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Widdhi Bodhi
Universitas Sam Ratulangi
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UJI EFEK ANALGETIK NANOPARTIKEL EKSTRAK RIMPANG JAHE MERAH (Zingiber officinale var Rubrum) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Kaunang, Christian Excelino; Bodhi, Widdhi; Edi, Hosea Jaya
PHARMACON Vol 9, No 2 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.29269

Abstract

ABSTRACTRed Ginger (Zingiber officinale var rubrum) has long been known that its properties can cure various diseases. Chemical components such as gingerol, shogaol, and zigeron that can provide pharmacological and physiological effects such as analgesic, antioxidant, carcinogenic, and non-mutagenic effects even at high concentrations. This study aims to determine whether the nanoparticles of red ginger rhizome extracts can provide analgesic effects in white male wistar rats (Rattus norvegicus). The red ginger rhizome was extracted using maceration method with ethanol as a solvent and nanoparticle formulation of red ginger extract was made using an ionic gelation method. The test mice animals were divided into 5 kinds of treatments and each treatment performed 3 repetitions. Test of the analgesic effect was carried out by the method of thermic induction using waterbath and was observed as many as 5 times, namely before giving test material, the 30th minute, 60th minute, 90th minute, and 120th minute. Group I as negative control was given 1% CMC, group II as positive control was given paracetamol, group III-V was treated using nanoparticles red ginger extract with multilevel doses of 0.0215g, 0.043g, and 0.086g. Based on the ANOVA test, the results obtained of analgesic effects significantly different with p = 0.019 (p < 0.05). Keywords: analgesic, nanoparticles, red ginger.  ABSTRAKJahe merah (Zingiber officinale var rubrum) sudah lama diketahui khasiatnya yaitu dapat menyembuhkan berbagai macam penyakit. Komponen kimia seperti gingerol, shogaol, dan zigeron yang dapat memberikan efek farmakologi maupun efek fisiologi seperti efek analgetik , antioksidan, karsinogenik, dan non mutagenik meskipun pada konsentrasi yang tinggi. Penelitian ini bertujuan untuk mengetahui apakah nanopartikel ekstrak rimpang jahe merah dapat memberikan efek analgetik pada tikus putih jantan galur wistar (Rattus norvegicus). Rimpang jahe merah diekstraksi menggunakan metode maserasi dengan etanol sebagai pelarut dan dibuat formulasi nanopartikel ekstrak rimpang jahe merah dengan metode gelasi ionik. Hewan uji tikus dibagi menjadi 5 macam perlakuan setiap perlakuan dilakukan 3 kali pengulangan. Untuk pengujian efek analgetik dilakukan dengan metode induksi termik menggunakan waterbath dan dilakukan pengamatan sebanyak 5 kali yaitu sebelum pemberian bahan uji, menit ke-30, menit ke-60, menit ke-90, dan menit ke-120. Kelompok I sebagai kontrol negatif diberi CMC 1%, kelompok II sebagai kontrol positif diberi parasetamol, kelompok III-V diberi perlakuan menggunakan nanopartikel ekstrak rimpang jahe merah dengan dosis yang bertingkat yaitu 0,0215g, 0,043g, dan 0,086g. Berdasarkan hasil uji ANOVA didapatkan efek analgetik yang berbeda secara bermakna dengan p = 0,019 (p<0,05). Kata Kunci: Jahe merah, analgetik, nanopartikel.
UJI EFEK ANALGESIK EKSTRAK ETANOL DAUN KEJI BELING (Strobilanthes crispus L) PADA TIKUS PUTIH GALUR WISTAR (Rattus norvegicus) Olii, Ariesthya D. C.; Bodhi, Widdhi; Edi, Hosea J.
PHARMACON Vol 9, No 2 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.29267

Abstract

ABSTRACT Pain is an unpleasant sensory and emotional experience due to tissue damage both actual and potential. Analgesics are a drug used to relieve pain without losing consciousness. Keji beling leaves (Strobilanthes crispus L) contain glycosidic ester compounds from caffeic acid, which have analgesic effects. This study aims to determine whether there is an analgesic effect on the ethanol extract of keji beling leaves with different doses, namely dose 0.0023g / 200gBW, 0.0047g / 200gBW, and 0.0094g / 200gBW in test animals of wistar strain male rats. This study uses a laboratory experimental research design using wistar strain male white rat as a test animal. The analgesic effect test was carried out by the heat stimulation method using a 53 °C water bath. The rat response was observed in the form of movements of licking the hind legs or jumping from before giving test material and after giving test material at 30, 60, 90 and 120 minutes, respectively. From the results of statistical data analysis with One Way Anova and LSD showed that the extracts keji beling leaves has an analgesic effect. Where among those three doses the best dose was 0.0023g / 200gBW. Keywords: Analgesic, anova, keji beling leaves, white male wistar rats. ABSTRAK Rasa nyeri merupakan pengalaman sensorik dan emosional yang tidak menyenangkan akibat kerusakan jaringan baik aktual maupun potensial. Analgesik ialah suatu obat yang digunakan untuk menghilangkan rasa sakit tanpa menghilangkan kesadaran. Daun keji beling (Strobilanthes crispus  L) mengandung senyawa glikosidik ester dari asam caffeic yang memiliki efek analgesik. Penelitian ini bertujuan untuk mengetahui ada tidaknya efek analgesik pada ekstrak etanol daun keji beling dengan dosis berbeda-beda yaitu dosis 0,0023g/200gBB, 0,0047g/200gBB, dan 0,0094g/200gBB pada hewan uji tikus putih jantan galur wistar. Penelitian ini menggunakan Rancangan penelitian eksperimental laboratorium dengan menggunakan hewan uji tikus putih jantan galur wistar. Pengujian efek analgesik dilakukan dengan metode rangsangan panas menggunakan waterbath suhu 53°C. Respon tikus diamati berupa gerakan menjilat kaki belakang atau melompat dari sebelum pemberian bahan uji dan sesudah pemberian bahan uji  berturut-turut pada menit ke 30, 60, 90 dan 120. Dari hasil analisis data secara statistika dengan One Way Anova dan LSD menunjukkan bahwa ekstrak daun keji beling memiliki efek analgesik. Dimana antara ketiga dosis tersebut yang paling terbaik ialah dosis 0,0023 g/200gBB. Kata kunci : Analgesik, Anova, Daun Keji Beling, tikus putih jantan galur wistar
UJI DAYA HAMBAT EKSTRAK RIMPANG LENGKUAS PUTIH (Alpinia galanga L. Swartz) TERHADAP PERTUMBUHAN BAKTERI Klebsiella pneumoniae ISOLAT SPUTUM PADA PENDERITA PNEUMONIA RESISTEN ANTIBIOTIK SEFTRIAKSON Hasan, Puput Herawati; Fatimawali, Fatimawali; Bodhi, widdhi
PHARMACON Vol 8, No 1 (2019): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.8.2019.29229

Abstract

ABSTRACT             White galangal rhizome (Alpinia galanga L. Swartz) is one of the plants which has the antibacterial properties from the zingiberaceae family. Empirically it can treat various diseases such as chest pain, throat inflammation, stomach inflammation, rheumatism, diabetes and skin diseases. White galangal rhizome contains flavonoids, tannins, quinones and terpenoids. This study aims to determine the antibacterial activity of white galangal rhizome extract (Alpinia galanga L. Swartz) and test its inhibition against the growth of Klebsiella pneumoniae bacteria which are resistant to ceftriaxone antibiotics. The white galangal rhizome was extracted by maceration method using 96% ethanol solvent and antibacterial activity was tested using the disc and well method with a concentration difference of 100%, 75%, 50%, 25% and 12.5%. The results showed that white galangal rhizome extract (Alpinia galanga L. Swartz) had antibacterial activity against the bacterium Klebsiella pneumoniae and could inhibit the growth of Klebsiella pneumoniae bacteria. On the disc method for concentrations of 100%, 75%, 50%, 25% and 12.5%, the inhibitors were categorized as medium. Whereas in the well method for concentrations of 100% and 75%, the inhibitors were categorized as strong, for concentrations of 50%, 25%, and 12.5%, which have a medium category.Keywords: White Galangal Rhizome (Alpinia galanga L. Swartz), Klebsiella pneumoniae ABSTRAK Rimpang Lengkuas putih (Alpinia galanga L. Swartz) merupakan salah satu tanaman yang memiliki khasiat sebagai antibakteri dari family zingiberaceae. Secara empiris dapat mengobati berbagai penyakit seperti nyeri dada, radang tenggorokkan, radang lambung, rematik, diabetes dan penyakit kulit. Rimpang Lengkuas putih mengandung senyawa flavonoid, tanin, kuinon dan terpenoid. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak rimpang Lengkuas putih (Alpinia galanga L. Swartz) dan menguji daya hambatnya terhadap pertumbuhan bakteri klebsiella pneumoniae yang resisten terhadap antibiotik seftriakson. Rimpang Lengkuas putih diekstraksi dengan metode maserasi menggunakan pelarut etanol 96% dan dilakukan pengujian aktivitas antibakteri dengan menggunakan metode cakram dan sumuran dengan perbedaan konsentrasi 100%, 75%, 50%, 25% dan 12,5%. Hasil penelitian menunjukkan bahwa ekstrak rimpang Lengkuas putih (Alpinia galanga L. Swartz)  memiliki aktivitas antibakteri terhadap bakteri Klebsiella pneumoniae dan dapat menghambat pertumbuhan bakteri Klebsiella pneumoniae. Pada metode cakram untuk konsentrasi 100%, 75%, 50%, 25% dan 12,5% memiliki daya hambat yang dikategorikan sedang. Sedangkan pada metode sumuran untuk konsentrasi 100% dan 75%  memiliki daya hambat yang dikategorikan kuat, untuk kosentrasi 50%, 25%, dan 12,5% memiliki daya hambat yang dikategorikan sedang.Kata Kunci: Rimpang lengkuas putih (Alpinia galanga L. Swartz), Klebsiella pneumoniae
SKRINING FITOKIMIA, UJI AKTIVITAS ANTIOKSIDAN, DAN TOKSISITAS DARI EKSTRAK DAUN KERSEN (Muntingia calabura L.) DENGAN METODE 1.1-diphenyl-2-picrylhydrazyl (DPPH) dan Brine Shrimp Lethality Test (BSLT) Widjaya, Selin; Bodhi, Widdhi; Yudistira, Adithya
PHARMACON Vol 8, No 2 (2019): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.8.2019.29297

Abstract

ABSTRACTKersen (Muntingia calabura L.) is a plant that has begun to be eliminated and was rarely used because it is often considered to have no economic value and lack of knowledge about its utilization, whereas kersen plants contain flavonoids, saponins, and tannins which were have high benefit for health. The content of metabolites is affected by soil nutrient elements and difference place of growth. This study aims to determine the potential of kersen leaves grown in North Minahasa based on phytochemical content, ability of antioxidant activity, and toxicity. Kersen leaves were extracted using sequential maceration method with n-hexane, ethyl acetate, and ethanol as solvents. Phytochemical Screening using several reagents which tailored to the type of phytochemical test. 1.1-diphenyl-2-picrylhydrazyl (DPPH) method is used to evaluate antioxidant activity, and Brine Shrimp Lethality Test (BSLT) method is used to evaluate toxicity. The result of this study indicate that the n-hexane extract contains phenols, flavonoids, and tannins, with IC50 value 12.54 μg/mL, and LC50 value 881 μg/mL. Ethyl acetate extract contains phenols, flavonoids, tannins, and saponins, with IC50 value 61.3 μg/mL, and LC50 value 1758 μg/mL. Ethanol extract has phenol, flavonoid, tannin, saponin, and terpenoid content, with IC50 value 9.01 μg/mL, and LC50 value 106 μg/mL. Keywords : Kersen leaves, Antioxidant, Toxicity, IC50, LC50 ABSTRAKKersen (Muntingia calabura L.) merupakan tanaman yang sudah mulai tersingkirkan dan jarang dimanfaatkan karena sering dianggap tidak punya nilai ekonomis dan kurangnya pengetahuan tentang pemanfaatannya, padahal tanaman kersen memiliki kandungan flavonoid, saponin, dan tanin yang bermanfaat tinggi untuk kesehatan. Kandungan senyawa metabolit dipengaruhi oleh unsur hara tanah dan perbedaan tempat tumbuh. Penelitian ini bertujuan untuk mengetahui potensi dari daun kersen yang tumbuh di Minahasa Utara berdasarkan kandungan fitokimia, kemampuan aktivitas antioksidan, dan toksisitasnya. Ekstrak daun kersen diekstraksi dengan metode maserasi sekuensial menggunakan pelarut n-heksan, etil asetat, dan etanol.  Skrining fitokimia menggunakan beberapa reagen yang disesuaikan dengan jenis uji fitokimia. Metode 1.1-diphenyl-2-picrylhydrazyl (DPPH) digunakan untuk mengevaluasi aktivitas antioksidan, dan metode Brine Shrimp Lethality Test (BSLT) digunakan untuk mengevaluasi toksisitas. Hasil penelitian ini menunjukkan bahwa ekstrak n-heksan memiliki kandungan fenol, flavonoid, dan tanin, nilai IC50 12,54 μg/mL, dan nilai LC50 881 μg/mL. Ekstrak etil asetat memiliki kandungan fenol, flavonoid, tanin, dan saponin, nilai IC50 61,3 μg/mL, dan nilai LC50 1758 μg/mL. Ekstrak etanol memiliki kandungan fenol, flavonoid, tanin, saponin, dan terpenoid, nilai IC50 9,01 μg/mL, dan nilai LC50 106 μg/mL. Kata kunci : Daun Kersen, Antioksidan, Toksisitas, IC50, LC50
UJI EFEK ANALGETIK EKSTRAK ETANOL RIMPANG JAHE PUTIH (Zingiber officinale Rosc.var. Amarum) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Lahamendu, Beatriks; Bodhi, Widdhi; Siampa, Jainer P.
PHARMACON Vol 8, No 4 (2019): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.8.2019.29372

Abstract

ABSTRACTWhite Ginger Rhizome (Zingiber officinale Rosc.var. Amarum) contains secondary metabolites such as flavonoids, there are also several compounds such as gingerol, shogaol, and zhigeron which provide anti-inflamatory, antioxidant, analgesic, anticarsinogenic and cardiotonic effects. This study aims to determine the analgesic effect of ethanol extracts of white ginger rhizome with different doses, namely the treatment group 1, dose 0.006 g, the Treatment  Group 2, dose 0.012 g and the Treatment Group 3, dose 0.024 g tested on white male wistar strain rats. This study uses a laboratory experimental research design using male white rats as experimental animals. The result of the study using LSD showed a difference between the group of negative control and the group of positive control, and also the treatment group with extracts with significance value (0.014, 0.008, 0.012 and 0.005 ) the value <0.05, which indicates that according to the hypothesis namely rejecting H0 and accepting H1, which means significantly different between the negative control group with  positive control group and the treatment group with extracts, but there is no difference between the positive control group and the treatment group with extract which means there is no difference because they both have analgesic effects. From the results of the study it can be concluded that the ethanol extracts of white ginger rhizome at a dose 0.006 g, 0.012 g, and 0.024 g has analgesic effects in male white wistar strain rats can be seen from the decreasing number of rat responses (licks and jumps).Keywords: Analgesic, anova, White Ginger Rhizome, White male wistar strain ABSTRAKRimpang Jahe putih (Zingiber officinale Rosc.var amarum ) mengandung metabolit sekunder seperti flavonoid juga terdapat beberapa senyawa seperti gingerol, shogaol, dan zingeron yang memberikan efek antiinflamasi, antioksidan, analgetik, antikarsinogenik dan kardiotonik. Penelitian ini bertujuan untuk mengetahui adanya efek analgetik dari ekstrak etanol rimpang jahe putih dengan dosis yang berbeda-beda yaitu Kelompok Perlakuan 1 dosis 0,006 g, kelompok Perlakuan 2 dosis 0,012 g dan Kelompok Perlakuan 3 dosis 0,024 g yang diuji pada tikus putih jantan galur wistar. Penelitian ini menggunakan rancangan penelitian eksperimental laboratorium dengan menggunakan tikus putih jantan sebagai hewan percobaan. Hasil penelitian menggunakan LSD menunjukkan adanya perbedaan antara kelompok kontrol negatif dengan kelompok kontrol positif, dan juga kelompok perlakuan dengan ekstrak dengan nilai signifikansi (0,014, 0,008, 0,012 dan 0,005) nilai tersebut <0,05 yang menandakan bahwa sesuai hipotesis yaitu menolak H0 dan menerima H1 yang berarti berbeda secara signifikan antara kelompok kontrol negatif dengan kontrol positif dan kelompok perlakuan dengan ekstrak,tapi tidak terdapat perbedaan antara kelompok kontrol positif dengan kelompok perlakuan dengan ekstrak yang berarti tidak memiliki perbedaan karena sama-sama memiliki efek analgetik. Dari hasil penelitian dapat disimpulkan bahwa ekstrak etanol rimpang jahe putih dengan dosis 0,006 g, 0,012 g dan 0,024 g memiliki efek analgetik pada tikus putih jantan galur wistar dapat dilihat dari menurunnya jumlah respon tikus (jilatan dan lompatan).Kata kunci : Analgetik, anova, rimpang Jahe putih, tikus Putih jantan galur wistar
UJI EFEK ANALGESIK EKSTRAK ETANOL DAUN KUCAI (Allium tuberosum) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) Turama, Dwilanda E.; Bodhi, Widdhi; Jayanto, Imam
PHARMACON Vol 9, No 3 (2020): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.9.2020.30026

Abstract

ABSTRACTKucai (Allium tuberosum) leaves contain metabolite compounds such as alkaloids, saponins, tannis which are potential sources to be developed as medical plants. Flavonoid is a derivative pf a phenol that has an analgesic properties. This study aims to determine whether there is an analgesic effect on the ethanol extract of kucai leaves. This study uses a laboratory experimental research design using wistar strain male white rats as an experiment animal. The ethanol extract of kucai leaves are given with different doses, group 1 doses 3,6 mg, group 2 doses 7,2 mg and group 3 doses 14,4 mg. Stimulation method in rats was carried out by using a 55°C hot plate. Rats was observed before and after giving test material at 30, 60, 90 and 120 minutes respectively and observed their responses by the form of licking legs and jumping. From the result of data in the form of tables and charts show that the ethanol extract of kucai leaves with doses 3,6 mg, 7,2 mg, and 14,4 mg has analgesic effect. It can be concluded that the best analgesic effect of doses is doses 14,4 mg.Keyword : Analgesic, kucai, male white ratsABSTRAK Daun Kucai (Allium tuberosum) memiliki kandungan senyawa metabolit seperti alkaloid, saponin, tanin, dan flavonoid yang merupakan sumber potensial untuk dikembangkan sebagai tanaman obat. Flavonoid merupakan turunan senyawa fenol yang memiliki sifat analgetik. Penelitian ini bertujuan untuk mengetahui adanya efek analgesik dari ekstrak etanol daun kucai. Penelitian ini menggunakan Rancangan Penelitian eksperimental laboratorium menggunakan tikus putih jantan galur wistar sebagai hewan percobaan. Ekstrak etanol daun kucai diberikan dengan dosis yang berbeda-beda yaitu kelompok perlakuan 1 dengan dosis 3,6 mg, perlakuan 2 dengan dosis 7,2 mg, perlakuan 3 dengan dosis 14,4 mg. Metode rangsangan pada tikus dilakukan dengan menggunakan hot plate dengan suhu 550C. Tikus di amati sebelum dan setelah pemberian bahan uji, menit ke 30, 60, 90, dan 120. Respon tikus yang diamati berupa menjilat kaki dan melompat. Dari hasil analisis data dalam bentuk tabel, grafik dan diagram menunjukkan bahwa ekstrak etanol daun kucai dengan dosis 3,6 mg, 7,2 mg, dan 14,4 mg memiliki efek analgesik. Dapat disimpulkan bahwa dosis yang memiliki efek analgesik terbaik ialah dosis 14,4 mg.Kata kunci: Analgesik, kucai, tikus putih jantan
UJI EFEK ANALGETIK EKSTRAK RUMPUT TEKI (CYPERUS ROTUNDUS L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (RATTUS NOVERGICUS) Pandey, Putri Virgie; Bodhi, Widdhi; Yudistira, Adithya
PHARMACON Vol 2, No 2 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.1579

Abstract

Pain is defined as a sensory and emotional experience that is not associated with tissuedamage. Nut grass (Cyperus rotundus L.) is traditionally used as a pain reliever. Theobjectives of this research were to find out analgesic effect of nut grass extract withconcentration 3,15 g/KgBB, 6,3 g/KgBB and 12,6 g/KgBB on white male wistar. The subjectin this research were 15 white male wistar which divided into 5 groups, each group consist of3 white male wistar. Negative control group were administered with aquadest, positivecontrol group were administered with paracetamol, and experiment groups were administeredwith nut grass extract. Analgesic test were examined by giving pain stimulation to treatedanimals, such as 65°C heat stimulation. The response which observed were rats licking feetor jumping response. The observation was conducted for 1 minute.Observations wereconducted before extract administration, then at 30, 60, 90 and 120 minutes afteradministered. The results shows thatnut grass extract with concentration 3,15 g/KgBB, 6,3g/KgBB and 12,6 g/KgBB possess analgesic effect on white male wistar, especiallyconcentration 6,3 g/KgBB.Keywords: analgesic, nut grass extract, pain
UJI EFEKTIVITAS EKSTRAK KULIT BUAH SALAK (Salacca zalacca (Gaertn.) Voss) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI SUKROSA Kanon, Muharli Qadri; Fatimawali, Fatimawali; Bodhi, Widdhi
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.486

Abstract

This study aimed at finding out the effectivity of Salacca (Salacca zalacca [Gaertn]Voss) rind extract on blood sugar decrease of white male wistar (Rattus norvegicus L.)induced with sucrose. Completely randomized design method was used in this experiment.The subject of the experiment were 15 white male wistar which were divided into 3 (three)groups namely negative control group, treatment group with the dose of 150 mg extract/kgbody weight, and positive control group using glibenclamide 0.45 mg/kg body weight. Dataobtained from the examination of the fasting blood sugar were 30 minutes after inductionwith sucrose and at minute 15, 30, 60, and 120 after treatment was given. The data isprocessed using ANOVA and LSD test to compare between the negative control group,treatment, and a positive control. The analysis revealed a significant difference betweennegative control and treatment, negative control and positive control, but did not show asignificant difference between treatment groups with the positive control. The conclusion ofthis study is Salacca rind extract has an effect on blood sugar levels decrease of white malewistar induced with sucrose.Keywords: Salacca zalacca (Gaertn.) Voss, Salacca rind extract, blood sugar level, sucrose
Pengaruh Jus Buah Apel Merah (Pyrus malus L.) Terhadap Kadar Kolesterol HDL (High Density Lipoprotein) Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Nelwan, Gabriel N; Wullur, Adeanne C; Bodhi, Widdhi
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.511

Abstract

The aims of this research were to study the effect of red apple juice (Pyrus malus L.)on Blood HDL cholesterol (High Density Lipoprotein) of white male mice strain wistar(Rattus norvegicus).This research using experimental method,and Pre and Post testRandomized Controlled Group Design. The subjects in these research were 25 mices, whichpossess 180-200g weight. Mices were divided into 5 groups, namely negative control(aquadest), positive control (Simvastatin) and Pyrus malus juice treatments concentration 2ml per day treatment (P1), 4 ml/day treatment (P2) and 8 ml/day treatment (P3). Every groupconsists of five mices.Treatment starts by feds mices with high content of lipids diet for tendays.At day eleven, all mices were analyzedits HDL cholesterol (pre-test).Thenall miceswere feds with high content of lipids diet and its treatment.After ten days of treatment, posttestwere conducted.Data were analyzed using spss ver.19. The differences betweentreatmentswere analyzed usingone way ANOVA. The results shows that 8 ml/day Pyrusmalus juice significantly increase HDL cholesterol of white male wistar(p<0,05). Pyrusmalus juice(P3)possess activity as simvastatin.Keywords: Pyrus malus L., Rattus norvegicus L., HDL cholesterol
UJI EFEK HEPATOPROTEKTOR EKSTRAK ETANOL DAUN BENALU LANGSAT (Dendrophthoe petandra (L.) Miq.) terhadap KADAR MALONDIALDEHID (MDA) pada HATI TIKUS PUTIH JANTAN GALUR WISTAR yang DIINDUKSI KARBON TETRAKLORIDA (CCl4) Tristanti, Irma; Fatimawali, Fatimawali; Bodhi, Widdhi
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2383

Abstract

ABSTRACTLeaves of Langsat parasite (Dendrophthoe petandra (L.) Miq.) contains flavonoids. Theobjective of this research was to examine hepatoprotector effect of leave extract from langsatparasite on white male rats induced with CCl4. Treatment was conducted for 8 days to 13 rats,which group I (P1) were administered with EDBL 35mg/KgBB,group II (P2) wereadministered with EDBL 70mg/KgBB,group III (K+) were administered withCurcuma81mg/KgBB orally. Group IV (K-) and V (KP) were administered with aquadestad libitum.At 8th day, all groups except (KP) were induced with CCl4 1mL/KgBB intraperitoneally.Eighteen hours after inducing time, all rats in every group were sacrafied to take its liver.Rats liver were analyzed using TBARS (Thiobarbituric Acid Reactive Subtance) method tocalculate MDA (Malondialdehid) level that were the end product of lipid peroxidation in ratsliver.MDA content of P1 were 2,715μM, P2 were 2,080μM, K+ were 1,708μM, and K- were3,413μM. Data analysis using SPSS ver.20 by One-Way ANOVA and Duncan Multiple RangeTest.Keywords : leave of Langsat parasite, hepatoprotector effect,CCl4, MDA
Co-Authors Aaltje E. Manampiring Aaltje Manampiring Adeanne C Wullur Adithya Yudistira Assa, Stevano M. Billy J. Kepel Billy Kepel Billy Senduk, Billy Brily Lombogia, Brily Budiarso, Fona Hermina Dwiana Budiarso, Fone D.H. Cheryl Kawatu Clara Pongantung Clementia Luigy Moot Datu, Olvie Syenni Debra Tiwow Deviwanti Batara, Deviwanti Edi, Hosea J. Edi, Hosea Jaya Eggy P. J. Ngantung, Eggy P. J. Ekawati Tallei, Trina Elly Suoth Fatimawali , Fatimawali Fatimawali . Felomina Jempormase, Felomina Fitria Angela Umar Fona Budiarso Gabriel N Nelwan Gabriela V.Ch Walewangko Gemi Nastiti Gerungan, Yizreel Y. Hasan, Puput Herawati Hasan, Puput Herawati Said Hosea Jaya Edy I Made Putra Suwertayasa Irma Tristanti Jayanto, Imam Jeane Mongi Julianri Sari Lebang, Julianri Sari Jusuf, Deva Dewanti Karen Tizia Mogi Kaunang, Christian Excelino Kaunang, Matthias D. Kepel, Billy Johnson Lady zha-zha Luntungan Lahamendu, Beatriks Lebang, Julianri S. Lengkong, Cheisy Anastasya Gratia Ley, Gabriella Therezia Ley Malino, Angeline Priscillia Manampiring, Aaltje Ellen Manopo, Chintia M. Marina Mamarimbing Mery A R Sinaga Mokalu, Frinsia Rutly Muharli Qadri Kanon Nainggolan, Ivana C. Ni Putu Ratna Sari Ningsi Hadji Ali Nofri P. Kurama Novel Kojong Olii, Ariesthya D. C. Olii, Ariesthya Dwi Cahyani Pangow, Sofia Paulina yamlean Pingkan, Aprilia Polii, Reiner C. Prasetio, Nathanael F. Putri Virgie Pandey Ratu, Belinda D. P. M. Rompas, Imanuela Zefanya Rompis, Tessalonicha J. Rumangu, Chrisa P. Siampa, Jainer Pasca Siringo-Ringo, Aurian Fricilia Sumakul, Gilbert Samuel Sumual, Priskila Feicy Sutanto, Stella Tamahiwu, Natasya Ester Rebeca Tulung, Grace Laury Turama, Dwilanda E. Turangan, Pricilia Dona Valentino Rakasiwi, Valentino Weny Wiyono Widjaya, Selin Yoas P. Simangunsong, Yoas P.