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Efek Sinergis Bahan Aktif Tanaman Obat Berbasiskan Jejaring Dengan Protein Target Syahrir, Nur Hilal A.; Afendi, Farit Mochamad; Susetyo, Budi
Jurnal Jamu Indonesia Vol. 1 No. 1 (2016): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v1i1.6

Abstract

Medicinal plants contain inherently active ingredients. Such ingredients are beneficial to prevent and cure diseases, as well as to perform specific biological functions. In contrast to synthetic drugs, which is based on one single chemicals, medicinal plants exert their beneficial effects through the additive or synergistic action of several chemical compounds. Those chemical compound act on single or multiple targets (multicomponent therapeutic) associated with a physiological process. Active ingredients combinations show a synergistic effect. This means that the combinational effect of several active ingredients is greater than that of individual one acting separately. A network target can be used to identify synergistic effects of plants active ingredients. The method of NIMS (Network target-based Identification of Multicomponent Synergy) is a computational approach to identify the potential synergistics effect of active ingredients. It also assessess synergistic strength of any active ingradients at the molecular level by synergy scores. We investigate these synergistic on a Jamu formula for diabetes mellitus type 2. The Jamu formula is composed of four medicinal plants, namely Tinospora crispa , Zingiber officinale, Momordica charantia, and Blumea balsamivera. Our work succesfully demonstrates that the highest synergy scores on medicinal plants synergy can be seen in pairs of several active ingredients in Zingiber officinale. On the other hand, the synergy of pairs of active ingredients in Momordica charantia and Zingiber officinale posseses a relatively high score. The same occurs in Tinospora crispa and Zingiber officinale.
Analisis Gerombol Simultan dan Jejaring Farmakologi antara Senyawa dengan Protein Target pada Penentuan Senyawa Aktif Jamu Anti Diabetes Tipe 2 Qomariasih, Nurul; Susetyo, Budi; Afendi, Farit Mochamad
Jurnal Jamu Indonesia Vol. 1 No. 2 (2016): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v1i2.16

Abstract

Selama ini pembuatan obat untuk menyembuhkan suatu penyakit masih menargetkan hanya satu protein khusus yang menjadi penyebab penyakit tersebut, yang tentu hanya menggunakan satu senyawa aktif. Padahal selain menimbulkan efek samping, penanganan suatu penyakit perlu menyasar banyak protein sekaligus. Sehingga, baru-baru ini terjadi perubahan paradigma dari “one drug, one target” menjadi “multi-components, network target”. Paradigma baru ini telah melahirkan beberapa penelitian untuk menghasilkan formulasi jamu, hal ini dikarenakan konsep formulasi jamu memerlukan beberapa senyawa aktif yang terlibat. Formula jamu yang diteliti sebagai upaya menyembuhkan penyakit Diabetes Melitus (DM) tipe 2 terdiri dari 4 tanaman yaitu Pare (Momordica charantia), Sembung (Blumea balsamifera), bratawali (Tinospora crispa), dan jahe (Zingiber officinale) berdasarkan hasil penelitian Nurishmaya tahun 2014 serta berdasarkan ramuan jamu yang sedang dikembangkan di Pusat Studi Biofarmaka, Bogor. Evaluasi senyawa yang berkaitan dengan DM tipe 2 dilakukan dengan terlebih dahulu menambahkan 19 obat sintetis yang ditujukan untuk DM tipe 2 dari basis data Drug Bank. Sehingga terdapat total sebanyak 74 senyawa aktif yang terdiri dari 55 senyawa alami dari tanaman dan 19 senyawa sintetis obat. Sebanyak 100 protein yang berkaitan erat dengan masing-masing senyawa diperoleh melalui hasil skor konkordan DrugCHIPER. Skor konkordan tersebut kemudian digunakan dalam analisis gerombol simultan antara senyawa dan protein target. Plot komponen utama dan submatrix penggerombolan simultan menunjukkan 2 dari 3 senyawa dari bratawali sangat dekat dengan kelompok sintetis. Selain itu, ada 11 dari 44 senyawa dari Jahe terkumpul bersama dengan senyawa sintetis tetapi dalam jarak yang jauh. Sedangkan berdasarkan jejaring kemiripan, lebih spesifik lagi terdapat 17 dari 19 senyawa obat sintetis yang memiliki kemiripan berdasarkan protein target dengan 2 senyawa tanaman Bratawali dan 5 senyawa tanaman Jahe.
Analysis of Covid-19 Risk Perception Survey Result Using Generalized Structured Component Analysis: Analisis Hasil Survei Persepsi Risiko Covid-19 Menggunakan Generalized Structured Component Analysis Robert, Zahira Rahvenia; Rizki, Akbar; Susetyo, Budi; Amir, Sulfikar
Indonesian Journal of Statistics and Applications Vol 6 No 2 (2022)
Publisher : Statistics and Data Science Program Study, SSMI, IPB University, in collaboration with the Forum Pendidikan Tinggi Statistika Indonesia (FORSTAT) and the Ikatan Statistisi Indonesia (ISI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/ijsa.v6i2p336-347

Abstract

The capital city of Indonesia, Jakarta, became the province with the highest number of Covid-19. Response this situation, LaporCovid-19 collaborate with the Social Resilience Lab, Nanyang Technological University conducted a survey to measure how Jakarta residents perceive the risk of Covid-19 from May 29 to June 20 2020. Factors of risk perception are variables that cannot be measured directly, so they are analyzed used a Structural Equation Modeling (SEM) approach, namely Generalized Structured Component Analysis (GSCA). The Likert scale used can be considered as interval or ordinal depending on the point of view of the theory built. Therefore, this study will compare the GSCA method with the nonlinear GSCA and evaluate six variables, namely risk perception, knowledge, information, health behavior , social capital, and economy. Evaluation of the overall model showed that the nonlinear GSCA model can explain the diversity of qualitative data better than the GSCA model with FIT > 0.9. Based on GSCA nonlinear model, information has significantly influence of knowledge, economy and social capital have a real reciprocal relationship, along knowledge and risk perception have significantly influence of health behavior.
Cluster Level Time Series Forecasting on Indonesian Banking Stock Prices Using the Gated Recurrent Unit Method Faisal Arkan; Susetyo, Budi; Anisa, Rahma
Indonesian Journal of Statistics and Applications Vol 9 No 2 (2025)
Publisher : Statistics and Data Science Program Study, SSMI, IPB University, in collaboration with the Forum Pendidikan Tinggi Statistika Indonesia (FORSTAT) and the Ikatan Statistisi Indonesia (ISI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/ijsa.v9i2p261-273

Abstract

In recent years, there has been a significant increase in the number of Single Investor Identification registrations in the Indonesian capital market, as reported by the Financial Services Authority. Many investors favor stocks for their potential for high returns and liquidity. However, stock investments come with high risks due to their fluctuating prices, which are influenced by multiple factors. With 47 listed banking companies in the Indonesia Stock Exchange, clustering can help identify investor patterns. Forecasting stock prices is essential for anticipating future fluctuations. The large number of issuers and the tendency of stock prices to fluctuate increase the potential for outliers, requiring an appropriate clustering method. A study using the k-medoid method and dynamic time warping distance revealed 41 banking companies clustered into 5 clusters with a silhouette coefficient of 0.524. The Gated Recurrent Unit modeling, based on prototypes from the formed clusters, showed an excellent forecasting performance with root mean squared error and mean absolute percentage error ranging from 1-10%. The forecast for the next 8 weeks indicated varying price increases for each cluster. The first and third clusters are recommended for investors looking to maximize capital gains, due to their price increases and diverse cluster member characteristics. Additionally, investors should consider dividends provided by certain banking companies in their investment decision-making process.
Application of the Spatial Durbin Panel Model and Geographically Weighted Panel Regression on Poverty Data in West Java Province Anis Sulistiyowati; Masjkur, Mohammad; Budi Susetyo
Indonesian Journal of Statistics and Applications Vol 9 No 2 (2025)
Publisher : Statistics and Data Science Program Study, SSMI, IPB University, in collaboration with the Forum Pendidikan Tinggi Statistika Indonesia (FORSTAT) and the Ikatan Statistisi Indonesia (ISI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/ijsa.v9i2p240-260

Abstract

Poverty is one of the priority issues in the Sustainable Development Goals. In 2024, West Java Province became the province with the second-highest number of people living in poverty in Indonesia. This study aims to identify the variables that significantly affect the percentage of people living in poverty in districts/cities of West Java Province from 2019 to 2023, using the spatial Durbin panel model and geographically weighted panel regression. The data used is secondary data on poverty indicators in West Java Province from 2019 to 2023, sourced from Statistics Indonesia of West Java. The spatial Durbin panel model developed in this study is a fixed-effects spatial Durbin panel model. The model shows that average years of schooling and expenditure per capita have significant effects. In addition, the spatial lags of the percentage of households living in appropriate housing, the percentage of the population covered by local health insurance, and average years of schooling also have significant effects. The geographically weighted panel regression model, estimated using a fixed effect panel regression with a Gaussian fixed kernel as the optimal weighting function, produces distinct models for each region. The average year of schooling is the dominant factor influencing the percentage of people living in poverty in districts/cities in West Java Province.
SURVIVAL ANALYSIS OF CHRONIC KIDNEY FAILURE PATIENTS USING THE COX STRATIFIED MODEL AND RANDOM SURVIVAL FOREST Hamid, Assyifa Lala Pratiwi; Susetyo, Budi; Kurnia, Anang
BAREKENG: Jurnal Ilmu Matematika dan Terapan Vol 20 No 2 (2026): BAREKENG: Journal of Mathematics and Its Application
Publisher : PATTIMURA UNIVERSITY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/barekengvol20iss2pp1527-1540

Abstract

This study aims to analyze the factors influencing the survival of chronic kidney failure patients undergoing hemodialysis and to compare the performance of the Cox Stratified Model with the Random Survival Forest (RSF) using retrospective data from 741 patients at Asy-Syifa General Hospital, Indonesia. Data were analyzed using the Cox Stratified Model to address violations of the proportional hazards assumption and RSF to capture non-linear patterns and complex interactions among variables. The results showed that age, hypertension, diabetes, anemia, and hemodialysis frequency significantly affected survival, with a C-Index of 0.66 for the Cox Stratified Model and 0.6558 for RSF. The limitations of this study include its single-center retrospective design, which may limit generalizability, potential residual confounding from unmeasured variables, as well as the interpretability limitations and higher computational demands of RSF. The originality of this research lies in the direct comparison between advanced statistical models and machine learning methods in a cohort of chronic kidney failure patients in Indonesia, providing new insights for improving risk stratification and clinical prediction.
School Accreditation Prediction Based on Literacy and Numeracy: Ordinal Logistic Regression vs KNN Syukri, Nabila; Hiola, Yani Prihantini; Putri, Mega Ramatika; Susetyo, Budi
Bulletin of Computer Science Research Vol. 6 No. 1 (2025): December 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/bulletincsr.v6i1.861

Abstract

School accreditation in Indonesia has traditionally relied on administrative inputs and institutional documentation, which often fail to capture the actual quality of student learning. In contrast, the National Assessment provides direct evidence of student literacy and numeracy outcomes, offering a more objective and outcome-based measure of educational quality. Leveraging these results as predictors for accreditation rankings is therefore crucial, as they reflect the competencies most relevant to effective learning delivery. This study aims to develop and evaluate classification models for school accreditation rankings using literacy and numeracy results as predictor variables. The dataset consists of secondary data from the 2023 and 2024 National School Assessments, covering 789 schools across four provinces: DKI Jakarta, Yogyakarta, Bali, and Banten. Two methods were applied, Ordinal Logistic Regression and K-Nearest Neighbors (K-NN) under two scenarios: with and without class imbalance handling. To address imbalance, two techniques were employed: Synthetic Minority Oversampling Technique (SMOTE) and Class Weight. The results indicate that K-NN consistently outperformed Ordinal Logistic Regression in both scenarios. On data without imbalance handling, K-NN achieved Accuracy, Precision, Recall, and F1-Score of 0.803, 0.705, 0.587, and 0.619, respectively. with imbalance treatment using SMOTE, the values were 0.753, 0.619, 0.686, and 0.644. While class balancing did not significantly improve overall accuracy, it enhanced the model’s ability to recognize minority classes. These findings highlight the strong relationship between literacy and numeracy outcomes and school accreditation status, demonstrating that outcome-based measures can complement traditional accreditation instruments, and that conventional statistical approaches are still relevant for modeling school accreditation.
The Innovation and the Transformation of Indonesian Schools Accreditation Management System Budi Susetyo; Sylvia P. Soetantyo; Muhammad Sayuti; Darfiana Nur
Indonesian Journal on Learning and Advanced Education (IJOLAE) Vol. 4, No. 2, May 2022
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ijolae.v4i2.17113

Abstract

All schools at the primary and secondary education levels in Indonesia must be accredited. An independent body called the National Accreditation Board for Schools/Madrasah (BAN-S/M) as an external quality assurance agency, accredits schools throughout Indonesia. Since 2005, the percentage of schools accredited in levels A and B has always increased from year to year based on the accreditation results. However, the improvement of school quality based on accreditation did not strongly correlate with the national exam and PISA results. This article discusses the facts of the experience of implementing accreditation for 15 years which became the basis for accreditation reform in Indonesia. BAN-S/M started the reformation in 2020 with three fundamental changes. First, the change in the accreditation instrument from compliance-based to performance-based. Second, the recruitment of new assessors based on cognitive competence and personality. Third, the changes of the accreditation business process through the dashboard monitoring system that will select schools with automatic accreditation extensions without visitation and schools that assessors must visit. implementation of Innovation and accreditation management reform can reduce accreditation costs by more than 60% and is expected to increase the accuracy of school quality assessment results. The findings strengthen the current transformation to the new, more efficient, rational accreditiation management system for schools/madrasah.
Perbandingan Metode GWR, MGWR, dan MGWR-SAR pada Data Persentase Penduduk Miskin di Pulau Jawa Andina Fahriya; Budi Susetyo; I Made Sumertajaya
Limits: Journal of Mathematics and Its Applications Vol. 22 No. 2 (2025): Limits: Journal of Mathematics and Its Applications Volume 22 Nomor 2 Edisi Ju
Publisher : Pusat Publikasi Ilmiah LPPM Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/limits.v22i2.3057

Abstract

The primary goal of Sustainable Development Goals (SDGs) is to end poverty everywhere in all its forms. Poverty is defined as the inability to meet basic needs, such as food, clothing, shelter, education, and healthcare. In Indonesia, the poor population has reached 26.36 million people, with half of them residing on Java Island. Extensive research has been conducted on poverty, particularly using a spatial approach. Spatial regression is a statistical method that explicitly incorporates geographical aspects into a model framework. In spatial regression, two main challenges arise: spatial dependence and heterogeneity. These two effects are inherently interconnected and must be considered simultaneously. Mixed Geographically Weighted Regression with Spatial Autoregressive (MGWR-SAR) is a combination of Mixed Geographically Weighted Regression (MGWR) and Spatial Autoregressive (SAR). MGWR-SAR effectively addresses both spatial dependence and spatial heterogeneity simultaneously. This study aims to determine the best method for modeling the percentage of poor population on Java. The variables used included PPM, BPJSPBI, PPKM, PLSMP, PPTB, BPNT, NCPR, and IPM. The kernel function was selected based on the smallest cross-validation (CV) value, which was a Fixed Gaussian with a CV of 603.8268. Based on the GWR model, the global variables identified were PPTB, BPNT, and IPM, whereas the remaining variables were local. The MGWR-SAR method was found to be the best model for predicting the percentage of poor population, with an AIC = 448.9645, RMSE = 1.9075, and  = 75.23%.
Evaluation of Tree-Based Models for Predicting Social Assistance Recipient Status Based on National Socio-Economic Survey (SUSENAS) 2024 Yani Prihantini Hiola; Zulhijrah; I Gusti Ngurah Sentana Putra; Syella Zignora Limba; Bagus Sartono; Aulia Rizki Firdawanti; Budi Susetyo; Gerry Alfa Dito
Journal of Mathematics, Computations and Statistics Vol. 9 No. 1 (2026): Volume 09 Issue 01 (March 2026)
Publisher : Jurusan Matematika FMIPA UNM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/xyyv0f37

Abstract

Abstract. Poverty is a major socioeconomic challenge in Indonesia that affects the effectiveness of social protection programs. In response to this challenge, the government has created social assistance programs to improve the welfare of the people. However, the distribution of social assistance is often considered to be inaccurate, resulting in households that are deemed eligible for social assistance not being identified as recipients. One solution to improve the accuracy of distribution is the application of machine learning in the context of classification. Several tree-based models, such as LightGBM, Random Forest, and XGBoost, were selected because of their superior capabilities compared to classical models such as logistic regression, especially in handling complex data and fulfilling model assumptions. This study compares the performance of these three models in predicting social assistance recipient status using data from the 2024 West Java Provincial National Socioeconomic Survey (SUSENAS). Model evaluation was conducted on several data pre-processing scenarios involving outlier handling, class balancing, and feature engineering. The results show that LightGBM consistently outperforms the other models on six metrics, namely Accuracy, Balanced Accuracy, F1-Score, ROC-AUC, PR-AUC, and Brier Score, out of a total of eight evaluation metrics used. SHAP analysis identifies Social Assistance History and Asset Score as the most influential features for model prediction. Friedman and Nemenyi nonparametric tests confirmed significant performance differences between LightGBM and other models based on the F1-Score, PR-AUC, and Brier Score metrics. These findings indicate that tree-based models, particularly LightGBM, can support the development of a more targeted and data-driven social assistance targeting system. Keywords: Social Assistance; Tree-Based; SHAP; SUSENAS; Hybrid Bayesian Optimization
Co-Authors Aam Alamudi Aceng Komarudin Mutaqin Aditya Ramadhan adwendi, satria june Agus Mohamad Soleh Ahmad Ansori Mattjik Aji Hamim Wigena Akbar Rizki Amir, Sulfikar Anak Agung Istri Sri Wiadnyani Anang Kurnia Andi Illa Erviani Nensi Andina Fahriya Anis Sulistiyowati Anisa, Rahma ASEP SAEFUDDIN Aulia Dwi Oktavia Aulia Rizki Firdawanti Aunuddin Aunuddin Bagus Sartono Bambang H. Trisasongko Bambang Juanda Brian G. Lees Cici Suhaeni Cut N. Ummu Athiyah DAMAYANTI BUCHORI Darfiana Nur Dela Gustiara Dewi Jasmina Dewi Jasmina, Dewi Dhea Dewanti Dian Kurniasari Dito, Gerry Alfa Dyah R. Panuju Endah Febrianti Erfiani Erfiani Fadjrian Imran Fahriya, Andina Faisal Arkan Farit Mochamad Afendi Fitrianto, Anwar Gerry Alfa Dito H Karwono Hafidz Muksin Hamid, Assyifa Lala Pratiwi Hari Wijayanto Herlina Herlina Hermawati, Neni Hiola, Yani Prihantini I Gusti Ngurah Sentana Putra I Made Sumertajaya Inayatul Izzati Diana Yusuf Indahwati Indahwati Indahwati Indahwati, NFN Intan Juliana Panjaitan Iswan Achlan Setiawan Izzati Rahmi HG Jap Ee Jia Jia, Jap Ee Karwono, H Kesuma Millati Khairil Anwar Notodiputro Khikmah, Khusnia Nurul Kristuisno Martsuyanto Kapiluka Kriswan, Suliana Kusman Sadik Kusni Rohani Rumahorbo La Ode Abdul Rahman La Ode Abdul Rahman La Ode Abdul Rahman M Nur Aidi M Nur Aidi, M Nur Mahmud A. Raimadoya Mohammad Masjkur Muh Nur Fiqri Adham Muhammad Amirullah Yusuf Albasia Muhammad Nur Aidi Muhammad Sayuti Mustofa Usman Nurfadilah, Khalilah Nurfajrin, Tria Ermina Nurul Qomariasih Pannu, Abdullah Pika Silvianti Pika Silvianti Putri, Mega Ramatika Qalbi, Asyifah Qomariasih, Nurul Rachman, Nurul Aulia Rahma Anisa Rahmawat, NFN Rahmawati, nFN Rais Ratnasari, Andika Putri Rifannisa Bahar Rifki Hamdani Rizki Alifah Putri Rizki, Akbar Robert, Zahira Rahvenia Safitri, Wa Ode Rahmalia Sanusi, Ratna Nur Mustika Satriyo Wibowo Sembiring, Febryna Shalshabilla Shafa Sri Ningsih Desi Afriany Sulandra, Ardelia Maharani Sulfikar Amir Suliana Kriswan Supriatin, Febriyani Eka Syahrir, Nur Hilal A. Syahrir, Nur Hilal A. Syella Zignora Limba Sylvia P. Soetantyo Syukri, Nabila Tina Aris Perhati Tiya Wulandari Ulfa Afilia Shofa Utami Dyah Syafitri Wan Muhamad, Wan Zuki Azman Wan Zuki Azman Wan Muhamad Wan Zuki Azman Wan Muhamad Warsono Wulan Andriyani Pangestu Yani Prihantini Hiola Yasmin Erika Faridhan Zahira Rahvenia Robert Zainal A Koemadji Zulhijrah