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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat International Islamic Medical Journal CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Surabaya Biomedical Journal
Eric Mayo Dagradi
Faculty Of Medicine, Hang Tuah University Surabaya, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PENGARUH LATIHAN RENANG INTENSITAS SUBMAKSIMAL TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH BETINA KELOMPOK TERLATIH DAN TIDAK TERLATIH Alexander, Michael; Dagradi, Eric Mayo; Andisari, Hendrata Erry
Surabaya Biomedical Journal Vol. 4 No. 1 (2024): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i1.118

Abstract

Olahraga adalah kegiatan fisik yang dilakukan untuk meningkatkan kesehatan tubuh. Dengan meningkatnya jumlah masyarakat yang berolahraga, penting untuk memahami batasan intensitas olahraga yang dilakukan. Intensitas olahraga yang melampaui kemampuan tubuh akan menyebabkan munculnya stres oksidatif. Stres oksidatif akan menimbulkan berbagai masalah fisiologis tubuh, termasuk metabolisme glukosa. Jenis penelitian adalah eksperimental laboratoris. Tikus putih (Rattus norvegicus) betina galur Wistar usia 2 bulan dengan berat badan 180-200 gram dikelompokkan ke dalam 5 kelompok melalui teknik random sampling. K1 merupakan kontrol, K2 diberi latihan setiap hari selama 2 minggu, K3 diberi latihan sekali seminggu selama 2 minggu, K4 diberi latihan setiap hari selama 2 minggu, dan K5 diberi latihan sekali seminggu selama 2 minggu. Semua kelompok setelahnya diistirahatkan selama 1 minggu. K1, K2, dan K3 tidak diberi intervensi. K4 dan K5 diberi intervensi latihan submaksimal 85% rerata waktu tenggelam pertama. Penelitian diterminasi dan dilakukan pengambilan sampel untuk pengujian kadar glukosa darah acak. Hasil kadar glukosa darah acak diolah statistik dengan uji parametrik one-way Anova dan uji post hoc LSD. Hasil kadar glukosa darah (K1) 127,8 mg/dL, (K2) 133,4 mg/dL, (K3) 186,4 mg/dL, (K4) 160,6 mg/dL, dan (K5) 140,6 mg/dL. Uji one-way Anova menunjukkan perbedaan signifikan (p<0,05). Uji post hoc LSD menunjukkan tidak ada perbedaan bermakna antara kelompok terlatih dengan intervensi dan tidak terlatih dengan intervensi (p>0,05). Intervensi latihan submaksimal setelah istirahat satu minggu pada kelompok terlatih dan tidak terlatih dengan latihan submaksimal tidak memiliki pengaruh terhadap kadar glukosa darah tikus putih (Rattus norvegicus) betina galur Wistar.
Analisis Aktivitas Quercetin Moringa oleifera terhadap Inhibisi Acetylcholinesterase (AChE) pada Terapi Alzheimer dengan Pendekatan In Silico JULIA ANGELINA SAFITRI; TAMAM JAUHAR; PETER GUNAWAN TANDEAN; ERIC MAYO DAGRADI
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.762

Abstract

Many plants contain active compounds that can be used to treat various diseases. One of these plants is Moringa oleifera Lam. (drumstick tree), which is known for its benefits in treating Alzheimer’s disease. The active compound quercetin found in Moringa oleifera has the ability to inhibit acetylcholinesterase (AChE), one of the primary causes of Alzheimer’s disease. Quercetin also has similar potential and functions to donepezil, a drug commonly used in Alzheimer’s therapy. This study aimed to examine the role of quercetin in inhibiting AChE as part of Alzheimer’s therapy using an in silico approach. The research utilized molecular docking, pharmacokinetic ADME predictions, and toxicity predictions to evaluate the active compound quercetin. The results showed that quercetin has similar potential to donepezil in inhibiting AChE, as they both share the same binding sites. Pharmacokinetic predictions revealed that quercetin is well-absorbed in the intestine and has better skin permeability compared to donepezil, although its ability to cross the Blood-Brain Barrier (BBB) is limited. Quercetin has a limited distribution in the body, a high binding affinity to plasma proteins, and acts as an inhibitor of CYP1A2 and CYP2C9 enzymes. Additionally, quercetin is effectively excreted by the body. It is predicted to have potential as an oral medication and is categorized as a class III compound based on its LD50 toxicity value Keywords : Alzheimer’s disease, In silico, Acetylcholinesterase (AChE), Moringa oleifera, Quercetin
Co-Authors AMIRIL MU’MININ Andisari, Hendrata Erry Anindya, Pramita Annisa Ulya Rasyida Budipramana , Vicky Sumarki Cinthya Fitri Paramitha Diah Purwaningsari Hisnindarsyah, Hisnindarsyah Indri Ngesti Rahayu JULIA ANGELINA SAFITRI Komalasari, Intan Michael Alexander Mita Herdiyantini Muhamarudin Nexiary, Azzahra Banafsaj Altima Peter Gunawan Tandean Rofiq, Akhmad SATRIOAJI, ABDILLAH MAULANA STEFANUS DJONI HUSODO Sukmana, Judya Tamam Jauhar TARUNA, DODY Wijayanti, Ni Luh Putu Ratih