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Journal : Research Journal of Life Science

Immunomodulation Effects of Bryophyllum Pinnatum on Pregnant Pristane-Induced Lupus Mice Model Nurdiana Nurdiana; Elvira Sari Dewi; Yuni Sari; Rahmawati Wahyuni; Aminah Maya; Nursari Abdul Syukur; Mirza Zaka Pratama; Wisnu Barlianto; Umi Kalsum; Kusworini Handono
Research Journal of Life Science Vol 3, No 3 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (755.245 KB) | DOI: 10.21776/ub.rjls.2016.003.03.8

Abstract

Objective: To determine the effect of Bryophyllum pinnatum treatment in modulating immune response and the pregnancy outcomes of pregnant pristane-induced lupus mice model.Methods: Sixteen Balb/c mice were intraperitoneally injected with single 0.5 cc pristane to induce lupus manifestations. After 12 weeks of injection, mice were mated and considered as gestational day 0 (GD0). Mice were divided into 4 groups based on the dosages of Bryophyllum pinnatum: control (no treatment), B1 (10.5 mg/kg), B2 (21 mg/kg), and B3 (42 mg/kg). The treatment was given orally every day started from GD9 until 9 days. At the end of the study, blood pressure and fetal size were measured. Serum anti-dsDNA and urine albumin levels were measured by ELISA. Spleen T helper (Th) and mature B cells percentages were measured by flow cytometry.Results: Administration of Bryophyllum pinnatum reduced the percentages of Th1 (p=0.006), Th2 (p=0.005), Th17 (p=0.000), and mature B cells (p=0.007) in dose-dependent manner. B1 and B2 had significantly lower of systolic blood pressure compared to control (p=0.026 and p=0.022 respectively). Significantly lower of anti-dsDNA levels were found in B1 group compared to control (p=0.014). However, no significantly different of urine albumin levels were found between groups. Bryophyllum pinnatum also significantly increased the fetus body weight in dose-dependent manner (p=0.000).Conclusion: Treatment of Bryophyllum pinnatum could improve the pregnancy outcome and modulate the immune response in pregnant pristane-induced lupus mice. Therefore, Bryophyllum pinnatum is a potential herb which can be developed as an immunosuppressive agent in the future.
Co-Authors Abd. Rasyid Syamsuri Adelheid Riswanti Herminsih, Adelheid Riswanti Aditya, Muhammad Reva Agustina Tri Endharti Al Faizah, Belinda Nabiila Anang Endaryanto Annisa Muhyi Ardiansyah, Esha Aris Soewondo Ariyanto Harsono Asasain, Rayi I. Atho'illah, Mochammad Fitri Azwin Lubis Debby Christinne Sumantri, Debby Christinne Desfryda, Elynca Putri desy wulandari Desy Wulandari Desy Wulandari Desy Wulandari Desy Wulandari Desy Wulandari Dewi Purnama Sari Dian Hasanah Dian Kusumaningtyas, Dian Dicky Faturrachman Dwinadella, Sephia Dyahris Koentartiwi Elvira Sari Dewi Erawati, Dini Rachma Ery Olivianto Fadlilah, Dawama Nur Hajeng Wulandari Handono Kalim Hani Susianti Heksa Trisnawati Hermanto, Ifirlana Hittoh Fattory, Hittoh HMS Chandra Kusuma Indira Ratih Izati, Rahmi Kalsumy, Umi Karyono Mintaroem Kavitarna, Septhyanti Aprilia Kurniawan Taufiq Kadafi Kusworini Handono Kusworini Handono M Fahrul Udin Mawaddah, Shohipatul Mega Ulfah, Mega Micho, Rahma Mohamad Slamet Chandra Kusuma Muhammad Anshory, Muhammad Mutaqin, Fadilah Naila, Centaura Ni Luh Putu Herli Mastuti Ni Luh Putu HM Nisak Humairok Nurdiana Nurdiana Nurdiana Nurdiana Nursari Abdul Syukur Perdana Aditya Rahman Pratama, Mirza Zaka Putri, Choirinnisa Meilia Ayu Ra. Aminah Maya Rachmaningrum, Rafika R. Rahmawati Wahyuni Rifa'i, Muhaimin Rinik Eko Kapti, Rinik Eko Rizka Yunita Sa'adah, Nur Alfi Maghfirotus Sanarto Santoso Sari, Tita L. Sari, Tita Luthfia Satrio Wibowo Setyagisna, Farhan Ardiyanta Setyawati Karyono Shinta Oktya Wardhani, Shinta Oktya Siti Nur Arifah, Siti Nur Solly Aryza Sony Wicaksono Sumarno . Suryanto Suryanto Susanto Nugroho Susanto Nugroho Tita Luthfia Sari Tita Luthfia Sari Vivin Detriana, Vivin Wahono, Cesarius Singgih Wirawan, Tommy Nugroho YOGA DWI JATMIKO Yuni Sari Zaenal Kusuma