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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology JFIOnline Pharmaceutical Sciences and Research (PSR) Jurnal Kefarmasian Indonesia
Anton Bahtiar
Departemen Farmasi, FMIPA Universitas Indonesia
Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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A Preliminary Study of Formulations of Transfersomes for Improved Transdermal Peptide Delivery Hutabarat, Rahmi; Bahtiar, Anton; Suryadi, Herman; Surini, Silvia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.55269

Abstract

Peptide-containing dosage forms are often administered through invasive injection. However, due to their great ultra-mobility, transfersomes offer a promising alternative for non-invasive and non-allergenic transdermal peptide delivery. Therefore, this study aimed to conduct preliminary investigations into the formulations of transfersomes for transdermal peptide delivery. Transfersomes were prepared using the thin-layer hydration method with Tweenâ 80 as an edge activator and Phospholiponâ 90G as vesicle formers. Four formulations: F1, F2, F3, and F4 were optimized with various ratios of the two components, including 90:10, 85:15, 80:20, and 75:25. Particle size, zeta potential, deformability index, polydispersity index (PDI), and vesicle morphology were used to assess transfersomes. As a result, the zeta potential was -37.2 ± 2.19, the deformability index was 1.78 ± 0.03 and the smallest vesicle size (147 ± 1.93), PDI value of 0.105 ± 0.01 and spherical were all found in the optimal formula, F3, with an 80:20 ratio. These results suggest significant potential for the further development of transfersomes using Tweenâ 80 and Phospholiponâ 90G as effective transdermal peptide delivery systems.
Co-Authors . Azizahwati Aprilita Rina Yanti Arry Yanuar Dina Rahmawanty Effionora Anwar Fitri Nurhayati Handayani, Nur Hayati Dwi Herman Suryadi Ika Puspitasari Indriani, Lusi Joshita Djajadisastra, Joshita Maksum Radji Melva Louisa Puspita Eka Wuyung Putri, Risani Andalusia Putri, Sartika Harka Rahmawanty, Dina Rahmi Hutabarat Retnosari Andrajati Silvia Surini Sitompul, Fransiska Soetanto, Sriangky Soetanto, Sriangky Sumali Wiryowidagdo Sunarmi Sunarmi tri wahyuni Yeyen, Arnita Yeyen, Arnita