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Expression of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Increases After 8-Weeks of Endurance Training in Obese Females Arya Dwi Prastickho; Desiana Merawati; Sugiharto Sugiharto
COMPETITOR: Jurnal Pendidikan Kepelatihan Olahraga Vol 15, No 2 (2023): June
Publisher : UNIVERSITAS NEGERI MAKASSAR

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26858/cjpko.v15i2.47705

Abstract

This study aimed to prove the effect of moderate-intensity aerobic exercise on increasing Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1α) levels in obese women. A total of 12 women aged 20-25, with body mass index (BMI) of 25-30 kg/m2, normal systolic blood pressure, and normal resting heart rate as subjects in the study. Subjects were randomly divided into 2 groups, namely K1 (n=6; control without intervention) and K2 (n=6; aerobic exercise). The exercise was carried out with an intensity of 60% -70% HRmax, frequency 3x/week for 8 weeks. Pretest and posttest PGC-1α levels were analyzed using the Enzyme-linked immunosorbent assay (ELISA) method. The data analysis technique uses the Paired Sample T-Test with a significant level of 5%. Based on the results of the study it was concluded that aerobic exercise with an intensity of 60% -70% HRmax with a frequency of 3x/week for 8 weeks affected increasing PGC-1α levels in obese women.
Irisan Profile of Obese Women After Moderate Intensity Aerobic Exercise Naufal Firdaus; Sugiharto Sugiharto; Desiana Merawati
COMPETITOR: Jurnal Pendidikan Kepelatihan Olahraga Vol 15, No 2 (2023): June
Publisher : UNIVERSITAS NEGERI MAKASSAR

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26858/cjpko.v15i2.47729

Abstract

Irisin in obesity was found to be lower than in individuals with normal weight. Low irisin levels lead to decreased metabolism. Low metabolism causes a decrease in muscle mass, storage of triglyceride energy, and accumulation of excess fatty acids in the body which can lead to the risk of obesity. This study aims to prove the effect of moderate-intensity aerobic exercise on increasing irisin levels in obese women. This research method is true experimental with a random calculation design between pretest-posttest groups. A total of 18 obese women aged 20-25 years were actively involved in research activities and were divided into two groups, namely KK (n = 9; control group), and KE (n = 9; experimental group). Aerobic exercise was given using a set intensity of 60-70% HRmax with a treadmill for 45 minutes, 3x/week for 8 weeks. Irisin levels were evaluated before and after the intervention using the ELISA Kit method. The data analysis technique used the Paired Sample T-Test with a 5% confidence level. The results showed the average irisin level between before and after the intervention in KK (0.83±0.97 vs. 0.86±1.25 ng/mL, p=0.961), KE (0.69±0.64 vs. 2.77±1.26 ng/mL, p=0.003). Based on the results of the study it was concluded that aerobic exercise with a set intensity of 60-70% HRmax performed 3x/week for 8 weeks can increase irisin levels in obese women.
Efek Latihan Aerobik Terhadap Irisin Dalam Mencegah Obesitas Naufal Firdaus; Sugiharto Sugiharto; Desiana Merawati
KORSA: Jurnal Kajian Ilmu Keolahragaan dan Kesehatan Vol 2, No 1 (2023): Mei
Publisher : Program Studi Ilmu Keolahragaan

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Abstract

Aerobic exercise is rated as the most effective strategy for treating obesity. Aerobic exercise induces irisin to stimulate tissue browning. The important role of irisin in the regulation of metabolism and reduction of body fat is that it can increase energy expenditure. The method of this article is to look at several journal articles that compare one journal to another. In practice, the results of the analysis of research journals are combined based on their respective similarities and differences to produce new conclusions. The results Aerobic exercise induces the release of irisin via peroxisome proliferation activated receptor-γ (PPAR-γ) and PGC-1α. Exercise that is performed at intervals increases PGC-1α activation, especially in the heart and skeletal muscles and improves various metabolic parameters such as insulin sensitivity and signaling, promotes AMPK activation, PGC1α phosphorylation and FNDC5 production, followed by cleavage of FNDC5 to produce irisin which will be released into the blood circulation. . The release of irisin into the blood circulation activates the AMPK pathway by reducing intracellular ATP or by increasing the intracellular calcium concentration in muscle cells, causing increased glucose and lipid uptake and increased fat metabolism. Aerobic exercise can increase irisin in an obese person which has an effect on energy expenditure so that fat in the body is reduced and subsequently results in weight loss.
Latihan Fisik & Sekresi PGC-1α Pada Obesitas Arya Dwi Prastickho; Desiana Merawati; Sugiharto Sugiharto
KORSA: Jurnal Kajian Ilmu Keolahragaan dan Kesehatan Vol 2, No 1 (2023): Mei
Publisher : Program Studi Ilmu Keolahragaan

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Abstract

Peroxisome proliferator activates gamma coactivator 1α (PGC-1α) receptors associated with oxidizing activity in adipose tissue and muscle, which is the prevention of increased obesity through non-pharmacological therapy. Physical exercise is believed to be a trigger for PGC-1α secretion as a strategy to prevent an increase in the prevalence of obesity and prevent the occurrence of metabolic syndrome. Physical exercise also improves metabolic health in obese individuals. Physical exercise is also believed to increase PGC-1α levels in obese individuals. after exercise, the thermogenic gene is expected to remain active. These conditions are favorable and attractive for the browning process to maintain homeostasis in response to a decrease in the AMP/ATP ratio and increased biogenesis in mitochondria. The decrease in AMP/ATP led to active AMPK, the ratio observed 3 hours after exercise. AMPK activation triggers activation of the PGC-1α gene receptor stimulating an increase in FNDC-5, which then cleaves into circulating irisin to activate UCP-1. Consequently, PGC-1α-induced UCP-1 activation enhances browning. The method of this article is to look at several journal articles and compare one journal with another, in the sense that the results of the analysis of research journals are combined based on their similarities and differences to draw new conclusions. According to previous studies, it was also shown that moderate and high-intensity exercise was proven to increase PGC-1α levels in obese individuals, both acutely and chronically.
MEDIASI LATIHAN ANGKAT BEBAN TERHADAP PENINGKATAN EKSPRESI PGC-1α PADA REMAJA PEREMPUAN PENDERITA OBESITAS Moh. Alfino Arisandi; Desiana Merawati; Sugiharto Sugiarto
KORSA: Jurnal Kajian Ilmu Keolahragaan dan Kesehatan Vol 2, No 1 (2023): Mei
Publisher : Program Studi Ilmu Keolahragaan

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Abstract

Peroxisome proliferator activated receptor-gamma coactivator 1 (PGC-1α) is closely related to metabolic status in obese patients. This study aims to analyze the response of lifting weights to increased levels of PGC-1α as a metabolic status in obese people. This study was a true experimental study with the randomized pretest-posttest control group design using 14 female adolescents aged 20-25, body mass index (BMI) 25-30 kg/m2, normal systolic blood pressure, normal resting heart rate, Percentage of body fat ≥ 30%, and divided into 2 groups randomly, namely the control group without intervention 7 subjects and the group given weight training intervention 6 subjects. PGC-1α levels were examined using the Enzyme Link Immunosorbent Assay (ELISA) kit (Cat.No.:E-EL-H6017; Elabscience, Inc., USA). Data analysis techniques using SPSS version 21.0. The results of the analysis of the average pretest and posttest PGC-1α levels in K1 (1.19 ± 0.89 vs 1.27 ± 0.65 ng/mL, p = 0.746), and K2 (1.07 ± 0.26 vs 2.60 ± 0.40 ng/mL, p = 0.000). It is recommended for future research using male and female subjects, so that the results of the study can be generalized to both sexes.
Profil Brain Derived Neurotrophic Factor Wanita Obesitas Setelah Olahraga Dengan Kombinasi Puasa Alfindo, Bernadito Wildan; Sugiharto, Sugiharto; Merawati, Desiana
Jurnal Ilmu Keolahragaan Vol 7, No 1 (2024): JURNAL ILMU KEOLAHRAGAAN
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jilo.v7i1.76709

Abstract

Peningkatan pengeluaran energi expeditur dengan olahraga dan kombinasi puasa diyakini dapat memaksimalkan pengeluaran kalori dan meningkatkan kadar BDNF, oleh karena itu penelitian ini bertujuan untuk membuktikan perubahan profil BDNF wanita obesitas yang disebabkan oleh olahraga dengan kombinasi puasa. Penelitian ini melibatkan 16 perempuan obesitas sebagai subyek penelitian, kemudian, subjek dibagi   menjadi 2 kelompok : kelompok kontrol (K1; n = 8) dan kelompok kombinasi olahraga dan puasa (K2; n = 8). Olahraga aerobik dengan menggunakan treadmill selama 40 menit, intensitas sedang, sedangkan puasa dilakukan dengan puasa intermittent : puasa yang dilakukan 16 jam, dilanjutkan dengan tidak berpuasa selama 8 jam. Kombinasi olahraga dengan puasa dilakukan selama 2 minggu. Pengambilan sampel darah untuk mengukur kadar BDNF diambil dari vena cubiti sebanyak 4 mL, yang dilakukan sebelum dan setelah perlakuan. Analisis data mengunakan paired sample t test dengan tingkat signifikan 5%. Berdasarkan hasil penelitian terdapat perbedaan yang signifikan. Peningkatan kadar BDNF antara kelompok perlakuan dengan kontrol (p ≤ 0,05). Hasil penelitian tersebut menunjukkan olahraga aerobik dengan selama berpuasa intermittent meningkatkan kadar BDNF dan menghambat laju energi yang masuk pada wanita obesitas. Olahraga aerobik dengan kombinasi puasa dapat menjadi program yang disarankan untuk meningkatkan kadar BDNF dan pengurangan massa lemak akibat puasa yang berpengaruh terhadap metabolisme pada wanita obesitas.
Capacity Building Santri Husada sebagai Peer Educator “Cegah Stunting Sedari Dini” Menggunakan Peraga Flip Chart dan Food Model Di Surabaya Hasanah, Zumroh; Merawati, Desiana; Puriastuti, Alifia Candra; Amelia, Dessy; Zariroh, Zirroh Alin
Jurnal Peduli Masyarakat Vol 6 No 3 (2024): Jurnal Peduli Masyarakat: September 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v6i3.4568

Abstract

Stunting adalah masalah kesehatan internasional yang harus ditangani segera. Data SSGI tahun 2022 di Jawa Timur prevalensi stunting yakni 19,2%. Meskipun berbagai upaya telah dilakukan, angka ini masih jauh dari target yang ditetapkan yaitu 14% pada 2024. Hal ini menunjukkan bahwa pencegahan dan penanganan stunting memerlukan intervensi yang lebih efektif dan menyentuh berbagai lapisan masyarakat, termasuk remaja yang berada di lingkungan pesantren. Pengabdian Masyarakat ini bertujuan untuk meningkatkan pengetahuan dan kesadaran santri husada tentang pentingnya pencegahan stunting sejak remaja serta membangun kemampuan mereka dalam menyampaikan informasi tersebut kepada teman sebaya menggunakan model peraga edukatif flip chart dan food model melalui kegiatan pendidikan kesehatan disertai demonstrasi dan roleplay kegiatan peer educator pada 37 santri husada Pondok Pesantren Assalafi Al-Fithrah Surabaya. Evaluasi program dilakukan melalui tiga tahap: evaluasi proses, output, dan outcome untuk mengukur keberhasilan dan dampak program secara menyeluruh. Hasil menunjukkan bahwa terdapat peningkatan nilai rata-rata yang menunjukkan bahwa edukasi dengan pendekatan visual dan interaktif mampu meningkatkan daya serap peserta. Dengan capaian ini, diharapkan dapat memberikan dampak jangka panjang, baik dalam meningkatkan literasi pencegahan stunting santri maupun dalam menurunkan risiko stunting di komunitas sasaran.
Upaya Cegah Stunting Sedari Dini Menggunakan E-Book “Dietary Patterns: Prevent Stunting” Pada Santriwati Remaja di Surabaya Hasanah, Zumroh; Amelia, Dessy; Puriastuti, Alifia Candra; Merawati, Desiana; Fadilah, Aisya Nur
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 3 (2025): Volume 8 No 3 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i3.17993

Abstract

ABSTRAK Salah satu masalah gizi kronis yang masih menjadi masalah besar global dan Indonesia adalah stunting. Rencana Aksi Nasional Percepatan Penurunan Angka Stunting Indonesia Tahun 2021-2024 menyebutkan, salah satu kelompok prioritas penanganan stunting adalah kelompok remaja. Remaja putri memiliki peran krusial dalam menentukan kualitas generasi berikutnya. Intervensi yang lebih efektif diperlukan untuk mencegah dan menangani stunting, termasuk remaja santriwati yang tinggal di pesantren. Pengabdian ini bertujuan untuk meningkatkan pengetahuan santriwati akan pencegahan stunting sejak remaja melalui pendidikan kesehatan menggunakan e-book “Dietary Patterns: Prevent Stunting” pada 105 santriwati berusia 10-18 tahun di Pondok Pesantren Assalafi Al Fitrah. Hasil pengabdian menunjukkan bahwa terdapat peningkatan pada kategori tingkat pengetahuan baik semula 8,6% menjadi 78%, pada kategori tingkat pengetahuan cukup mengalami penurunan dari 84,7% menjadi 20% dan pada kategori tingkat pengetahuan kurang juga turut mengalami penurunan dari 6,7% menjadi 2% berdasarkan hasil pre-posttest sebelum dan sesudah dilaksanakan kegiatan pengabdian. Pendidikan kesehatan menggunakan e-book “Dietary Patterns: Prevent Stunting” dapat menjadi salah satu strategi dalam meningkatkan pengetahuan santriwati terkait pencegahan stunting sejak remaja. Kedepannya diharapkan kegiatan serupa dapat terus dilakukan untuk menekan angka stunting dan meningkatkan derajat kesehatan masyarakat dimulai sejak dini. Kata Kunci: E-book, Remaja, Santriwati, Stunting  ABSTRACT One of the chronic nutritional problems that remains a major problem globally and in Indonesia is stunting. The National Action Plan for Accelerating the Reduction of Stunting Rates in Indonesia for 2021-2024 states that the adolescent group is one of the priority groups for handling stunting. Adolescent girls have a crucial role in determining the quality of the next generation. More effective interventions are needed to prevent and treat stunting, including adolescent santri who live in pesantren. This community service aims to increase santriwati's knowledge of early stunting prevention through health education using the e-book “Dietary Patterns: Prevent Stunting” to 105 female students aged 10-18 years at the Assalafi Al Fitrah Islamic Boarding School. The results of the service showed that there was an increase in the category of good knowledge from 8.6% to 78%, in the category of sufficient knowledge decreased from 84.7% to 20%, and in the category of poor knowledge reduced from 6.7% to 2% based on the results of the pre-posttest before and after the community service activities were carried out. Health education using the e-book “Dietary Patterns: Prevent Stunting” can be one of the strategies in increasing santriwati's knowledge of preventing stunting since adolescence. In the future, it is hoped that similar activities can continue to be carried out to reduce stunting rates and improve public health status starting early. Keywords: Adolescent, E-book, Santriwati, Stunting
The correlation between the amount of weight gain and physical activity levels in Depot Medroxyprogesterone Acetate (DMPA) users Hasanah, Zumroh; Merawati, Desiana; Azidin, Raja Mohammed Firhad Raja; Amelia, Dessy; Puriastuti, Alifia Candra; Novembriani, Rizqie Putri; Viandika, Nurya; Dewi, Putri Nurika
Indonesian Journal of Research in Physical Education, Sport, and Health Vol. 3 No. 1 (2025): Indonesian Journal of Research in Physical Education, Sport, and Health (IJRPES
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um086v3i12025p18-26

Abstract

Background: DMPA is a widely used contraceptive in Indonesia due to its accessibility and effectiveness. However, side effects such as weight gain are a concern, with more than 90% of the 600 users in 2022-2023 experiencing them. Objective: This study aimed to examine the correlation between the amount of weight gain and physical activity levels in DMPA users. Methods: This study used a cross-sectional design with consecutive sampling, involving 82 women (aged 19-51 years, average weight 58 kg) selected using the Slovin formula. Data were collected through structured interviews and questionnaires covering demographics, medical history, and physical activity level based on IPAQ. Body weight was measured with a calibrated digital scale, and association analysis was performed using the Chi-Square test (p < 0.05 was considered significant). Result: Analysis showed no statistically significant association between physical activity level and the amount of weight gain in DMPA users (p > 0.05). Conclusion: Other factors beyond physical activity, such as diet and metabolism, may play a more significant role in weight gain in DMPA users, so further research is needed. Future research should clarify these relationships by considering a broader range of influencing factors, including demographic variables, metabolic health, lifestyle behaviors, etc., to develop a more comprehensive understanding of how DMPA use affects weight management.
Secretion Of PGC-1α By Modulating Physical Exercise To Protect Improving Obesity Prevalence Moch Nasmay Lupita; Desiana Merawati; Sugiharto Sugiharto
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i2.299

Abstract

This study aims to analyze the response of physical exercise as a modulation of PGC-1α to protect against the increasing prevalence of obesity. This research is a true experimental design with the randomized pretest-posttest control group design using 15 obese women aged 18-22 years, Body Mass Index (BMI) 25-35 kg/m2, normal blood pressure, Resting Heart Rate (RHR) normal, VO2max 25-35 ml/kg/min and randomly divided into three groups, namely CONT (n=5, Control Without Intervention), MIIE (n=5, Moderate Intensity Interval Exercise) and MICE (n=5, Moderate Intensity Continuous Exercise). The intervention was carried out at 07.00-09.00 a.m. MIIE and MICE interventions carried out for 40-45 minutes using a treadmill. Pre-exercise blood sampling and 10 minutes post-exercise. Measurement of PGC-1α levels used the Enzyme-Linked Immunosorbent Assay (ELISA) method. Data analysis techniques used ANOVA test and LSD post hoc test with the Statistical Package for Social Science (SPSS)