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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Pharmascience Medical Laboratory Technology Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Kreativitas PKM Jurnal Mandala Pharmacon Indonesia Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International Journal of Health and Pharmaceutical (IJHP) Jurnal Bakti Untuk Negeri FISIO MU: Physiotherapy Evidences Jurnal Pengabdian Ikifa
Nazhipah Isnani
Politeknik Unggulan Kalimantan
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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ANALYSIS OF RISK FACTORS AND TREATMENT PHASES ON THE SEVERITY OF HEPATOTOXICITY DUE TO ANTI-TUBERCULOSIS DRUGS Isnani, Nazhipah; hadi, Samsul; Sandi, Dita Aulia Dwi; Rahmatullah, Satrio Wibowo; Adikusuma, Wirawan; Saksono, Reni Yustiati; Auralia, Najma; Maulida, Khelda; Setiawan, Feri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2911

Abstract

Hepatotoxicity caused by anti-tuberculosis drugs (OAT) is one of the adverse effects of tuberculosis therapy and may lead to liver dysfunction. This study aimed to analyze the relationship between age, gender, and treatment phase with the severity of OAT induced hepatotoxicity, as well as to assess factors influencing the increase in hepatotoxicity grade. This research employed a retrospective cross-sectional design and was conducted at Ulin Regional Hospital Banjarmasin using a total sampling method involving 45 tuberculosis patients. Secondary data were obtained from medical records of TB patients in 2024–2025. The results showed that 62.2% of patients were under 60 years old and 37.8% were over 60 years old. Male patients accounted for 75.6%, while females accounted for 24.4%. The distribution of hepatotoxicity grades was 40% normal, 28.9% grade 1, 20% grade 2, and 11.1% grade 3. Based on the treatment phase, 91.1% of patients were in the intensive phase and 8.9% were in the continuation phase. The Chi square test revealed no significant association between age, gender, or treatment phase and the severity of hepatotoxicity.
Co-Authors Agustina, Ni Kadek Ayu Akbar, Nabila Hadiah Amali, Dzikra Aulia Andalusia, Rizka Anna Khumaira Sari Aulia, Hilya Auralia, Najma Ayuchecaria, Noverda Buih, Putri Helena Junjung Devia Pratiwi Dewi Wulandari Dewi Wulandari Dyah Aryani Perwitasari Enny Fauziah Fitria, Raudatul Haridini Intan Mahdi Haridini Intan Mahdi Haridini Intan Mahdi Hikmah, Siti Nur Humaidy, Mizan Iqlima Iqlima Ira Maya Sari Izma, Hayatun Jamil, Muhammad Muhtadin Jhudi Bonosari Soediono Juwita Ramadhani Khairunnisa Khoirunnisa Muslimawati Kumala, Dinna Fitria Liling Triyasmono Mahdi, Haridini Intan Malahayati, Siti Maulida Rahmah Maulida, Khelda Mochammad Maulidie Alfiannor Saputera Muhammad Arif Riyadi Muhammad Ikhwan Rizki Muhammad Muhatadin Jamil Muhammad Zaini Muhammad Zaini Muhammad Zaini Muliyani muliyani muliyani Muliyani Muliyani muliyani, muliyani muliyani muliyani, muliyani muliyani Nabila Hadiah Akbar Nafi'ah Nafi'ah Nafi’ah, Nafi’ah Nur Aulya Aulya Popong Nur Apipah Putra, Aditya Maulana Perdana Putri Sheila Wardhani Rahmatullah, Satrio Wibowo Rahmi Annisa Ramadhani , Syahrizal Ravenalla Abdurrahman Al Hakim Sampurna Putra S Redanti, Hema Novita Rini Audina Rizka Andalusia Rizka Andalusia Rizka Andalusia Saksono, Reni Yustiati Samsul Hadi Sandi, Dita Aulia Dwi Sandi, Dita Ayulia Dwi Sari , Anna Khumaira Setiawan, Feri Taufik Muhammad Fakih Widodo, Ridho Dwi Wirawan Adikusuma Wulandari, Ihya