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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Journal of Innovation and Applied Technology Research Journal of Life Science Indonesian Journal of Human Nutrition Berkala Ilmu Kesehatan Kulit dan Kelamin The Indonesian Biomedical Journal Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Kesehatan Mesencephalon International Journal of Community Service Learning Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Pengabdian Masyarakat dalam Kesehatan Jurnal Mandala Pengabdian Masyarakat Narra J Caring : Jurnal Pengabdian Masyarakat Pediatric Sciences Journal
Wisnu Barlianto
Divisi Alergi-Imunologi-Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Brawijaya/Rumah Sakit Dr.Saiful Anwar Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Effects of Nigella sativa on disease activity, T lymphocytes and inflammatory cytokine profiles in pediatric systemic lupus erythematosus: A randomized controlled trial Barlianto, Wisnu; Wulandari, Desy; Sari, Tita L.; Rachmaningrum, Rafika R.; Asasain, Rayi I.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1063

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, requiring long-term treatment that can have side effects, particularly in pediatric patients. Nigella sativa (NS) has shown potential for improving SLE symptoms due to its anti-inflammatory and immunomodulatory effects. The aim of this study was to investigate the immunomodulatory effect of N. sativa oil (NSO) on disease activity, T lymphocyte activity and inflammatory cytokine profiles in pediatric SLE patients. A randomized, double-blinded, placebo-controlled clinical trial was conducted at Saiful Anwar Hospital in Malang, Indonesia, from January 2022 to January 2023. Pediatric patients with SLE were randomly assigned to receive either one gram of NSO or a placebo containing starch in capsule form as adjunct therapy alongside their SLE primary treatment. Blood samples were collected before treatment and after eight weeks of daily capsules. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K); flow cytometry was used to identify T helper lymphocytes, and serum cytokine levels were measured using ELISA. The statistical analysis tests were performed to compare the outcomes between groups at baseline or after the treatment, and within-group comparisons before and after the study period, as appropriate. A total of 32 patients were included in the study. A significant decrease in the SLEDAI-2K score was observed at post-treatment in both the NSO and placebo groups (p<0.001 and p=0.025, respectively). The percentage of T helper 17 (Th17) cells was significantly reduced in both the NSO and placebo groups post-treatment compared to pre-treatment (p=0.026 and p=0.034, respectively). Conversely, the post-treatment percentage of regulatory T (Treg) cells increased significantly in both groups. A significant reduction in interleukin (IL)-2 levels was observed in the NSO and placebo groups at post-treatment compared to pre-treatment (p=0.006 and p=0.046, respectively). Additionally, there were increases in IL-4 and IL-6 serum levels in both groups at post-treatment compared to pre-treatment (p<0.05). This study highlights that although disease activity was not significantly different between NSO and placebo groups, NSO could affect the inflammatory cytokine profiles in pediatric SLE patients.
Co-Authors Abd. Rasyid Syamsuri Adelheid Riswanti Herminsih, Adelheid Riswanti Aditya, Muhammad Reva Agustina Tri Endharti Al Faizah, Belinda Nabiila Anang Endaryanto Annisa Muhyi Ardiansyah, Esha Aris Soewondo Ariyanto Harsono Asasain, Rayi I. Atho'illah, Mochammad Fitri Azwin Lubis Debby Christinne Sumantri, Debby Christinne Desfryda, Elynca Putri Desy Wulandari Desy Wulandari desy wulandari Desy Wulandari Desy Wulandari Desy Wulandari Dewi Purnama Sari Dian Hasanah Dian Kusumaningtyas, Dian Dicky Faturrachman Dwinadella, Sephia Dyahris Koentartiwi Elvira Sari Dewi Erawati, Dini Rachma Ery Olivianto Fadlilah, Dawama Nur Hajeng Wulandari Handono Kalim Hani Susianti Heksa Trisnawati Hermanto, Ifirlana Hittoh Fattory, Hittoh HMS Chandra Kusuma Indira Ratih Izati, Rahmi Kalsumy, Umi Karyono Mintaroem Kavitarna, Septhyanti Aprilia Kurniawan Taufiq Kadafi Kusworini Handono Kusworini Handono M Fahrul Udin Mawaddah, Shohipatul Mega Ulfah, Mega Micho, Rahma Mohamad Slamet Chandra Kusuma Muhammad Anshory, Muhammad Mutaqin, Fadilah Naila, Centaura Ni Luh Putu Herli Mastuti Ni Luh Putu HM Nisak Humairok Nurdiana Nurdiana Nurdiana Nurdiana Nursari Abdul Syukur Perdana Aditya Rahman Pratama, Mirza Zaka Putri, Choirinnisa Meilia Ayu Ra. Aminah Maya Rachmaningrum, Rafika R. Rahmawati Wahyuni Rifa'i, Muhaimin Rinik Eko Kapti, Rinik Eko Rizka Yunita Sa'adah, Nur Alfi Maghfirotus Sanarto Santoso Sari, Tita L. Sari, Tita Luthfia Satrio Wibowo Setyagisna, Farhan Ardiyanta Setyawati Karyono Shinta Oktya Wardhani, Shinta Oktya Siti Nur Arifah, Siti Nur Solly Aryza Sony Wicaksono Sumarno . Suryanto Suryanto Susanto Nugroho Susanto Nugroho Tita Luthfia Sari Tita Luthfia Sari Vivin Detriana, Vivin Wahono, Cesarius Singgih Wirawan, Tommy Nugroho YOGA DWI JATMIKO Yuni Sari Zaenal Kusuma