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All Journal Dentika Dental Journal Journal of Dentistry Indonesia Indonesian Journal of Biotechnology ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Interdental Jurnal Kedokteran Gigi (IJKG) Narra J Makara Journal of Health Research Cakradonya Dental Journal Odonto dental journal Narra X Journal of Innovative and Creativity Jurnal of Syiah Kuala Dentistry Society SDJ

Endang W Bachtiar

Department Of Oral Biology, Faculty Of Dentistry, Universitas Indonesia

Author-ID : 239494

Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

Published : 35 Documents Claim Missing Document

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Construction and Immunogenicity Testing of Salmonella, STM1 Vaccine Vector Expressing HIV-1 Antigen Endang Winiati Bachtiar; Peter Smooker; Peter J Coloe
Indonesian Journal of Biotechnology Vol 14, No 2 (2009)
Publisher : Universitas Gadjah Mada

Objective of this study: to determine the ability of Salmonella enterica serovar Typhimurium STM1 as a delivery vehicle for the HIV p24 gene and HIV env gene. The STM1 delivery HIV-p24 vaccination was carried out in the form of a recombinant or a DNA vaccine whereas only a DNA vaccine was used for HIV env. Naked DNA vaccination was also tested and immune responses were evaluated following immunisation in mouse model. Results: vaccination cellular immune responses induced by recombinant p24 STM1 (STM1/pHly-p24) were greater than those elicited by the p24 DNA vaccine in STM1 (STM1/VR-p24), (but statistically not significance) than those induced by oral vaccination. However, IgA responses induced by oral vaccination with either a recombinant or DNA vaccine of p24 in STM1 are higher than those induced by IP vaccination. Conclusions: This result confirms</div><div>other studies that Salmonella was able to deliver HIV antigens to the immune system and induced specific immune responses to the HIV antigen.

Antigen Presentation Ability of Salmonella Carrying DNA Vaccine Model and MCP-3 gene Endang Winiati Bachtiar; Peter Smooker; Peter J Coloe
Indonesian Journal of Biotechnology Vol 16, No 1 (2011)
Publisher : Universitas Gadjah Mada

The objective of this study is to determine the antigen presentation ability of a DNA vaccine model that is co-delivered with that of recombinant Salmonella enterica serovar Typhimurium (STM1) expressing chemokine macrophage chemotactic protein-3 (MCP-3). The DNA vaccine, pVROVA, was constructed by amplification of the ovalbumin coding region from sOVA-C1. Dendritic cells (DCs) were obtained from IL-4 and GMCSF stimulated mouse bone marrow stem cell. Cultured DCs were incubated with STM1 carrying a model ovalbumin gene (pVROVA). Furthermore, MHC class I antigen presentation of a dominant OVA peptide was assayed in vitro. The experiments were designed to determine the effect of co-delivering MCP-3 with that of ovalbumin in STM1. Our results show that a plasmid pROVA-carrying ovalbumin gene was succesfully constructed and sequence analysis of the ovalbumin-coding revealed an identity match of 100% with that of the chicken ovalbumin DNA sequences from the GenBank database. We also found that the presence of the MCP-3 encoding plasmid in STM1 or E. coli DH1 could increase the recovery of both STM1 and E. coli DH1 over those that carry the empty plasmids. Antigen presentation assay also indicates that MCP-3 can positively influence the presentation of ovalbumin. Conclusion: the infection of DCs by STM1-carrying DNA vaccine and MCP-3 results in an increase of processing and presentation of ovalbumin in vitro.Keywords : DNA vaccine, MCP-3, APC, Salmonella, Dendritic cells

Pertimbangan Penggunaan Implan Gigi pada Lansia Nissia Ananda; Lilies Dwi Sulistyani; Endang Winiati Bachtiar
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 6, No 1 (2017)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.6181

Saat ini terjadi perkembangan populasi lansia di Indonesia sehingga isu kesehatan lansia merupakan sesuatu yangesensial. Lansia adalah individu yang telah mengalami proses menua sehingga terjadi berbagai perubahan biologispada tubuhnya, sehingga berpengaruh terhadap penurunan fungsi organ. Kehilangan gigi adalah salah satu masalahyang umum pada lansia sehingga kebutuhan untuk pemasangan gigi tiruan merupakan hal penting yang perludiperhatikan masyarakat kelompok lansia. Implan gigi tiruan merupakan salah satu alternatif pengganti kehilangangigi yang memiliki banyak keuntungan dibandingkan gigi tiruan lain. Namun perlu disadari bahwa penggunaan implangigi memiliki pertimbangan-pertimbangan kondisi rongga mulut dan sistemik tertentu untuk menunjang keberhasilanperawatan. Pemahaman mengenai terjadinya proses menua dan hubungannya dengan pertimbangan penggunaanimplan sangat penting untuk diperhatikan oleh klinisi sebelum merencanakan perawatan, terutama berkaitan denganperubahan pada sistem pertahanan tubuh yang terjadi seiring proses menua.

The frequency of bottle feeding as the main factor of baby bottle tooth decay syndrome Mochamad Fahlevi Rizal; Heriandi Sutadi; Boy M Bachtiar; Endang W Bachtiar
Dental Journal (Majalah Kedokteran Gigi) Vol. 43 No. 1 (2010): March 2010
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Dental caries remains as main problem in Indonesia and its prevalence is high (90.05%). However, there is no appropriate data that can be used to analyze dental caries in toddlers, especially baby bottle tooth decay syndrome (BBTD), though the number of BBTD cases is high in some pediatric dental clinics (90% of patients visiting the clinics). Even though some factors have already been considered to be the risk factor of BBTD, the main risk factor of BBTD is still unknown, especially BBTD in Indonesia. Purpose: This research was aimed to obtain data relating with bottle-feeding habit in 3-5 year old children in Indonesia and its caries risk. Method: The study was an observational research conducted with clinical examination through caries status (deft) of each child deserved by pediatric dentists and through questionnaire distributed to parents to examine the risk factor of BBTD. Observation was conducted on 62 children in the range of age 3 to 5 years old with bottle-feeding habit. Result: The results revealed that status of caries was various. The data showed that the frequency of bottle feeding more than twice could trigger BBTD 2.27 times higher than other factors such as the use of bottle feeding as a pacifier prior sleeping, the period of bottle-feeding, and the breast-feeding experience. Conclusion: though milk as subtract can possibly become a factor triggering caries, the frequency of bottle-feeding is highly considered as main factor. Since it could modulated the bacterial colonization on dental surface, which affects its virulence.Latar belakang: Karies masih menjadi masalah utama di Indonesia. Dalam praktek sehari-hari prevalensi karies masih sangat tinggi (90.05%). Belum ada data yang memadai dalam penelaahan karies yang spesifik pada anak balita selama ini khususnya kasus sindroma karies botol (SKB) sementara itu kasus SKB ditemukan sangat tinggi di beberapa klinik gigi anak (90% dari jumlah pasien yang datang ke klinik). Beberapa faktor menjadi resiko kejadian SKB dan belum diketahui faktor resiko utama kejadian karies khususnya di Indonesia. Tujuan: Penelitian ini dilakukan guna mendapatkan data yang berhubungan dengan kebiasaan minum susu botol pada anak usia 3-5 tahun di Indonesia serta resiko kejadian karies yang ditimbulkannya. Metode: Penelitian ini merupakan penelitian observasional yang dilakukan dengan metode pemeriksaan klinis melalui pencatatan status karies (deft) setiap anak oleh dokter gigi anak serta pengisian kuesioner yang dilakukan oleh orang tua untuk menentukan faktor resiko kejadian SKB. Pengamatan dilakukan pada 62 orang anak usia 3-5 tahun yang mempunyai kebiasaan minum susu botol sesuai dengan kriteria inklusi. Hasil: Hasil pemeriksaan klinis dan kuesioner memberikan gambaran status karies yang bervariasi. Data yang didapat dari penelitian ini menjelaskan, bahwa frekuensi minum susu botol lebih dari dua kali menyebabkan SKB 2.27 kali lebih besar dibandingkan dengan beberapa faktor lain, seperti menjadikannya pengantar tidur, lamanya mengonsumsi, dan riwayat minum ASI. Kesimpulan: Susu sebagai subtrat mungkin dapat dijadikan alasan kejadian karies akan tetapi yang menjadi resiko utama kejadian adalah frekuensi konsumsi susu botol itu sendiri. Kondisi ini dapat dihubungkan dengan modulasi substrat terhadap perkembangan kolonisasi bakteri di permukaan gigi, sehingga secara tidak langsung juga mempengaruhi virulensinya.

The ability of IgY to recognize surface proteins of Streptococcus mutans Basri A. Gani; Santi Chismirina; Zinatul Hayati; Endang Winiati B; Boy M. Bachtiar; I. Wayan T. Wibawan
Dental Journal (Majalah Kedokteran Gigi) Vol. 42 No. 4 (2009): December 2009
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Streptococcus mutans are gram positive bacteria classified into viridians group, and have a role in pathogenesis of dental caries. It’s adhesion to the tooth surface is mediated by cell surface proteins, which interact with specific receptor located in tooth pellicle. Glucan binding protein, Glukosyltransferase, and antigen I/II are basic proteins of S. mutans, which have a role in initiating the interaction. A previous study showed that chicken’s IgY can interfere the interaction. Purpose: The objective of this study was to assess the ability of IgY in recognizing the surface molecule of Streptococcus mutans expressed by various serotypes (c, d, e, f) and a strain derived from IPB, Bogor. Method: Western blot was used as a method to determine such capability. Result: The result showed that IgY has a potency to recognize antigen I/II, but not the other proteins on the cell surface of all bacteria tested. Conclusion: The ability of IgY to bind the surface protein, antigen I/II, indicates that this avian antibody could be used as a candidate for anti-adhesion in preventing dental caries.

Effect of coral Goniopora Sp scaffold application on human osteoblast-like MG-63 cell activity in vitro Julia, Vera; Abbas, Basril; Bachtiar, Endang W; Latief, Benny S; Kuijpers-Jagtman, Anne M
Makara Journal of Health Research Vol. 23, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Coral is an osteo-conductive biomaterial that can act as an alternative scaffold for osteogenesis. In this in vitro study we analyzed the activity of osteoblast-like cells after treatment with the coral Goniopora. Methods: Human osteoblast-like MG-63 cells were incubated in α-minimal essential medium supplemented with 10% fetal bovine serum and 300 ng/mL amphotericin B plus 1% penicillin-streptomycin and stored in a 5% CO2 incubator at 37°C. The Goniopora were smashed into size A (20 mesh), B (1–2 mm), and C (200 mesh) particles, sterilized using gamma radiation and applied to cells. Protein and alkaline phosphatase (ALP) concentrations were evaluated after incubation for 24 and 48 h. Results: The protein assay of 24 h and 48 h cultured osteoblasts illustrated that treated cells, whether with coral size A, B and C exhibited a lower mean value compared to the untreated cells. For ALP levels there were statistically significant differences at 48 h between B and C (p = 0.004), and A and C (p = 0.09). Conclusions: No significant differences in total protein concentrations were found among all groups after 24 and 48 h. Smaller coral size and longer incubation time tended to facilitate osteogenesis. These results require further empirical validation.

PORPHYROMONAS GINGIVALIS DAN PATOGENESIS DISFUNGSI KOGNITIF: ANALISIS PERAN SITOKIN NEUROINFLAMASI Citra Feriana Putri; Endang Winiati Bachtiar
Cakradonya Dental Journal Vol 12, No 1 (2020): Februari 2020
Publisher : FKG Unsyiah

Porphyromonas gingivalis merupakan bakteri utama penyebab penyakit periodontal. Bakteri ini memiliki faktor virulensi seperti lipopolisakarida dan gingipain. Faktor virulensi ini dapat membuatnya lolos dari sistem imun periodontal lalu masuk ke dalam sirkulasi darah atau bakterimia. Bakterimia yang terjadi kemudian menyebabkan bakteri berpindah ke sistem saraf pusat sehingga mengaktivasi mikroglia dan respon neuroinflamasi. Neuroinflamasi merupakan proses inflamasi kompleks yang terjadi di sistem saraf pusat sebagai mekanisme pertahanan dalam melawan patogen, toksin, atau faktor yang menyebabkan neurodegenerasi. Proses neuroinflamasi ini diregulasi oleh aktivitas sel neuron, glia, dan sel endotel di dalam sistem neurovaskular. Produksi mediator inflamasi yang berlebihan oleh sel-sel tersebut dapat menyebabkan kematian sel neuron dan berhubungan dengan terjadinya disfungsi kognitif, seperti penyakit Alzheimer. Dalam tinjauan pustaka ini akan dipaparkan tentang imunopatogenesis Porphyromonas gingivalis pada disfungsi kognitif melalui aktivasi neuroinflamasi di otak.

Efficacy of non-surgical therapy on IL-6 levels in patients with chronic periodontitis: A systematic review Winiati, Endang; Alwiyansyah, Annisa Nurrahma; Sebastian, James; Owen, Kevin; Anggun, Gheta
Dentika: Dental Journal Vol. 27 No. 1 (2024): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v27i1.15272

Chronic periodontitis-affected tissues have an increased production of pro-inflammatory cytokines relative to anti-inflammatory counterparts, including IL-6. Therefore, this systematic review aimed to synthesize and appraise the available literature to provide a comprehensive analysis of the efficacy of non-surgical therapy, specifically focusing on the therapeutic effect of IL-6 in patients with chronic periodontitis. This review focused on seven studies including 308 patients with moderate to severe chronic periodontitis across five different countries. The RoB assessment showed a moderate to low risk of bias studies. Moreover, the studies found a statistically significant decrease in IL-6 levels in patients after receiving non-surgical therapy. There were statistically significant alterations in periodontal indices and IL-6 levels over time, which showed the efficacy of non-surgical treatment based on various literature. Hence, decreasing IL-6 could serve as a therapeutic indicator of inflammatory response.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v12i1.17068

Vitamin administration on orthodontic tooth movement animal model: A systematic review Lubis, Hilda Fitria; Idrus, Erik; Suniarti, Dewi Fatma; Amir, Lisa Rinanda; Bachtiar, Endang Winiati; Lestari, Widya
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 2 (2025): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i2.p207-218

Background: Duration is a very important aspect of orthodontic treatment and is still challenging for orthodontists. Numerous studies investigating the effects of biological substances, including dietary supplements, on orthodontic tooth movement (OTM) rate indicate positive results. Efforts to improve the OTM rate can be classified into four main categories: biological, biomechanical, physical, and surgical. Numerous animal studies have evaluated the impact of biological substances on the rate of OTM, yielding positive outcomes compared to those not given biological substances. Purpose: This systematic review investigated the impact of dietary supplement delivery both locally and systemically on the rate of OTM. Methods: Nine databases were searched until January 31, 2023, for animal studies evaluating the effect of supplement administration on OTM. The Systematic Review Center for Laboratory Animal Experimentation’s (SYRCLE) risk of bias tools were employed. This review’s reporting adhered to the PRISMA guidelines. Results: Sixteen studies were identified for inclusion. Local injections of vitamin D exhibited variable effects. Vitamin C and zinc, as well as vitamin A, showed insignificant effects based on the OTM rate. Vitamin E showed conflicting results. Combined prostaglandin E2 (PGE2) and calcium can increase the OTM. Effects of systemic administrations of omega-3 fatty acids can decrease the OTM in vivo. Conclusion: The pace of tooth movement in animals may vary depending on the local or systemic administration of vitamins, as applied to OTM animal models.

Co-Authors Aimee Monica Aimee Monica Alphianti, Likky T. Alwiyansyah, Annisa Nurrahma Amarila Malik Amir, Lisa Rinanda Ananda, Nissia Anggun, Gheta Annisa Qashdina Alghassani Armelia Sari Widyarman Asmarinah Basri A. Gani Basri A.Gani Basril Abbas Benny S Latief Boy Bachtiar Citra Feriana PUTRI Devi Dwipriastuti Dewi Fatma Suniarti Dita Septiani Erik Idrus Erwin Gunawan Eva Fauziah Farida Isroani Haluanry Santoso Heriandi Sutadi Hery Widijanto I. Wayan T. Wibawan Idson Kamal Ikrima, Abidah Ira Tanti Kuijpers-Jagtman, Anne M Lisa Prihastari, Lisa Lubis, Hilda Fitria Megantoro, Aryo Mindya Yuniastuti Mindya Yuniastuty Mindya Yuniastuty Mochamad Fahlevi Rizal Nadiya Nurul Nissia Ananda Nurhadi Ibrahim Nurtami Soedarsono Owen, Kevin Paulina N. Gunawan Peter J Coloe Peter J Coloe, Peter J Peter Smooker Peter Smooker, Peter Prayitno Rachmi Fanani Hakim Rachmi Fanani Hakim Ratna Meidyawati Ratna Ramadhani Refyan, Sarah Athiyyahmaulidya Rintoko, Bimo Rizki Amanda Rizky Aditiya Irwandi, Rizky Rohmah, Devi Kartika Santi Chismirina Sebastian, James Septiwidyati, Tienneke Riana Silvia Sulistiani Sophie Yolanda Stella Pranoto Sulistiani, Silvia Sulistyani, Lilies Dwi Susan Rahayu Theodorea, Citra Fragrantia Tiara Aninditha Valencia Halim Vera Julia Wahyu Sulistiadi Wairooy, Valeria Widita Widyarman, Armelia Sari Yuniarti Soeroso Zaki Mubarak Zinatul Hayati

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