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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Biomedical Journal of Indonesia Jurnal Pemberdayaan Masyarakat Madani (JPMM) Journal of Islamic Medicine Jurnal Medika Malahayati Fullerene Journal of Chemistry JFM (Jurnal Farmasi Malahayati) Jurnal Pengabdian Farmasi Malahayati (JPFM) Majalah Farmasetika Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Pharmacoscript Jurnal Farmagazine Jurnal Ilmiah Wahana Pendidikan Journal of Biobased Chemicals (JOBC) Jurnal Pengabdian Masyarakat Bangsa Indonesian Journal of Cosmetics Pharmacon: Jurnal Farmasi Indonesia JOURNAL OF Pharmacy and Tropical Issues
Angga Saputra Yasir
Institut Teknologi Sumatera
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Pharmacoscript

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FORMULASI DAN UJI AKTIVITAS GEL KOMBINASI EKSTRAK ETANOL DAUN LIDAH BUAYA (Aloe vera) DAN DAUN KEMANGI (Ocinum sanctum L.) SEBAGAI ANTI JERAWAT TERHADAP BAKTERI Staphylococcus epidermidis Angga Saputra Yasir; Selvi Marcellia; Lintang Buwana Wijaya; Tika Rahayu Putri
Pharmacoscript Vol. 4 No. 1 (2021): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v4i1.610

Abstract

Jerawat merupakan penyakit kulit yang disebabkan oleh bakteri antara lain yaitu bakteri Staphylococcus epidermidis. Lidah buaya (Aloe vera) dan daun kemangi (Ocinum sanctum L.) mengandung saponin, flavonoid, dan tanin yang mampu menghambat pertumbuhan bakteri sehingga memiliki daya antibakteri. Penelitian ini bertujuan untuk mengetahui tingkat efektivitas dari kombinasi ekstrak lidah buaya (Aloe vera) dan daun kemangi (Ocinum sanctum L.) dalam bentuk sediaan gel terhadap bakteri Staphylococcus epidermis. Metode yang digunakan dalam ekstraksi adalah maserasi menggunakan etanol 96% dengan nilai rendemen yang didapat pada lidah buaya sebesar 22,32% dan pada daun kemangi sebesar 22,70%. Uji antibakteri menggunakan metode difusi cakram. Perbandingan ekstrak (lidah buaya : daun kemangi) dan daya hambat ekstrak terhadap bakteri Staphylococcus epidermis berturut-turut adalah 1:1, 16,82 mm; 1:2, 15,22 mm; 2:1, 14,59 mm; 1:0, 14,75 mm; 0:1, 15,21 mm. Analisis data kombinasi ekstrak menggunakan one way ANOVA menunjukan adanya perbedaan bermakna antar setiap kelompok perlakuan P>0,05. Selanjutnya uji sediaan gel dari kombinasi ekstrak 1:1, kontrol positif dan basis sediaan gel menghasilkan zona hambatberturut-turut sebesar 20,05 mm; 31,37 mm; 9,17 mm. Analisis data gel kombinasi menggunakan one way ANOVA hasil menunjukan tidak adanya perbedaan bermakna antar setiap kelompok perlakuan P<0,05. Sediaan gel dengan kombinasi ekstrak lidah buaya dan daun kemangi (1:1) memiliki efektivitas terhadap pertumbuhan bakteri Staphylococcus epidermis penyebab jerawat
IN VITRO AND MOLECULAR DOCKING ANALYSIS OF NUTMEG EXTRACT ANTIBACTERIAL ACTIVITY AGAINST Propionibacterium acnes Angga Saputra, Yasir; Indah Puspita, Sari; Veni Putri, Nurhayati; Aida Febina, Sholeha
Pharmacoscript Vol. 8 No. 2 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i2.2107

Abstract

This study investigated the antibacterial activity of nutmeg (Myristica fragrans Houtt.) extract against Propionibacterium acnes  through in vitro and molecular docking approaches. The nutmeg flesh was extracted using ultrasonication with 96% ethanol, yielding 8.21% extract. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, and steroids. The antibacterial activity was evaluated using the microdilution method, determining Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values of 0.5% and 1%, respectively. Molecular docking analysis was performed to understand the interaction between nutmeg's bioactive compounds and three essential Propionibacterium Acnes proteins: Sialidase (7LBV), lipase (5H6G), and Penicillin-Binding Protein 2 (3UPO). Among the tested compounds, myristicin showed the strongest binding affinity with 7LBV (-6.8 kcal/mol), while lignan exhibited notable interactions with 3UPO (-6.6 kcal/mol) and 5H6G (-5.9 kcal/mol). The molecular interactions were primarily stabilized through hydrophobic interactions and hydrogen bonding with specific amino acid residues. These findings suggest that nutmeg extract possesses significant antibacterial activity against Propionibacterium Acnes, potentially mediated through multiple molecular targets, supporting its development as a natural anti-acne ingredient.
Co-Authors Abdul Hamid Al Fikri Achmad Gus Fahmi Ade Maria Ulfa Ade Maria Ulfa Ade Maria Ulfa Agesta Yesti Renita Aida Febina Sholeha Aida Febina, Sholeha Ambarita, Petrus Alvin Peter Angin, Martinus Perangin Br Barus, Emia Athena Chusairil Pasa Entin Sari Fachry Abda El Rahman Ghifari, M Alvien Gusti Ayu Rai Saputri Handayani, Kiki Yuli Helisya Putri Herawati, Nenti Hermawan, Dessy Indah Puspita Sari Indah Puspita Sari, Indah Puspita Indah Puspita, Sari Indarto I Iwan Syahjoko Saputra Jayanti, Merly Kiki Handayani Lintang Buwana Wijaya Made Wike Wiranti Maria Ulfa, Ade Martianus Perangin Angin MARTIANUS PERANGIN ANGIN Merly Jayanti Mochammad Imron Awalludin Muhtar, Wafiq Azizah Ni Wayan Wulantika Niken Feladita Nofita Nofita Nofita, Nofita Noviantoro, Tri Nurhayati, Veni Putri, Tikarahayu Raihannisa, Cantika Raysa Rara Rista Putri Rery Tri Berliyanti Robiyun, Robiyun RR. Ella Evrita Hestiandari Sandika, Agung Ngurah Feri Saputri, Gusti Ayu Rai Selvi Marcellia Sholeha, Aida Sholeha, Aida Febina Sinta Bella Triyanti Siti Zulaicha, Annisaa Sofyan, Shefira Suryaneta Syahjoko, Iwan Tika Rahayu Putri Tutik Tutik Umu Wafika Veni Putri Nurhayati Veni Putri, Nurhayati Widianti, Reika Aqni Yohan Alfianys Yudhi Chandra Zulaicha, Annisaa