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Fona Budiarso
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary

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Evaluating the Efficacy of Clerodendrum minahassae Ethanol Extract on Insulin Regulation in Diabetic Wistar Rats Rumangu, Chrisa P.; Fatimawali, Fatimawali; Manampiring, Aaltje Ellen; Kepel, Billy Johnson; Budiarso, Fona Dwiana Hermina; Bodhi, Widdhi
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.137

Abstract

Leilem plant (Clerodendrum minahassae Teisjm & Binn.) from the genus Clerodendrum has the potential as antidiabetic, antihypertensive, anti-inflammatory, antioxidant, antimalarial, antitumor, antidiarrheal, antimicrobial and antihyperlipidemic. This study aimed to see the effect of ethanol extract of Clerodendrum minahassae (CM) leaves on increasing insulin levels in diabetic Wistar rats induced with streptozotocin. This study was conducted in vivo, using 20 rats as experimental animals. The experimental animals were divided into four groups, namely the negative control group (Na-CMC 0.5%), the ethanol extract group of leilem leaves 250 mg and 500 mg, and the positive control group (glibenclamide) as a comparison. Each experimental animal was induced streptozotocin intraperitoneally; then, each solution was given for 14 days according to the test group. After the treatment, the animals were terminated for blood collection; the blood was then centrifuged to obtain blood plasma serum. Blood plasma serum was measured by the ELISA Kit (Rat/Mouse Insulin) method, and then the results were read on a spectrophotometric device. The results of the sample insulin concentration obtained showed that 250 mg/kgBW and 500 mg/kgBW of the CM ethanol extract group could increase insulin levels in diabetic Wistar rats, the same as the positive control group glibenclamide. In contrast, the Na-CMC 0.5% as a negative control group did not show a significant increase in insulin levels. Leilem leaves can be developed for further research on their antidiabetic activity both in vitro, in vivo, and in silico, as well as their toxicity.
Characterization of Thelenota ananas and Its Potential as a Natural Source of Antioxidants Budiarso, Fona; Sorisi, Angle; Fatimawali, Fatimawali
JURNAL BIOS LOGOS Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v16i1.63976

Abstract

The sea cucumber Thelenota ananas, commonly found in tropical waters, possesses significant biological potential. This study aims to assess the antioxidant potential of Thelenota ananas extract obtained from the Manado sea. The simplicia was analyzed for organoleptic properties, moisture content (9.8%), and ash content (23%). Bioactive compounds were identified through color and foam reactions, while antioxidant activity was measured using the DPPH method. The extract was found to contain saponins, terpenoids, and alkaloids. The antioxidant activity of the extract, with an IC50 value of 99.8 ppm, demonstrates strong antioxidant properties, though less potent than the control, vitamin C (IC50 of 45.5 ppm). These findings suggest that while Thelenota ananas extract exhibits substantial antioxidant activity, it is still less effective than vitamin C. This research highlights the potential of Thelenota ananas as a natural antioxidant source for the development of health products.
From Knowledge to Practice: Strengthening Handwashing with Soap Behaviors among Elementary School Students Through an Interactive School-Based Health Promotion Program in Indonesia Ottay, Ronald Imanuel; Budiarso, Fona Dwiana Hermina; Sumampouw, Oksfriani Jufri; Nelwan, Jeini Ester; Sumampouw, Jeanneprita Jeksi Yesinta Endarini; Sumampouw, Jeannedria Jeisi Yuniar Eleanor
Komunitas: Hasil Kegiatan Pengabdian Masyarakat Indonesia Vol. 4 No. 1 (2026): Februari : Komunitas : Hasil Kegiatan Pengabdian Masyarakat Indonesia
Publisher : Asosiasi Riset Ilmu Tanaman Dan Hewani Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/komunitas.v4i1.378

Abstract

This community service program aimed to improve students’ knowledge and practical skills regarding proper HWWS at SDN 107 Manado. The program was conducted on September 9, 2025, using a group-based health education approach. Educational activities included interactive lectures, audiovisual media, posters, educational songs, demonstrations, and supervised practice of the six-step handwashing technique recommended by the World Health Organization (WHO). Program evaluation was conducted through observation, interactive questioning, and pretest–posttest assessment of students’ knowledge. Initial observations indicated that many students had limited understanding of the importance of HWWS and were unable to correctly perform the recommended handwashing procedures. Following the intervention, most participants demonstrated improved knowledge and were able to correctly perform the six-step handwashing technique. Students also showed high enthusiasm during practical sessions and actively participated in the learning process. In conclusion, the program effectively enhanced students’ knowledge and handwashing skills, highlighting the importance of interactive school-based health education in promoting healthy behaviors and preventing communicable diseases among elementary school students.
Co-Authors . Fatimawali Aaltje E. Manampiring Aaltje E. Manampiring Aaltje Ellen Manampiring Aaltje Manampiring Aaltje Manampiring Aaltje Manampiring Andrew Pangemanan, Andrew Angelique C. M. Tanan Angle Sorisi Bella Lestari, Bella Billy J. Kepel Billy J. Kepel Billy Johnson Kepel Billy Kepel Billy Kepel Bodhi , Widdhi Brily Lombogia, Brily Christine Hendra, Christine Devianitta Sarapi Dos D. L. E. Br Siagian Ekawati Tallei, Trina Fatimawali . Fatimawali Fatimawali Gemi Nastiti Gerungan, Yizreel Y. Inggrid V. Gandu Kepel, Billy Johnson Kepel, Regina E.M. Krispela Trifosa Oktavia Siregar Lisa Kepel Lumanto, Priscilla R. Malino, Angeline Priscillia Manampiring, Aaltje Ellen Mokoginta, Farah S. Nelwan, Ester Jeini Novi Budiarso Pangow, Sofia Paukiran, Degol Paulina yamlean Paulina Yamlean Prasetio, Nathanael F. Rahmad Dian Ratu, Belinda D. P. M. Rianna J Sumampouw Rimporok, Aprilia Rompis, Tessalonicha J. Ronald I. Ottay Ronald Imanuel Ottay Rumangu, Chrisa P. Sensea R. Rambitan Sompie, Intan P.R. Sumampouw, Jeannedria Jeisi Yuniar Eleanor Sumampouw, Jeanneprita Jeksi Yesinta Endarini Tiara C. Pradani Trina Tallei Widdhi Bodhi Widdhi Bodhi Widdhi Bodhi widdhi Bodhi Winston Pontoh