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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina E-Jurnal Medika Udayana JBN (Jurnal Bedah Nasional) Majalah Kedokteran Andalas ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Cermin Dunia Kedokteran Indonesian Journal of Cancer Eduvest - Journal of Universal Studies
Putu Anda Tusta Adiputra
Bedah Onkologi, Fakultas Kedokteran, Universitas Udayana
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KUALITAS HIDUP PASIEN KANKER KEPALA DAN LEHER DI RSUP SANGLAH Nirmala, Made Sinta Ayu Suci; Tusta Adiputra, Putu Anda; Setiawan, I Gede Budhi; Yuniawaty Wetan, Ni Gusti Ayu Agung Manik
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P02

Abstract

Head and neck cancer ranked as the fifth most common cancer in the world. A series of treatment is likely to cause changes in the quality of life in cancer patients. This study aims to determine the factors that affect the patient's quality of life and the relationship between EORTC QLQ-H&N35 and Karnofsky Performance Scale (KPS). This study is analytic with a cross sectional approach. The technique is total sampling adjusted to the inclusion and exclusion criteria. Data obtained were gender, age, anatomical location of head and neck cancer, stage of cancer, therapy, KPS, and EORTC QLQ-H&N35. Data was collected for 3 months and 45 samples were obtained. There were 24 patients ((53.3%) above 45 years old. 33 men (73.3%) and 12 women (26.7%). The most cases were nasopharyngeal cancer is 25 people (55.6%). A total of 19 patients (42.2%) were in stage IV. The most used therapies were surgery, chemotherapy, and radiotherapy is 19 people (41.3%). The mean KPS is 72.23 ± 16.992. The factor affect the quality of life of head and neck cancer patients the most is weight loss with a mean of 59.49 ± 49.989 and a significant correlation (p=0.000, p<0.05) between EORTC QLQ-H&N35 and KPS.
Pentingnya Respon Komplit Patologi Paska Kemoterapi Neoadjuvan pada Penanganan Kasus Kanker Payudara Stadium Awal Adiputra, Putu Anda Tusta
JBN (Jurnal Bedah Nasional) Vol 8 No 2 (2024): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBN.2024.v08.i02.p01

Abstract

Saat ini kemoterapi neoajuvan (Neoadjuvant Chemotherapy/NAC) semakin banyak digunakan sebagai lini pertama untuk penanganan kanker payudara lokal yang berisiko tinggi. Kemoterapi neoajuvan untuk kanker payudara adalah pilihan terapi yang ditetapkan untuk kanker payudara berisiko tinggi, kanker payudara lokal dengan stadium lanjut, kanker payudara yang tidak dapat dioperasi, atau untuk meningkatkan peluang dilakukannya operasi konservasi payudara (Breast Conserving Surgery). Selain NAC, ada kemoterapi ajuvan yang ditujukan untuk mengatasi mikrometastasis yang tidak terlihat, sehingga mengurangi resiko kekambuhan lokal maupun sistemik. Pencapaian respon komplit patologi terkait dengan kelangsungan hidup jangka panjang dan oleh karena itu FDA merekomendasikannya sebagai titik akhir utama dalam uji coba NAC dengan harapan dapat meningkatkan angka kelangsungan hidup pada pasien dengan kanker payudara. Target respon komplit patologi dapat dipertimbangkan pada pasien dengan subtipe kanker payudara agresif yang memiliki respon baik sebelum dilakukan operasi.
Purple Sweet Potato Extract Effects On Tnf-Α And Gut Injury Chandrakirana, Anak Agung Ayu Hellin; Roy R.H. Hamid, Agus; Hendra Sanjaya, I Gusti Putu; Sri Mahendra Dewi, I Gusti Ayu; Tusta Adiputra, Putu Anda
Eduvest - Journal of Universal Studies Vol. 5 No. 9 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i9.52149

Abstract

The purpose of this study was to evaluate the effect of oral administration of purple sweet potato (Ipomoea batatas L.) extract on serum and tissue TNF-α levels in the gaster and duodenum, as well as on gastrointestinal damage in Wistar rats (Rattus norvegicus) with major burns. This experimental research used a Randomized Post-Test Only Control Group Design with Wistar rats as subjects, divided into a control group (P0) and a treatment group (P1). The results showed that serum TNF-α levels were significantly lower in the treatment group compared to the control group (p = 0.002). Tissue TNF-α levels also decreased significantly (p = 0.049), suggesting a local anti-inflammatory effect on the intestinal mucosa. Statistical analysis demonstrated that mucosal thickness was higher in the treatment group, with a mean difference of 270.32 µm (p < 0.001). However, there was no significant difference in villi width between groups (p = 0.129). Significant differences were observed in mucosal necrosis lesions (p < 0.001), hemorrhage lesions (p < 0.001), and inflammation lesions (p = 0.001) between the treatment and control groups. In conclusion, oral administration of purple sweet potato extract effectively reduced serum and tissue TNF-α levels, increased intestinal mucosal thickness, and protected against mucosal damage in rats with major burns. These findings indicate the potential of purple sweet potato extract as an adjuvant therapy to reduce systemic inflammation and improve intestinal mucosal integrity in burn conditions.
Probiotics and Vitamin D for Gastrointestinal Damage in Burn Injury Widia Putri, Gracia; Putu Hendra Sanjaya, I Gusti; Ayu Sri Mahendra Dewi , I Gusti; Roy Rusly Hariantana Hamid, Agus; Anda Tusta Adiputra, Putu
Eduvest - Journal of Universal Studies Vol. 5 No. 10 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i10.52120

Abstract

Curling’s ulcer, a stress-induced gastrointestinal injury, commonly occurs in patients with major burns due to ischemia and mucosal necrosis. Complications may include perforation, hemorrhagic shock, and death. While standard treatments involve PPIs, sucralfate, and early enteral feeding, probiotics may help restore gut microbiota, and vitamin D can reduce inflammation and dysbiosis. However, studies on their combined efficacy remain limited, particularly in Indonesia. This research aims to evaluate whether oral probiotics and vitamin D reduce TNF-α levels and gastrointestinal damage in Wistar rats with major burns. The study employed an experimental design using 32 Wistar rats with 25% TBSA burns. Subjects were divided into four groups: control (K), probiotics only (P1), vitamin D only (P2), and probiotics + vitamin D (P3). Interventions were administered for two weeks. Measured parameters included blood and tissue TNF-α levels, as well as gastric and intestinal histopathology. Data were analyzed using SPSS. Results showed that group P3 had the lowest tissue TNF-α levels (136.11 ± 50.14; p = 0.046) and intestinal mucosal thickness (914.54 ± 170.08; p = 0.007). Indicators of gastric damage—macrophage count, necrosis, and bleeding—were significantly reduced in the treatment groups (p = 0.000). No significant difference was observed in villi width (p = 0.974). Combined oral probiotics and vitamin D significantly reduced tissue TNF-α levels and gastrointestinal damage, with better outcomes than single-agent treatments. This combination therapy shows potential as an adjunctive approach for gastrointestinal protection in major burns.
Co-Authors Agung Bagus S. Satyarsa and I. B. T. Wibawa-Manuaba Annisa Alviariza Aqilah, Nadya Zalfa Aryo Wibisono Ayu Nursantisuryani Jahya Ayu Sri Mahendra Dewi , I Gusti Chandrakirana, Anak Agung Ayu Hellin Desak Made Wihandani Dewa Putu Satria Juristiasa Dewi Prima Christian, Dewi Prima Gede Andry Nicolas Andry Nicolas Gusti Ngurah Agung Adi Paramartha Hendra P. Setiawan Hendra Sanjaya, I Gusti Putu Herman Saputra I Dewa Made Sukrama I G A Mirah K I G. P. Supadmanaba I Gde Made Satya Wangsa Satya Wangsa I Gusti Ayu M Prita Dewi I Gusti Ngurah Gde Dwi Aryanata I Ketut Wiargitha I Made Arya Winangun I Made Bagus Adhi Paramitha I Nengah Wiadnyana Steven Christian I W. Sudarsa I Wayan Niryana I. B. Tjakra Wibawa Manuaba Ida Bagus Yorky Brahmantya Inge Kurniawati Jasmine Stephanie Christian Jasmine Stephanie Christian K. Aditya Prayudi, Pande Kadek Santi Diahswari Widyadari Ketut Siki Kawiyana Made Agus Dwianthara Sueta Made Revina Chandradewi Manuaba, Ida Bagus Tjakra Wibawa Ni Gusti Ayu Agung Manik Yuniawaty Wetan Ni Ketut Hanny Puspita Ni Putu Ayu Pande Arista Dewi Ni Wayan Ariani Vitriasari Nirmala, Made Sinta Ayu Suci P. Setiawan, Hendra Pande K. Aditya Prayudi Permatasari, Yulan Putu Diahpradnya Oka Partini Putu Gupta Arya Gumilang Putu Hendra Sanjaya, I Gusti Reni Widyastuti Ronald Natawidjaja Roy R.H. Hamid, Agus Roy Rusly Hariantana Hamid, Agus Setiawan, I Gede Budhi Sri Mahendra Dewi, I Gusti Ayu Sri Maliawan Tham Hong Yuan Thomas Arie Satya Wardhana Trisye Septiawati W Steven Chr, W Steven Wetan, Ni Gusti Ayu Agung Manik Yuniawaty Widia Putri, Gracia Wisescistiati, Made Visvayoni Yulan Permatasari Yuniawaty Wetan, Ni Gusti Ayu Agung Manik Yusuf Alfi Mulia