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All Journal International Journal of Public Health Science (IJPHS) Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Forestry Research Jurnal Penelitian Hutan dan Konservasi Alam Jurnal Penelitian Hasil Hutan Indonesian Journal of Tropical and Infectious Disease Jurnal Penelitian Ekosistem Dipterokarpa Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Jurnal Ilmiah Rekayasa Pertanian dan Biosistem Health Notions Buletin Farmatera Jurnal Respirasi (JR) Biomolecular and Health Science Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Edukasi: Journal of Educational Research AKSONA Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Folia Medica Indonesiana
Abdurachman Abdurachman
Department Of Anatomy And Histology, Faculty Of Medicine, Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : Buletin Farmatera

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MODULATION OF BONE TISSUE HISTOMORPHOMETRY AND MALONDIALDEHYDE EXPRESSION LEVELS BY VITAMIN C IN RODENTS AFTER PRENATAL NOISE EXPOSURE Taya Elsa Savista; Viskasari Pintoko Kalanjati; Abdurachman Abdurachman
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (401.357 KB) | DOI: 10.30596/bf.v4i2.2571

Abstract

Abstract: Vitamin C is proposed as an antioxidant to combat the oxidative stress of prenatal noise exposure in bone tissue of newborn Wistar rats. Thirty-two Wistar mothers were administered oral vitamin C 150 mg/kg BW/day from D1 of pregnancy until delivery; white noise exposure of 95 dB, 4 hr/day was given from D15 of pregnancy until delivery. Newborn rats were divided into 4 groups equally (n=24): K1 (distilled water), K2 (vitamin C), P1 (distilled water + WN), P2 (vitamin C + WN). The osteoblast and osteoclast mean cell numbers, the osteoid volume, and an oxidative stress expression level marker of malondialdehyde (MDA) were calculated from two adjacent longitudinal slices of newborn rats’ tibiae using Cell Sense and ImageJ softwares (4 μ; 400x of light microscope magnification). Data were analyze using either ANOVA and LSD post-test or Brown-Forsythe and Games Howell post- test; significance level if p<0.05. In P2, the mean number of the osteoblast was significantly higher than in P1 (p<0.001); whilst the osteoclast mean number was significantly lower compared to other groups (p=0.03). In P2, the osteoid volume was significantly higher than in P1 (p=0.021); with lower MDA levels than P1 (p=0.074). From this study, vitamin C could protect the newborn rat bones exposed by prenatal noise as an oxidative stressor.Keywords: vitamin C, prenatal noise, osteogenesis, malondialdehyde
Co-Authors Agus Ismanto Agus Rubiyanto Ahmad Sukandar Ami Ashariati Amiril Saridan, Amiril Andi Yasmin Wijaya Andianto Andianto, Andianto Andika Darmawan Wahono Arinda Putri Auna Vanadia Asmaul Lutfi Marufah Astri Dewayani Atika Atika Atika Atika Atsira, Olga Putri Bambang E. Suwito Bambang Edi Suwito Bambang Purwanto Bambang Purwanto Barly Barly Bonfilio Neltio Ariobimo Chorisma Permata Putri Nurazizah Dian Eka Indriani, Dian Eka Dion K. Dharmawan Dominicus Martono, Dominicus Dzanuar Rahmawan Efrida Basri Erikavitri Yuliati Erliza Noor Farida Herry Susanty Fedik Abdul Rantam Hanafiah Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Hilmy Yafi Zuhair I'tishom, Reny Ida Lanniari, Ida Irwadi, Irfiansyah Jamal Balfas Jasni Jasni Khairina Khairina Krisdianto Sugiyanto Krisnawan A. Pradana Krisnawan Andy Pradana Lukman Hakim Luqman Hakim Andira Margarita Maramis, Margarita Marjono Dwi Wibowo Martin, Tomas Marcelino A. Martono Tri Utomo Massofian Noor, Massofian Musa Musa Nurwati Hadjib Oktariza, Rury Tiara Olga Putri Atsira Prastiya Indra Gunawan Pratiwi, Wahyu Nur Rahmawan, Dzanuar S.Pd. M Kes I Ketut Sudiana . Saefudin Saefudin Sita Setyowatie SOETJIPTO . Steven Sheng Looi Subagyo Subagyo Sunarti, Titi Chandra Tajuddin Bantacut Taya Elsa Savista Tjahjono, Agus Eko Ujianto Ujianto Ulfi Qomariyah Hanum Viskasari P. Kalanjati Wahyu N. Pratiwi Winona May Hendrata Yudi Her Oktaviono, Yudi Her Yuliati, Erikavitri