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Kunci Tadabbbur dan Integrasi Al-Qur’an dalam Pembelajaran Biologi Mujahidin Ahmad; Eko Budi Minarno; Suyono Suyono
Bioeduca : Journal of Biology Education Vol 2, No 2 (2020): Bioeduca : Journal of Biology Education
Publisher : Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/bioeduca.v2i2.6319

Islam sebagai agama yang sempurna (din-al kamil) dan universal (din-asy syamil) selalu menarik dijadikan sebagai sumber inspirasi pemikiran. Hal ini karena Al-Qur’an tidak hanya mengatur aspek hubungan manusia dengan tuhannya namun juga termasuk mengatur hubungannya dengan sesama makhluk. Upaya pendekatan hubungan antara sains dan al-quran khusunya biologi adalah sebuah upaya implementasi sains dalam kehidupan sehari hari terutama sebagai masyarakat yang religius. Diharapkan dengan adanya pengenalan model baru dapat memudahkan upaya integrasi Al-Qur’an dalam pembelajaran biologi. Metode yang digunakan dalam penelitian ini adalah telaah pustaka. Dalam pembelajaran Biologi, integrasi Sains-Islam dapat dilakukan dengan tiga macam model pendekatan yaitu; Model Integrasi Al-Qur’an sebagai Sumber Inspirasi, Konfirmasi dan Dogma-empiris. Ketiga model pendekatan dapat dijalankan secara simultan dalam proses pembelajaran Biologi.

Aktivitas Antioksidan Isolat Steroid Hasil Kromatografi Lapis Tipis dari Fraksi n-Heksana Hydrilla verticillata Ahmad Ghanaim Fasya; Bagas Purwantoro; Lulu'atul Hamidatu Ulya; Mujahidin Ahmad
ALCHEMY:Journal of Chemistry Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Hydrilla verticillata is one of Allah SWT creations that potential as an antioxidant. This study’s objectives were to determine antioxidant activity and identify steroid isolates of n-hexane fraction of H. verticillata. The steroid compounds were extracted using methanol solvent. The methanol extract was hydrolyzed with HCl 2 N and partitioned using n-hexane. The n-hexane fraction was tested phytochemically and separated using thin-layer chromatography (TLC). The steroids compounds were identified using UV-Vis spectrophotometer, FTIR, and LC-MS/MS. The result showed that maceration extraction produced 5.14% yield, whereas n-hexane fraction produce 47.95% yield. Steroid separation through analytical TLC revealed that n-hexane: ethyl acetate (4:1) as the best eluant with 12 spots, while separation using preparative TLC yielded 19 spots. Steroid isolate from TLC preparative has antioxidant activity with EC50 of 5.109 ppm. Identification of steroid compounds using UV-Vis produced maximum wavelengths at 203.9 and 276 nm, while using FTIR indicated the presence of O-H group, geminal dimethyl, C=O, C=C, secondary C-OH, and =C-H (alkene) which might contain steroid compounds. The result of LC-MS/MS showed the presence of β-sitosterol. Hydrilla verticillata merupakan salah satu ciptaan Allah SWT yang memiliki potensi sebagai antioksidan. Penelitian ini bertujuan mengetahui aktivitas antioksidan dan mengidentifikasi senyawa steroid pada isolat hasil pemisahan fraksi n-heksana H. verticillata. Senyawa steroid diekstraksi menggunakan pelarut metanol. Ekstrak pekat metanol dihidrolisis dengan HCl 2 N dan dipartisi dengan n-heksana. Fraksi n-heksana hasil partisi diuji fitokimia dan dipisahkan senyawanya menggunakan KLT (Kromatografi Lapis Tipis). Identifikasi dilakukan menggunakan UV-Vis, FTIR, dan LC-MS/MS. Hasil penelitian menunjukkan ekstraksi maserasi menghasilkan rendemen 5,14%, sedangkan rendemen partisi n-heksana sebesar 47,95%. Pemisahan steroid menggunakan KLT analitik menunjukkan bahwa variasi eluen terbaik adalah n-heksana: etil asetat (4:1) dengan 12 noda, sedangkan pemisahan KLT preparatif menghasilkan 19 noda. Isolat steroid hasil KLT preparatif memiliki aktivitas antioksidan dengan EC50 5,109 ppm. Identifikasi senyawa steroid menggunakan UV-Vis menunjukkan bahwa panjang gelombang maksimum sebesar 203,9 dan 276 nm, sedangkan untuk identifikasi isolat steroid menggunakan FTIR menunjukkan gugus fungsi O-H, geminal dimetil, C=O, C=C, C-OH sekunder dan =C-H (alkena) yang diduga merupakan senyawa steroid. Hasil LC-MS/MS menunjukkan adanya senyawa steroid β-sitosterol.

Herpetofauna In the Ledok Ombo Natural Tourism Area, Malang District, East Java Berry Fakhry Hanifa; Ahmad Panji Baihaqi; Mujahidin Ahmad; Kiptiyah Kiptiyah; Muhammad Asmuni Hasyim
Al-Hayat: Journal of Biology and Applied Biology Vol 5, No 2 (2022)
Publisher : Fakultas Sains dan Teknologi, UIN Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/ah.v5i2.13566

The purpose of this study was to determine the diversity of herpetofauna in the Ledok Ombo Nature Tourism Area, Malang Regency. Herpetofauna specimens were collected using a Visual Encoumter Survey, Purposive Sampling at 07-11 PM. Specimens were collected 3 times one week apart in March 2022. The data was analyzed using Shannon Weiener Diversity, Pielou Evenness, Margalef Richness, and Simpson Dominance indices. Habitat Characteristic were recorded. Water-air temperature and air humidity were recorded. The results showed 9 species of amphibians (Chalcorana chalconota, Microhyla achatina, Duttaphrynus melanostictus, Phrynoidis aspera, Leptobrachium hasseltii, Odorrana hosii, Rhacoporus reinwardtii, Polypedates leucomystax, Occydozyga lima) and 9 species of reptiles (Cyrtodactylus marmoratus, Hemydactylus frenatus, Gonocephalus kuhlii, Broncochela jubata, Eutropis multifasciata, Pareas carinatus, Ahetulla prasina, Dendrelaphis pictus, Lycodon subcinctus). The index values of diversity, evenness, richness, and dominance are 1,591, 0,088, 3,250, 0,398 respectively. Habitat character affect the composition of herpetofauna. Physical factors value range for water temperature 23 - 24.55°C, air temperature 25.05 - 27.15°C, and air humidity 77.25 - 84.75%.

IDENTIFIKASI JENIS POLIMER MIKROPLASTIK PADA IKAN TONGKOL LISONG (Auxis rochei) DI PANTAI DAMAS PRIGI KABUPATEN TRENGGALEK JAWA TIMUR Nindia Sukma Trivantira; Fitriyah Fitriyah; Mujahidin Ahmad
Binar – Biology Natural Resources Journal Vol 1 No 2 (2023)
Publisher : Prodi Biologi Universitas PGRI Ronggolawe

Plastic has a fairly wide distribution in human life. The use of microplastics is very difficult to avoid because it has reduced various human activities. The use of plastics on a large and wide scale raises a problem for the environment and ecosytem through the degradation of plastics into microplastics. Microplastics have the potential to pose a threat to the environment and organisms, especially in water areas. Their small size allows microplastics to be ingested by zooplankton up to a higher trophic level. Damas Beach is one of the marine tourism destinations in the Prigi bay area with a potential fishery sector in East Java. The high activity of tourism and fishing causes Damas beach to be potentially polluted by microplastics. This study aims to determine the type of plastic polymer in the digestive tract of lisong tuna obtained in the Damas beach area, Prigi Bay, Treanggalek Regency, East Java. This study used a purposive sampling method with two repetitions. Types of microplastic polymers were analyzed using FTIR. The results of the analysis showed that the types of plastic polymers found in the digestive tract of lisong tuna include High Density Polyethylene (HDPE), Polyvinyl chloride (PVC), nylon (polyamide, Polyethylene Terephthalate (PET), Polypropylene (PP), and Polystyrene (PS).

DEVELOPING HALAL VACCINE PRODUCTION IN INDONESIA: CHALLENGES AND FUTURE OPPORTUNITIES Mujahidin Ahmad
El-Hayah Vol 9, No 1 (2022): EL-HAYAH (VOL 9, NO 1 SEPTEMBER 2022)
Publisher : Program Study of Biology, Science and Technology Faculty, UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v9i1.18026

When the Covid19 pandemic occurred, Indonesia was the largest country in Southeast Asia with the most positive confirmed victims and the highest death rate. The consequences of the government's efforts to prevent the government from ordering vaccines reached 450 million doses for 187 million people in order to achieve individual immunity and herd immunity. As a country with the largest Muslim population in the world, the halal status of vaccines is very important. Of the six types of vaccines in Indonesia, namely; only the Sinovac vaccine received halal status, while other vaccines such as AstraZeneca, Pfizer, Moderna, Sinofarm were ultimately still used for emergency reasons due to insufficient halal vaccines. In the future, Muslim countries need to continue to develop alternative technologies and materials to ensure that the vaccines given are halal. Use of cell lines to produce vaccines such as Vero (Monkey), MDCK (Dog), BHK21 (Hamster), HEK (Human), PER (Human). The medium used for cell growth (upstream process) also contains Human Blood (HuS), Horse Blood (HS), Cow Blood (FBS). Likewise, the use of Pig and Animal Trypsin that is not slaughtered in a halal way, as well as the use of stabilizers in vaccine formulations such as Human or bovine (cow) Serum, Porcine or Cow Gelatin, Ethanol are critical points for fatwa institutions such as not passing the halal category. The use of alternative materials in vaccine production such as insect cells, yeast, fungi, non-animal medium and vegetable stabilizers has the opportunity to replace mainstream materials. The independence of halal vaccine production provides an opportunity to increase national resilience.

Effect of pegagan (Centella asiatica) nanoparticle coated with chitosan on the cytokine profile of chronic diabetic mice Muchtaromah, Bayyinatul; Firdaus, Ana MK.; Ansori, Arif NM.; Duhita, Maharani R.; Minarno, Eko B.; Hayati, Alfiah; Ahmad, Mujahidin; Analisa, Izza
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.697

Diabetes is closely related to immune response problems when it occurs chronically. Pegagan (Centella asiatica) is a medicinal plant with active compounds. Madecassoside is beneficial in treating diabetes, and nanoparticle technology is expected to enhance the medicinal potential and availability of pegagan compounds. The aim of this study was to determine the effect of chitosan-coated pegagan nanoparticles on the cytokine profile of chronic diabetic mice, which included CD4+TNF-α+, CD8+TNF-α+, CD4+IFN-γ+, CD8+IFN-γ+ and IL-6+. An experimental study with a randomized complete block design (CRD) consisting of six treatments with seven replicates was conducted. The groups were: healthy mice as negative control; diabetic mice treated with distilled water as positive control and diabetic mice treated with nanoparticle coated with chitosan (NPC) 20 mg/kg, 30 mg/kg, 40 mg/kg, and metformin 130 mg/kgBW. The data were tested using one-way analysis of variance (ANOVA) with a significance level of 5% and continued with the Duncan’s multiple range test. The results showed that pegagan NPC could significantly reduce the relative number of CD4+TNF-α+, CD8+TNF-α+, CD4+IFN-γ+ and CD8+IFN-γ+ and IL-6 in the dose of 20 mg/kg, 30 mg/kg and 40 mg/kg (p<0.05). The treatment dose of 20 mg/kg reduced CD4+TNF-α+, CD8+TNF-α+, CD4+IFN-γ+, CD8+IFN-γ+ to the levels of healthy mice and a dose of 30 mg/kg could reduce IL-6 as in healthy mice. These findings suggest that chitosan-coated pegagan nanoparticles are a promising therapy for diabetes, as they have the potential to modulate the immune response associated with chronic diabetes.

KARAKTERISTIK LARVA Culex sp. DARI PERKEBUNAN KARET DI WILAYAH BANJARBARU KALIMANTAN SELATAN Muhamat, Muhamat; Mujahidin, Ahmad; Gunawan, Gunawan
BIOTIKA Jurnal Ilmiah Biologi Vol 22, No 1 (2024): BIOTIKA JUNI 2024
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/biotika.v22i1.53751

Perkebunan karet di wilayah Banjarbaru menjadi habitat berbagai spesies nyamuk. Tahapan pradewasa dijumpai di wadah getah karet. Beberapa jenis larva nyamuk dapat hidup bersama dalam satu wadah getah yang salah satu larva dari genus Culex. Larva Culex dicirikan mempunyai sifon lebih panjang dari segmen ke 10 dan duri-duri pekten tidak sampai ujung sifon. Penelitian ini mengidentifikasi salah satu spesies dari genus Culex di perkebunan karet dengan menggunakan kunci identifikasi. Pengambilan sampel dengan metode jelajah mengikuti keberadaan wadah getah yang berisi air. Larva yang diambil adalah larva yang mempunyai sifon dengan perbandingan panjang: lebar adalah 11:1. Pengamatan karakteristik morfologi larva dilakukan pada bagian antenna, dorsomentum, pekten, sifon, dan segmen abdomen ke-10. Hasil penelitian ini diperoleh bahwa bagian ujung antenna spesimen berbentuk tumpul dan terdapat 3 setae, sebanyk 18 gigi dorsomentum, barisan pekten tidak sampai ujung sifon dengan panjang. Segmen abdomen ke-10 tidak sampai tertutup saddle. Karakteristik spesimen ini mempunyai kesamaan dengan karakteristik larva Cx. phangngae endemik Thailand.

Immunomodulatory Activity of Allium sativum, Curcuma mangga, and Acorus calamus Combination Nanoparticle on Mice Leukocytes Profile Muchtaromah, Bayyinatul; Analisa, Nur Izzah; Ahmad, Mujahidin; Fitriasari, Prilya Dewi; Habibi, Soraya; Hayati, Alfiah; Fajriyah, Ely Nuril
Jurnal Biodjati Vol 7 No 1 (2022): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i1.11879

Immunomodulators are substances acting as stimulants or suppressants against the immune system, either to specific or non-specific activity. The non-specific through the production of leukocytes as the first response in fighting against an attacking antigen. Meanwhile, the specific, hrough recognition of antigens by lymphocytes during reattack. This research aimed to determine the immunomodulatory activity of the extracts combination nanoparticles of Allium sativum, Curcuma mangga, and Acorus calamus on the leukocyte profile of mice. This study used 5 treatments and 6 repetitions. The treatment groups were K- (untreated group), P1 (extracts combination nanoparticle dose of 25 mg/kg), P2 (extracts combination nanoparticle dose of 50 mg / kg), P3 (subur kandungan herbal medicine dose of 75 mg / kg), and P4 (Clomiphene citrate dose of 0.9 mg / kgBW). The parameters used included the total number of leukocytes and their differential value. The data that met the parametric assumptions, such as normally distributed and homogeneous were examined usingÂ the One Way ANOVAÂ test, and when there was a significant difference, it was processed with theÂ DuncanÂ assessment. While those that did not meet the assumptions were evaluated using a non-parametric analysis. The statistical results showed that administration of extracts combination nanoparticles of A. sativum, C. mangga, and A. calamus at doses of 25 mg/kg and 50 mg/kg were able to suppress the inflammatory reaction by decreasing the total number of leukocytes. However, the differential leukocyte count was able to maintained or modulate immune system, indicating by the percentage of neutrophil, basophil, and eosinophil in the normal range. At a dose of 50 mg/kg, decreased the percentage of lymphocytes, while for monocytes, all dosage ranges were able to increase their number.

Herpetofauna In the Ledok Ombo Natural Tourism Area, Malang District, East Java Hanifa, Berry Fakhry; Baihaqi, Ahmad Panji; Ahmad, Mujahidin; Kiptiyah, Kiptiyah; Hasyim, Muhammad Asmuni
Al-Hayat: Journal of Biology and Applied Biology Vol. 5 No. 2 (2022)
Publisher : Fakultas Sains dan Teknologi, UIN Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/ah.v5i2.13566

The purpose of this study was to determine the diversity of herpetofauna in the Ledok Ombo Nature Tourism Area, Malang Regency. Herpetofauna specimens were collected using a Visual Encoumter Survey, Purposive Sampling at 07-11 PM. Specimens were collected 3 times one week apart in March 2022. The data was analyzed using Shannon Weiener Diversity, Pielou Evenness, Margalef Richness, and Simpson Dominance indices. Habitat Characteristic were recorded. Water-air temperature and air humidity were recorded. The results showed 9 species of amphibians (Chalcorana chalconota, Microhyla achatina, Duttaphrynus melanostictus, Phrynoidis aspera, Leptobrachium hasseltii, Odorrana hosii, Rhacoporus reinwardtii, Polypedates leucomystax, Occydozyga lima) and 9 species of reptiles (Cyrtodactylus marmoratus, Hemydactylus frenatus, Gonocephalus kuhlii, Broncochela jubata, Eutropis multifasciata, Pareas carinatus, Ahetulla prasina, Dendrelaphis pictus, Lycodon subcinctus). The index values of diversity, evenness, richness, and dominance are 1,591, 0,088, 3,250, 0,398 respectively. Habitat character affect the composition of herpetofauna. Physical factors value range for water temperature 23 - 24.55°C, air temperature 25.05 - 27.15°C, and air humidity 77.25 - 84.75%.

Herpetofauna In the Ledok Ombo Natural Tourism Area, Malang District, East Java Hanifa, Berry Fakhry; Baihaqi, Ahmad Panji; Ahmad, Mujahidin; Kiptiyah, Kiptiyah; Hasyim, Muhammad Asmuni
Al-Hayat: Journal of Biology and Applied Biology Vol. 5 No. 2 (2022)
Publisher : Fakultas Sains dan Teknologi, UIN Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/ah.v5i2.13566

The purpose of this study was to determine the diversity of herpetofauna in the Ledok Ombo Nature Tourism Area, Malang Regency. Herpetofauna specimens were collected using a Visual Encoumter Survey, Purposive Sampling at 07-11 PM. Specimens were collected 3 times one week apart in March 2022. The data was analyzed using Shannon Weiener Diversity, Pielou Evenness, Margalef Richness, and Simpson Dominance indices. Habitat Characteristic were recorded. Water-air temperature and air humidity were recorded. The results showed 9 species of amphibians (Chalcorana chalconota, Microhyla achatina, Duttaphrynus melanostictus, Phrynoidis aspera, Leptobrachium hasseltii, Odorrana hosii, Rhacoporus reinwardtii, Polypedates leucomystax, Occydozyga lima) and 9 species of reptiles (Cyrtodactylus marmoratus, Hemydactylus frenatus, Gonocephalus kuhlii, Broncochela jubata, Eutropis multifasciata, Pareas carinatus, Ahetulla prasina, Dendrelaphis pictus, Lycodon subcinctus). The index values of diversity, evenness, richness, and dominance are 1,591, 0,088, 3,250, 0,398 respectively. Habitat character affect the composition of herpetofauna. Physical factors value range for water temperature 23 - 24.55°C, air temperature 25.05 - 27.15°C, and air humidity 77.25 - 84.75%.

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