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All Journal Pharmaciana: Jurnal Kefarmasian Science and Technology Indonesia Jurnal Penelitian Sains Indonesian Journal of Chemistry Pharmacoscript Jurnal 'Aisyiyah Medika Babul Ilmi Jurnal Ilmiah Multi Science Kesehatan Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Pada Masyarakat Pharmacon: Jurnal Farmasi Indonesia
Shaum Shiyan
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Sriwijaya, Indralaya, Indonesia
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OPTIMASI FORMULA LIPSTIK EKSTRAK BIJI COKLAT (Theobroma cacao L.) DENGAN KOMBINASI BASIS CARNAUBA WAX DAN PARAFFIN WAX MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN Pratiwi, Galih; Arina, Yudi; Tari, Mayang; Shiyan, Shaum; Anggun Prasasty, Mas Ayu
Jurnal 'Aisyiyah Medika Vol 8, No 1: Februari 2023 Jurnal 'Aisyiyah Medika
Publisher : stikes 'aisyiyah palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36729/jam.v8i1.982

Abstract

Latar Belakang: Lipstik merupakan salah satu kosmetik yang digunakan untuk mewarnai bibir sehingga dapat meningkatkan estetika dalam tata rias wajah dan memberikan ekspresi wajah yang menarik. Ekstrak biji coklat (Theobroma cacao L.) mengandung antosianin yang berpotensi sebagai zat warna alami. Metode simplex lattice design (SLD) mudah digunakan dan dapat digunakan untuk memprediksi formula optimum sediaan lipstik ekstrak biji coklat. Tujuan: Diketahuinya komposisi bahan carnauba wax dan paraffin wax penyusun formula optimum lipstik dan karakteristiknya Metode: Pendekatan design of experiment (DoE) dengan SLD menggunakan piranti lunak design expert. Penelitian dilaksanakan dari bulan Mei sampai Agustus 2022 di Laboratorium Farmasi Sekolah Tinggi Ilmu Kesehatan ‘Aisyiyah Palembang. Parameter yang diuji meliputi organoleptis, homogenitas, daya oles, titik leleh, pH, daya lekat. Analisis data menggunakan pendekatan DoE. Hasil: Formula optimum yang diperoleh dari sediaan lipstik kombinasi carnauba wax dan paraffin wax yaitu berturut-turut 5,561 % dan 19,439 %. Formula optimum memiliki daya lekat 82 ± 13,25 detik dan titik leleh 68 ± 1,89. Lipstik biji coklat berwarna ungu dengan bau khas coklat, homogen, merata dengan warna intensif Saran: Perlu dilakukan pengujian lebih lanjut terhadap kandungan kimia ekstrak biji coklat. Kata Kunci: Lipstik, Theobroma cacao, optimasi, design of experiment, simplex lattice design
NARATIVE REVIEW: PROFIL FITOKIMIA DAN POTENSI FARMAKOLOGI Citrus limon Shiyan, Shaum; Pratiwi, Galih; Sari, Ayu Ratna; Alta, Ulik
Jurnal 'Aisyiyah Medika Vol 7, No 2: Agustus 2022 Jurnal 'Aisyiyah Medika
Publisher : stikes 'aisyiyah palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36729/jam.v7i2.851

Abstract

Latar Belakang: Jeruk lemon banyak digunakan sebagai bahan makanan atau mimuan, obat-obatan, kosmetik, deterjen dan aromaterapi. Lemon kaya dengan kandungan senyawa yang berpotensi dapat digunakan sebagai alternatif pengobatan, diantaranya adalah  glikosida flavonoid, kumarin, β dan ɤ-sitosterol, dan senyawa volatil. Tujuan: Untuk membahas profil fitokimia dan potensi farmakologi lemon. Metode: Informasi dalam penulisan artikel diperoleh dari berbagai database seperti science direct, google scholar dan pubmed. Pembahasan: Analisis fitokimia lemon sudah banyak dilakukan dengan berbagai macam metode, sehingga dapat diketahui kandungan dari lemon yang memiliki efek farmakologi, seperti antibakteri, antivirus, antioksidan dan bahkan sudah mulai dikembangkan sebagai antikanker. Kesimpulan: Lemon kaya akan senyawa aktif dan sudah terbukti efektif untuk pengobatan berbagai penyakit, sehingga sangat potensial untuk dikembangkan menjadi sediaan farmasi. Kata Kunci: Citrus limon, Lemon, Aktivitas Farmakologi
Phytopharmaceutical modification of papaya (Carica papaya) seed extract on sperm quality using self-nano emulsion as contraception potential : Phytopharmaceutical of papaya seed extract self-nano emulsion as contraception Shiyan, Shaum; Nuria , Siti Azzahra; Alzuraiqi, Lutfi Muhammad; Pratiwi, Galih; Nalindra, Wahyu Naga; Aisyah , Jasmine Rani
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.7467

Abstract

Carica papaya is known to reduce the quality of spermatozoa in morphology and viability of spermatozoa. Biochemical compound in Carica papaya is unstable and can easily degraded in disgetive track. Formulation of papaya seeds in the form of self-nano emulsion (SNE) is an alternative drug delivery system to increase bioavailability by lipophilic means. The sample consisted of 18 rats which were divided into 3 groups, namely the control group which was not given any treatment; the treatment group which was given papaya seed ethanol extract as much as 100 mg/kgBW and the treatment group which was given papaya seed extract-SNE as much as 100 mg/kgBW, the administration was carried out orally for 28 days. Examination of the quality of rat spermatozoa includes morphology, motility, and viability. Data analysis using One Way ANOVA and Chi-Square test. The results of the analysis showed that the decrease in morphology and viability of spermatozoa was significantly different with a result (p < 0.05) between treatment groups. As for motility, it does not have a significant difference with a result (p > 0.05) between treatment groups.. Based on the results of the study, it can be concluded that the administration of papaya seed ethanol extract and papaya seed SNE extract significantly reduces the quality of spermatozoa in the form of morphology and viability, and does not significantly reduce the motility of Wistar strain white rat spermatozoa.
Study of Potential α-Glucosidase Inhibitor from Tithonia diversifolia: In Vitro, Pharmacokinetics, Toxicology, and Molecular Docking Alfarado, Daniel; Shiyan, Shaum; Ferlinahayati, Ferlinahayati
Indonesian Journal of Chemistry Vol 25, No 2 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.103111

Abstract

The kipahit plant (Tithonia diversifolia) is commonly used in traditional medicine to treat various diseases, particularly diabetes. Investigating the bioactive compounds of T. diversifolia as α-glucosidase enzyme inhibitors is very promising to be carried out for antidiabetic drug development. A combination of in vitro and in silico studies was conducted to determine the inhibitory interaction of these compounds. In vitro assay was performed using the spectrophotometry method on methanol extracts and revealed that the stems (IC50 = 105.0 ppm) exhibited higher bioactivity than the leaves (IC50 > 500 ppm). Metabolite profiling of the methanol extract of the T. diversifolia stems revealed 94 compounds, which continued for in silico methods (pharmacokinetics and toxicology, followed by molecular docking with flexible-rigid method) for antidiabetic activity and drug-likeness parameters. Among the identified compounds, eight showed promise as drug candidates for inhibiting the α-glucosidase enzyme. The compound 1-(7-hydroxy-2-(hydroxymethyl)-2-methyl-2H-chromen-6-yl)ethanone was the most effective candidate among the eight candidates, based on its high similarity liked positive control, the lowest binding affinity value (−7.739 kcal/mol), and the inhibition constant (97.0 μM). The research findings suggested that the compounds in T. diversifolia had the potential to inhibit the α-glucosidase enzyme and could be developed into antidiabetic drugs.
Investigation of Physical Properties, Solubility, Dissolution Profiles, and Flow Properties of Solid Dispersion Loading Cefixime Using Chitosan and Sodium Alginate Mardiyanto; Fithri, Najma Annuria; Shiyan, Shaum; Satrio, Fakhri D.
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.943-951

Abstract

The co-grinding method has been used to produce solid dispersions that increase the solubility of drug substances by utilizing hydrophilic polymers. The purpose of this study was to evaluate the effect of chitosan and variations of sodium alginate as polymers on the dissolution rate of cefixime solid dispersion using the co-grinding technique. The cefixime solid dispersion formulation was made in three variations of sodium alginate formulas, namely 200 mg, 250 mg, and 300 mg. Sample characterization was carried out using XRD, FTIR, SEM, solubility testing, dissolution rate, and flow properties. The results showed that Formula 2 (F2) cefixime solid dispersion was the best formula because the degree of crystallinity decreased to 21.71%, and FTIR analysis showed the functional group interaction. Evaluation of cefixime solid dispersion showed changes in particle morphology. In addition, there was an increase in the transmittance percentage in SIF of 98.587 ± 0.019 and an increase in the dissolution rate of cefixime of 83.61%, an increase in the flow rate of 6.3 ± 0.14 grams/second, an angle of repose of 26.4 ± 0.4◦, a compressibility index of 16.3 ± 0.29%, and a Hausner ratio of 1.19 ± 0.35.
Analisis Thermogravimetri dan Sifat Mekanis Edible Film Rumput Laut Gracillaria sp. Sebagai Bahan Alternatif Bioplastik Prasetyo, M Yosi; Hendri, Muhammad; Shiyan, Shaum
Jurnal Penelitian Sains Vol 26, No 2 (2024)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v26i2.1016

Abstract

Rumput laut memiliki banyak manfaat potensial yang dapat dikembangkan. Rumput laut berkontribusi secara positif terhadap kebutuhan dan konsumsi nutrisi manusia serta dapat diolah dan dimanfaatkan sebagai produk inovatif yang memiliki nilai tambah tertentu, salah satunya sebagai bahan film bioplastik yang edible untuk mengurangi penggunaan kemasan plastik. Kelebihan edible film yang dibuat dari hidrokoloid diantaranya memiliki kemampuan yang baik untuk melindungi produk terhadap oksigen, karbondioksida, dan lipida serta memiliki sifat mekanis yang diinginkan dan meningkatkan kesatuan struktur produk. Tujuan penelitian ini adalah menganalisis karakteristik sifat fisik dan kimia edible film rumput laut Gracilaria sp. yang dikoleksi dari Perairan Pantai Selatan Gunung Kidul, Yogyakarta. Metode pengujian berupa preparasi sampel, pembuatan edible film, dan analisis karakteristik serta analisis Thermogravimetric Analysis (TGA). Hasil penelitian ini menunjukkan nilai ketebalan tertinggi 234 m, kuat tarik 17,15 N/mm2, elongasi 2,91%. Analisis termal didapatkan kadar air yang hilang 19,97% dan sisa residu abu 30,81%.Keywords: Bioplastik, Edible Film, TGA, Hidrokoloid, Gracilaria sp
Submikro Partikel Gelasi Ionik Pembawa Ekstrak Etanol Daun Inai (Lawsonia Inermis Linn.) Menggunakan Biopolimer Kitosan-Alginat Dan Kalsium Klorida Mardiyanto, Mardiyanto; Solihah, Indah; Shiyan, Shaum; Sari, Familia Maya
Jurnal Penelitian Sains Vol 27, No 2 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i2.1199

Abstract

Ekstrak daun inai memiliki senyawa aktif turunan dari flavonoid yang menunjukkan aktivitas antioksidan. Penelitian ini bertujuan untuk menjadikan ekstrak etanol daun inai menjadi submikropartikel dengan metode gelasi ionic: menginteraksikan ekstrak inai dengan kitosan selanjutnya pengikatan oleh natrium alginat dibantu CaCl2 sebagai agen sambung-silang. Jumlah total flavonoid pada ekstrak inai adalah 41,419 mg/g. Hasil pengamatan terhadap plat KLT mengindikasikan bahwa ekstrak inai memiliki senyawa flavonoid yang ditandai oleh angka Rf 0,77. Harga %efisiensi enkapsulasi (%EE) masing-masing formula F1, F2, dan F3 adalah 96,280%, 93,456%, dan 92,117%. Data property fisik produk: size, keseragaman, dan perbedaan potensial dari produk sebesar 593 nm, 0,248, dan +35,07 mV yang diukur dengan PSA. Hasil pengujian penyimpanan pada 6 siklus terhadap produk secara pengulangan panas-dingin terjadi penurunan kadar terbesar pada F3 yaitu sebesar 8,75% pada siklus ke 5.
OPTIMIZATION OF BUTTERFLY PEA EXTRACT PEEL-OFF MASK WITH VARIATIONS OF POLYVINYL ALCOHOL AND IOTA CARRAGEENAN USING FACTORIAL DESIGN Dina Permata, Wijaya; Shaum, Shiyan; Nabilah Putri, Hadiani; Herlina, Herlina; Mutia Sari, Wardana
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.1798

Abstract

ABSTRACT The butterfly pea flower (Clitoria ternatea) contains antioxidants that help combat premature skin aging. Peel-off masks are popular with consumers as topical formulations because they are unique and practical. An essential component of peel-off masks is the gelling agent Polyvinyl Alcohol (PVA), which acts as a film-forming agent. However, PVA at the wrong concentration can result poor mask physical properties. Combining PVA with other gelling agents can obtain peel-off masks with better physical properties. This study aims to identify the effect of PVA and iota carrageenan on the optimal formula of peel-off masks regarding physical properties, stability, and antioxidant activity. Butterfly pea flower extract was obtained by maceration in 70% ethanol. Optimization of PVA and iota carrageenan was conducted using a factorial design method, observing responses such as viscosity, spreadability, and drying time. Peel-off masks with butterfly pea flower extract were prepared with concentration variations of PVA (6%, 10%) and iota carrageenan (0.5%, 1%). The optimal formula was then tested for stability using cycling test method and for antioxidant activity using DPPH method. Increasing concentrations of PVA and iota carrageenan significantly affects viscosity, spreadability, and drying time, with a p-value < 0.05. The optimal peel-off mask formula contained 16% PVA and 0.5% iota carrageenan, with a viscosity of 16.473 cPs, spreadability of 5.6 cm, and drying time of 23 minutes and 11 seconds. The optimal formula demonstrated good stability during storage, with a significance p-value > 0.05, and was categorized as having weak antioxidant activity with an IC50 value 171.738 µg/mL.
Co-Authors Aisyah , Jasmine Rani Alfarado, Daniel Alta, Ulik Alzuraiqi, Lutfi Muhammad Anggun Prasasty, Mas Ayu Arina, Yudi Arsela, Della Ayu Ratna Sari Bella, Annisa Mutiara Della Arsela Dina Permata, Wijaya Elmiawati Latifa Ferlinahayati Ferlinahayati Friska, Audia Galih Pratiwi Galih Pratiwi, Galih Herlina . Herlina Herlina Indah Solihah Jessica Nathasia Khoirin, Khoirin Laida Neti Mulyani Latifa, Elmiawati Mardiyanto Mardiyanto Mardiyanto Misirti Maulidia Anis Marketama Muhammad Hendri Mutia Sari Wardana Nabilah Putri, Hadiani Najma Annuria Fithri, Najma Annuria Nalindra, Wahyu Naga Nuria , Siti Azzahra Prasetyo, M Yosi Pratiw, Galih R, Anidita Rachmah Rianasari Puspita Rasyid Saputri, Mutiara Ariani Sari, Familia Maya Satrio, Fakhri D. Soilia Fertilita Solihah, Indah Suprayetno Suprayetno Suprayetno Suprayetno Tari, Mayang Trisakti, Intan Viva Starlista Yudi Arina