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Analisis Gerombol Simultan dan Jejaring Farmakologi antara Senyawa dengan Protein Target pada Penentuan Senyawa Aktif Jamu Anti Diabetes Tipe 2 Nurul Qomariasih; Budi Susetyo; Farit Mochamad Afendi
Jurnal Jamu Indonesia Vol. 1 No. 2 (2016): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1519.787 KB) | DOI: 10.29244/jji.v1i2.16

Abstract

Selama ini pembuatan obat untuk menyembuhkan suatu penyakit masih menargetkan hanya satu protein khusus yang menjadi penyebab penyakit tersebut, yang tentu hanya menggunakan satu senyawa aktif. Padahal selain menimbulkan efek samping, penanganan suatu penyakit perlu menyasar banyak protein sekaligus. Sehingga, baru-baru ini terjadi perubahan paradigma dari “one drug, one target” menjadi “multi-components, network target”. Paradigma baru ini telah melahirkan beberapa penelitian untuk menghasilkan formulasi jamu, hal ini dikarenakan konsep formulasi jamu memerlukan beberapa senyawa aktif yang terlibat. Formula jamu yang diteliti sebagai upaya menyembuhkan penyakit Diabetes Melitus (DM) tipe 2 terdiri dari 4 tanaman yaitu Pare (Momordica charantia), Sembung (Blumea balsamifera), bratawali (Tinospora crispa), dan jahe (Zingiber officinale) berdasarkan hasil penelitian Nurishmaya tahun 2014 serta berdasarkan ramuan jamu yang sedang dikembangkan di Pusat Studi Biofarmaka, Bogor. Evaluasi senyawa yang berkaitan dengan DM tipe 2 dilakukan dengan terlebih dahulu menambahkan 19 obat sintetis yang ditujukan untuk DM tipe 2 dari basis data Drug Bank. Sehingga terdapat total sebanyak 74 senyawa aktif yang terdiri dari 55 senyawa alami dari tanaman dan 19 senyawa sintetis obat. Sebanyak 100 protein yang berkaitan erat dengan masing-masing senyawa diperoleh melalui hasil skor konkordan DrugCHIPER. Skor konkordan tersebut kemudian digunakan dalam analisis gerombol simultan antara senyawa dan protein target. Plot komponen utama dan submatrix penggerombolan simultan menunjukkan 2 dari 3 senyawa dari bratawali sangat dekat dengan kelompok sintetis. Selain itu, ada 11 dari 44 senyawa dari Jahe terkumpul bersama dengan senyawa sintetis tetapi dalam jarak yang jauh. Sedangkan berdasarkan jejaring kemiripan, lebih spesifik lagi terdapat 17 dari 19 senyawa obat sintetis yang memiliki kemiripan berdasarkan protein target dengan 2 senyawa tanaman Bratawali dan 5 senyawa tanaman Jahe.
REFORMASI AKREDITASI SEKOLAH/MADRASAH: PENDEKATAN MODEL PREDIKSI Budi Susetyo; Hafidz Muksin
Jurnal Pendidikan dan Kebudayaan Vol. 7 No. 1 (2022)
Publisher : Badan Standar, Kurikulum, dan Asesmen Pendidikan, Kemendikdasmen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24832/jpnk.v7i1.2423

Abstract

Proses bisnis akreditasi yang saat ini berjalan memerlukan sumber daya yang besar, sehingga Badan Akreditasi Nasional Sekolah dan Madrasah tidak dapat melaksanakan sesuai amanat peraturan perundangan. Hasil akreditasi seyogyanya konsisten dengan indikator mutu lainnya. Tujuan utama penelitian yaitu untuk menganalisis komitmen penganggaran dalam pelaksanaan akreditasi dan konsistensi hasil akreditasi dengan indikator mutu pendidikan lainnya. Penelitian ini juga bertujuan mengkaji penggunaan model statistik untuk pendugaan peringkat hasil akreditasi sekolah/madrasah. Metode yang digunakan adalah analisis secara deskriptif dan inferensia terhadap data sekunder hasil akreditasi, perencanaan anggaran, ujian nasional, dan hasil PISA. Hasil penelitian menunjukkan bahwaterdapat tiga masalah substansial sebagai pendorong dilakukannya reformasi akreditasi. Pertama, keterbatasan anggaran untuk pemenuhan target akreditasi. Kedua, ketidakkonsistenan hasil akreditasi dengan ujian nasional dan PISA. Ketiga, dapat dilakukannya pendugaan hasil akreditasi dengan menggunakan model statistik. Simpulan analisis hasil penelitian ini adalah perlunya dilakukan pengembangan model yang akurat untuk memprediksi peringkat akreditasi untuk menunjang kebijakan automasi akreditasi; penyempurnaan instrumen akreditasi berbasis pengukuran kinerja; peningkatan kualitas asesor; dan pengembangan sistem monitoring dasbor. Hasil sistem monitoring dasbor akan digunakan untuk penetapan sekolah/madrasah yang memperoleh perpanjangan sertifikat akreditasi secara automasi dan yang dilakukan melalui visitasi oleh asesor.
Comparing Outlier Detection Methods using Boxplot Generalized Extreme Studentized Deviate and Sequential Fences Anwar Fitrianto; Wan Zuki Azman Wan Muhamad; Suliana Kriswan; Budi Susetyo
Aceh International Journal of Science and Technology Vol 11, No 1 (2022): April 2022
Publisher : Graduate Program of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (410.433 KB) | DOI: 10.13170/aijst.11.1.23809

Abstract

Outliers identification is essential in data analysis since it can make wrong inferential statistics. This study aimed to compare the performance of Boxplot, Generalized Extreme Studentized Deviate (Generalized ESD), and Sequential Fences method in identifying outliers. A published dataset was used in the study. Based on preliminary outlier identification, the data did not contain outliers. Each outlier detection method's performance was evaluated by contaminating the original data with few outliers. The contaminations were conducted by replacing the two smallest and largest observations with outliers. The analysis was conducted using SAS version 9.2 for both original and contaminated data. We found that Sequential Fences have outstanding performance in identifying outliers compared to Boxplot and Generalized ESD.
Klasifikasi Keberhasilan Melanjutkan Pendidikan Tingkat SMA Provinsi Banten Menggunakan CART dan Random Forest Muhammad Amirullah Yusuf Albasia; Budi Susetyo; I. Made Sumertajaya
Xplore: Journal of Statistics Vol. 7 No. 3 (2018): 31 Desember 2018
Publisher : Department of Statistics, IPB

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dropout rate in Indonesia has a higher percentage as education levels grow. The percentage of continuing education to senior high school in Indonesia is at 77.50%. Banten is one of the provinces that has a higher dropout percentage when the education level is also higher. Beside that, Banten is the second lowest province in Indonesia in the percentage of continuing education to senior high school that is 68.92%. The study examines importance variables and performance classification that is generated by classification tree and random forest. The results showed that importance variables that is generated by both methods were same, that is per capita expenditure (X8) and proportion of household members who are less educated than senior high school (X10). Then, based on the AUC value that obtained by 10-fold cross validation showed that random forest is better than classification tree. Experiments with values ​​of accuracy, sensitivity, and specificity at some cuts off values ​​also show that random forest can provide more optimum prediction performance than classification tree.
Penerapan Regresi Peubah Ganda untuk Menentukan SNP yang Berpengaruh terhadap Prestasi Akademik SMA/MA Wulan Andriyani Pangestu; Budi Susetyo; Rahma Anisa
Xplore: Journal of Statistics Vol. 7 No. 3 (2018): 31 Desember 2018
Publisher : Department of Statistics, IPB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/xplore.v7i3.130

Abstract

The evaluation step in school accreditation process includes eight components of national education standard (SNP). The result of accreditation from the evaluation is believed to explicate the academic achievement of student, in this case is National Examination (UN). Thus, it is necessary to further observe the relation between the accreditation results and the score of national examination. One of the analysis that can be used is regression analysis, it is used to observe the relation between the accreditation result and the sroce of national examination also to identify the SNP components that affect the national examination score. However, since the study was conducted at senior high school level where the national examination score for this level covers six subjects, the analysis used is no longer a simple regression but a multiple variable regression. It is because of the relationship between the score of the national examination that characterizes an academic achievement. The application result of multiple variable regression method shows that there is a relation between SNP and national examination score.
Faktor-Faktor yang Berpengaruh dalam Mendapatkan Pekerjaan bagi Lulusan Statistika IPB dengan Menggunakan Metode CHAID Aulia Dwi Oktavia; Aam Alamudi; Budi Susetyo
Xplore: Journal of Statistics Vol. 8 No. 1 (2019): 30 April 2019
Publisher : Department of Statistics, IPB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/xplore.v8i1.156

Abstract

Unemployment is one of the economic problems in Indonesia. Judging from the level of education that was completed there were unemployment from the level of college graduates. This encourages the level of competition in getting jobs to be more stringent, so that college graduates (bachelor of Statistics in IPB) must have the preparation of various factors to maintain the quality of their graduates. The quality of college graduates can be seen from the length of time waiting to get a job. This study aims to determine the influential factors in getting a job for graduates of the IPB Statistics degree, so that the CHAID method can be used in this study. The results of CHAID's analysis in this study in the form of tree diagrams using α = 10% explained that the factors influencing the waiting period variables were sex, internship, and the ability to master statistical software, where the accuracy value generated by the classification model was 79.3 %.
Penggerombolan Daerah 3T di Indonesia Berdasarkan Rasio Tenaga Kesehatan dengan Metode Penggerombolan Berhierarki dan Cluster Ensemble Kesuma Millati; Cici Suhaeni; Budi Susetyo
Xplore: Journal of Statistics Vol. 10 No. 2 (2021)
Publisher : Department of Statistics, IPB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (684.898 KB) | DOI: 10.29244/xplore.v10i2.744

Abstract

Health is a major factor in community development. Inequality on health is most felt by people living in disadvantaged, outermost, and leading areas (3T) because of the difficulty of access to transportation and communication. Effective efforts are needed to achieve the optimal distribution of health services, one of which is by clustering 3T areas based on the ratio of health workers to see which areas are experiencing shortage of health workers and know the adequacy of the number of health workers spread in 3T areas. The object used in this research is 27 provinces 3T region in Indonesia and the applied statistical method is various hierarchical methods and Cluster Ensemble. Based on the results of this study, 3T area is divided into four clusters. The first cluster consists of 22 provinces and has good characteristics because all categories of the variables are in the medium category. The second and the third cluster consists of two provinces. The characteristics of the second cluster are good enough. The characteristics of the third cluster are not been good enough because there is one variable in the low category. The fourth cluster consists of one province and has characteristics that are not been good enough because there are several categories of the variables are in the low category.
Identifikasi Faktor-faktor yang Memengaruhi Hasil Akreditasi SMA di Indonesia Berdasarkan Data ARKAS Muh Nur Fiqri Adham; Budi Susetyo; Kusman Sadik; Satriyo Wibowo
Xplore: Journal of Statistics Vol. 10 No. 3 (2021)
Publisher : Department of Statistics, IPB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.898 KB) | DOI: 10.29244/xplore.v10i3.837

Abstract

Accreditation is an indicator of the quality of education at the education unit level. One affects the quality of education units is the school budget. School budgets are prepared in order to fulfill 8 national education standards. School budget management uses School Activity Plan and Budget Application (ARKAS) developed by the Ministry of Education, Culture, Research and Technology (Kemendikbudristek). ARKAS is an information system for managing school budget and expenditure planning. The Research is identifies the factors that influence the accreditation of high school (SMA) with accreditation as a response variable and 17 explanatory variables sourced from ARKAS and Dapodik data using ordinal logistic regression analysis. The best model stage is the model formed that has the smallest AIC value and has high model accuracy in determining the best model. The best model stage is the third model stage which is composed of 7 explanatory variables that affect the high school accreditation rating with AIC value of 1886,20 and model accuracy of 65,79%. The variables that affect to results of accreditation include school status, percentage of students eligible PIP, ratio of the number of students per number of teachers, percentage of teachers certified educators, ratio of the number of students per number of study groups, ratio of the number of students per number of computers, and ratio of the number of students per number of toilets
Penggerombolan Mutu SMA/MA per Provinsi Berdasarkan Hasil Akreditasi Menggunakan Metode Fuzzy C-Means Rifannisa Bahar; Pika Silvianti; Budi Susetyo
Xplore: Journal of Statistics Vol. 10 No. 3 (2021)
Publisher : Department of Statistics, IPB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (482.328 KB) | DOI: 10.29244/xplore.v10i3.842

Abstract

Mapping the quality of education in Indonesia needs to be studied so that the provincial government, as the institution responsible for secondary education management policies, can more easily determine priorities and what actions will be taken to improve the quality of education in Indonesia. One of the analytical methods that can be used to map the quality of education is fuzzy c-means. This research aims to classify the quality maps of provinces in Indonesia based on the results of SHS/MA accreditation using the fuzzy c-means method. The fuzzy c-means method can show the probability of objects entering a cluster with a degree of membership. The optimum cluster sizes obtained were 2 and 3. The final solution with cluster size 2 was 12 provinces categorized in cluster 1 and 22 provinces categorized in cluster 2. Clustering with cluster size 3 resulted in cluster 1 consisting of 11 provinces, cluster 2 consisting of 16 provinces, and cluster 3, which consists of 7 provinces. The main character of cluster 1 is a high national education standard score, while the main character of cluster 2 is a low national education standard score. Then the main character of group 3 is the national standard score, whose value is around the national average.
Perbandingan CART dan SMOTE CART dalam Mengklasifikasikan Kebutuhan KB Tidak Terpenuhi di Indonesia Ulfa Afilia Shofa; Muhammad Nur Aidi; Budi Susetyo
Xplore: Journal of Statistics Vol. 11 No. 2 (2022):
Publisher : Department of Statistics, IPB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (582.121 KB) | DOI: 10.29244/xplore.v11i2.917

Abstract

Indonesia is ranked fourth in the world as the country with the largest population. The high population growth in Indonesia can cause problems in several fields. The government seeks to suppress the rate of population growth through the Family Planning (KB) program. In Indonesia, the number of unmet needs for family planning is still relatively high and has not yet reached the BKKBN target. Therefore, it is necessary to identify the characteristics of unmet need for family planning among married women or living with partner. This study used the Classification and Regression Trees (CART) method. This study handling unbalanced data by Synthetic Minority Oversampling Technique (SMOTE). This study aims to compare the performance of the CART and SMOTE CART classification methods in classifying unmet need for family planning and to identify the characteristics of unmet need for family planning among married women or living with partner in Indonesia. The SMOTE CART model has better performance than the CART model, with the percentages of balanced accuracy, sensitivity, and specificity being respectively 54.83%, 34.96%, and 74.70%. In general, the characteristics of unmet need for family planning among married women or living with partner in Indonesia are having 1-4 living children, not getting information from mass media, not accessing the internet in the last month, having a primary or secondary education level, a husband with no education or with a primary or secondary education level, and aged more than 30 years old.     Keywords: CART, SMOTE CART, unmet need for family planning
Co-Authors Aam Alamudi Aceng Komarudin Mutaqin Aditya Ramadhan adwendi, satria june Ahmad Ansori Mattjik Aji Hamim Wigena Akbar Rizki Amir, Sulfikar Anak Agung Istri Sri Wiadnyani ASEP SAEFUDDIN Aulia Dwi Oktavia Aunuddin Aunuddin Bagus Sartono Bambang H. Trisasongko Bambang Juanda Brian G. Lees Cici Suhaeni Cut N. Ummu Athiyah DAMAYANTI BUCHORI Darfiana Nur Dewi Jasmina Dewi Jasmina, Dewi Dhea Dewanti Dian Kurniasari Dito, Gerry Alfa Dyah R. Panuju Endah Febrianti Erfiani Erfiani Fadjrian Imran Fahriya, Andina Farit Mochamad Afendi Fitrianto, Anwar H Karwono Hafidz Muksin Hari Wijayanto Herlina Herlina Hermawati, Neni I Made Sumertajaya Inayatul Izzati Diana Yusuf Indahwati Indahwati Indahwati Indahwati, NFN Intan Juliana Panjaitan Iswan Achlan Setiawan Izzati Rahmi HG Jap Ee Jia Jia, Jap Ee Karwono, H Kesuma Millati Khairil Anwar Notodiputro Khikmah, Khusnia Nurul Kristuisno Martsuyanto Kapiluka Kriswan, Suliana Kusman Sadik Kusni Rohani Rumahorbo La Ode Abdul Rahman La Ode Abdul Rahman La Ode Abdul Rahman M Nur Aidi M Nur Aidi, M Nur Mahmud A. Raimadoya Muh Nur Fiqri Adham Muhammad Amirullah Yusuf Albasia Muhammad Nur Aidi Muhammad Sayuti Mustofa Usman Nurfadilah, Khalilah Nurfajrin, Tria Ermina Nurul Qomariasih Pannu, Abdullah Pika Silvianti Pika Silvianti Qalbi, Asyifah Qomariasih, Nurul Rachman, Nurul Aulia Rahma Anisa Rahmawat, NFN Rahmawati, nFN Ratnasari, Andika Putri Rifannisa Bahar Rifki Hamdani Rizki, Akbar Robert, Zahira Rahvenia Safitri, Wa Ode Rahmalia Sanusi, Ratna Nur Mustika Satriyo Wibowo Sembiring, Febryna Sri Ningsih Desi Afriany Sulandra, Ardelia Maharani Sulfikar Amir Suliana Kriswan Supriatin, Febriyani Eka Syahrir, Nur Hilal A. Syahrir, Nur Hilal A. Sylvia P. Soetantyo Tina Aris Perhati Tiya Wulandari Ulfa Afilia Shofa Utami Dyah Syafitri Wan Muhamad, Wan Zuki Azman Wan Zuki Azman Wan Muhamad Wan Zuki Azman Wan Muhamad Warsono Wulan Andriyani Pangestu Yasmin Erika Faridhan Zahira Rahvenia Robert Zainal A Koemadji