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All Journal Dentika Dental Journal Journal of Dentistry Indonesia Indonesian Journal of Biotechnology ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Scientific Dental Journal Interdental Jurnal Kedokteran Gigi (IJKG) Cakradonya Dental Journal Odonto dental journal Jurnal of Syiah Kuala Dentistry Society
Endang Winiati Bachtiar
Department Of Oral Biology, Faculty Of Dentistry, Indonesia University
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Matrix Metalloproteinase-9 (MMP-9) Levels in Dentinal Fluid as a Diagnostic Biomarker for Irreversible Pulpitis Megantoro, Aryo; Wairooy, Valeria Widita; Meidyawati, Ratna; Bachtiar, Endang Winiati
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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Abstract

Objective: Pulpitis is an inflammatory condition of the dental pulp. The inflammatory status can be accurately assessed by histological examination. Biomarkers, such as matrix metalloproteinases (MMPs), are effective indicators of inflammation severity. Among these, matrix metalloproteinase-9 (MMP-9) has emerged as a key mediator of inflammatory processes associated with pulpitis. However, its clinical application as a biomarker remains limited owing to challenges in its extraction. This study aimed to evaluate the effectiveness of MMP-9 extracted from the dentinal fluid as a biomarker for pulpitis. Methods: Dentinal fluid was collected using the blunt tip of a sterile paper point, following clean excavation of the cavities. The paper point was placed in a sterile tube containing phosphate-buffered saline (PBS) and stored at −20 ºC. MMP-9 levels were analyzed using enzyme-linked immunosorbent assay (ELISA). Results: MMP-9 was detected in three of four patients diagnosed with irreversible pulpitis. Kruskal-Wallis test revealed a statistically significant difference in MMP-9 levels in the irreversible pulpitis group (p < 0.05). Conclusion: MMP-9 in dentinal fluid is a potential biomarker for irreversible pulpitis. However, further research is required to validate their diagnostic utility in clinical practice.
Co-Authors Amir, Lisa Rinanda Ananda, Nissia Annisa Qashdina Alghassani Basri A.Gani Boy M Bachtiar Boy Muchlis Bachtiar Citra Feriana PUTRI Dewi Fatma Suniarti Erik Idrus Erwin Gunawan Eva Fauziah Farida Isroani Hery Widijanto Ikrima, Abidah Lubis, Hilda Fitria Megantoro, Aryo Mindya Yuniastuti Nissia Ananda Nurtami Soedarsono Peter J Coloe Peter J Coloe, Peter J Peter Smooker Peter Smooker, Peter Rachmi Fanani Hakim Rachmi Fanani Hakim Ratna Meidyawati Ratna Ramadhani Refyan, Sarah Athiyyahmaulidya Rizky Aditiya Irwandi, Rizky Rohmah, Devi Kartika Septiwidyati, Tienneke Riana Stella Pranoto Sulistyani, Lilies Dwi Theodorea, Citra Fragrantia Wahyu Sulistiadi Wairooy, Valeria Widita Widyarman, Armelia Sari Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Zaki Mubarak