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Fona Budiarso
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Evaluating the Efficacy of Clerodendrum minahassae Ethanol Extract on Insulin Regulation in Diabetic Wistar Rats Rumangu, Chrisa P.; Fatimawali, Fatimawali; Manampiring, Aaltje Ellen; Kepel, Billy Johnson; Budiarso, Fona Dwiana Hermina; Bodhi, Widdhi
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.137

Abstract

Leilem plant (Clerodendrum minahassae Teisjm & Binn.) from the genus Clerodendrum has the potential as antidiabetic, antihypertensive, anti-inflammatory, antioxidant, antimalarial, antitumor, antidiarrheal, antimicrobial and antihyperlipidemic. This study aimed to see the effect of ethanol extract of Clerodendrum minahassae (CM) leaves on increasing insulin levels in diabetic Wistar rats induced with streptozotocin. This study was conducted in vivo, using 20 rats as experimental animals. The experimental animals were divided into four groups, namely the negative control group (Na-CMC 0.5%), the ethanol extract group of leilem leaves 250 mg and 500 mg, and the positive control group (glibenclamide) as a comparison. Each experimental animal was induced streptozotocin intraperitoneally; then, each solution was given for 14 days according to the test group. After the treatment, the animals were terminated for blood collection; the blood was then centrifuged to obtain blood plasma serum. Blood plasma serum was measured by the ELISA Kit (Rat/Mouse Insulin) method, and then the results were read on a spectrophotometric device. The results of the sample insulin concentration obtained showed that 250 mg/kgBW and 500 mg/kgBW of the CM ethanol extract group could increase insulin levels in diabetic Wistar rats, the same as the positive control group glibenclamide. In contrast, the Na-CMC 0.5% as a negative control group did not show a significant increase in insulin levels. Leilem leaves can be developed for further research on their antidiabetic activity both in vitro, in vivo, and in silico, as well as their toxicity.
Antioxidant Potential of Yellow Chrysanthemum (Chrysanthemum indicum) Leaves: In Vitro Analysis Using DPPH and FRAP Techniques Ley, Gabriella Therezia Ley; Kepel, Billy Johnson; Fatimawali, Fatimawali; Manampiring, Aaltje Ellen; Budiarso, Fona Dwiana Hermina; Bodhi, Widdhi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 2 (2025): October 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i2.68

Abstract

The shift from infectious diseases to non-communicable diseases (NCDs), driven by aging and unhealthy lifestyles, has led to an increase in degenerative diseases. The World Health Organization (WHO) reported that NCDs account for 74% of global deaths. An imbalance between free radicals and antioxidants contributes to the progression of these diseases, highlighting the need for research on plant-derived antioxidants. Secondary metabolites, particularly phenolic and flavonoid compounds, are abundant in Chrysanthemum indicum and are known for their potential antioxidant properties. This study aims to identify the secondary metabolites and evaluate the antioxidant activity of yellow chrysanthemum (Chrysanthemum indicum) leaves using two methods: Ferric Reducing Antioxidant Power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The extraction process was performed using the reflux method with 96% ethanol as the solvent. Antioxidant activity was assessed using the DPPH and FRAP methods, with absorbance measurements conducted via UV-Vis spectrophotometry. Phytochemical screening revealed the presence of phenols, flavonoids, tannins, steroids/triterpenoids, and alkaloids in the ethanol extract of yellow chrysanthemum leaves. The antioxidant activity assay using the DPPH method indicated a value of 64.34 ppm, signifying strong antioxidant activity. In contrast, the FRAP method showed weak antioxidant activity, with an IC50 value of 187.13 ppm.
Characterization of Thelenota ananas and Its Potential as a Natural Source of Antioxidants Budiarso, Fona; Sorisi, Angle; Fatimawali, Fatimawali
JURNAL BIOS LOGOS Vol. 16 No. 1 (2026): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v16i1.63976

Abstract

The sea cucumber Thelenota ananas, commonly found in tropical waters, possesses significant biological potential. This study aims to assess the antioxidant potential of Thelenota ananas extract obtained from the Manado sea. The simplicia was analyzed for organoleptic properties, moisture content (9.8%), and ash content (23%). Bioactive compounds were identified through color and foam reactions, while antioxidant activity was measured using the DPPH method. The extract was found to contain saponins, terpenoids, and alkaloids. The antioxidant activity of the extract, with an IC50 value of 99.8 ppm, demonstrates strong antioxidant properties, though less potent than the control, vitamin C (IC50 of 45.5 ppm). These findings suggest that while Thelenota ananas extract exhibits substantial antioxidant activity, it is still less effective than vitamin C. This research highlights the potential of Thelenota ananas as a natural antioxidant source for the development of health products.
Co-Authors . Fatimawali Aaltje E. Manampiring Aaltje E. Manampiring Aaltje Ellen Manampiring Aaltje Manampiring Aaltje Manampiring Aaltje Manampiring Andrew Pangemanan, Andrew Angelique C. M. Tanan Angle Sorisi Bella Lestari, Bella Billy J. Kepel Billy J. Kepel Billy Johnson Kepel Billy Kepel Billy Kepel Bodhi , Widdhi Brily Lombogia, Brily Christine Hendra, Christine Devianitta Sarapi Dos D. L. E. Br Siagian Ekawati Tallei, Trina Fatimawali . Fatimawali Fatimawali Gemi Nastiti Gerungan, Yizreel Y. Inggrid V. Gandu Kepel, Billy Johnson Kepel, Regina E.M. Krispela Trifosa Oktavia Siregar Ley, Gabriella Therezia Ley Lisa Kepel Lumanto, Priscilla R. Malino, Angeline Priscillia Manampiring, Aaltje Ellen Mokoginta, Farah S. Novi Budiarso Pangow, Sofia Paukiran, Degol Paulina yamlean Paulina Yamlean Prasetio, Nathanael F. Rahmad Dian Ratu, Belinda D. P. M. Rimporok, Aprilia Rompis, Tessalonicha J. Ronald I. Ottay Ronald Imanuel Ottay Rumangu, Chrisa P. Sensea R. Rambitan Sompie, Intan P.R. Tiara C. Pradani Trina Tallei Widdhi Bodhi Widdhi Bodhi Widdhi Bodhi widdhi Bodhi Winston Pontoh