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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan BALI MEDICAL JOURNAL (BMJ) Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Medicamento Journal Sport Science, Healt and Tourism of Mandalika (Jontak) Prosiding Workshop dan Seminar Nasional Farmasi (WSNF) Journal of Tropical Pharmacy and Chemistry Jurnal Farmasi Udayana
Ni Putu Ariantari
Study Program Of Pharmacist Profession, Faculty Of Mathematics And Natural Sciences, Udayana University, Jimbaran, Badung, Bali 80361
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Uji Aktivitas Antijamur Ekstrak Jamur Endofit dari Alga Chondrus sp. terhadap Candida albicans Ni Kadek Ari Kristiani; Ariantari, Ni Putu
Journal Sport Science, Health and Tourism of Mandalika (Jontak) e-ISSN 2722-3116 Vol. 4 No. 2 (2023)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jontak.v4i2.1869

Abstract

Endophytic fungi are an important source for the discovery and development of new drug molecules, including antifungals. Endophytic fungi associated with algae are one of the potential microorganisms to be further studied for their antifungal activity. This study aims to isolate and identify the endophytic fungi isolated from the algae Chondrus sp., to screen the content of secondary metabolites produced by these endophytic fungal isolates, and to test the activity of the extracts obtained against Candida albicans. The research began with the isolation and purification of endophytic fungi, fermentation in rice media, and extraction with ethyl acetate. The ethyl acetate extract obtained was then partitioned between methanol-water and n-hexane. The methanol extract was screened for chemical content and antifungal activity against C. albicans. In this study, 3 isolates of endophytic fungi were obtained with the codes A5-1-1, A5-1-2, and A5-2-1. Phytochemical testing showed that all methanol extracts of endophytic fungi from the algae Chondrus sp. contain alkaloid compounds, extracts from isolates A5-1-2 and A5-2-1 contain triterpene compounds, and extract A5-1-2 contains polyphenol compounds. The antifungal test showed that the endophytic fungi methanol extract with code A5-1-2 showed the best antifungal activity compared to the other two fungi extracts against C. albicans (MIC 500 μg/mL) which was included in the weak category.
Jamur dari Mangrove sebagai Sumber Senyawa Metabolit Sekunder Bioaktif yang Berpotensi sebagai Kandidat Antikanker: Review Literatur Kristiani, Ni Kadek Ari; Putra, I Putu Yogi Astara; Putri, Ni Wayan Prasanthi Swarna; Leliqia, Ni Putu Eka; Ujam, Nonye Treasure; Ariantari, Ni Putu
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.6910

Abstract

Cancer was the leading cause of death, which accounting for nearly 10 million deaths globally in 2020. Currently, cancer treatment still relies on chemotherapy, however, most anticancer drugs showed non-specific toxicity to normal cell proliferation resulting in various side effects, and are ineffective against many forms of cancer. In addition, the increasing case of chemoresistance of cancer cells to chemotherapy has boosted the discovery of new anticancer agents. Natural products are known as the origin of several clinically used anticancer agents, e.g. taxol and vincristine. Among natural products, mangrove-derived fungi are of particular scientific interest evidenced by the increasing rate of publications on cytotoxic secondary metabolites reported. Hence, this literature review aims to provide comprehensive information on cytotoxic secondary metabolites isolated from mangrove-derived fungi, which might contribute to the search for anticancer leads from natural resources. Data were collected from original research articles published on scientific-based sources such as Google Scholar, PubMed, Taylor and Francis, Elsevier, and MDPI, in the range of 2011-2022. Fifty-four cytotoxic secondary metabolites with IC50 values below 10 µM were described herein, which were classified in to 8 groups of metabolites. These compounds were reported from 16 genera of mangrove-associated fungi. Among them, Aspergillus and Penicillium were the most frequent producers of cytotoxic metabolites, suggesting their enormous potential as a source of pharmacophores for anticancer candidates.
Pharmacologically Active Secondary Metabolites from Psoralea corylifolia Ni Putu Ariantari; Elizabeth S. P. Ratnasantasyacitta
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.431

Abstract

Psoralea corylifolia has gained much attention, particularly in the cosmetic industry for the past few years owing to promising pharmacological activities of its metabolites. Seeds of P. corylifolia are the main source of bakuchiol, a meroterpene compound that is extensively harnessed in numerous skincare products. Furanocoumarins, psoralen and isopsoralen are other metabolites mainly from P. corylifolia seeds and known for their antipsoriatic activity. Moreover, various studies have reported several classes of secondary metabolites from this plant possessing diverse biological activities. This article highlights recent updates on P. corylifolia phytoconstituents and their promising pharmacological activities based on scientific publications during the last 10 years (2011-2021). The literature search was carried out through scientific-based websites and databases such as Google Scholar, NCBI, and PubMed. This paper included sixty-three bioactive metabolites reported in the last 10 years, belonging to the group of flavonoids, meroterpenes, furanocoumarins, coumestans, steroid and phenolic compounds. These phytoconstituents displayed a broad range of bioactivities including anti-inflammatory, antibacterial, antidiabetic, controlling obesity, hepatoprotective and cytotoxicity. Keywords: Bakuchiol, pharmacological activities, Psoralea corylifolia, bioactive metabolites.
Bioaktivitas dan Identifikasi Molekuler Jamur yang Diisolasi dari Sedimen di Pantai Amed dan Tulamben Wulandari, Ni Made Widya; Dwijayanti, Ni Kadek; Putri, Ni Putu Ananda Eka; Putra, I Putu Yogi Astara; Leliqia, Ni Putu Eka; Wibowo, Joko Tri; Dwija, Ida Bagus Nyoman Putra; Ariantari, Ni Putu
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.10745

Abstract

Marine fungi have demonstrated the ability to produce promising new bioactive compounds. This study aims to isolate fungi from the marine sediments collected from Amed and Tulamben Beaches, Bali, Indonesia and investigate the bioactivity of the fungal extracts. Following fungal isolation, pure isolates were obtained and fermented on rice media containing salt and without salt. Next, secondary metabolites were extracted with ethyl acetate, then separated by liquid-liquid extraction using methanol containing 10% water and n-hexane. The resulting MeOH extracts were analyzed for their phytochemical content and tested for their antimicrobial and antioxidant activities using the disc diffusion and 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, respectively. In total, three fungal isolates were obtained. Molecular identification from the Internal Transcribed Spacer (ITS) region of the isolates showed the closest relationship to Aspergillus sp., Aspergillus tamarii, and Trichoderma sp. Phytochemical analysis showed all fungal extracts contained alkaloids and polyphenols. Moreover, extract from Trichoderma sp. SED-TU (1) (NS) inhibited Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus mutans with inhibition zone diameters of 4.69±0.16; 3.51±0.01, and 3.49±0.25 mm, respectively. Extract from Aspergillus tamarii RM-S-SED-AM (S) inhibited Candida albicans with an inhibition zone of 7.04±0.22 mm and also had strong antioxidant activity with an IC50 value of 62.00±0.35 µg/mL. This study indicates that fungal isolates from marine sediments have great potential as a source of bioactive natural products.
Uji Toksisitas Ekstrak Metanol Jamur yang Diisolasi dari Spons Phyllospongia foliascens Menggunakan Metode Brine Shrimp Lethality Test (BSLT) Maria Esmeralda Elvira Ngedo Reo; Komang Tria Noviana Dewi; Ni Putu Eka Leliqia; Ni Putu Ariantari
Jurnal Farmasi Udayana Volume 14, Nomer 1, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.v14.i01.p08

Abstract

Jamur laut adalah mikroorganisme yang hidup di lingkungan laut dan dapat berasosiasi dengan berbagai organisme laut, seperti alga, spons, dan lainnya. Jamur ini dikenal memiliki kemampuan untuk menghasilkan metabolit sekunder dengan berbagai aktivitas farmakologi, termasuk senyawa sitotoksik. Dalam penelitian sebelumnya, Aspergillus nomiae, Penicillium steckii, Penicillium citrinum dan Aspergillus niger telah diisolasi dari spons Phyllospongia foliascens yang dikoleksi dari pantai Amed, Bali. Penelitian ini bertujuan untuk mengevaluasi toksisitas ekstrak metanol yang diperoleh setelah fermentasi pada media beras dari keempat jamur tersebut terhadap larva Artemia salina menggunakan metode Brine Shrimp Lethality Test (BSLT). Dalam pengujian ini, setiap kelompok perlakuan terdiri dari sepuluh larva A. salina dalam air laut buatan dan dipaparkan dengan masing-masing ekstrak pada konsentrasi antara 3,9 hingga 1000 µg/mL dalam lempeng 24-sumuran. Setelah diinkubasi selama 24 jam, jumlah larva yang mati di setiap sumur dihitung, dan nilai LC50 dihitung menggunakan analisis probit. Hasil penelitian ini menunjukkan bahwa ekstrak A. nomiae, P. steckii, P. citrinum dan A. niger memiliki efek toksik terhadap larva A. salina, dengan nilai LC50 masing-masing sebesar 68,47; 83,43; 85,04 dan 12,20 µg/mL. Selain itu hasil analisis KLT menunjukkan masing-masing ekstrak mengandung senyawa metabolit sekunder dari golongan alkaloid, flavonoid, terpenoid, triterpenoid, dan polifenol. Metode BSLT umum digunakan sebagai uji skrining untuk menilai kemungkinan potensi sitotoksisitas suatu ekstrak, sehingga penelitian lebih lanjut mengenai efek sitotoksik ekstrak A. nomiae, P. steckii, P. citrinum dan A. niger terhadap sel kanker perlu dilakukan.
Aktivitas Antimikroba dan Antioksidan Jamur Laut yang Berasosiasi dengan Spons Pseudoceratina sp. dari Perairan Pantai Amed Adi, I Made Agus Kusuma; Witantri, Ni Komang Diah Eka; Wulandari, Ni Made Widya; Leliqia, Ni Putu Eka; Wirajana, I Nengah; Wibowo, Joko Tri; Ware, Ismail; Ariantari, Ni Putu
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13356

Abstract

Background: Marine fungi are organisms capable of growth and spore production in the marine environment and establishing symbiotic relationships with other marine organisms. Because of their high biochemical diversity, marine fungi are considered a potential source for the discovery of new natural compounds with various biological activities.Objective: This study aims to conduct molecular identification and assess the bioactivity potential of the methanol extract obtained from endophytic fungi associated with the marine sponge Pseudoceratina sp. from the Amed Coastal Waters, Bali.Methods: Eight marine fungi were isolated in this study and identified through molecular biology protocol as Aspergillus tamarii SP-3-1-4, Aspergillus nomiae SP-3-2 (A), Penicillium citrinum SP-3-2-1, Aspergillus protuberus SP-3-2-3, Aspergillus sydowii SP-3-2-4, Aspergillus sydowii RM NS SP-3B, Aspergillus clavatonanicus RM NS SP-3-2 A, and Aspergillus nomiae RM NS SP-3-2 B. The fungi were subsequently fermented on rice media containing salt and/or without salt. In the final stage of fermentation, secondary metabolites were extracted using ethyl acetate, followed by liquid-liquid extraction using methanol containing 10% water and n-hexane. The resulting methanolic extracts were subjected to phytochemical analysis and bioassays.Results: The phytochemical screening results of the methanol extracts showed that all extracts contained alkaloids. Among the tested extracts, the extract obtained from the fermentation of the fungus A. protuberus SP-3-2-3 on rice medium with the addition of salt showed the highest activity against Methicillin-resistant Staphylococcus aureus ATCC 3351 with an inhibition zone diameter of 7.99±0.20 mm. The fungus A. sydowii SP-3-2-4 cultured with and without salt in rice media exhibited the most potent antioxidant capacity, with IC50 values of 37.02±1.12 and 32.48±0.81 µg/mL. Conversely, A. nomiae SP-3-2 (A), fermented without salt, displayed the highest toxicity with an LC50 value of 0.88±0.69 µg/mL.Conclusion: Based on the pharmacological potential of extracts produced by the marine fungi associated with the sponge Pseudoceratina sp. found in the present study, identification of bioactive secondary metabolites and their mode of action is propitious for further investigation.
Potensi Krim Solid Lipid Nanoparticle (SLN) Kombinasi Ekstrak Bunga Gemitir dan Alga Merah untuk Mengatasi Jerawat akibat Propionibacterium acnes Suari, Anak Agung Istri Padma; Kartini, Ni Komang Triayu Cita; Bandem, I Gede Yudistira Perdangga; Hantari, Ni Kadek Dwi Cahyani Cipta; Leliqia, Ni Putu Eka; Ariantari, Ni Putu
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 1 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i1.92332

Abstract

Bunga gemitir (Tagetes erecta L.) dan alga merah (Kappaphycus alvarezii (Doty) L.M.Liao) merupakan bahan alam yang telah dilaporkan memiliki aktivitas antibakteri dan antioksidan. Penelitian ini bertujuan untuk mengetahui efek antibakteri kombinasi ekstrak etanol bunga gemitir dan alga merah terhadap bakteri penyebab jerawat, Propionibacterium acnes ATCC 1223, serta aktivitasnya setelah diformulasi dalam bentuk sediaan sediaan krim solid lipid nanoparticle (SLN). Serbuk kering bunga gemitir dan alga merah diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Terhadap ekstrak yang diperoleh, dilakukan skrining fitokimia. Selanjutnya, masing-masing ekstrak diuji aktivitas antibakterinya terhadap P. acnes secara individual dengan metode mikrodilusi. Aktivitas antibakteri kombinasi kedua ekstrak selanjutnya diuji dengan metode mikrodilusi checkerboard. Berdasarkan hasil pengujian aktivitas antibakteri, 4 perbandingan kombinasi ekstrak dibuat dalam bentuk sediaan krim SLN yaitu formula F1, F2, F3, dan F4. Sediaan F1–F4 dievaluasi melalui uji organoleptis, homogenitas, pH, daya sebar, dan daya lekat. Aktivitas antibakteri krim SLN diuji dengan metode difusi sumuran. Berdasarkan uji skrining fitokimia yang dilakukan, flavonoid, alkaloid dan fenol terdeteksi pada kedua ekstrak, sedangkan steroid hanya terdeteksi pada ekstrak bunga gemitir. Pada pengujian aktivitas antibakteri ekstrak secara individual, ekstrak bunga gemitir dan alga merah memiliki aktivitas lemah dengan nilai konsentrasi hambat minimum (KHM) sebesar 4 dan 16 mg/mL. Kombinasi ekstrak bunga gemitir dan alga merah menghasilkan aktivitas antibakteri lebih tinggi daripada aktivitas masing-masing ekstrak secara individual terhadap P. acnes, dan dikategorikan memiliki efek aditif dengan nilai FKI sebesar 0,5312. Setelah diformulasi dalam bentuk krim SLN, hanya formula F4 yang mengandung 0,1 g ekstrak bunga gemitir dan 0,2 g ekstrak alga merah memberikan aktivitas antibakteri terhadap P. acnes dengan diameter zona hambat sebesar 16,762,46 mm. Hasil penelitian ini menunjukkan sediaan krim SLN F4 yang mengandung kombinasi ekstrak bunga gemitir dan alga merah potensial untuk diinvestigasi lebih lanjut untuk pengembangan sediaan untuk mengatasi jerawat berbasis bahan alam. 
Co-Authors 1Dwija, I.B.N.P Achmad Fuad Hafid Adi, I Made Agus Kusuma Adiluhur, I.M.P. Adiluhur, M. A. Agastia, I.P.A. Agastia, P. A. A. Anggreni, M Astuti, K.W. Astuti, M.A.P. Aty Widyawaruyanti Bandem, I Gede Yudistira Perdangga Caresya Insani Bangga Nabila Dewa Ayu Swastini Dewi, I Gusti Ayu Agung Gangga Samala Dewi, I. A. M. Dewi, I.A.M.K. Dwicandra, N.M.O. Dwija, I. B. N. P. Dwija, I.B.N.P Dwija, Ida Bagus Nyoman Putra Elizabeth S. P. Ratnasantasyacitta Hantari, Ni Kadek Dwi Cahyani Cipta I Ketut Juniarta I Made Kardena I Nengah Wirajana I Putu Yogi Astara Putra I Wayan Sudiarta I. Setyawati I.B.N.P. Dwija I.G.N.A.P. Putra Ida Bagus Nyoman Putra Dwija Joko Tri Wibowo, Joko Tri Karso, F. P. Kartini, Ni Komang Triayu Cita Ketut Widyani Astuti Komang Tria Noviana Dewi Kristiani, Ni Kadek Ari Lidya Tumewu Mahadewi, S. A. Mahadewi, S.A. Maria Esmeralda Elvira Ngedo Reo Mita Anggraeni, Mita N. W. Erawati Nallakrishna, I P. A. Ni Kadek Ari Kristiani Ni Kadek Dwijayanti Ni Luh Putu Indah Suryani Ni Luh Rustini Ni Made Suartini Ni Putu Eka Leliqia Ni Putu Eka Leliqia Ni Wayan Prasanthi Swarna Putri Nonye Treasure Ujam Normansyah, A. P. A. C. Kusuma P. A. C. Kusuma, P. A. C. Partiwisari, N.P.E. Priskila Putri Mairing Purwani, S. T. D Purwani, S. T. D. Putra, I Putu Yogi Astara Putra, I. G. N. R. Putra, Pramana Kumala Putri, Ni Putu Ananda Eka Putri, Ni Wayan Prasanthi Swarna Putu Aurora Vanadis Putu Oka Samirana Ramayati, N.P.A Rasmaya Niruri Rini Noviyani S. T. D Purwani, Sagun Chandra Yowani Samiantara, I. K. Sang Ayu Made Dwi Ariesta Putri Savitri, L.P.V.A Suari, Anak Agung Istri Padma Ujam, Nonye Treasure Ware, Ismail Witantri, Ni Komang Diah Eka Wulandari, Ni Made Widya Yanti, P. E. W.