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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Journal of Innovation and Applied Technology Research Journal of Life Science Indonesian Journal of Human Nutrition Berkala Ilmu Kesehatan Kulit dan Kelamin The Indonesian Biomedical Journal Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Kesehatan Mesencephalon International Journal of Community Service Learning Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Pengabdian Masyarakat dalam Kesehatan Jurnal Mandala Pengabdian Masyarakat Narra J Caring : Jurnal Pengabdian Masyarakat Pediatric Sciences Journal Women Midwives and Midwifery
Wisnu Barlianto
Divisi Alergi-Imunologi-Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Brawijaya/Rumah Sakit Dr.Saiful Anwar Malang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Pediatric Sciences Journal

 1 
Clinical and laboratory profiles of pediatric asthma patients with house dust mite (HDM)–specific subcutaneous immunotherapy: A single center, cross sectional study Desy Wulandari; Wisnu Barlianto
Pediatric Sciences Journal Vol. 1 No. 2 (2020): (Available online 1 December 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.696 KB) | DOI: 10.51559/pedscij.v1i2.17

Abstract

Introduction: House dust mite (HDM) allergy has been reported as an actual cause of asthma in children. Subcutaneous immunotherapy (SCIT) is a recommended treatment for HDM allergy patients. However, there were limited data about the characteristic of pediatric patients with HDM-SCIT, particularly in Indonesia. This study was aimed to evaluate the characteristic of pediatric patients with allergic asthma. Methods: Study participants were pediatric patients confirmed with HDM allergy from Skin Prick Test (SPT) in the pediatric allergy-immunology outpatient clinic in Saiful Anwar Hospital Malang, Indonesia. Patients who were treated with HDM-SCIT in the early build-up phase of treatment were included in this study. Demographic and clinical characteristics of the patients were recorded. Peripheral blood samples were drawn to evaluate the total eosinophil count (TEC), total basophil count (TBC), neutrophil-lymphocyte ratio (NLR), specific IgE (sIgE) and total IgE (t-IgE) level. Clinical diagnosis of asthma was classified according to the Global Initiative for Asthma (GINA) criteria. The evaluation of asthma control was assessed by the Asthma Control Test (ACT) score. Results: Thirty-two patients were enrolled in this study, including 14 male and 18 female. The mean age of children was 6.92 ± 2.60 years old. There were 21 subjects with uncontrolled asthma and 11 subjects with partially controlled asthma. Demographic characteristics including age, sex, nutritional status and family history were not significantly different between uncontrolled and partially controlled asthma groups (p> 0.05). TEC, TBC, NLR, and tIgE were not different significantly among groups (p> 0.05). This study showed that the mean of sIgE serum level was higher in uncontrolled asthma compared to partially controlled asthma group (p= 0.022). Moreover, it was a negative significant correlation between sIgE serum level and ACT score (p= 0.002, r= -0.532). Conclusion: Higher sIgE levels were correlated with poor asthma control in HDM-SCIT patients.
An Eleven Year Old Boy with Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Desy Wulandari; Wisnu Barlianto; Nisak Humairok
Pediatric Sciences Journal Vol. 2 No. 1 (2021): (Available online 1 June 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (377.389 KB) | DOI: 10.51559/pedscij.v2i1.20

Abstract

Introduction: The prospective studies have estimated that the DRESS syndrome incidence rate is about 1 per 1000 to 10,000 with the mortality rate is to be around 10% to 20%. Case: We have been reported a case of DRESS in an eleven-year-old boy who came to the emergency room with the chief complaint of maculopapular rash in the body that had been happened for three days. The rash was first appeared in the arms area and thus spread to the trunk, abdomen, and lower extremities. The erythema was well-demarcated, purplish in color. There was a history of fever a week before admission which reached 40 0 Celcius. There are multiple histories of drug administration, either orally or intravenously to this patient, and made the diagnosis of drug reaction is highly possible. The management of these patients consists of suspending suspected drugs and implementing supportive measures. Conclusion: Regarding pharmacological treatment, the use of systemic corticosteroids for a prolonged period with a gradual decrease is suggested, to avoid relapses.
A case of oligoarthritis juvenile idiopathic arthritis in a 3-year-old male child: challenges in early diagnosis and management Heksa Trisnawati; Setyagisna, Farhan Ardiyanta; Aditya, Muhammad Reva; Barlianto, Wisnu; Wulandari, Desy
Pediatric Sciences Journal Vol. 6 No. 2 (2025): In Press Online : December 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i2.126

Abstract

Introduction: Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in children, characterized by persistent joint inflammation. However, early diagnosis is often challenging due to heterogeneous clinical manifestations. Among its subtypes, oligoarthritis is the most common, involving up to four joints within six months of symptom onset. This case is distinctive due to its very early onset at the age of 3 years, prolonged diagnostic delay despite multiple healthcare visits, and diagnostic challenges related to nonspecific initial symptoms. Delayed diagnosis can result in joint deformity, growth retardation, and long-term disability, highlighting the importance of early recognition and timely management. Case Presentation: A 3-year-old male child presented with progressive joint pain, morning stiffness, and recurrent joint swelling that was initially associated with a history of trauma. Symptoms had been present since the age of 1.5 years, leading to a significant delay in definitive diagnosis. Based on clinical evaluation, imaging findings, and laboratory investigations, a diagnosis of oligoarticular Juvenile Idiopathic Arthritis was established according to the International League of Associations for Rheumatology (ILAR) criteria. The diagnostic process was further complicated by trauma-associated symptom onset and involvement of the temporomandibular joint (TMJ), which underscores the need for heightened clinical suspicion. The patient received multidisciplinary management, including pharmacological therapy, physical rehabilitation, and nutritional support. Conclusion: This case illustrates the complexity of diagnosing and managing oligoarticular JIA in pediatric patients, particularly in cases with very early onset, delayed diagnosis, and TMJ involvement. A comprehensive multidisciplinary approach, along with increased clinical awareness and early diagnosis, is essential to control inflammation, preserve joint function, and prevent long-term complications in children with JIA.
Co-Authors Abd. Rasyid Syamsuri Adelheid Riswanti Herminsih, Adelheid Riswanti Aditya, Muhammad Reva Agustina Tri Endharti Al Faizah, Belinda Nabiila Anang Endaryanto Annisa Muhyi Ardiansyah, Esha Aris Soewondo Ariyanto Harsono Asasain, Rayi I. Atho'illah, Mochammad Fitri Azwin Lubis Debby Christinne Sumantri, Debby Christinne Desfryda, Elynca Putri desy wulandari Desy Wulandari Desy Wulandari Desy Wulandari Desy Wulandari Desy Wulandari Dewi Purnama Sari Dian Hasanah Dian Kusumaningtyas, Dian Dicky Faturrachman Dwinadella, Sephia Dyahris Koentartiwi Elvira Sari Dewi Erawati, Dini Rachma Ery Olivianto Fadlilah, Dawama Nur Hajeng Wulandari Handono Kalim Hani Susianti Heksa Trisnawati Hermanto, Ifirlana Hittoh Fattory, Hittoh HMS Chandra Kusuma Indira Ratih Izati, Rahmi Kalsumy, Umi Karyono Mintaroem Kavitarna, Septhyanti Aprilia Kurniawan Taufiq Kadafi Kusworini Handono Kusworini Handono M Fahrul Udin Mawaddah, Shohipatul Mega Ulfah, Mega Micho, Rahma Mohamad Slamet Chandra Kusuma Muhammad Anshory, Muhammad Mutaqin, Fadilah Naila, Centaura Ni Luh Putu Herli Mastuti Ni Luh Putu HM Nisak Humairok Nurdiana Nurdiana Nurdiana Nurdiana Nursari Abdul Syukur Perdana Aditya Rahman Pratama, Mirza Zaka Putri, Choirinnisa Meilia Ayu Ra. Aminah Maya Rachmaningrum, Rafika R. Rahmawati Wahyuni Rifa'i, Muhaimin Rinik Eko Kapti, Rinik Eko Rizka Yunita Romandita, Shalna Faizza Sa'adah, Nur Alfi Maghfirotus Sanarto Santoso Sari, Tita L. Sari, Tita Luthfia Satrio Wibowo Setyagisna, Farhan Ardiyanta Setyawati Karyono Shinta Oktya Wardhani, Shinta Oktya Siti Nur Arifah, Siti Nur Solly Aryza Sony Wicaksono Sumarno . Suryanto Suryanto Susanto Nugroho Susanto Nugroho Tita Luthfia Sari Tita Luthfia Sari Vivin Detriana, Vivin Wahono, Cesarius Singgih Wirawan, Tommy Nugroho YOGA DWI JATMIKO Yuni Sari Zaenal Kusuma