarawati Diah Titik Mutiarawati Edy Haryanto Edy Haryanto Edy Haryanto Ellies Tunjung Sari Maulidiyanti Endah Astuti Sri Sulami Endah Astuti, Sri Sulami Endarini, Lully Hanni Evy Diah Woelansari Fadia Rakhmalia Farah Adelia Qotrunnada Fitria Yulfirda Arini Fridayanti, Ni Made Risma Hapipah Hapipah Hikma , Candra Triana Ilma Ainun Nisa Jihan Azzahra Arsyi Juliana Christyaningsih Juliawan Apurwatama Kadek Profit Hartani Liliek Soetjiatie Luthfi Rusyadi Mamik Mamik Masdiva Putri Hidayah Maulida Azmi Wimasni Inah Minarti Minarti Mohd Nazil Salleh Monica Putji Astuti Museyaroh, Museyaroh Nada Nabilah Wulandari Ni Wayan Lisna Marheni Nur Alina Hidayatur Rizki Nur Vita Purwaningsih, Nur Vita Puji Lestari Atsania Putri Putri, Tiara Dewanti Rahayuningsih, Christ Kartika Rahmania, Adelia Prisma Retno Sasongkowati Rinza Rahmawati Samsudin Sri Sulami , Endah Astuti Sri Sulami Endah Astuti Sri Utami Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suliati Suliati Syamsul Arifin Syamsul Arifin Tjipto Rini Winarni Winarni Wisnu Istanto Yuni Eka Cahyana