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All Journal Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Padjadjaran Journal of Dentistry SOEPRA Jurnal Hukum Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Integrasi Kesehatan dan Sains Bandung Conference Series : Medical Science Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Noormartany
Universitas Islam Bandung
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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PERBANDINGAN ANGKA POSITIVITAS DAN WAKTU DETEKSI PERTUMBUHAN MYCOBACTERIUM TUBERCULOSIS ANTARA MEDIA BIAKAN CAIR KOLOROMETRIK DAN MEDIA PADAT OGAWA PADA SPESIMEN SPUTUM,CAIRAN PLEURA, DAN CAIRAN SEREBROSPINAL Indahwaty, -; Parwati, Ida; Soeroto, Arto Yuwono; Noormartany, -
Majalah Kedokteran Bandung Vol 41, No 2
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Biakan merupakan pemeriksaan baku emas untuk diagnosis tuberkulosis (TB). Pertumbuhan M. tuberculosis pada medium padat memerlukan waktu 3-4 minggu, sedangkan pada medium cair lebih cepat tumbuh. Penelitian ini bertujuan membandingkan angka positivitas dan waktu deteksi pertumbuhan M. tuberculosis antara medium cair kolorimetrik dan medium padat Ogawa. Penelitian dilakukan di Laboratorium Patologi Klinik RSHS periode Juni- Desember 2007. Subjek penelitian adalah penderita tersangka TB paru, pleura, atau meningen. Analisis statistik menggunakan chi square dan independent t test. Spesimen penelitian terdiri dari 71 sputum, 24 cairan pleura, dan 20 cairan serebrospinal (CSS). Pada medium cair biakan positif M. tuberculosis dari sputum adalah 69%, cairan pleura 41,7%, CSS 60%; pada medium padat dari sputum 52,1%, cairan pleura 25%, CSS 20%. Angka positivitas medium cair berbeda bermakna untuk sputum dan CSS (p<0,05). Rerata waktu deteksi pertumbuhan pada medium cair untuk sputum 15,2 (±8,7) hari, cairan pleura 8 (±12,7) hari, CSS 13,5 (±19,5) hari. Rerata waktu deteksi pertumbuhan pada medium padat untuk sputum 23 (±9) hari, cairan pleura 36 (±18,3) hari, dan CSS 32 (±11,4) hari. Waktu deteksi pertumbuhan M. tuberculosis pada medium cair berbeda bermakna untuk sputum dan cairan pleura (p<0,05). Medium cair memberikan angka positivitas lebih tinggi dan waktu deteksi pertumbuhan M. tuberculosis lebih cepat dibandingkan medium padat, sehingga baik untuk diagnosis TB.Kata kunci: M. tuberculosis, sputum, cairan pleura, CSS, medium padat, medium cair, angka positivitas, waktu deteksi pertumbuhanCOMPARISON OF THE POSITIVITY AND MEAN DETECTION TIME OF MYCOBACTERIUM TUBERCULOSIS GROWTH USING COLORIMETRIC LIQUID MEDIA AND OGAWA SOLID MEDIA WITH SPECIMENS FROM SPUTUM, PLEURAL FLUID AND CEREBROSPINAL FLUIDCultivation is the gold standard in diagnosing tuberculosis (TB). M. tuberculosis needs 3-4 weeks to growth in solid media, but it is growing faster in liquid media. The aim of this study was to compare the positivity rate and detection time of M. tuberculosis growth using colorimetric liquid and Ogawa solid media. This study did in Laboratory of Clinical Pathology Hasan Sadikin Hospital during June-Desember 2007. The subject was pulmonary, pleuritis or meningitis TB patients. The statistic analyzed using chi square and independent t test. The specimens were 71 sputums, 24 pleural fluids, 20 cerebrospinal fluids (CSF). The positivity rate of liquid media for sputums were 69%, pleural fluids 41.7%, CSF 60%. The positivity rate of solid media for sputums were 52.1%, pleural fluids 25%, CSF 20%. The positivity rate in liquid media was significant for sputum and CSF (p=0..05). The mean detection time in liquid media for sputums were 15.2 (±8.7) days, pleural fluids 8 (±12.7) days, CSF 13.5 (±19.5) days. The mean detection time in solid media for sputums 23 (±9) days, pleural fluids 36 (±18.3) days, CSF 32 (±11.4) days. The mean detection time in liquid media was significant for sputum and pleural fluid (p=0.05). The positivity rate and detection time of M. tuberculosis growth in colorimetric liquid media are higher and faster than in Ogawa solid media, so it is better for diagnosing TB.Key words: M. tuberculosis, sputum, pleural fluid, CSF, liquid media, solid media, positivity rate, mean detection time DOI: http://dx.doi.org/10.15395/mkb.v41n2.262
Validitas Kidney Injury Molecule-1 Urin Metode Mikro Enzyme-Linked Immunosorbent Assay Sebagai Penanda Dini Gangguan Ginjal Akut pada Sepsis Balqis, Lulu Fahrizah; Noormartany, Noormartany; Gondodiputro, Rubin Surachno; Rita, Coriejati
Majalah Kedokteran Bandung Vol 48, No 1 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v48n1.729

Abstract

Gangguan ginjal akut (GgGA) adalah penurunan fungsi ginjal ditandai peningkatan kreatinin serum ≥0,3 mg/dL atau >1,5 kali dibanding dengan kadar sebelumnya atau penurunan urine output <0,5 mL/jam lebih dari 6 jam. Sepsis merupakan penyebab tersering GgGA (20–50%). Kidney injury molecule-1 (KIM-1) adalah glikoprotein transmembran tipe-1. Kadar KIM-1 urin penderita GgGA akibat sepsis meningkat lebih awal dibanding dengan kreatinin serum. Penelitian bertujuan mengetahui validitas KIM-1 urin sebagai penanda dini GgGA pada sepsis, dilakukan di Rumah Sakit Dr. Hasan Sadikin Bandung periode Februari–Mei 2013. Bentuk penelitian observasional analitik khusus dengan rancangan potong lintang. Subjek penelitian adalah penderita sepsis yang didiagnosis klinisi sesuai kriteria The American College of Chest Physician/The Society of Critical Care Medicine 2001, berdasarkan consecutive admission sampling. Metode yang digunakan mikro enzyme-linked immunosorbent assay. Analisis dengan chi-kuadrat, Mann-Whitney, tabel 2x2, dan kurva receiver operating curve untuk menghitung validitas. Subjek terdiri atas 25 penderita sepsis dengan GgGA dan 25 penderita sepsis tanpa GgGA. Kadar KIM-1 urin penderita sepsis dengan GgGA meningkat dibanding dengan tanpa GgGA. Kadar KIM-1 urine cut-off >0,8 ng/mL memiliki sensitivitas 96%, spesifisitas 60%, nilai duga positif 70,6%, nilai duga negatif 93,8%, dan akurasi 78%. Simpulan, sensitivitas KIM-1 urin tinggi, spesifisitas sedang sehingga dapat digunakan sebagai skrining GgGA pada penderita sepsis. [MKB. 2016;48(1):19–25]Kata kunci: GgGA, KIM-1, sepsis, validitas Validity of Urinary Kidney Injury Molecule-1 Using Micro Enzyme-Linked Immunosorbent Assay Method as an Early Marker of Acute Kidney Injury in Sepsis PatientsAAcute kidney injury (AKI) is a rapid decline in renal function marked by increased serum creatinine of ≥0.3 mg/dL or >1.5 times higher than the previous levels or decreased urine output of <0.5 mL/hour for more than 6 hours. Sepsis is the most common cause of AKI (20–50%). Kidney injury molecule-1 (KIM-1) is a type-1 transmembrane glycoprotein. Urinary KIM-1 levels of sepsis patients due to AKI increases earlier than the serum creatinine levels; thus KIM-1 may serve as an AKI marker. This study aimed to determine the validity of urinary KIM-1 as the early marker in sepsis patients with AKI. The study was a specific observational analytical study with cross-sectional design, conducted in Dr. Hasan Sadikin General Hospital Bandung in February–May 2013. Subjects were patients diagnosed with sepsis by clinicians according to the criteria of the The American College of Chest Physician/The Society of Critical Care Medicine 2001 and were selected by consecutive sampling admissions. Urinary KIM-1 levels were measured by micro enzyme-linked immunosorbent assay. The data were analyzed by chi-square, Mann-Whitney, 2x2 tables, and receiver operating curve to measure validity. Subjects consisted of 25 sepsis patients with AKI and 25 sepsis patients without AKI. Urinary KIM-1 level of sepsis patient with AKI increased compared to patients without AKI. Level of urinary KIM-1 with a cut-off of >0.8 ng/mL presented 96% sensitivity, 60% specificity, 70.6% positive predictive value, 93.8% negative predictive value and 78% accuracy. In conclusion, the level of urinary KIM-1 has high sensitivity and moderate specificity thus can be used for AKI screening in sepsis patients. [MKB. 2016;48(1):19–25]Key words: AKI, KIM-1, sepsis, validity
The correlation between serum neuron-specific enolase level in adult patients of oromaxillofacial fracture with mild head injury M. Ruslin; HY Yusup; MZ Arifin; N. Noormartany
Padjadjaran Journal of Dentistry Vol 21, No 3 (2009): November 2009
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.105 KB) | DOI: 10.24198/pjd.vol21no3.14114

Abstract

Oromaxilofacial fracture will have associated with head injury due to its adjacent location and structure. The oromaxillofacial structure is considered to be as force silencer for trauma so that it can protect the intracranial structures. Neuron-specific enolase (NSE) is a specific enzyme within neuron cells and can be detected rapidly in serum. The objective of the study was to investigate the increased serum NSE level in adult patients with oromaxillofacial fracture with mild head injury; and to investigate the correlation between serum NSE level and the location of oromaxillofacial fracture (upper, middle, lower regions, or the combinations) in adult patients with mild head injury. This study used the analytical observational method with a cross-sectional design, that conducted in Department of Neurosurgery, Department of Oral and Maxillofacial Surgery, and Laboratory of Clinical Pathology, Dr Hasan Sadikin Hospital, Bandung, from August to October 2008. The serum NSE level examination was undertaken by blood sample taking then examined with electrochemiluminescence immunoassay (ECLIA). The data were analyzed using Mann-Whitney test to seek the increased serum NSE level; using Kruskal-Wallis to seek the mean of increased serum NSE levels by location of oromaxillofacial fracture; and using Spearman ranked correlation test to seek the correlation between the increased serum NSE levels and location of oromaxillofacial fracture in adult patients with mild head injury. The study results indicated that there was an increased serum NSE level in adult patients with oromaxillofacial fracture with mild head injury by 13.12 ng/mL compared to adult healthy group by 7.72 ng/mL (p<0.001). By upper, middle, and lower regions of oromaxillofacial fracture, the serum NSE level of oromaxillofacial fracture at combined upper-middle-lower region was significantly the highest, i.e., 21.14 ng/mL (p=0.049). A positive correlation between the increased serum NSE level and location of oromaxillofacial fracture caused by mild head injury existed (rs=0.33, p=0.020). In conclusion, there was an increased serum NSE level in adult patients with oromaxillofacial fracture with mild head injury; and there was also a positive correlation between the increased serum NSE level and location of oromaxillofacial fracture due to mild head injury.
Korelasi Jumlah CD4 dan Total Lymphocyte Count (TLC) pada Penderita HIV/AIDS dengan dan tanpa Terapi Antiretroviral Ivana Agnes Sulianto; Agnes R. Indrati; Rudi Wisaksana; Noormartany Noormartany
Global Medical & Health Communication (GMHC) Vol 1, No 1 (2013)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1399.512 KB) | DOI: 10.29313/gmhc.v1i1.1516

Abstract

Jumlah CD4 merupakan parameter laboratorium yang digunakan untuk memulai dan memantau terapi antiretroviral (ART) pada penderita HIV/AIDS. Pemeriksaan jumlah CD4 membutuhkan peralatan laboratorium yang mahal dan tenaga terlatih. World Health Organization (WHO) merekomendasikan total lymphocyte count (TLC) sebagai pengganti CD4 dalam memulai terapi. Penelitian ini bertujuan untuk melihat korelasi antara jumlah CD4 dan TLC pada data dasar, pemantauan pertama dan kedua penderita HIV/AIDS sebagai dasar digunakannya TLC untuk pemantauan terapi. Penelitian ini merupakan penelitian observasional analitik dan bagian dari penelitian kohort IMPACT (Integrated Management for Prevention And Care and Treatment of HIV/AIDS) pada pasien HIV/AIDS di RS Dr. Hasan Sadikin Bandung. Data tersebut dibagi menjadi kelompok tanpa ART dan dengan ART, masing-masing kelompok dibagi berdasarkan jenis kelamin. Analisis korelasi dilakukan pada data CD4 dan TLC dari tiap kelompok. Penelitian ini menggunakan 2.239 data. Korelasi antara CD4 dan TLC pada data dasar pria tanpa ART adalah 0,644 (p=0,01), wanita tanpa ART adalah 0,74 (p=0,01), pria dengan ART 0,67 adalah (p=0,01), wanita dengan ART adalah adalah 0,601 (p=0,01). Korelasi antara CD4 dan TLC pemantauan pertama pria tanpa ART 0,56 (p=0,01), wanita tanpa ART adalah 0,606 (p=0,01), pria dengan ART adalah 0,569 (p=0,01), wanita dengan ART adalah 0,466 (p=0,01). Korelasi antara CD4 dan TLC pemantauan kedua pria tanpa ART adalah 0,697 (p=0,01), wanita tanpa ART adalah 0,306 (p=0,01), pria dengan ART adalah 0,556 (p=0,01), wanita dengan ART adalah 0,561 (p=0,01). Simpulan, terdapat korelasi yang baik antara jumlah CD4 dan TLC, sehingga TLC dapat digunakan sebagai alternatif pemantauan terapi sebelum penderita melakukan pemeriksaan CD4. CORRELATION OF CD4 AND THE TOTAL NUMBER OF LYMPHOCYTE COUNT (TLC) IN HIV/AIDS PATIENTS WITH AND WITHOUT ANTIRETROVIRAL THERAPYCD4 count is a marker for initial and follow up antiretroviral therapy (ART) in HIV/AIDS patients. It requires expensive equipment and skill to performed. World Health Organization (WHO) recommends total lymphocyte count (TLC) as a substitute marker for CD4 count to start ART. The aim of this study is to evaluate the correlation between CD4 count and TLC in baseline and follow up data as a guide for follow up therapy. This study was an analytical observational study of HIV/AIDS patients data in Dr. Hasan Sadikin Hospital Bandung. It is part of IMPACT (Integrated Management for Prevention And Care and Treatment of  HIV/AIDS) study. The sample of 2,239  was divided into non ART and ART groups. The data was analyzed using correlation analysis. The results showed that the correlation between CD4 and TLC at baseline in male without ART was 0.644 (p=0.01), female without ART was 0.74 (p=0.01), male with ART was 0.67 (p=0.01), and female with ART was 0.601 (p=0.01). The correlation between CD4 and TLC at first follow up in male without ART was 0.056 (p=0.01), female without ART was 606 (p=0.01), male with ART was 0.569 (p=0.01), female with ART was 0.466 (p=0.01). The correlation between CD4 and TLC at second follow up in male without ART was 0.697 (p=0.01), female without ART was 0.306 (p=0.01), male with ART was 0.556 (p=0.01), female with ART was 0.561 (p=0.01). In conclusion, there is a good correlation between CD4 count and TLC so that TLC can be used as an alternative marker for follow up therapy.
Analysis of Out of Court Medical Dispute Resolution According to the Laws and Regulations Applicable in Indonesia Ariko Rahmat Putra; Noormartany Noormartany; Dony Septriana Rosady
SOEPRA Vol 7, No 1: Juni 2021
Publisher : Universitas Katolik Soegijapranata Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24167/shk.v7i1.3266

Abstract

Abstract: The medical profession is a noble profession because it upholds human values. In carrying out the medical profession, there is a legal relationship between doctors and patients, both civil, criminal and state administration. In civil terms, if one of the parties defaults, it will cause a medical dispute. Medical dispute resolution is not only done in court but can also be done outside the court.The purpose of this research is to find out alternative medical dispute resolution outside the court in accordance with the prevailing laws and regulations.This research is juridical-normative research. This research describes medical dispute resolution in Indonesia based on the prevailing laws and regulations in Indonesia. Then, analyze each medical dispute resolution option contained in statutory regulations.The doctor-patient relationship in terms of civil law is a therapeutic agreement. If in the agreement one of the parties is in default, such as a doctor who has committed an act that is detrimental to the patient, it can lead to a medical dispute. Civil medical dispute resolution is not only resolved in court but can also be carried out outside the court through several mechanisms, namely consultation, negotiation, mediation, conciliation and expert opinion.Keyword: The Settlement, Medical Dispute, Outside the Court Abstrak: Profesi dokter merupakan profesi yang mulia karena menjunjung tinggi nilai kemanusiaan. Dalam melaksanakan profesi kedokteran terdapat hubungan hukum antara dokter dan pasien, baik secara perdata, pidana, maupun tata usaha negara. Secara perdata, jika salah satu pihak melakukan wanprestasi maka menimbulkan sengketa medik. Penyelesaian sengketa medik tidak hanya di dalam pengadilan, tetapi juga dapat dilakukan di luar pengadilan.Tujuan penelitian ini untuk mengetahui alternatif penyelesaian sengketa medik di luar pengadilan yang sesuai dengan peraturan perundang-undangan yang berlaku.Penelitian ini merupakan penelitian yuridis-normatif. Penelitian ini mendeskripsikan penyelesaian sengketa medik di Indonesia berdasar atas peraturan perundang-undangan yang berlaku di Indonesia. Kemudian, menganalisis setiap pilihan penyelesaian sengketa medik yang terdapat di peraturan perundang-undangan.Hubungan dokter-pasien ditinjau dari hukum perdata merupakan perjanjian terapeutik. Jika dalam perjanjian salah satu pihak melakukan wanprestasi seperti dokter yang melakukan tindakan yang merugikan pasien maka dapat menimbulkan sengketa medik. Penyelesaian sengketa medik secara perdata tidak hanya diselesaikan dipengadilan saja, tetapi juga dapat dilakukan di luar pengadilan melalui beberapa mekanisme, yaitu konsultasi, negosiasi, mediasi, konsiliasi, dan pendapat ahli.Kata Kunci: Penyelesaian, Sengketa Medik, Luar Pengadilan
PENGELOLAAN SUMBER DAYA MANUSIA LABORATORIUM KLINIK Noormartany Noormartany
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 1 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i1.354

Abstract

Clinical laboratories should have higher competitiveness and healthiness to be survived in the globalization era. The very basic assets are vision, mission, and objectives which are agreed upon them. To establish these objectives are required the availability of the human resources which can perform professionally. They can serve efficiently and effectively due to their increasing professionalism. This happened by a continuing enhanced development of the human resources. The only way to achieve this objective is by effecting the Total Quality Management which emphasizes the personal development through an objective appraisal system
Fenomena Dose Dependent Manner Efek Jahe Gajah terhadap Cedera Jaringan Hati pada Sindrom Metabolik Agista Rohani; Noormartany Noormartany; Arief Budi Yulianti; Anita Indriyanti; Maya Tejasari
Jurnal Integrasi Kesehatan dan Sains Vol 1, No 2 (2019): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v1i2.4332

Abstract

Sindrom metabolik merupakan kelainan metabolik kompleks yang memiliki komponen utama obesitas, resistensi insulin, dislipidemia, dan hipertensi. Penyakit ini dapat berlanjut menjadi penyakit perlemakan hati non-alkoholik yang ditandai dengan cedera jaringan hati. Parameter yang dapat menandakan cedera jaringan hati adalah peningkatan kadar AST dan ALT. Peningkatan stres oksidatif mendasari terjadi penyakit ini sehingga untuk mengatasinya dapat menggunakan antioksidan, salah satunya adalah jahe. Penelitian ini bertujuan mengetahui pengaruh pemberian fraksi etil asetat jahe gajah terhadap kadar AST dan ALT pada mencit sindrom metabolik. Penelitian ini merupakan penelitian eksperimental in vivo menggunakan mencit galur Swiss Webster yang terbagi dalam empat kelompok, yaitu kelompok kontrol yang tidak diberikan perlakuan dan tiga kelompok perlakuan yang diberi fraksi etil asetat jahe gajah dengan konsentrasi 0,78 mg/kgBB/hari, 1,56 mg/kgBB/hari, dan 3,12/kgBB/ hari. Hasil penelitian menunjukkan kelompok perlakuan 1 memiliki kadar AST dan ALT lebih rendah dibanding kelompok kontrol, sedangkan kelompok perlakuan 2 dan 3 lebih tinggi dibanding dengan kelompok kontrol. Hal ini menunjukan bahwa pada kelompok perlakuan satu, fraksi jahe dapat mencegah cedera jaringan hati, sedangkan pada kelompok perlakuan dua dan tiga justru merusak jaringan hati. Simpulan fraksi etil asetat jahe gajah memengaruhi cedera jaringan hati pada mencit model sindrom metabolik secara dose dependent manner. DOSE DEPENDENT MANNER PHENOMENON OF GINGER EFFECTS IN METABOLIC SYNDROME LIVER INJURYMetabolic syndrome is a complex metabolic disorder that has a major component are obesity, insulin resistance, dyslipidemia, and hypertension. This disease can progress to non-alcoholic fatty liver disease characterized by liver injury. Parameters that can indicate liver tissue injury are an increase in AST and ALT levels. Increased oxidative stress underlies the occurrence of this disease, so to overcome it can use antioxidants, one of which is ginger. This study aims to determine the effect of ethyl acetate fraction ginger on AST and ALT levels in mice of metabolic syndrome. This study was an experimental study in vivo using Swiss Webster mice models divided into four groups: untreated control group and three treatment groups given ethyl acetate fraction ginger with concentration 0.78 mg/ kgBW/day, 1.56 mg/kgBW/day, 3.12/kgBW/day. The results showed that the treatment group 1 had AST and ALT levels lower than the control group, while the 2 and 3 treatment groups were higher than the control group. This suggests that in the treatment group one, the ginger fraction can prevent liver injury while in the treatment group two and three actually damage the liver tissue. It can be concluded that the elephant glycol ethyl acetate fraction affects liver injury in metabolic syndrome mice model by dose dependent manner.
ANGKA FIB-4 DAN HIGHLY ACTIVE ANTI RETROVIRAL THERAPY DI ANTARA PASIEN PENGIDAP INFEKSI HIV Liliana A; Noormartany Noormartany; Sugianli AK
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 2 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i2.1071

Abstract

Liver disease in patients with HIV infection can be caused by hepatotropical virus co infection or as a side effect of antiretroviraltherapy. The cause of HAART effects on liver fibrosis among patients with HIV infection is not yet known. The monitoring of the incidenceof liver fibrosis can be done with non-invasive markers, such as FIB 4 score. FIB-4 score is calculated by the formula: Age x AST/totalplatelet x √ALT. This is carried out to know the comparison of the FIB-4 score in HIV patients before and after first-line HAART therapy,with or without HCV coinfection. This study was a comparative analysis of retrospective data of patients at the Outpatient Teratai Clinic,Dr. Hasan Sadikin Hospital, from 2003 through 2013. The research subjects consisted of 64 patients with HIV infection who receivedfirst-line HAART therapy for more than 12 months. Statistical analysis was performed by Wilcoxon test for two paired samples. Themedian scores of FIB-4 from HIV infection patients with or without HCV co infection before and after the administration of first-lineHAART therapy were 0.854 and 0.906 (p=0.837). The HCV co infected patients had median scores of FIB-4 before and after treatment at0.854 and 0.899 (p=0.204). Those without HCV co infection had median scores of FIB-4 before and after treatment at 2.726 and 0.912(p=0.013).Treatment with first-line HAART did not lead to a change in the FIB-4 score. Those who were co infected with HCV showed nodifferences in the FIB-4 scores before and after treatment with first-line HAART.
KADAR HEMOGLOBIN RETIKULOSIT DI ANEMIA DAN NONANEMIA AKIBAT DEFISIENSI BESI ABSOLUT DI GAGAL GINJAL TERMINAL TERKAIT HEMODIALISIS (Reticulocyte Hemoglobin Level of Absolute Iron Deficiency Anemia and NonAbsolute Iron Deficiency Anemia In End State Renal Disease Undergoing Maintenance Hemodialysis) Amelia Rachmiwatie; Noormartany Noormartany; Rubin Surachno Gondodiputro; Delita Prihatni
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1256

Abstract

Absolute Iron Deficiency Anemia (IDA) is one of the complications in the End State Renal Disease (ESRD) patients undergoingmaintenance hemodalysis, with an incidence of 76.4%. If this condition is not properly addressed, it can lead to impaired cardiac functionand increased mortality. The incidence of this case is between 30−45%. The determination of the iron status in ESRD patients wqs setby the Perhimpunan Nefrologi Indonesia 2011 using serum ferritin and transferrin saturation, but they do not provide a meaningfulchange in the value of the initial state of the iron deficiency. This condition should be examined with other parameters combination aswell as those influenced by diurnal variation and infection-inflammation condition. Reticulocyte hemoglobin (Ret-He) parameter canbe used as a marker of bone marrow iron availability because these reticulocytes are young erythrocytes released from the bone marrowinto the circulation. These conditions were circulated only within a short time about 1-2 days before becoming mature erythrocytes. Theaim of this study was to determine the Ret-He level diferentiation between absolute IDA and non absolute IDA states in ESRD patientswhom underwent maintenance hemodialysis. This research was conducted in the Laboratory of Clinical Pathology-RSHS-Bandung fromSeptember 2012 to June 2013. The study design was cross-sectional. All subjects were ESRD patients undergoing hemodialysis maintenancefor at least three (3) months and consisted of absolute IDA and non-absolute IDA based on the results of the ferritin and transferrinsaturation calculations according to the criteria of Pernefri 2011 Reticulocyte hemoglobin levels were checked using a fluorescenceflowcitometry principle in the automated hematology analyzer. In this study it was found that the Ret-He mean in the absolute IDA was26.1 pg/cell and 35.9 pg/cell in non absolute IDA. Statistical analysis was performed using Independent T-test. A total of 61 undergoingmaintenance hemodialysis subjects participating in this study comprised patients with absolute IDA and non-absolute IDA who met theinclusion and exclusion criteria. It can be concluded that the Ret-He level in statistical analysis showed absolute IDA which was meaningfullower than nonabsolute IDA in ESRD patients undergoing maintenance hemodialysis (p<0.001).
KESEPANCARAN (HOMOLOGI) LEGIONELLA PNEUMOPHILA JARINGAN DISTRIBUSI AIR DAN PNEUMONIA NOSOKOMIAL Noormartany .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.1028

Abstract

L. pneumophila is one of the nosocomial pneumonia causes that contaminated hospital water distribution system. The aim of this study was to determine the homology between L. pneumophila 16S rRNA base sequence found in the water distribution systemand the sequence derived from the sputum of nosocomial pneumonia patients identified at RSHS Bandung as well as the homology of L. pneumophila 16S rRNA found in the same system network. The study also include the nosocomial pneumonia patients at RSHSBandung with L. pneumophila from GenBank. The research using descriptive bioinformatics BLAST method by comparative analyticapproach, which performed from April 2006 to February 2008. The material consists of 60 biofilm samples from water distributionsystem and pneumonia nosocomial patient’s sputum is positive L.pneumophila from water distribution system in her/his room. Inthe result was found: out of the 60 biofilm samples from the water distribution system, there are seven (7) L. pneumophila positivePCR and culture. During the 12 months of observation, there is only one (1) out of 31 pneumonia nosocomial patients with positively L. pneumophila PCR and culture. The conclusion so far can be mentioned that: The water distribution system in RSHS for patient roomsmay become the source for nosocomial pneumonia transmission of L. pneumophila and also was detected a new species of L. pneumophilathat is genetically different from that has been found in GenBank.
Co-Authors - Syuhada, - Achmad Mauludin Agista Rohani Agnes R Indrati, Agnes R Agnes R. Indrati Aisyah Elliyanti Alfiyya Nur Mahdiyyah Amelia Rachmiwatie Arief Budi Yulianti Ariko Rahmat Putra Arto Yuwono Soeroto Coriejati Rita Dany Hilmanto Delita Prihatni Dewi Susanna Emmy Pranggono Fenny, - Florencia Idajanti Tandhana Hikmat Permana HY Yusup HY Yusup, HY Ida Parwati Indahwaty, - Ismet Muchtar Nur Ismu Huzen Ivana Agnes Sulianto Ivana Agnes Sulianto, Ivana Agnes Johan S. Masjhur, Johan S. Kristina Wiharjo Lelly Yuniarti Liliana A Lulu Fahrizah Balqis, Lulu Fahrizah M. Ruslin M. Ruslin, M. Maya Tejasari Moudy Emma Unaria Djami Muhammad Alamsyah Muhammad Arkan Bastian MZ Arifin MZ Arifin Nadjwa Zamalek Dalimoenthe neli sumanti Nina Susana Dewi Nina Tristina Puspita, Sara R. Anita Indriyanti Raden Anita Indriyanti Ratri Dwitiya Nestiti, Ratri Dwitiya Rika Nilapsari Rosady, Dony Septriana Rubin Surachno Gondodiputro Rudi Wisaksana Salma Aulya Fitriani Siti Annisa Devi Trusda, Siti Annisa Devi Sugianli AK Sylvia Rachmayati Tenny Putri Wikayani, Tenny Putri Tiene Rostini, Tiene Toni M. Aprami Tri Hanggono Achmad Victor Immanuel Yani Triyani Yenolinsky, Yolanda Yuktiana Kharisma