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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan BALI MEDICAL JOURNAL (BMJ) Journal Pharmaceutical Science and Application (JPSA) Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Farmasi Udayana Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Medicamento Journal Sport Science, Healt and Tourism of Mandalika (Jontak) Prosiding Workshop dan Seminar Nasional Farmasi (WSNF) Journal of Tropical Pharmacy and Chemistry
Ni Putu Ariantari
Study Program Of Pharmacist Profession, Faculty Of Mathematics And Natural Sciences, Udayana University, Jimbaran, Badung, Bali 80361
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Uji Aktivitas Antijamur Ekstrak Jamur Endofit dari Alga Chondrus sp. terhadap Candida albicans Ni Kadek Ari Kristiani; Ariantari, Ni Putu
Journal Sport Science, Health and Tourism of Mandalika (Jontak) Vol. 4 No. 2 (2023)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jontak.v4i2.1869

Abstract

Endophytic fungi are an important source for the discovery and development of new drug molecules, including antifungals. Endophytic fungi associated with algae are one of the potential microorganisms to be further studied for their antifungal activity. This study aims to isolate and identify the endophytic fungi isolated from the algae Chondrus sp., to screen the content of secondary metabolites produced by these endophytic fungal isolates, and to test the activity of the extracts obtained against Candida albicans. The research began with the isolation and purification of endophytic fungi, fermentation in rice media, and extraction with ethyl acetate. The ethyl acetate extract obtained was then partitioned between methanol-water and n-hexane. The methanol extract was screened for chemical content and antifungal activity against C. albicans. In this study, 3 isolates of endophytic fungi were obtained with the codes A5-1-1, A5-1-2, and A5-2-1. Phytochemical testing showed that all methanol extracts of endophytic fungi from the algae Chondrus sp. contain alkaloid compounds, extracts from isolates A5-1-2 and A5-2-1 contain triterpene compounds, and extract A5-1-2 contains polyphenol compounds. The antifungal test showed that the endophytic fungi methanol extract with code A5-1-2 showed the best antifungal activity compared to the other two fungi extracts against C. albicans (MIC 500 μg/mL) which was included in the weak category.
Jamur dari Mangrove sebagai Sumber Senyawa Metabolit Sekunder Bioaktif yang Berpotensi sebagai Kandidat Antikanker: Review Literatur Kristiani, Ni Kadek Ari; Putra, I Putu Yogi Astara; Putri, Ni Wayan Prasanthi Swarna; Leliqia, Ni Putu Eka; Ujam, Nonye Treasure; Ariantari, Ni Putu
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6910

Abstract

Cancer was the leading cause of death, which accounting for nearly 10 million deaths globally in 2020. Currently, cancer treatment still relies on chemotherapy, however, most anticancer drugs showed non-specific toxicity to normal cell proliferation resulting in various side effects, and are ineffective against many forms of cancer. In addition, the increasing case of chemoresistance of cancer cells to chemotherapy has boosted the discovery of new anticancer agents. Natural products are known as the origin of several clinically used anticancer agents, e.g. taxol and vincristine. Among natural products, mangrove-derived fungi are of particular scientific interest evidenced by the increasing rate of publications on cytotoxic secondary metabolites reported. Hence, this literature review aims to provide comprehensive information on cytotoxic secondary metabolites isolated from mangrove-derived fungi, which might contribute to the search for anticancer leads from natural resources. Data were collected from original research articles published on scientific-based sources such as Google Scholar, PubMed, Taylor and Francis, Elsevier, and MDPI, in the range of 2011-2022. Fifty-four cytotoxic secondary metabolites with IC50 values below 10 µM were described herein, which were classified in to 8 groups of metabolites. These compounds were reported from 16 genera of mangrove-associated fungi. Among them, Aspergillus and Penicillium were the most frequent producers of cytotoxic metabolites, suggesting their enormous potential as a source of pharmacophores for anticancer candidates.
LEADS SEARCH FOR ACETYLCHOLINESTERASE INHIBITORS DERIVED FROM SECONDARY METABOLITES OF ENDOPHYTIC FUNGI: A REVIEW Putra, Pramana Kumala; Dewi, I Gusti Ayu Agung Gangga Samala; Putri, Ni Wayan Prasanthi Swarna; Wirajana, I Nengah; Ariantari, Ni Putu
Journal Pharmaceutical Science and Application Vol 6 No 1 (2024): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2024.v06.i01.p06

Abstract

Background: Acetylcholinesterase inhibitors (AChEIs) are substances that act by increasing acetylcholine levels in the brain to prevent neurotransmitter degradation. AChEIs are the most widely used agents for Alzheimer's disease (AD) therapy so far. Objective: This study aims to give insight into AChEIs produced by endophytic fungi through literature reviews, which are promising for further studies on their mode of action. Methods: Data search was conducted through scientific-based websites such as Google Scholar, Science Direct, and PubMed, which involved scientific publications from January 2000 to December 2022. Results: Fifteen genera, including Aspergillus, Cladosporium, Colletotrichum, and Penicillium, were reported to produce twenty-four secondary metabolites with AChEI activity. These compounds were classified based on their chemical skeleton into alkaloids, steroids, terpenoids, polyketides, and peptides. Conclusion: Endophytic fungi are promising sources of lead compounds possessing AChE inhibitory activity. Further research on molecular mechanisms of secondary metabolites from endophytic fungi with AChEI activity can provide new insight into the development of more potent AChEIs for AD treatment. Keywords: Acetylcholinesterase inhibitors (AChEIs); Alzheimer’s disease; endophytic fungi; secondary metabolites.
Pharmacologically Active Secondary Metabolites from Psoralea corylifolia Ni Putu Ariantari; Elizabeth S. P. Ratnasantasyacitta
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.431

Abstract

Psoralea corylifolia has gained much attention, particularly in the cosmetic industry for the past few years owing to promising pharmacological activities of its metabolites. Seeds of P. corylifolia are the main source of bakuchiol, a meroterpene compound that is extensively harnessed in numerous skincare products. Furanocoumarins, psoralen and isopsoralen are other metabolites mainly from P. corylifolia seeds and known for their antipsoriatic activity. Moreover, various studies have reported several classes of secondary metabolites from this plant possessing diverse biological activities. This article highlights recent updates on P. corylifolia phytoconstituents and their promising pharmacological activities based on scientific publications during the last 10 years (2011-2021). The literature search was carried out through scientific-based websites and databases such as Google Scholar, NCBI, and PubMed. This paper included sixty-three bioactive metabolites reported in the last 10 years, belonging to the group of flavonoids, meroterpenes, furanocoumarins, coumestans, steroid and phenolic compounds. These phytoconstituents displayed a broad range of bioactivities including anti-inflammatory, antibacterial, antidiabetic, controlling obesity, hepatoprotective and cytotoxicity. Keywords: Bakuchiol, pharmacological activities, Psoralea corylifolia, bioactive metabolites.
Bioaktivitas dan Identifikasi Molekuler Jamur yang Diisolasi dari Sedimen di Pantai Amed dan Tulamben Wulandari, Ni Made Widya; Dwijayanti, Ni Kadek; Putri, Ni Putu Ananda Eka; Putra, I Putu Yogi Astara; Leliqia, Ni Putu Eka; Wibowo, Joko Tri; Dwija, Ida Bagus Nyoman Putra; Ariantari, Ni Putu
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.10745

Abstract

Marine fungi have demonstrated the ability to produce promising new bioactive compounds. This study aims to isolate fungi from the marine sediments collected from Amed and Tulamben Beaches, Bali, Indonesia and investigate the bioactivity of the fungal extracts. Following fungal isolation, pure isolates were obtained and fermented on rice media containing salt and without salt. Next, secondary metabolites were extracted with ethyl acetate, then separated by liquid-liquid extraction using methanol containing 10% water and n-hexane. The resulting MeOH extracts were analyzed for their phytochemical content and tested for their antimicrobial and antioxidant activities using the disc diffusion and 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, respectively. In total, three fungal isolates were obtained. Molecular identification from the Internal Transcribed Spacer (ITS) region of the isolates showed the closest relationship to Aspergillus sp., Aspergillus tamarii, and Trichoderma sp. Phytochemical analysis showed all fungal extracts contained alkaloids and polyphenols. Moreover, extract from Trichoderma sp. SED-TU (1) (NS) inhibited Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus mutans with inhibition zone diameters of 4.69±0.16; 3.51±0.01, and 3.49±0.25 mm, respectively. Extract from Aspergillus tamarii RM-S-SED-AM (S) inhibited Candida albicans with an inhibition zone of 7.04±0.22 mm and also had strong antioxidant activity with an IC50 value of 62.00±0.35 µg/mL. This study indicates that fungal isolates from marine sediments have great potential as a source of bioactive natural products.
Co-Authors 1Dwija, I.B.N.P Achmad Fuad Hafid Adiluhur, I.M.P. Adiluhur, M. A. Agastia, I.P.A. Agastia, P. A. A. Anggreni, M Astuti, K.W. Astuti, M.A.P. Aty Widyawaruyanti Caresya Insani Bangga Nabila Dewa Ayu Swastini Dewi, I Gusti Ayu Agung Gangga Samala Dewi, I. A. M. Dewi, I.A.M.K. Dwicandra, N.M.O. Dwija, I. B. N. P. Dwija, I.B.N.P Dwija, Ida Bagus Nyoman Putra Elizabeth S. P. Ratnasantasyacitta I Ketut Juniarta I Made Kardena I Nengah Wirajana I Putu Yogi Astara Putra I Wayan Sudiarta I. Setyawati I.B.N.P. Dwija I.G.N.A.P. Putra Ida Bagus Nyoman Putra Dwija Joko Tri Wibowo, Joko Tri Karso, F. P. Ketut Widyani Astuti Kristiani, Ni Kadek Ari Lidya Tumewu Mahadewi, S. A. Mahadewi, S.A. Mita Anggraeni, Mita N. W. Erawati Nallakrishna, I P. A. Ni Kadek Ari Kristiani Ni Kadek Dwijayanti Ni Luh Putu Indah Suryani Ni Luh Rustini Ni Made Suartini Ni Putu Eka Leliqia Ni Wayan Prasanthi Swarna Putri Nonye Treasure Ujam Normansyah, A. P. A. C. Kusuma P. A. C. Kusuma, P. A. C. Partiwisari, N.P.E. Priskila Putri Mairing Purwani, S. T. D Purwani, S. T. D. Putra, I Putu Yogi Astara Putra, I. G. N. R. Putra, Pramana Kumala Putri, Ni Putu Ananda Eka Putri, Ni Wayan Prasanthi Swarna Putu Aurora Vanadis Putu Oka Samirana Ramayati, N.P.A Rasmaya Niruri Rini Noviyani S. T. D Purwani, Sagun Chandra Yowani Samiantara, I. K. Sang Ayu Made Dwi Ariesta Putri Savitri, L.P.V.A Ujam, Nonye Treasure Wulandari, Ni Made Widya Yanti, P. E. W.