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Assessment of Knowledge, Perception, and Attitude of Health Cadres Toward Zoonotic Diseases in Rural Area, Malang Regency Milanitalia Gadys Rosandy; Didi Candradikusuma; Dewi Indiastari; Niniek Budiarti; Heri Sutanto; Sinta Silvia
Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Vol. 13 No. SI1 (2025): Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Educat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpk.V13.ISI1.2025.27-38

Background: Zoonotic diseases are infections transmitted between animals and humans. Human life is closely intertwined with animals, as many people live alongside animals, consume animal meat, and so forth, which increases their exposure to zoonotic infections. Objectives: This study aims to assess the level of knowledge, perception, and attitude of health cadres toward zoonotic diseases in rural area of Malang Regency. Methods: This study used a cross-sectional approach with a sample size of 108 selected using simple random sampling in rural area of Malang Regency. Data were collected through a questionnaire, including respondent characteristics as well as predisposing, knowledge, perception, and attitude factors for zoonotic diseases. Data were analyzed using a chi-square test for bivariate analysis and a logistic regression test for multivariate analysis. Results: The average age of respondents was 48.1±14,3 years the majority graduating from elementary school (47.2%) and working as farmers (63.9%). The average knowledge score on zoonotic diseases was 8.0 ± 3.9, with 63.9% of respondents scoring below average. The average perception score was 13.4 ± 1.8, with 44.4% of respondents scoring below average. Additionally, 63.9% of respondents had below-average attitude scores (17.3±2,2). The level of education and occupation had a significant relationship with the level of knowledge, perception, and attitude of respondents. Conclusions: The results indicate that the knowledge, perceptions, and attitudes of respondents toward zoonotic diseases are still insufficient. There is a need for enhanced education in this disease to improve public understanding and facilitate early detection.

Exploring a rare oncologic complication: alveolar rhabdomyosarcoma in HIV patient Santoso, Dimas; Santoso, Budi; Kristyana, Septian; Candradikusuma, Didi; Natasia, Septalisa; Evatta, Arde
Deka in Medicine Vol. 1 No. 2 (2024): August 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2024.e277

BACKGROUND: Alveolar rhabdomyosarcoma is one of the rare oncological complications in Human Immunodeficiency Virus (HIV) patients, but it has a serious impact. Therefore, case report study discussing case of alveolar rhabdomyosarcoma in HIV patient is very important. CASE: A 22-year-old man complained of pain and a growing lump behind his right knee for 9 months. The lump, initially small, became larger and more painful, affecting his ability to move his leg. The patient was diagnosed with HIV 3 years ago and also had leprosy. Additionally, the patient had a history of weight loss and a low body mass index (BMI). Physical examination revealed a 10x15x10 cm mass behind the right knee. Magnetic Resonance Imaging (MRI) of the right knee showed a complex cystic solid lesion involving several muscles and blood vessels. Fine Needle Aspiration Biopsy (FNAB) suggested a High-Grade Sarcoma. Open biopsy confirmed alveolar rhabdomyosarcoma with aggressive features and high mitotic activity. CONCLUSION: In conclusion, our study reported the first case of alveolar rhabdomyosarcoma in an HIV patient. Our study emphasizes the importance of thorough diagnosis for suspected malignancies in HIV patients.

Diagnosis dan Manajemen Obstruksi Jalan Napas Atas (Jackson 1) Akibat Infeksi Difteri pada Wanita Hamil Dwikarlina, Intan; Wijaya, Rendy; Yulia Rusmayanti, Mega; Antariksa, Genta; Candradikusuma, Didi
Jurnal Klinik dan Riset Kesehatan Vol 4 No 2 (2025): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.2.9

Diphtheria is an infectious disease caused by Corynebacterium diphtheria, which generally causes inflammation of the airways, leading to severe symptoms that can be life-threatening. Indonesia is listed as one of the ten countries with the highest cases of diphtheria worldwide. However, studies on cases of diphtheria infection, especially in the pregnant women population, have rarely been reported. A 28-year-old woman presented with shortness of breath. Complaints accompanied by difficulty swallowing and speaking. The patient had a child who died due to similar symptoms. Signs of airway obstruction are found as inspiratory stridor and suprasternal retraction, pseudomembranes in the pharynx, and subcutaneous crepitation in the colli. Diphtheria infection was confirmed through a throat swab examination with Neisser staining and culture. In addition to isolation, the patients were administered oxygen therapy, anti-diphtheria toxin, penicillin procaine, dexamethasone, and additional supportive therapy. Diphtheria infection is transmitted through direct contact, droplets or contaminated items. Manifestations of laryngeal diphtheria generally come from the extension of tonsillar-pharyngeal diphtheria symptoms, including sore throat, hoarseness, and advanced respiratory obstruction. A definite diagnosis is made by isolating the bacteria or finding an increase in serum antibodies. Therapies targeting infectious conditions and supporting obstetrics help improve the overall patient condition. Diphtheria is a highly contagious and potentially fatal disease, especially for pregnant women; thus, immediate diagnosis is needed. Isolation and appropriate management alleviate upper airway obstruction. Diphtheria management should include both curative therapy and preventive to protect the community further and prevent outbreaks from emerging.

Association of Antiretroviral Regimens and CD4 Counts with Dyslipidemia in HIV Patients: Implications for Metabolic Management Rosandy, Milanitalia Gadys; Candradikusuma, Didi; Yudha, Nyoman Satvika Dharma
Indonesian Journal of Medicine Vol. 10 No. 1 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.1.797

Background: Dyslipidemia, a key risk factor for cardiovascular disease, is prevalent among people living with HIV/AIDS receiving antiretroviral therapy. This study aims to evaluate the impact of different ART regimens on lipid profiles in HIV patients and identify regimens with better outcomes in lipid profile levels. Subjects and Method: An observational study was conducted from June to August 2024 at Dr. Saiful Anwar Regional General Hospital, Malang, Indonesia. Participants were recruited using consecutive random sampling, including HIV patients on ART for at least three months. Independent variables included ART regimens and CD4 counts, while the dependent variable was dyslipidemia status. Data were collected via demographic forms, medical record reviews, and lipid profile analysis. Statistical analysis was performed using chi-square and t-tests, with significance set at p < 0.05. Results: Of the 110 participants, 38.2% were identified with dyslipidemia. The highest dyslipidemia rates were observed in patients using the Duviral Alluvial regimen (80.0%), followed by Duviral Neviral (71.4%). Newer regimens, TLD and TLE, were associated with lower dyslipidemia rates (31.3% and 36.0%, respectively; p = 0.045). A significant association was also noted between dyslipidemia and CD4 counts, with dyslipidemic patients showing higher mean CD4 counts (560.29 cells/μL) compared to non-dyslipidemic individuals (378.40 cells/μL; p = 0.009). Conclusion: Newer ART regimens such as TLD and TLE are associated with better lipid profile outcomes and lower dyslipidemia risk compared to older regimens. Higher CD4 counts may reflect an increased risk of lipid abnormalities, emphasizing the need for lipid monitoring and regimen optimization in HIV care.

Association Between Personal Hygiene Practices and Peripheral Blood Profiles in Agrarian Workers: An Analysis with Socio-demographic and Helminthiasis Considerations Indiastari, Dewi; Didi Candradikusuma; Milanitalia Gadys Rosandy; Niniek Budiarti; Heri Sutanto; Sinta Silvia
The Indonesian Journal of Occupational Safety and Health Vol. 14 No. 2 (2025): The Indonesian Journal of Occupational Safety and Health
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijosh.v14i2.2025.164-179

Introduction: Helminthiasis remains a significant public health issue in Indonesia, negatively impacting nutrition and cognitive development, particularly among individuals who are in direct contact with soil. To mitigate this issue, improving personal hygiene and awareness of infection prevention is essential. This study aims to examine the correlation between sociodemographic factors and personal hygiene with blood profiles among workers in agrarian areas. Methods: A cross-sectional approach was used, with 144 samples collected through purposive sampling in the agrarian area of Malang Regency. Data were gathered using questionnaires covering sociodemographic factors and personal hygiene, as well as through hematology tests results obtained from blood samples taken from respondents, which were tested at the dr. Saiful Anwar Malang General Hospital. For data analysis, the Chi-square test was utilized for bivariate analysis, while logistic regression was employed for multivariate analysis. Results: The mean age of respondents was 48.1 ± 14.1 years, with a majority having attained only an elementary education (51.4%) and primarily working as farmers (66.7%). Approximately 38.2% of respondents demonstrated poor personal hygiene. Significant associations were found between personal hygiene and hemoglobin levels (p=0.031), as well as eosinophil counts (p=0.007). Multivariate analysis showed that respondents who did not wash their hands before eating had 1.8 times higher odds of having abnormal blood profiles compared to those who practiced handwashing. Conclusion: The results of this study suggest that sociodemographic factors and personal hygiene are associated with the quality of blood profile among respondents. Enhanced education is needed to raise community awareness regarding personal hygiene.

Diagnosis dan Manajemen Obstruksi Jalan Napas Atas (Jackson 1) Akibat Infeksi Difteri pada Wanita Hamil Dwikarlina, Intan; Wijaya, Rendy; Yulia Rusmayanti, Mega; Antariksa, Genta; Candradikusuma, Didi
Jurnal Klinik dan Riset Kesehatan Vol 4 No 2 (2025): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.2.9

Diphtheria is an infectious disease caused by Corynebacterium diphtheria, which generally causes inflammation of the airways, leading to severe symptoms that can be life-threatening. Indonesia is listed as one of the ten countries with the highest cases of diphtheria worldwide. However, studies on cases of diphtheria infection, especially in the pregnant women population, have rarely been reported. A 28-year-old woman presented with shortness of breath. Complaints accompanied by difficulty swallowing and speaking. The patient had a child who died due to similar symptoms. Signs of airway obstruction are found as inspiratory stridor and suprasternal retraction, pseudomembranes in the pharynx, and subcutaneous crepitation in the colli. Diphtheria infection was confirmed through a throat swab examination with Neisser staining and culture. In addition to isolation, the patients were administered oxygen therapy, anti-diphtheria toxin, penicillin procaine, dexamethasone, and additional supportive therapy. Diphtheria infection is transmitted through direct contact, droplets or contaminated items. Manifestations of laryngeal diphtheria generally come from the extension of tonsillar-pharyngeal diphtheria symptoms, including sore throat, hoarseness, and advanced respiratory obstruction. A definite diagnosis is made by isolating the bacteria or finding an increase in serum antibodies. Therapies targeting infectious conditions and supporting obstetrics help improve the overall patient condition. Diphtheria is a highly contagious and potentially fatal disease, especially for pregnant women; thus, immediate diagnosis is needed. Isolation and appropriate management alleviate upper airway obstruction. Diphtheria management should include both curative therapy and preventive to protect the community further and prevent outbreaks from emerging.

The Role of Plasma Osmolarity in the Mortality of Patients with Covid-19 Indiastari, Dewi; Candradikusuma, Didi; Sutanto, Heri; Budiarti, Niniek; Samsu, Nur
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.12

Covid-19 (Coronavirus disease 2019) is a new infectious disease that attacks the respiratory tract and is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), causing multiorgan failure, often requiring temporary support such as the use of a ventilator or hemodialysis equipment. This condition is related to an imbalance in fluid distribution associated with changes in osmolarity or hyperosmolarity. This research aims to explain the role of plasma osmolarity in Covid-19 patients at dr. Saiful Anwar Hospital, Malang, in patient outcomes, especially death outcomes. The sample for this study was 205 medical records of Covid-19 patients, recorded from September 2021 to May 2022. This study used a retrospective cohort design to describe plasma osmolarity in Covid-19 patients and the outcome of hospitalized patients. There were 205 patient data obtained, with 85 patients dying aged <65 years. Sixty-eight patients of Covid-19 with comorbidities (DM, HT, AKI, CKD, combination) died. There was no difference in plasma osmolarity for living and deceased patients. Repeated plasma osmolarity (retest) had a good degree of accuracy in predicting the outcome of Covid-19 patients, where sensitivity was 71.3% and specificity was 73.4% at a cut-off value of 277.32mOsm/L. The repeat plasma osmolarity value of ≥277.32 had a PPV value of 75%, while plasma osmolarity <277.32 had an NPV value of 69.3%. The OR value was 6.77, meaning that Covid-19 patients with repeated plasma osmolarity levels ≥277.32 would have 6.77 times the risk of mortality compared to Covid-19 patients with repeated plasma osmolarity levels <277.32.

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