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All Journal e-GIGI Jurnal e-Biomedik PHARMACON JURNAL BIOMEDIK The Studies of Social Sciences Heca Journal of Applied Sciences Malacca Pharmaceutics Grimsa Journal of Science Engineering and Technology
Widdhi Bodhi
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Physics Social Sciences

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Journal : PHARMACON

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UJI EFEK ANTIPIRETIK INFUSA DAUN SESEWANUA (Clerodendron squamatum Vahl.) TERHADAP KELINCI JANTAN YANG DIINDUKSI VAKSIN DTP HB Moot, Clementia Luigy; Bodhi, Widdhi; Mongi, Jeane
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2379

Abstract

ABSTRACTSesewanua leaves (Clerodendron squamatum Vahl.) empirically used for an alternavite fevertreatment. The aims of this study was to investigate infuse of Sesewanua leaves hadantipyretic effectts for rabbits induced by vaccine DTP HB. This assay uses 15 rabbitsgrouped into 5 groups, the negative control (destilled water), the treatment (infuse ofSesewanua leaves 20%, 40% and 80%) and a positive (parasetamol). Rabbits induced pyrexiawith vaccine DTP HB doses 0,25ml/KgBB by intramuscular route. Rabbit’s rectaltemperature was measured every 1 hour until 4 hours after the oral administration. Thedecrease of rabbit’s rectal temperatur were analyzed by one way ANOVA and LSD test (α =0,05%). The result showed that infuse of Sesewanua in concentrates 20%, 40% and 80% hadantipyretics effect for rabbits induced by vaccine DTP HB.Keywords : Antipyretics effect test, Clerodendron squamatum Vahl., Vaccine DTP HB,rabbits
EFFECTS OF ETHANOL EXTRACT OF LEILEM LEAVES (Clerodendrum minahassae) ON BLOOD GLUCOSE LEVELS OF MALE WHITE RATS Lengkong, Cheisy Anastasya Gratia; Bodhi, Widdhi; Datu, Olvie Syenni; Fatimawali
PHARMACON Vol. 13 No. 2 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49750

Abstract

Diabetes mellitus is a global chronic disease with more than 500 million patientes. Leilem leaf is an endemic plant of North Sulawesi from the genus Clerodendrum which is believed potentially antidiabetic. The purpose of this study was to determine the effect of ethanol extract of leilem leaf on blood glucose levels and body weight of male white rats. The extraction of leilem leaves using maceration method with 96% ethanol solvent. This study used the pretest posttest control group design method with 5 groups, namely group I positive control of metformin, group II negative control of 0.5% Na-CMC, group III, IV, and V were extract doses of 100, 200, and 400 mg/kgBW. All groups were induced with 120 mg/kg BW of alloxan. The results showed that leilem leaf extract had a significant effect (Asymp. Sig. (2-tailed) 0.001) on rats blood glucose levels with the best percentage in group V extract dose of 400 mg/kgBW and had no significant effect on body weight.
ANTIDIABETIC ACTIVITY TEST OF ETHANOL EXTRACT OF YELLOW PUMPKIN LEAVES (Cucurbita moschata) ON MALE WHITE RATS (Rattus norvegicus) Tamahiwu, Natasya Ester Rebeca; Bodhi, Widdhi; Datu, Olvie Syenni; Fatimawali , Fatimawali
PHARMACON Vol. 13 No. 2 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.49751

Abstract

Pumpkin is a plant that contains many natural phenolic compounds, making it potential as an antioxidant, antidiabetic and antihyperglycemic. The aims of this study was to determine the antidiabetic activity of ethanol extract of pumpkin leaves on blood glucose levels and body weight on male white rats induced by alloxan at a dose of 120 mg/kgBW. The type of research used in this study was an experimental laboratory using the pre test and post test with control group design methods. Rats was divided into 5 groups, each group consisting of 3 rats. Group I as the positive control was given metformin, group II as the negative control was given 0,5% CMC Na, groups III, IV and V as the treatment group were given extract doses of 150 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. The results showed that the ethanol extract of pumpkin leaves had a significant effect on decreasing blood glucose levels of rats P(< 0,05) and had no significant effect on the body weight of rats P(> 0,05) and the dose of the extract was the best in reducing glucose levels blood of rats is a dose of 600 mg/kgBW
Test of Anti-inflammatory Effectiveness of Ethanol Extract of Green Betel Leaves (Piper betle L.) on White Rats (Rattus norvegicus) Induced with Formaldehyde Turangan, Pricilia Dona; Bodhi, Widdhi; Lebang, Julianri Sari
PHARMACON Vol. 13 No. 2 (2024): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.13.2024.55130

Abstract

Green betel leaves are known to contain tannin and flavonoid compounds which have the potential to provide anti-inflammatory effects. This study aims to determine the effect of ethanol extract of green betel leaves with several variations as an anti-inflammatory on edema of white rat’s paw induced by 1% formaldehyde given intraplantarly. Animals that had been induced by formaldehyde were given ethanol extract of green betel leaves after 30 minute,then the diameter of the rat's paw edema was measured using a caliper. The results showed that the negative control experienced an increase in the percentage of inflammation by 77.87% which was significantly different from the positive control, while the extract test group with doses of 25 mg/200gBW, 30 mg/200gBW, and 40 mg/200gBW could provide a decrease in the percentage value of inflammation respectively. - respectively 34.07%, 21.76%, and 4.80% and all three were not significantly different from the positive control (Asymptotic significance≥0.05). Based on research results, ethanol extract of green betel leaves can provide anti-inflammatory effects at a dose of 40 mg/200gBW as the best dose in reducing the diameter of rat paw edema.
Co-Authors Aaltje E. Manampiring Aaltje Manampiring Adeanne C Wullur Adithya Yudistira Assa, Stevano M. Billy J. Kepel Billy Kepel Billy Senduk, Billy Brily Lombogia, Brily Budiarso, Fona Hermina Dwiana Budiarso, Fone D.H. Cheryl Kawatu Clara Pongantung Clementia Luigy Moot Datu, Olvie Syenni Debra Tiwow Deviwanti Batara, Deviwanti Edi, Hosea J. Edi, Hosea Jaya Eggy P. J. Ngantung, Eggy P. J. Ekawati Tallei, Trina Elly Suoth Fatimawali , Fatimawali Fatimawali . Felomina Jempormase, Felomina Fitria Angela Umar Fona Budiarso Gabriel N Nelwan Gabriela V.Ch Walewangko Gemi Nastiti Gerungan, Yizreel Y. Hasan, Puput Herawati Hasan, Puput Herawati Said Hosea Jaya Edy I Made Putra Suwertayasa Irma Tristanti Jayanto, Imam Jeane Mongi Julianri Sari Lebang, Julianri Sari Jusuf, Deva Dewanti Karen Tizia Mogi Kaunang, Christian Excelino Kaunang, Matthias D. Kepel, Billy Johnson Lady zha-zha Luntungan Lahamendu, Beatriks Lebang, Julianri S. Lengkong, Cheisy Anastasya Gratia Ley, Gabriella Therezia Ley Malino, Angeline Priscillia Manampiring, Aaltje Ellen Manopo, Chintia M. Marina Mamarimbing Mery A R Sinaga Mokalu, Frinsia Rutly Muharli Qadri Kanon Nainggolan, Ivana C. Ni Putu Ratna Sari Ningsi Hadji Ali Nofri P. Kurama Novel Kojong Olii, Ariesthya D. C. Olii, Ariesthya Dwi Cahyani Pangow, Sofia Paulina yamlean Pingkan, Aprilia Polii, Reiner C. Prasetio, Nathanael F. Putri Virgie Pandey Ratu, Belinda D. P. M. Rompas, Imanuela Zefanya Rompis, Tessalonicha J. Rumangu, Chrisa P. Siampa, Jainer Pasca Siringo-Ringo, Aurian Fricilia Sumakul, Gilbert Samuel Sumual, Priskila Feicy Sutanto, Stella Tamahiwu, Natasya Ester Rebeca Tulung, Grace Laury Turama, Dwilanda E. Turangan, Pricilia Dona Valentino Rakasiwi, Valentino Weny Wiyono Widjaya, Selin Yoas P. Simangunsong, Yoas P.