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Journal : CERATA

Optimasi Formula Sirup Ekstrak Etanol Daun Sukun (Artocarpus altilis) Dengan Pemanis Sorbitol dan Co – Solvent Propilen Glikol Nurul Hidayati; Ivan Nuryanto; Saifudin Zukhri
CERATA Jurnal Ilmu Farmasi Vol 10 No 2 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v10i2.80

Abstract

Breadfruit leaves (Artocarpus altilis) are effective in reducing high blood sugar levels. One of the uses of breadfruit is by making it into syrup. The manufacture of breadfruit leaf ethanol extract is expected to improve the bitter taste of breadfruit leaves. This study aims to determine the effect of variations of sorbitol and propylene glycol and to obtain the optimum value of sorbitol and propylene glycol on the physical properties and hedonic value of syrup preparations. Breadfruit leaveswas extracted by multilevel maceration with 70% ethanol. Thick breadfruit leaf extract made syrup preparations in 5 runs with variations of sorbitol: propylene glycol, namely Run 1 (20%: 25%), Run 2 (35%: 10%), Run 3 (31.25%: 13.75% ), Run 4 (27.5%: 17.5%) and Run 5 (23.75%: 21.25%). The syrups were tested for their physical properties including organoleptic, viscosity, pH and hedonic tests. The test results are optimized with Simplex Lattice Design. The optimum formula of the predicted results is verified by analysis of one sample t-test with a 95% confidence level.The results showed an increase in sorbitol and propylene glycol increased the pH and hedonic values but did not affect the viscosity value of syrup preparations. Sorbitol concentration of 30,0005% and propylene glycol 14.9995% produced syrup with pH and hedonic value optimum differed insignificantly with p-values> 0.05.
FORMULASI DAN UJI MUTU FISIK SEDIAAN KRIM ANTI JERAWAT DARI EKSTRAK DAUN PEPAYA (Carica papaya L.) Zukhri, Saifudin; Andasari , Sholikhah Deti; Muchson , Muchson
CERATA Jurnal Ilmu Farmasi Vol 9 No 2 (2018): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v9i2.123

Abstract

Extract leaves pepaya compound containing karpain alkaloid can bring to a bitter taste and having activity of obstruent against bacteria propionibacterium acnes that causes for acne.This report aims to understand extract leaves papaya can be made in the preparation anti acne cream, and influence distinction concentration extract leaves pepaya of physical preparations quality and cream having influence optimal with low extract leaves pepaya % 1, 2 %, 3 %. Extract of papaya leaves made by maceration for 5 days using solvent ethanol 96 %. Extract of papaya leaves made cream with M/ A type. Cream extract leaves papaya made with low different, the 1st formula with low extract 1%, 2nd formulas with low extract 2%, 3rd formula with low extract 3% and 4th formula without concentration extract. Cream and physical tested quality, quality testing covering the physical: organoleptic, the homogenity, the southwestern spread, the southwestern attaching, the pH, and the southwestern protection. Data analyzed normality with kolmogrov-smirnov followed by test homogeneity with homogency of variances and analyzed by statistic one-way anova if there is a difference followed by tukey HSD. The result showed that leaves papaya with concentration 1% , 2% , 3% can be made of preparations cream affecting physical cream quality preparations .Cream extract leaves papaya on formula II (concentration extract 2 %) has its attaching of 1.65±0.23 seconds , the spread 6.40±0.17 cm is the result of higher than the to a formula I (concentration extract 1 %) power attaching of 1.08±0.05 seconds, the spread of 6.26±0.30 cm and formula iii (concentration extract 3%) has its attaching 1.25 ± 1.11 seconds, the spread 7.03±0.32 cm.