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Formulation of Ethanol Extract Lotion from Snake Fruit (Salacca zalacca) as an Antioxidant Purba, Novandi; Aminah; Intan
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/vy39nj40

Abstract

The skin is the outermost layer of the body that functions as the main protector from environmental exposure, including free radicals that can cause cell damage such as premature aging, dry skin, and various other skin disorders. Efforts to maintain healthy skin can be done through the use of appropriate cosmetic products, one of which is in the form of lotion. Lotion is a topical preparation that is easy to apply and can increase moisture and provide protection to the skin. Snake fruit (Salacca zalacca), a plant native to Indonesia that grows in tropical areas, is known to contain various bioactive compounds such as anthocyanins, flavonoids, flavonols, polyphenols, and β-carotene which have potential as antioxidants. This study aims to formulate and evaluate body lotion preparations based on ethanol extract of snake fruit (Salacca zalacca) as an antioxidant. The research methods include the preparation of simple drugs, extraction with ethanol solvents, body lotion formulations with varying extract concentrations (3%, 6%, and 9%), as well as physical quality evaluations including organoleptic tests, homogeneity, spreadability, pH, and irritation tests on volunteers. Antioxidant activity was tested using the DPPH (2,2- diphenyl-1-picrylhydrazyl) method. The results showed that all body lotion formulations met the physical evaluation requirements, with stable, homogeneous characteristics, good spreadability, and a pH that matched the skin's pH. The  irritation test showed that the preparation was safe to use because it did not cause irritation reactions on the volunteers' skin. Antioxidant activity testing showed that the ethanol extract of snake fruit had relatively strong antioxidant activity, with activity increasing along with increasing extract concentration in the preparation. Based on the results of the study, it can be concluded that the ethanol extract of snake fruit (Salacca zalacca) has the potential to be formulated into a stable, safe, and effective body lotion as an antioxidant to protect the skin from damage caused by free radicals.
Co-Authors -, Alfina Adeliana Aditia Aida Aldi Alisukma, M. Taufan AMINAH Anis Wulandari, Anis Ardliansyah, Moelki Fahmi Arnianti Awan Darmawan Dedi Masri Dewi Hastuty Dewi Putri, Lestari Dhaifullah, M. Naufal Dharmawan, Wawan Dini Dwi Yanti, Yuniar Epi, Yus Ezmar Fadhilah Nasrudin Fadhilla fadilah, Nurulfadilah Fatimah Az Zahra FAUZI Febi Angla Adelia Finkan Fitrianti, Linda Habibi, Mohammad Hady, Abdul Malik Hafeyza Haitsam Halimah Handayani, Dei Herliani Iis Maimunah Imda, Intan Indah Ramadhani Indang Rukayah Laluas Ismail Istinganatul Khumaida Jalil Kardo , Rici kasmayani M. ARIF RAHMAN HAKIM Marian Tonis Mubarrak, Zaki Muh. Darwis Muhammad Alfiansyah Muhammad Munir Nur Haliza Nurul Fadilah, Nurul Purba, Novandi Putri Meylita, Anggi Rahma Alviana Ramadani, Nova Ratih Permana Sari Rifqa Ayu Dasila Riyanti Selian, Sri Nurhayati Shafira Shopiah Suryaningsih, Liana Syahrani Syanhabi, Aan Tiara Wae, Rahmawati Wahyudi, Faisal Dwi Yanti, Rahma