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All Journal Medical Journal of Indonesia Berkala Kedokteran eJournal Kedokteran Indonesia Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Kedokteran Meditek Cermin Dunia Kedokteran
Rinadewi Astriningrum
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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KOMORBIDITAS PADA AKNE Andira Hardjodipuro Hardjodipuro; Rinadewi Astriningrum; Irma Bernadette; Lili Legiawati; Sandra Widaty
Media Dermato-Venereologica Indonesiana Vol 49 No 2 (2022): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i2.334

Abstract

Akne vulgaris (AV) merupakan salah satu penyakit kulit yang paling sering ditemui, terutama pada remaja dan dewasa muda. Patogenesis terjadinya AV setidaknya diperankan oleh empat faktor penting, yaitu hiperproliferasi lapisan epidermis pada folikel, peningkatan produksi sebum, proses peradangan, dan kolonisasi Cutibacterium acnes. Proses tersebut juga dipengaruhi oleh berbagai faktor, antara lain faktor genetik, hormonal, psikologis, gaya hidup, dan lingkungan. Lesi AV bersifat polimorfik dan memiliki derajat keparahan yang beragam. Lesi tersebut diketahui memberikan dampak terhadap kualitas hidup penderitanya. Berbagai studi terkini melaporkan bahwa terdapat berbagai komorbiditas yang dapat memberikan beban tambahan atau memperburuk kondisi AV. Komorbiditas didefinisikan sebagai penyakit yang terjadi secara simultan. Berbeda dengan sindrom yang memiliki arti sekumpulan gejala yang terjadi serentak atau sekumpulan tanda yang menandakan suatu penyakit tertentu. Komorbiditas akne yang telah banyak diinvestigasi antara lain resistensi insulin, hipovitaminosis D, 1 hipervitaminosis B12, gangguan gastrointestinal, gangguan psikologis, disfungsi kelenjar tiroid, dislipidemia, defisiensi seng, dan hipovitaminosis A dan E.
KASUS RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA-MITIS YANG TERDIAGNOSIS PADA SAAT LANJUT USIA Inadia Putri Chairista; Shannaz Nadia Yusharyahya; Lili Legiawati; Rahadi Rihatmadja; Rinadewi Astriningrum
Media Dermato-Venereologica Indonesiana Vol 50 No 1 (2023): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i1.402

Abstract

Introduction: Recessive dystrophic epidermolysis bullosa (RDEB) is a rare bullous disease caused by mutations in the COL7A1 gene encoding anchoring fibril collagen that maintains skin integrity. Case: Male, 67-year-old, presented with blisters and wound on various parts of the body, worsening in the recent year. They had been known to easily appear after trauma since. Vesicles-bullae, erosions-excoriations, milia, and atrophic scars were found on the axillae, groins, and limbs, as well as hyperkeratosis and anonychia of the hands and. Histopathological examination showed subepidermal cleft, milia and fibrosis, without immunoglobulin deposits on immunofluorescence. Discussion: Contrary to classical RDEB, blisters in mitis variant do not always cause impairment. The pronounced symptoms in advanced age might be mistaken for epidermolysis bullosa acquisita. Negative immunoglobulin deposition is the diagnostic key, confirming that blister does not result from an autoimmune process, but rather, from trauma to the abnormal skin, more so by flattening of the rete ridges in the elderly. In the absence of definitive therapy, treatment is symptomatic. Conclusion: The diagnosis RDEB-mitis might be missed in geriatric. Correct diagnosis has implication on management because not only does RDEB-mitis require no immunosuppressant, measures to minimize blister formation is more important to save patient from complication.
Diagnosis dan Tata Laksana Hydroa Vacciniforme Reisa Reshinta; Githa Rahmayunita; Rahadi Rihatmadja; Rinadewi Astriningrum
Cermin Dunia Kedokteran Vol 51 No 5 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i5.902

Abstract

Hydroa vacciniforme (HV) is a rare photodermatoses with the most frequent onset in childhood. The exact pathogenesis of HV is still not known. This disease is a spectrum with almost similar clinical symptoms, but with a very different prognosis. Classic HV has the best prognosis, but affects the quality of life due to scar formation, while hydroa vacciniforme-like lymphoma (HVLL) is the variant with the worst prognosis. HV needs to be considered as a differential diagnosis, especially in childhood-onset photodermatoses. Classical HV must be distinguishes from hydroa vacciniforme-like lymphoproliferative disorders (HVLPD) because it is related to prognosis. There is still no consensus or guidelines on diagnosis and management for HV. 
Herpes Zoster dengan Manifestasi Eritema Multiforme Bulosa pada Pasien Geriatri Imunokompromais: Laporan Kasus Halim, Dionisius Ivan Yonathan; Legiawati, Lili; Yusharyahya, Shannaz Nadia; Astriningrum, Rinadewi
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.531

Abstract

   Pendahuluan: Herpes zoster (HZ) merupakan sekumpulan gejala dan manifestasi klinis yang disebabkan oleh reaktivasi varicella-zoster virus (VZV). Faktor predisposisinya antara lain: usia lanjut, keadaan imunokompromi, obat imunosupresif, keganasan, stres psikologis, trauma, dan tindakan pembedahan. Manifestasinya bervariasi, namun manifestasi eritema multiforme (EM) bulosa jarang dilaporkan. Kasus: Seorang perempuan berusia 65 tahun mengeluhkan bercak gatal pada kedua lengan dan tungkai sejak 3 hari yang lalu. Pasien sedang menjalani kemoterapi atas indikasi kanker payudara metastasis tulang dengan multikomorbid. Pada pemeriksaan ditemukan lesi target tipikal EM yang beberapa berkembang menjadi EM bulosa. Terdapat riwayat demam. Pasien ditatalaksana dengan kortikosteroid serta terapi simptomatik. Satu minggu kemudian ditemukan lenting berkelompok di lengan kiri atas sampai ke leher kiri sesuai dermatom C4 dan C7 yang disertai rasa nyeri dan terbakar. Kortikosteroid dihentikan dan diobati dengan valasiklovir 3 x 1000 mg selama 10 hari dan terapi simptomatik. Setelah 2 minggu terdapat perbaikan klinis dan gejala. Diskusi: Kasus HZ aberans dengan manifestasi EM bulosa dapat terjadi pada individu dengan komorbid dan keadaan imunokompromi. Pada pasien ini terdapat usia lanjut riwayat kanker payudara, obat kemoterapi, serta komplikasi infeksi sekunder pasca tindakan pembedahan. Manifestasi HZ mirip dengan EM minor karena ditemukannya lesi target tipikal pada kedua ekstremitas tanpa lesi mukosa. Perubahan perjalanan penyakit menjadi vesikel berkelompok sesuai dermatom, kemungkinan HZ aberans lebih dipertimbangkan. Kesimpulan: Herpes zoster dapat menimbulkan manifestasi EM. Terapi dengan obat antiviral menunjukkan perbaikan baik klinis maupun gejala. Kemungkinan manifestasi EM pada HZ harus dipertimbangkan untuk diagnosis dini dan tatalaksana efektif.
PENDEKATAN KONSERVATIF PADA SINDROM BART: SEBUAH LAPORAN KASUS Sukmara, Isni Maulina; Agustin, Triana; Astriningrum, Rinadewi
Media Dermato-Venereologica Indonesiana Vol 52 No 3 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i3.544

Abstract

Pendahuluan: Sindrom Bart (SB), dikenal sebagai aplasia kutis kongenita (AKK) tipe VI, adalah kelainan genetik yang jarang ditemui, ditandai dengan AKK, pembentukan bula pada kulit dan selaput lendir, serta deformitas kuku. Pilihan pengobatan meliputi intervensi bedah terutama pada lesi yang luas. Pendekatan terapi secara konservatif berperan penting dalam mencegah kerusakan jaringan lebih lanjut dan mendukung proses penyembuhan. Kasus: Seorang bayi perempuan berusia 4 hari dibawa ibunya berobat dengan luka pada kedua tungkai bawah sejak lahir. Riwayat serupa ditemukan pada ayah pasien. Pasien lahir melalui persalinan pervaginam tanpa komplikasi. Pemeriksaan fisis menunjukkan kehilangan kulit dengan erosi-ekskoriasi pada kedua tungkai bawah, disertai krusta merah-kekuningan, skar hipopigmentasi, dan milia. Luka dirawat dengan balutan antibakteri, busa silikon, dan perban elastis yang diganti setiap tiga hari. Dalam dua bulan, luka menyembuh namun terjadi pembentukan bula pada kaki dan mukosa mulut hingga usia enam bulan. Berdasarkan riwayat penyakit dan pemeriksaan fisis, pasien didiagnosis sebagai SB. Diskusi: Diagnosis SB terutama ditegakkan berdasarkan temuan klinis. Epitelisasi cepat pada lesi AKK di ekstremitas telah dilaporkan pada beberapa kasus. Terapi konservatif efektif dalam mencegah kerusakan jaringan lebih lanjut dan mendukung penyembuhan. Kesimpulan: Laporan kasus ini menyoroti keberhasilan penggunaan terapi konservatif dalam menangani SB, sehingga tidak memerlukan intervensi bedah.
Perbaikan Klinis Green Nail Syndrome yang Signifikan pada Lanjut Usia dengan Terapi Kombinasi: Sebuah Serial Kasus Marizki Ramadhani, Reinanda; Nadia Yusharyahya, Shannaz; Legiawati, Lili; Astriningrum, Rinadewi; Gunardi, Keiko Yolanda; Reshinta, Reisa
Jurnal Kedokteran Meditek Vol 31 No 2 (2025): MARCH
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i2.3383

Abstract

Introduction: Green nail syndrome is a common bacterial infection of the nails and is characterized by green discolouration of the nail plate caused by Pseudomonas aeruginosa. It frequently occurs in people who are exposed to constant water and due to mechanical trauma, especially in elderly patients. Case Illustration: We reported 2 cases treated with a combination therapy of oral ciprofloxacin, 1% acetic acid dressing, gentamicin ointment and showed a significant clinical improvement. There are two cases: a 67-year-old man and a 64-year-old woman complained of black-greenish discolouration on his right big toenail, which has been accompanied by changes in the shape of the nail for 3 months. Both patients have a history of frequent and prolonged contact with water—dermoscopy results in greenish-black discolouration in the nail plate.  The culture results of both patients, Pseudomonas aeruginosa was found. Combination treatment showed significant clinical improvement in both patients. Discussion: Dressing of 1% acetic acid was useful as an adjuvant to improve the ointment penetration, inhibiting the formation of Pseudomonas aeruginosa biofilms. Gentamicin and ciprofloxacin are effective against aerobic gram-negative bacterial infections, such as Pseudomonas aeruginosa. Conclusion: The use of ciprofloxacin is recommended, especially in elderly patients. Combination therapy with oral ciprofloxacin, 1% acetic acid dressing, and gentamicin ointment is an effective option for patients with green nail syndrome
Diagnosis dan Tata Laksana Hydroa Vacciniforme Reshinta, Reisa; Rahmayunita, Githa; Rihatmadja, Rahadi; Astriningrum, Rinadewi
Cermin Dunia Kedokteran Vol 51 No 5 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i5.902

Abstract

Hydroa vacciniforme (HV) is a rare photodermatoses with the most frequent onset in childhood. The exact pathogenesis of HV is still not known. This disease is a spectrum with almost similar clinical symptoms, but with a very different prognosis. Classic HV has the best prognosis, but affects the quality of life due to scar formation, while hydroa vacciniforme-like lymphoma (HVLL) is the variant with the worst prognosis. HV needs to be considered as a differential diagnosis, especially in childhood-onset photodermatoses. Classical HV must be distinguishes from hydroa vacciniforme-like lymphoproliferative disorders (HVLPD) because it is related to prognosis. There is still no consensus or guidelines on diagnosis and management for HV. 
Characteristics of pressure injuries among geriatric patients at an Indonesian tertiary hospital: a cross-sectional study Yusharyahya, Shannaz Nadia; Legiawati, Lili; Astriningrum, Rinadewi; Jonlean, Reganedgary; Andhira, Vega
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.237092

Abstract

BACKGROUND Pressure injury develops due to sustained pressure at the bony prominence of the skin and tissues. Geriatric patients often have multiple comorbidities, predisposing them to pressure injury. Data on the characteristics of the geriatric with pressure injuries are still limited. This study aimed to report the characteristics of geriatric patients with pressure injuries admitted at a tertiary hospital in Indonesia. METHODS This cross-sectional study used medical records of geriatric patients admitted with all stages of pressure injuries consulted to the Department of Dermatology and Venereology at a tertiary hospital in Indonesia between January 2017 and April 2021. Pressure injuries were classified based on the 2019 National Pressure Injury Advisory Panel guideline. RESULTS 39 patients presented with varied pressure injury characteristics. The sacral region was the most reported site (36%), with stage 2 pressure injury being the most commonly found stage in the patients (74%). Interestingly, 22% of the patients had pressure injuries found on the atypical sites due to prolonged surgery or the pressure of medical devices. More than half of the patients used conventional dressings (51.3%). Immobility was found in 35.9% of the patients due to being bedridden. CONCLUSIONS No characteristics were found as a significant risk factor for pressure injury formation during or outside the admission period. However, a history of surgery might be related to pressure injury formation during admission.
Effectiveness and safety of moisturizing wash and cream in the treatment of elderly xerosis cutis Legiawati, Lili; Yusharyahya, Shannaz Nadia; Astriningrum, Rinadewi; Puteri, Fathirah Rahmatiah; Ilyas, Nabila Chalisya
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The skin undergoes degenerative and metabolic changes with aging, increasing susceptibility to dermatological conditions. Xerosis cutis, characterized by rough, scaly skin on the lower legs, is the most common cause of pruritus in elderly patients, with a prevalence of 38–85%. Treating xerosis cutis is challenging due to its multifactorial causes, especially in the elderly. Moisturizers remain the primary and most effective treatment, providing convenience and efficacy. This study aimed to evaluate the effects of QV Intensive Moisturizing Cleanser™️ and QV Intensive Cream™️ (Ego Pharmaceuticals, Australia), which contain humectants, emollients, and occlusives. Case Illustration: This observational case series involved six elderly subjects (>60 years) with xerosis cutis. Exclusion criteria included medications that cause dry skin, use of topical moisturizers within 2 weeks, or oral supplements (hyaluronic acid, vitamin C, and ceramide) within 4 weeks before the study. Over four weeks, subjects used only the specified cleanser and moisturizer on affected skin. Improvement was assessed subjectively using the Smoothness, Redness, Roughness, Cracking (SRRC) score, the Dermatology Life Quality Index (DLQI), and the 5D Pruritus Scale. Objective measures included transepidermal water loss (TEWL) via Tewameter® TM300 and skin capacitance (SCap) via Corneometer® CM825 (Courage+Khazaka Electronic GmbH, Germany). Discussion: All subjects showed improvement in SRRC, 5D Pruritus Scale, DLQI, TEWL, and SCap after four weeks of cleanser and moisturizer use, with no side effects or irritation observed. Conclusion: Cleansers and moisturizers containing humectants, emollients, and occlusives were found to be safe and effective for treating xerosis cutis in geriatric patients.
ELAINAN KUKU AKIBAT PENGGUNAAN CAT DAN RIAS KUKU Mahda Rizki Liana; Larisa Paramitha Wibawa; Rinadewi Astriningrum; Windy Keumala Budianti; Shannaz Nadia Yusharyahya
Media Dermato-Venereologica Indonesiana Vol 53 No 2 (2026): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v53i2.608

Abstract

   Kuku memiliki fungsi penting sebagai pelindung ujung jari, penunjang fungsi sensorik, serta aspek estetika yang berperan dalam menunjang penampilan dan kepercayaan diri. Seiring meningkatnya minat terhadap perawatan dan keindahan kuku, penggunaan kosmetik kuku seperti cat kuku, kuku akrilik, cat kuku gel, dan berbagai teknik rias kuku semakin meluas. Meskipun secara umum relatif aman, penggunaan cat dan rias kuku dapat menimbulkan berbagai kelainan kuku akibat faktor mekanis, traumatis, infeksi, maupun reaksi terhadap bahan kimia yang terkandung di dalam produk. Tinjauan pustaka ini bertujuan untuk membahas jenis-jenis kelainan kuku yang dapat terjadi akibat penggunaan cat kuku dan rias kuku, termasuk kuku rapuh, onikolisis, dermatitis kontak, infeksi, perubahan warna kuku, hingga risiko jangka panjang akibat paparan sinar ultraviolet pada penggunaan cat kuku gel. Berbagai bahan seperti formaldehid, akrilat, metakrilat, dan pelarut organik diketahui berperan dalam timbulnya efek samping tersebut. Pemahaman mengenai teknik perawatan kuku, bahan kosmetik yang digunakan, serta potensi komplikasinya sangat penting bagi klinisi agar dapat melakukan diagnosis yang tepat, memberikan edukasi pencegahan, dan menentukan tata laksana yang sesuai pada pasien dengan kelainan kuku akibat kosmetik. 
Co-Authors Adistri, Kara Aldri Frinaldi Andhira, Vega Andira Hardjodipuro Hardjodipuro Arini Astasari Widodo Arini Astasari Widodo Ariyati Yosi Azizah, Fitri Chandrakesuma, Vivianne Christine Lieana Eyleny Meisyah Fitri Githa Rahmayunita Githa Rahmayunitha Gunardi, Keiko Yolanda Halim, Dionisius Ivan Yonathan Hanny Nilasari Hartanto, David Dwiadiputra Henry W. Lim Henry W. Lim Hoemardani, Aida SD Ilyas, Nabila Chalisya Inadia Putri Chairista Irma Bernadette Isni Maulina Sukmara, Isni Maulina Jonlean, Reganedgary Kenny Andrianus Kusmarinah Bramono Kusumawardhani, Dina Larisa Paramitha Lili Legiawati Lili Legiawati Lim, Henry W. Mahda Rizki Liana Marizki Ramadhani, Reinanda Menaldi, Sri Linuwih Susetyo Wardhani Mughni, Fadhli Aulia Nadia Yusharyahya, Shannaz Narla, Shanthi Natalia Rania Sutanto Puteri, Fathirah Rahmatiah Putu Martha Gerynda Sukma Putu Martha Gerynda Sukma Rahadi Rihatmadja Rahadi Rihatmadja Rahadi Rihatmadja Rahman, Yusnita Reisa Reshinta Reshinta, Reisa Rheza, Agung Mohamad Riani Laurensia Sampurna, Adhimukti T. Sandra Widaty Sari Chairunnisa Shannaz Nadia Yusharyahya Shannaz Nadia Yusharyahya Shannaz Nadia Yusharyahya Shanthi Narla Shanthi Narla Shwayder, Tor Sirait, Sondang Panjaitan Sutarjo, Agassi Suseno Tor Shwayder Tor Shwayder Triana Agustin Triana Agustin Valdi Ven Japranata Vivianne Chandrakesuma Windy Keumala Budianti Wresti Indriatmi B. Makes Yosi, Ariyati