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All Journal Transformasi: Jurnal Pengabdian Masyarakat WMJ (Warmadewa Medical Journal) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) The Indonesian Biomedical Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal SOLMA Meditory : The Journal of Medical Laboratory Majalah Patologi Indonesia Jurnal Sewaka Bhakti Aesculapius Medical Journal Warmadewa Minesterium Medical Journal BHAKTI PERSADA Jurnal Aplikasi IPTEKS (Journal of Applied Sciences and Technology) Indonesian Journal of Cancer Journal of Comprehensive Science The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy INCOME: Indonesian Journal of Community Service and Engagement Jurnal Pandu Husada
Desak Putu Oki Lestari
Universitas Warmadewa
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Correlation of Age, Tumor Size, and Histopathological Type with Indicator Tumor Progression of Penile Squamous Cell Carcinoma in Bali Astuti, Ni Luh Putu Vina Juni; Lestari, Desak Putu Oki; Sari, Ni Luh Putu Eka Kartika; Armerinayanti, Ni Wayan; Evayanti, Luh Gde; Perdana, I Gede Sukma Okta
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1340

Abstract

Background: Penile cancer is a rare malignancy globally, but Bali accounts for approximately 40% of Indonesia’s cases. Age, tumor size, and histopathological type are recognized factors influencing penile cancer progression, with grade, depth of invasion, lymph node metastasis, and distant metastasis serving as key indicators. However, the prognostic value of these factors, particularly depth of invasion, remains debated. This study aimed to evaluate the correlation between age, tumor size, and histopathological type with indicators of tumor progression in penile squamous cell carcinoma (SCC) in Bali.Method: A cross-sectional analytical study was conducted on 160 cases of penile SCC. Dependent variables included tumor grade, depth of invasion, and lymph node metastasis, while independent variables were age, tumor size, and HPV status (inferred from histopathology). Age was categorized as 60 or ≥60 years, tumor size as 4 cm or ≥4 cm, and depth of invasion as T1–T4. Multivariate analysis using the chi-square test was performed to assess associations.Results:  Most patients were aged ≥ 60 years, had HPV-independent SCC, tumor size ≥ 4 cm, grade 2 tumors, and T1 depth of invasion, with lymph node metastasis observed in a minority. Multivariate analysis revealed significant correlations between age, tumor size, and histopathological type with grade (p = 0.026, R² = 0.056), depth of invasion (p 0.001, R² = 0.445), and lymph node metastasis (p = 0.004, R² = 0.075). Tumor size demonstrated the strongest association with depth of invasion (OR = 9.618, p 0.001) and lymph node metastasis (OR = 6.846, p 0.001).Conclusion: Tumor size is a significant predictor of both depth of invasion and lymph node metastasis in penile SCC. Clinical assessment of tumor size should be emphasized as a key prognostic factor to guide early intervention strategies in patients with penile SCC in Bali.
Peningkatan Peran Tokoh Desa Dalam Pengenalan Faktor Resiko, Gejala Klinis Dan Deteksi Dini Kanker Kolorektum di Desa Candikuning Tabanan Analysa, Analysa; Primadi, Putu; Oki Lestari, Desak Putu; I Gusti, Alit Artha; I Nym, Putu Riasa; Yusuf, M. Yusuf
Jurnal SOLMA Vol. 13 No. 2 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v13i2.15076

Abstract

Background: Dalam 5 tahun ini terdapat 15/6.324 orang atau 30/100.000 penduduk yang menderita kanker kolon dan rektum di kecamatan Baturiti, Tabanan. Tingginya angka kematian disebabkan sebagian besar 11/15 (73,33%) datang pada stadium lanjut yaitu stadium III dan IV. Tujuan kegiatan ini untuk meningkatkan peran kepala desa dan tokoh masyarakat untuk mensosialisasikan faktor resiko, gejala klinis dan deteksi dini kanker kolorektal di masyarakat. Metode: Mitra kegiatan yaitu kepala desa dan tokoh adat Desa Candikuning, Bali beserta 40 penduduk setempat. Metode yang dilakukan, pertemuan dengan masyarakat, sistem belajar bersama dengan cara praktik langsung, melakukan sosialisasi dan penyuluhan, dan evaluasi kemampuan Mitra serta evaluasi hasil pada masyarakat. Pengambilan data dilakukan dengan observasi berupa ceklis, kuesioner berupa pretest dan posttest.  Hasil: Kegiatan ini menunjukkan bahwa terjadi peningkatan pengetahuan para tokoh dan masyarakat terhadap pengetahuan serta gejala klinis sebesar 99,1%, peningkatan sikap dalam pencegahan kanker kolorektal sebesar 90,8%. Kesimpulan: Disimpulkan bahwa peran kepala desa dan tokoh masyarakat dapat meningkatkan pengetahuan dan sikap terhadap gejala klinis dan pencegahan kanker kolorektal pada masyarakat.
Risiko Kandidiasis Serviks pada Wanita Usia Subur Akseptor Kontrasepsi Hormonal Ni Wayan Armerinayanti; Desak Putu Oki Lestari
WMJ (Warmadewa Medical Journal) Vol 3 No 1 (2018): May 2018
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.3.1.640.21-26

Abstract

Abstrak Kontrasepsi Hormonal merupakan salah satu metode kontrasepsi yang paling diminati oleh Wanita Usia Subur (WUS) di Indonesia termasuk di Bali. Dewasa ini mulai timbul pro dan kontra mengenai penggunaan kontrasepsi hormonal terkait berbagai efek samping yang ditimbulkan, salah satunya dikatakan berkaitan dengan kandidiasis serviks. Tujuan penelitian ini adalah untuk mengetahui risiko kandidiasis serviks pada WUS akseptor kontrasepsi hormonal. Penelitian ini menggunakan rancangan case control yang disarangkan pada penelitian pap smear (nested case control). Kemudian akan dibandingkan seberapa besar efek paparan kontrasepsi hormonal antara kelompok kasus (kandidiasis serviks) dengan kelompok kontrol (non kandidiasis serviks) secara deskriptif analitik melalui uji statistik chi-square dengan p
Specific Histologic Type of Leiomyoma Related to Estrogen Receptor Expression Ni Wayan Armerinayanti; Desak Putu Oki Lestari; I Gde Sastra Winata
WMJ (Warmadewa Medical Journal) Vol 7 No 2 (2022): November 2022
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.7.2.4601.55-59

Abstract

Uterine Leiomyoma or fibroid is the most common gynecologic benign neoplasm which arising from monoclonal proliferation of smooth muscle cells in uterine wall. Some specific types of uterine leiomyoma, such ascellular leiomyoma, symplastic leiomyoma, mitotically active leiomyoma andmyxoid leiomyomahave different histomorphology from usual type leiomyoma. It also have wide variety of tumors size, but this study found that no correlation between type of leiomyoma and its size. Additional non-invasive therapy that predominantly developed in leiomyoma include many antagonist agents of estrogenic receptor. So, important to determine of estrogen receptor activity before that hormonal therapy prescription.Histopathology parameter that predict estrogen receptor activity in leiomyoma was not well understood. This study also try to correlate between specific histologic type of leiomyoma and estrogen receptor activity. This study was a retrospective crossectional study which analized by pearson chi-square test with p value < 0.05 and CI 95%. Result: There was significant correlation between specific histologic type of leiomyoma and estrogen receptor expression (p=0.007; p<0.05). Key Words: Leiomyoma, Estrogen Receptor
Prevalensi Ekspresi Epidermal Growth Factor Receptor (EGFR) pada Karsinoma Penis Gede Khrisnanda Arya Dharma; Desak Putu Oki Lestari; Ni Wayan Armerinayanti; Ni Luh Putu Eka Kartika Sari
Aesculapius Medical Journal Vol 1 No 1 (2021): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.1.1.2021.38-44

Abstract

Abstract[Prevalence of Epidermal Growth Factor Receptor (EGFR) Expression in Penis Carcinoma] Penile cancer is a malignancy in men, which is the highest in Bali compared to other regions in Indonesia. About 95% of malignancies in the penis are squamous cell carcinoma (SCC). The development of cancer therapy has now reached targeted therapy, while there has not been much research on penile cancer. Targeted therapy based on EGFR overexpression has developed and has been used as individual therapy, especially in lung cancer. This study aims to determine the expression of EGFR in the SCC of the penis. This study is a descriptive observational study to determine the prevalence of EGFR expression from immunohistochemical examination, tumor cells stained with intense brown color surrounding the entire tumor cell membrane. The results of the study of 141 samples of penile squamous cell carcinoma taken from biopsies, partial penectomy, and total penectomy. The prevalence of EGFR expression that was stained positively in penile cancer tumor cells was 8 cases (5.7%) with the highest age distribution in the age group 41-60 years as many as 66 cases (46.8%). Knowledge of EGFR overexpression in penile cancer can be used to reference anti-EGFR administration, especially in advanced penile cancer.
Penyuluhan Keberlanjutan Kegiatan Inspeksi Visual Asetat (IVA) dan Pap Smear Bidan Puskesmas Pembantu Kelurahan Kesiman Ni Wayan Armerinayanti; Oki Lestari Desak Putu
Warmadewa Minesterium Medical Journal Vol. 4 No. 2 (2025): Mei 2025
Publisher : Warmadewa University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmmj.4.2.2025.171-175

Abstract

Kanker serviks merupakan salah satu jenis kanker yang paling umum menyerang wanita di Indonesia. Deteksi dini melalui pemeriksaan Inspeksi Visual dengan Asam Asetat (IVA) dan Pap Smear adalah langkah penting dalam pencegahan dan pengobatan kanker serviks. Namun, kesadaran dan pengetahuan masyarakat tentang pentingnya pemeriksaan rutin masih rendah. Kader puskesmas memiliki peran strategis dalam menyebarluaskan informasi kesehatan dan mendorong masyarakat untuk melakukan pemeriksaan dini. Kelurahan Kesiman, seperti banyak daerah lainnya, menghadapi tantangan dalam meningkatkan kesadaran dan partisipasi masyarakat dalam program deteksi dini kanker serviks. Banyak wanita yang belum memahami pentingnya pemeriksaan IVA dan Pap Smear, serta takut atau enggan untuk melakukannya. Kader puskesmas, sebagai ujung tombak pelayanan kesehatan di masyarakat, memerlukan pengetahuan dan keterampilan yang memadai untuk memberikan edukasi dan motivasi kepada warga. Hasil pengabdian ini adalah mitra PKM menunjukkan peningkatan pemahaman dan komitmen mengenai pentingnya pelaksanaan pelayanan deteksi dini kanker serviks di wilayah kerja mitra. Demi keberlanjutan program berikutnya, akan lebih baik jika bersama-sama disusun alur rujukan temuan deteksi abnormal.
Hubungan antara Ukuran Tumor, Grade, Invasi Uretra, Intravasa, Perineural dan Overekspresi COX-2 pada Metastasis Karsinoma Sel Skuamosa Penis ke Kelenjar Getah Bening Inguinal Desak Putu Oki Lestari; Ketut Mulyadi Mulyadi
Majalah Patologi Indonesia Vol. 24 No. 3, September 2015
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Penile cancer was a health problem in Bali. Clinicopathology and biological marker COX-2 were important predictive factor used for inguinal lymph node metastasis. The aim of this study was to find out relationship between clinicopathological prognostic factors (tumor size, grade, urethral invasion, intra vasa invasion, perineural invasion) and COX-2 exprerssion in metastases of SCC penile to the inguinal lymph nodes. Methods This observational crossectional study included 47 samples of SCC penis preparation from penectomy with inguinal lymphadenectomy since January 1st 2008-Desember 31st 2013 at Department of Anatomical Pathology Faculty of Medicine University of Udayana/Sanglah Hospital Denpasar. Sample of this study was divided into 2 groups: 16 cases SCC positive metastasis and 31 cases negative metastasis. Rediagnosis clinico-pathological prognostic factor was done, immunohistochemistry COX-2 staining was performed. The data were analized using chi-square (α=0.05). Results This study show significant positive correlation between tumor size ≥5 cm (p=0.002), grade (p=0.002), urethra invasion (p=0.014), intra vasa invasion (p=0.00), perineural invasion (p=0.00) with metastasis. COX-2 expression (+2) and (+3) have higher risk on occurrence of metastasis than (0) and (+1) (p=0.00). Conclusion Clinico-pathologic factors and COX-2 expression could be used to predict metastases of SCC penile to the inguinal lymph nodes. Key words: clinicopathologic prognosis factor, COX-2, inguinal lymph nodes metastasis, squamous cells carcinoma penis.
ASSOCIATION BETWEEN MID-UPPER ARM CIRCUMFERENCE AND HEMOGLOBIN CONCENTRATION IN ADOLESCENT GIRLS: A CROSS-SECTIONAL STUDY Luh Putri Wulandari dewi; Sri Ratna Dewi; Ni Wayan Armerinayanti dewi; Desak Putu Oki Lestari dewi; Putu Indah Budi Apsari dewi; Kadek Agus Kurniawan; Dewa Ayu Agung Alit Suka Astini
Meditory : The Journal of Medical Laboratory Vol. 14 No. 1 (2026): Meditory, Volume 14 No. 1 Tahun 2026
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v14i1.5203

Abstract

Background: Anemia remains a relevant nutritional concern among adolescent girls. Mid-upper arm circumference (MUAC) is a practical anthropometric measurement that may be associated with hemoglobin concentration and may help identify adolescents with limited nutritional reserves. Objective: This study aimed to examine the association between MUAC length and hemoglobin concentration in adolescent girls at SMA N 1 Tegalalang, Gianyar Regency. Methods: This analytical observational study used a cross-sectional design. A total of 147 female students were recruited using consecutive sampling. MUAC was the independent variable, and hemoglobin concentration was the dependent variable. Hemoglobin was measured using a point-of-care testing device. Data were analyzed using ANCOVA in IBM SPSS Statistics version 27, with the control of age and menstrual duration. Results: Most participants had a MUAC of ≥23.5 cm (50.34%) and normal hemoglobin concentration (≥12 g/dL; 93.9%). After adjustment for age and menstrual duration, MUAC was significantly associated with hemoglobin concentration (F = 5.257, p = 0.024, partial η² = 0.047). Conclusions: A significant association was observed between MUAC and hemoglobin concentration among female adolescents. MUAC may be considered a practical anthropometric measure for identifying adolescents who could benefit from further nutritional assessment and hemoglobin testing.
Effect of Annona muricata Leaf Extract on Hepatic Histopathology and Hepatocyte Index in a Diabetic Rattus norvegicus Model Dewa Ayu Agung Alit Suka Astini; Desak Putu Oki Lestari; Luh Gde Evayanti; Ni Putu Diah Witari; Komang Trisna Sumadewi; Fransiscus Fiano Anthony Kerans; Ida Ayu Laxmi Ananda Dewi Manuaba; Ni Made Gita Kusuma Dewi; Syaifiyatul H
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol. 27 No. 2 (2026): VOLUME 27, NUMBER 2, August, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2722026127-133

Abstract

Background: The oxidative stress caused by diabetes mellitus (DM) damages hepatocytes and reduces liver function. In this context, flavonoids and acetogenins found in soursop (Annona muricata L.) leaf have hepatoprotective and antioxidant qualities. Therefore, this study aimed to assess the effect of Annona muricata leaf extract on hepatocyte index and hepatic histopathology in diabetic Wistar rats.Methods: In a laboratory experiment, 16 male Wistar rats weighing 100–150 g and aged 2-3 months were given a high-fat diet and an injection of streptozotocin (27.5 mg/kg BW) to induce type 2 diabetes. Rats were placed in a randomized posttest-only control group. For 21 days, these experimental animals were split into two groups at random, namely control (n = 8) receiving aquadest, and treatment group (n = 8) receiving Annona muricata leaf extract at a dose of 100 mg/kg BW. Hematoxylin-eosin staining was used to analyze hepatic histopathology, and a quantitative evaluation of hepatocyte index was conducted. The independent t-test and Mann-Whitney U test were adopted to assess the data. Results: There was a significant difference (p=0.041) in hepatocyte index between treatment and control groups. Treatment group had less hepatocyte deterioration than the control, according to histopathological scoring (p=0.037).Conclusion: Diabetic Wistar rats treated with Annona muricata leaf extract showed better hepatocyte index and decreased hepatic degeneration, suggesting hepatoprotective potential
Pemberdayaan OSIS dalam Pencegahan Kanker Serviks, Bahaya Game Online, dan Pinjaman Online pada Siswa SMA di Kawasan Pariwisata Bali Desak Putu Oki Lestari; Komang Adi Kurniawan Saputra; Nyoman Putu Riasa; Fransiscus Fiano Anthony Kerans; Analysa
Bhakti Persada Vol. 12 No. 1 (2026): Mei (2026): Bhakti Persada Jurnal Aplikasi IPTEKS
Publisher : Unit Publikasi Ilmiah, P3M, Politeknik Negeri Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31940/bp.v12i1.39-47

Abstract

Remaja sekolah menengah atas (SMA) yang berada di kawasan pariwisata memiliki kerentanan tinggi terhadap berbagai permasalahan kesehatan dan sosial, seperti rendahnya kesadaran pencegahan kanker serviks, bahaya kecanduan game online, serta risiko pinjaman online ilegal. Kondisi ini diperparah oleh rendahnya literasi kesehatan reproduksi dan literasi keuangan di kalangan siswa. Kegiatan Pengabdian kepada Masyarakat (PKM) ini bertujuan memberdayakan Organisasi Siswa Intra Sekolah (OSIS) sebagai agen edukasi sebaya melalui penyuluhan terpadu, pelatihan komunikasi efektif, pendampingan lapangan, serta pemberian vaksinasi HPV gratis. Kebaruan program ini terletak pada integrasi edukasi kesehatan reproduksi, literasi digital, dan literasi keuangan melalui pendekatan peer education berbasis OSIS yang dikombinasikan dengan layanan vaksinasi HPV. Kegiatan dilaksanakan pada tiga SMA di Bali dengan melibatkan 150 pengurus OSIS. Evaluasi dilakukan menggunakan pre-test dan post-test yang dianalisis secara deskriptif dan statistik inferensial. Hasil kegiatan menunjukkan peningkatan yang signifikan pada seluruh domain yang diukur (p < 0,001), yaitu pengetahuan meningkat dari 30,75 menjadi 87,87 (185,7%), sikap meningkat dari 39,92 menjadi 81,47 (104,1%), dan perilaku meningkat dari 39,19 menjadi 91,13 (132,6%). Selain itu, terjadi peningkatan keberanian dan kemampuan komunikasi pengurus OSIS dalam menyampaikan edukasi kepada rekan sebaya. Pemberdayaan OSIS sebagai agen perubahan terbukti efektif dalam meningkatkan kesadaran dan perilaku preventif siswa SMA. Model PKM ini layak direplikasi sebagai pendekatan promotif dan preventif yang berkelanjutan di lingkungan sekolah.
Co-Authors Alexandria Stephanie Suparman Analysa Analysa Analysa - Analysa Analysa Artha, I Gusti Alit Astuti, Ni Luh Putu Vina Juni Ayu Savitri Siskayani Cahyawati, Putu Nita Fransiscus Anthony Kerans Fransiscus Fiano Anthony Kerans Fransiscus Fiano Anthony Kerans Gede Khrisnanda Arya Dharma Gede Khrisnanda Arya Dharma I Gde Sastra Winata I Gde Sastra Winata I Gusti Alit Artha I Gusti, Alit Artha I Made Toya Ariawan I Nym, Putu Riasa I Nyoman Putu Riasa I Nyoman Putu Riasa I Wayan Sudiarta I Wayan Suwarna Ida Ayu Laxmi Ananda Dewi Manuaba Ini Luh Putu Eka Kartika Sari Kadek Agus Kurniawan Kartika Sari Ketut Mulyadi Mulyadi Komang Adi Kurniawan Saputra Luh Gde Evayanti Luh Putri Wulandari dewi M. Yusuf M. Yusuf Yusuf, M. Yusuf Ni Luh Putu Eka Kartika Sari Ni Made Gita Kusuma Dewi Ni Putu Diah Witari, Ni Putu Ni Wayan Armerinayanti Ni Wayan Armerinayanti, Ni Wayan Novitasari Novitasari Nyoman Putu Riasa Perdana, I Gede Sukma Okta Primadi, Putu Putu Indah Budi Apsari dewi Riasa, I Nym Putu Riasa, I Nyoman Putu Sari, Ni Luh Putu Eka Kartika Septi Panca Sakti Sri Ratna Dewi Suka Astini, Dewa Ayu Agung Alit Sukmadewi, Desak Ketut Tristiana Syaifiyatul H Trisna Sumadewi, Komang Vivitri Dewi Prasasty Yudhi Nugraha