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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma International Islamic Medical Journal CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Surabaya Biomedical Journal
Eric Mayo Dagradi
Faculty Of Medicine, Hang Tuah University Surabaya, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PENGARUH PUASA INTERMITEN MENGGUNAKAN METODE PUASA DAUD TERHADAP KADAR SGOT TIKUS PUTIH (Rattus norvegicus) ALIRAN WISTAR YANG DIINDUKSI PARACETAMOL Eric Mayo Dagradi; Judya Sukmana; Indri Ngesti Rahayu
Surabaya Biomedical Journal Vol. 2 No. 1 (2022): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i1.43

Abstract

Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases. Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol. Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol. Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p > 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment. Conclusion: There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol. Keywords: intermittent fasting, SGOT, paracetamol
Pengaruh Pemberian Oksigen Hiperbarik Terhadap Diameter Calluspada Tikus Model Fraktur Diafisis Tulang Femur SATRIOAJI, ABDILLAH MAULANA; ROFIQ, AKHMAD; MAYO DAGRADI, ERIC
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.307

Abstract

Background : Fracture is a condition where the bone is cut off due to significant pressure which can be in the form of bending, twisting, or pulling due to trauma, work accidents, traffic accidents, as well as degeneration and pathological processes. Fractures can result in loss of productivity and individual disability. One of the adjuvant therapies to accelerate the bone healing process in patients with fractures is hyperbaric oxygen therapy.   Objective : The purpose of this study was to determine the effect of HBO therapy on the diameter of the callus formed in a rat model of fracture of the diaphysis of the femur.   Methods : This research is an experimental study using a post test only control group design. The object of this study is a rat fracture model with HBO therapy as the independent variable and a fracture model without HBO therapy as a control variable.   Results : The results of this study showed the effect of HBO therapy on increasing the diameter of the callus formed in the fracture of the rat model   Conclusion : There was a significant difference in the diameter of the callus formed in fracture model mice treated with HBO compared to those not treated with HBO.   Keywords : HBO therapy, Fracture, Callus, Wistar Rat
Pengaruh Latihan Submaksimal pada Intensitas Terlatih dan Tidak Terlatih Terhadap Kadar Eritrosit Darah Tikus Putih (Rattus norvegicus) Betina Galur Wistar HUSODO, STEFANUS DJONI; ERIC MAYO DAGRADI; AMIRIL MU’MININ
Hang Tuah Medical Journal Vol 21 No 2 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i2.474

Abstract

Penurunan aktivitas fisik serta perubahan gaya hidup dan pola makan yang tidak sehat di masa kini mengakibatkan semakin berkembangnya penyakit degeneratif dan penyakit infeksi. Eritrosit tubuh terutama eritrosit sangat berhubungan dengan terjadinya penyakit degeneratif. Untuk mendapatkan eritrosit yang baik dengan kadar eritrosit yang memadai dapat dilakukan dengan beberapa hal, salah satunya adalah olahraga dengan intensitas cukup dan teratur. Olahraga yang sesuai dengan kemampuan tubuh dapat mengaktifkan kerja eritrosit sehingga dapat meningkatkan eritrosit dan mencegah terjadinya penyakit degeneratif dan penyakit infeksi. Penelitian ini bertujuan untuk mengetahui pengaruh latihan submaksimal dengan intensitas terlatih dan tidak terlatih terhadap kadar eritrosit darah pada tikus putih betina galur wistar. Penelitian ini adalah penelitian eksperimen dengan menggunakan post test only control group design. Objek dalam penelitian ini adalah 25 tikus putih betina (Rattus norvegicus) galur wistar yang dibagi menjadi 5 kelompok. Hasil analisis statistik dengan uji One Way Anova yaitu p=0.034 Dari hasil uji didapatkan perbedaan yang bermakna antar kelompok perlakuan. hasil uji antar kelompok pada tabel 5.6 pada penelitian ini menunjukkan kelompok K1 dan K2 signifikan dengan nilai 0,46, kelompok K2 dan kelompok K3 signifikan dengan nilai 0,33, kelompok K2 dan kelompok K4 signifikan dengan nilai 0,19. Dapat disimpulkan terdapat perbedaan bermakna pada kadar eritosit antara latihan submaksimal intensitas terlatih dan tidak terlatih. Kata kunci : latihan submaksimal, terlatih, tidak terlatih, eritrosit
Analisis Aktivitas Quercetin Moringa oleifera terhadap Inhibisi Acetylcholinesterase (AChE) pada Terapi Alzheimer dengan Pendekatan In Silico JULIA ANGELINA SAFITRI; TAMAM JAUHAR; PETER GUNAWAN TANDEAN; ERIC MAYO DAGRADI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.762

Abstract

Many plants contain active compounds that can be used to treat various diseases. One of these plants is Moringa oleifera Lam. (drumstick tree), which is known for its benefits in treating Alzheimer’s disease. The active compound quercetin found in Moringa oleifera has the ability to inhibit acetylcholinesterase (AChE), one of the primary causes of Alzheimer’s disease. Quercetin also has similar potential and functions to donepezil, a drug commonly used in Alzheimer’s therapy. This study aimed to examine the role of quercetin in inhibiting AChE as part of Alzheimer’s therapy using an in silico approach. The research utilized molecular docking, pharmacokinetic ADME predictions, and toxicity predictions to evaluate the active compound quercetin. The results showed that quercetin has similar potential to donepezil in inhibiting AChE, as they both share the same binding sites. Pharmacokinetic predictions revealed that quercetin is well-absorbed in the intestine and has better skin permeability compared to donepezil, although its ability to cross the Blood-Brain Barrier (BBB) is limited. Quercetin has a limited distribution in the body, a high binding affinity to plasma proteins, and acts as an inhibitor of CYP1A2 and CYP2C9 enzymes. Additionally, quercetin is effectively excreted by the body. It is predicted to have potential as an oral medication and is categorized as a class III compound based on its LD50 toxicity value Keywords : Alzheimer’s disease, In silico, Acetylcholinesterase (AChE), Moringa oleifera, Quercetin
Co-Authors AMIRIL MU’MININ Andisari, Hendrata Erry Anindya, Pramita Annisa Ulya Rasyida Budipramana , Vicky Sumarki Cinthya Fitri Paramitha Diah Purwaningsari Indri Ngesti Rahayu Judya Sukmana JULIA ANGELINA SAFITRI Komalasari, Intan Michael Alexander Mita Herdiyantini Muhamarudin Peter Gunawan Tandean Rofiq, Akhmad SATRIOAJI, ABDILLAH MAULANA STEFANUS DJONI HUSODO Sukmana, Judya Tamam Jauhar TARUNA, DODY Wijayanti, Ni Luh Putu Ratih