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Pertimbangan Penggunaan Implan Gigi pada Lansia Nissia Ananda; Lilies Dwi Sulistyani; Endang Winiati Bachtiar
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 6, No 1 (2017)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.6181

Saat ini terjadi perkembangan populasi lansia di Indonesia sehingga isu kesehatan lansia merupakan sesuatu yangesensial. Lansia adalah individu yang telah mengalami proses menua sehingga terjadi berbagai perubahan biologispada tubuhnya, sehingga berpengaruh terhadap penurunan fungsi organ. Kehilangan gigi adalah salah satu masalahyang umum pada lansia sehingga kebutuhan untuk pemasangan gigi tiruan merupakan hal penting yang perludiperhatikan masyarakat kelompok lansia. Implan gigi tiruan merupakan salah satu alternatif pengganti kehilangangigi yang memiliki banyak keuntungan dibandingkan gigi tiruan lain. Namun perlu disadari bahwa penggunaan implangigi memiliki pertimbangan-pertimbangan kondisi rongga mulut dan sistemik tertentu untuk menunjang keberhasilanperawatan. Pemahaman mengenai terjadinya proses menua dan hubungannya dengan pertimbangan penggunaanimplan sangat penting untuk diperhatikan oleh klinisi sebelum merencanakan perawatan, terutama berkaitan denganperubahan pada sistem pertahanan tubuh yang terjadi seiring proses menua.

Isolation and Identification of Indonesian Lactobacillus reuteri strain from Saliva of Young Adults Armelia Sari Widyarman; Stella Pranoto; Citra Fragrantia Theodorea; Endang Winiati Bachtiar; Boy Muchlis Bachtiar
Scientific Dental Journal Vol. 2 No. 2 (2018): May
Publisher : Faculty of Dentistry, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26912/sdj.v2i2.2840

Background: Biofilms are involved in a wide variety of microbial infections, including dental caries and periodontitis. The use of probiotics has been a promising prevention and treatment modality with which to combat biofilm-related diseases in the oral cavity. The probiotic Lactobacillus reuteri has been proven to reduce gingivitis and plaque index inside the oral cavity. These bacteria can be found in the digestive system and also in the human oral cavity. Objective: The aim of this study was to identify L. reuteri in the saliva of Indonesian young adults. Methods: Forty saliva samples were collected from 18–24 year-old Indonesian subjects. DNA extraction was performed, and then, the identification of L. reuteri was accomplished using PCR. Six subjects showed positive results. The positive samples were cultured in Rogosa Agar for 24 hours at 37°C anaerobically. Several single colonies were further cultured separately in broth medium before DNA extraction and PCR identification were performed. The four thickest bands were selected for DNA sequencing. Results: An analysis performed using BLAST showed that two of the L. reuteri strains obtained from the Indonesian saliva isolates had 96% (isolate 3.11) and 95% (isolate 5.14) values. This confirmed the presence of new strains based on average nucleotide identity (ANI). The isolate strains of 3.11 and 5.14 have been registered at DDBJ/EMBL/GenBank under the accession number LC382415 and LC382416, respectively. Conclusion: L. reuteri novel strain can be isolated from the saliva of Indonesian young adults. Further studies involving biochemical tests and phenotypic analysis are needed to better understand these new L. reuteri strains.

PORPHYROMONAS GINGIVALIS DAN PATOGENESIS DISFUNGSI KOGNITIF: ANALISIS PERAN SITOKIN NEUROINFLAMASI Citra Feriana Putri; Endang Winiati Bachtiar
Cakradonya Dental Journal Vol 12, No 1 (2020): Februari 2020
Publisher : FKG Unsyiah

Porphyromonas gingivalis merupakan bakteri utama penyebab penyakit periodontal. Bakteri ini memiliki faktor virulensi seperti lipopolisakarida dan gingipain. Faktor virulensi ini dapat membuatnya lolos dari sistem imun periodontal lalu masuk ke dalam sirkulasi darah atau bakterimia. Bakterimia yang terjadi kemudian menyebabkan bakteri berpindah ke sistem saraf pusat sehingga mengaktivasi mikroglia dan respon neuroinflamasi. Neuroinflamasi merupakan proses inflamasi kompleks yang terjadi di sistem saraf pusat sebagai mekanisme pertahanan dalam melawan patogen, toksin, atau faktor yang menyebabkan neurodegenerasi. Proses neuroinflamasi ini diregulasi oleh aktivitas sel neuron, glia, dan sel endotel di dalam sistem neurovaskular. Produksi mediator inflamasi yang berlebihan oleh sel-sel tersebut dapat menyebabkan kematian sel neuron dan berhubungan dengan terjadinya disfungsi kognitif, seperti penyakit Alzheimer. Dalam tinjauan pustaka ini akan dipaparkan tentang imunopatogenesis Porphyromonas gingivalis pada disfungsi kognitif melalui aktivasi neuroinflamasi di otak.

PORPHYROMONAS GINGIVALIS DAN PATOGENESIS DISFUNGSI KOGNITIF: ANALISIS PERAN SITOKIN NEUROINFLAMASI Citra Feriana Putri; Endang Winiati Bachtiar
Cakradonya Dental Journal Vol 12, No 1 (2020): Februari 2020
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v12i1.17068

Porphyromonas gingivalis merupakan bakteri utama penyebab penyakit periodontal. Bakteri ini memiliki faktor virulensi seperti lipopolisakarida dan gingipain. Faktor virulensi ini dapat membuatnya lolos dari sistem imun periodontal lalu masuk ke dalam sirkulasi darah atau bakterimia. Bakterimia yang terjadi kemudian menyebabkan bakteri berpindah ke sistem saraf pusat sehingga mengaktivasi mikroglia dan respon neuroinflamasi. Neuroinflamasi merupakan proses inflamasi kompleks yang terjadi di sistem saraf pusat sebagai mekanisme pertahanan dalam melawan patogen, toksin, atau faktor yang menyebabkan neurodegenerasi. Proses neuroinflamasi ini diregulasi oleh aktivitas sel neuron, glia, dan sel endotel di dalam sistem neurovaskular. Produksi mediator inflamasi yang berlebihan oleh sel-sel tersebut dapat menyebabkan kematian sel neuron dan berhubungan dengan terjadinya disfungsi kognitif, seperti penyakit Alzheimer. Dalam tinjauan pustaka ini akan dipaparkan tentang imunopatogenesis Porphyromonas gingivalis pada disfungsi kognitif melalui aktivasi neuroinflamasi di otak.

Vitamin administration on orthodontic tooth movement animal model: A systematic review Lubis, Hilda Fitria; Idrus, Erik; Suniarti, Dewi Fatma; Amir, Lisa Rinanda; Bachtiar, Endang Winiati; Lestari, Widya
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 2 (2025): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i2.p207-218

Background: Duration is a very important aspect of orthodontic treatment and is still challenging for orthodontists. Numerous studies investigating the effects of biological substances, including dietary supplements, on orthodontic tooth movement (OTM) rate indicate positive results. Efforts to improve the OTM rate can be classified into four main categories: biological, biomechanical, physical, and surgical. Numerous animal studies have evaluated the impact of biological substances on the rate of OTM, yielding positive outcomes compared to those not given biological substances. Purpose: This systematic review investigated the impact of dietary supplement delivery both locally and systemically on the rate of OTM. Methods: Nine databases were searched until January 31, 2023, for animal studies evaluating the effect of supplement administration on OTM. The Systematic Review Center for Laboratory Animal Experimentation’s (SYRCLE) risk of bias tools were employed. This review’s reporting adhered to the PRISMA guidelines. Results: Sixteen studies were identified for inclusion. Local injections of vitamin D exhibited variable effects. Vitamin C and zinc, as well as vitamin A, showed insignificant effects based on the OTM rate. Vitamin E showed conflicting results. Combined prostaglandin E2 (PGE2) and calcium can increase the OTM. Effects of systemic administrations of omega-3 fatty acids can decrease the OTM in vivo. Conclusion: The pace of tooth movement in animals may vary depending on the local or systemic administration of vitamins, as applied to OTM animal models.

POTENSI CIGARETTE SMOKE CONDENSATE TERHADAP PENINGKATAN PEMBENTUKAN BIOFILM CANDIDA albicans ISOLAT ATCC 10261 Basri A.Gani; Annisa Qashdina Alghassani; Zaki Mubarak; Endang Winiati Bachtiar; Boy M.Bachtiar
Journal of Syiah Kuala Dentistry Society Vol 2, No 1 (2017): JANUARY
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar

Candida albicans (C. albicans) is the main agent in pathogenesis of oral candidiasis, and also the cigarette smoke is one of predisposing factors of C. Albicans virulence, mainly in biofilm formation that it the role as the initiator of adhesiononoral mucosal. This research aimed to identify the effect of Cigarette smoke condensate (CSC) on biofilm formation of C. albicans. Candida albicans was sensitized with CSC kretek and non-kretek that shown the increase of biofilm formation (p0,05) compared control, specifically in 24 hour. Its related with massa of biofilm formation that seem by microscope (400x) and also CSC non kretek better than CSC kretek in biofilm formation of C. albicans, mainly in 24 and 48 hours, that provisional, in 12 hours were the most dominant biofilm figuration of C. albicans sensitized by CSC kretek, although it intensity is lower than 24 hours. The research was concluded that CSC can be trigger to enhancement of biofilm formation of C. albicans in 24 hours and also CSC non kretek better than CSC kretek.Keyword: Candida albicans, Cigarrete smoke condensate, Biofilm

The Role of IL-6 and IGF-1 in Periodontitis Bone Destruction Ikrima, Abidah; Gunawan, Erwin; Rohmah, Devi Kartika; Bachtiar, Boy Muchlis; Bachtiar, Endang Winiati
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.127-135

Periodontitis is an inflammatory condition affecting the tissues supporting the teeth, destroying the periodontal ligament and alveolar bone. This condition is initiated by periodontal pathogens, which trigger an immune response resulting in tissue damage. Pro-inflammatory cytokines, particularly IL-6, have an important role in this process. IL-6, produced by various cells, including immune and periodontal ligament cells, enhances osteoclastogenesis by enhancing RANKL expression, thereby promoting bone resorption. Conversely, IGF-1, a hormone like insulin, is critical in bone homeostasis and regeneration. IGF-1, synthesised in the liver and locally in tissues, aids in the proliferation and differentiation of osteoblasts and osteoclasts, facilitating bone remodelling. IGF-1 also interacts with IL-6 to modulate inflammatory responses and osteoclast activity. Understanding the interplay between IL-6 and IGF-1 offers insights into the mechanism of bone resorption in periodontitis and identifies potential therapeutic targets. This study aims to elucidate the roles of IL-6 and IGF-1 in periodontitis-induced bone resorption and explore their therapeutic implications for periodontal health.

The Role of IL-6 and IGF-1 in Periodontitis Bone Destruction Ikrima, Abidah; Gunawan, Erwin; Rohmah, Devi Kartika; Bachtiar, Boy Muchlis; Bachtiar, Endang Winiati
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.127-135

Periodontitis is an inflammatory condition affecting the tissues supporting the teeth, destroying the periodontal ligament and alveolar bone. This condition is initiated by periodontal pathogens, which trigger an immune response resulting in tissue damage. Pro-inflammatory cytokines, particularly IL-6, have an important role in this process. IL-6, produced by various cells, including immune and periodontal ligament cells, enhances osteoclastogenesis by enhancing RANKL expression, thereby promoting bone resorption. Conversely, IGF-1, a hormone like insulin, is critical in bone homeostasis and regeneration. IGF-1, synthesised in the liver and locally in tissues, aids in the proliferation and differentiation of osteoblasts and osteoclasts, facilitating bone remodelling. IGF-1 also interacts with IL-6 to modulate inflammatory responses and osteoclast activity. Understanding the interplay between IL-6 and IGF-1 offers insights into the mechanism of bone resorption in periodontitis and identifies potential therapeutic targets. This study aims to elucidate the roles of IL-6 and IGF-1 in periodontitis-induced bone resorption and explore their therapeutic implications for periodontal health.

Effect of Bacterial Metabolites From Good Oral-Hygiene to Biofilm Formation From Poor Oral-Hygiene Refyan, Sarah Athiyyahmaulidya; Ratna Ramadhani; Bachtiar, Endang Winiati; Bachtiar, Boy Muchlis; Sulistiadi, Wahyu
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 2 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i2.9030

Introduction: Microbial variations and oral hygiene (OH) status of an individual are related to the oral biofilm formation. The metabolite of microorganisms influences biofilm formation. This research aims to analyse the effect of bacterial isolates' metabolites from a good OH individual on the in vitro biofilm of bacterial isolates from a poor OH individual. Materials and Methods: Spent medium of bacteria isolated from a good OH individual tongue swab that contains different protein and nitrate concentrations was treated in vitro with biofilm from a poor OH individual tongue swab to evaluate the cell viability and in vitro biofilm mass under aerobic conditions. The methods used include the Bradford test, Griess test, Crystal Violet test, and Total Plate Count. Results and Discussions: There were significant differences in the cell viability of bacteria isolated from poor OH individual treated by spent medium isolated from good OH individual with different concentrations of protein and nitrate (p value <0.05), as well as biofilm mass of the sample that was treated with spent medium containing different nitrate concentration (p value < 0.05). Conclusion: The protein and nitrate content in the spent medium from a good OH tongue swab can influence cell viability and in vitro biofilm mass from a poor OH individual tongue swab.

Ethyl acetate fractions of Cordyline fruticosa leaf: Chemical composition and cariogenic antimicrobial activity Alphianti, Likky Tiara; Bachtiar, Endang Winiati; Suniarti, Dewi Fatma; Fauziah, Eva
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.64444

Introduction: Early childhood caries (ECC) is a prominent oral health problem, especially among low socioeconomic status (SES) groups. The development of herbal agents for caries prevention is essential due to the elevated costs and potential adverse effects linked to existing synthetic pharmaceuticals. Cordyline fruticosa (L.) A. Chev. (CF), prevalent in Indonesian rural regions, is an ornamental plant recognised for its medicinal properties, especially its antimicrobial efficacy. This study aimed to identify the chemical compounds in the ethyl acetate fraction of CF leaf extract and evaluate its antibacterial and antifungal activities against Streptococcus mutans (S. mutans) and Candida albicans (C. albicans), the main microorganisms associated with early childhood caries. Methods: This study used a laboratory experimental method. CF leaf extract was fractionated using ethyl acetate. Phytochemical and GC-MS screening were performed to identify secondary metabolites and chemical compounds. S. mutans and C. albicans were isolated from supragingival plaque samples of pediatric patients with severe ECC. The Minimum Inhibitory Concentration (MIC) was determined via serial dilution and ELISA spectrophotometry by comparing absorbance or optical density (OD) values before and after incubation.Results: Phytochemical screening confirmed the presence of phenolic compounds, flavonoids, tannins, and triterpenoids. GC-MS identified 4 chemical compounds, of which the largest peak area (73.88%) corresponding to 5-hydroxymethylfurfural. The MIC for S. mutans was 3.125% and 1.56% for C. albicans. Conclusion: The ethyl acetate fraction of the CF leaf extract exhibits antibacterial and antifungal properties and may function as a cariogenic antimicrobial agent.

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