Article Per Year (5 Year)
p-Index From 2021 - 2026
1.325
P-Index
This Author published in this journals
All Journal Jurnal Pendidikan dan Pembelajaran Khatulistiwa (JPPK) JIMFE (Jurnal Ilmiah Manajemen Fakultas Ekonomi) Science Midwifery Cita Ekonomika: Jurnal Ilmu Ekonomi Jurnal Info Sains : Informatika dan Sains COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Pharmaceutical Sciences and Research (PSR) Riset Sains dan Teknologi Kelautan Journal of Natural Product for Degenerative Diseases Berita Biologi
Chaidir Chaidir
Universitas Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
Ethnopharmacological study on traditional medicinal plants of the anak dalam tribe in Bukit Dua Belas, Jambi Province as a treatment for diarrhea and antibacterial test Yolandari, Febby Ola; Djamil, Ratna; Chaidir, Chaidir
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1954

Abstract

The Anak Dalam Tribe or Orang Rimba is one of the tribes that live on the island of Sumatra, precisely located in Jambi Province. The Anak Dalam Tribe utilizes plants as a necessity in their lives, one of the benefits of plants used by the Anak Dalam Tribe community as a cure for a disease. This study aims to examine the potential of plants as a cure for diarrhea in the Anak Dalam Tribe, Bukit Dua Belas. This type of research is descriptive research with qualitative methods and snowball sampling techniques through open-ended interviews with 5 informants as Temenggung or tribal chiefs, and 1 informant who is a shaman using interview guidelines. Based on the results of the interview, 14 types of single plants and 4 types of plants in the form of potions were obtained which were used as diarrhea medicine. The plant organs that are utilized include roots, leaves, sap, mushrooms, tubers. The processing method is boiled, squeezed, burned, grated. While its use is by eating, drinking and, sticking to the part of the body that is sick. In the treatment process in the Anak Dalam Tribe, Bukit Dua Belas still uses spiritual methods by relying on the help of Dewo or supernatural powers. In the bacterial inhibition test, the average clear zone results were wider than the others in the test with 96% ethanol extract with Escherichia coli bacteria, the widest clear zone was found in the Lelisau plant at 14.1 mm, in Staphylococcus aureus bacteria, the widest clear zone was in the Mempalas plant at 10.7 mm so that it was included in the strong category. Testing the diameter of the inhibition power using water extract tested with Escherichia coli bacteria, the widest clear zone was found in the Lelisau leaves at 12.35 mm, in Staphylococcus aureus bacteria, the widest clear zone was in the Water Apple plant at 10.6 mm so that it was included in the strong category.
Gel Formulation from a Combination of Sidaguri Leaf Extract (Sida rhombofolia L.) and Chinese Petai Leaves (Leucaena leucocephala L) as Inhibitors of Acne-causing Bacteria (Propionibacterium acne and Staphylococcus aureus) Andriana, Andriana; Chaidir, Chaidir; Rahmat, Deni
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.4619

Abstract

Acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit, is the most common skin condition. Propionibacterium acnes and Staphylococcus aureus are two bacteria that can cause infections. Chinese Petai leaves are known to inhibit acne growth. Sidaguri leaves are also thought to have antibacterial activity. The aims of this study were to determine the effect of the combination of the two extracts on inhibiting the growth of acne-causing bacteria, also to test the gel formula to meet physical and chemical parameters as well as stability to temperature and storage, as well as to test acute dermal. irritation to rabbits. Each extract with a concentration of 0.19%; 0.39%; 0.78%; 1.56%; 3.125%; 6.25%; 12.5%; 25%; 50% were incubated and then the inhibition zone was measured, then the minimum inhibition zone concentration of the two extracts was determined to determine the lowest concentration of the extract that still provided antibacterial activity against the tested bacteria using the well-diffusion method. The extract combination is formulated in a gel preparation with Carbopol 940, Propylene glycol, Phenoxyethanol, TEA, and Aquadest as excipients. Test the antibacterial activity of gel preparations using the well method with positive control clindamycin gel. Then evaluation of the formula includes evaluation of physics, chemistry, and microbiology. The results showed that the combination gel had activity against P. acne and Staphylococcus aureus at a concentration of 3.12% : 1.56%. The combined gel preparation of the two extracts also has a synergistic effect in inhibiting acne bacteria. The formula is resistant to temperature and storage, and it can satisfy chemical and physical parameters.
Evaluasi Penghambatan Enzim ?-Glukosidase Secara Invitro Dari 5 Ekstrak Spesies Syzygium Serta Pengaruh Perbedaan Konsentrasi Pelarut Ulfa, Dina Amalia; Adnan, Adek Zamrud; Basuki, Witono; Chaidir, Chaidir; Lotulung, Puspa Dewi N; Minarti, Minarti
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 7 (2024): COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v4i7.2710

Abstract

Spesies Syzygium merupakan genus dengan jumlah spesies yang sangat banyak dan keanekaragaman yang tinggi. Genus ini banyak ditemukan di daerah tropis karena kesesuaiannya dengan iklim tropis. Lima spesies Syzygium yaitu daun salam (Syzygium polyanthurn), daun jambu air (Syzygium aqueum), daun jambu biji (Syzygium malaccense), daun jambu biji (Syzygium guazava), dan daun pucuk merah (Syzygium campanulatum Korth.) telah digunakan dalam pengobatan tradisional karena kandungan polifenolnya. Penelitian ini bertujuan untuk menghasilkan ekstrak paling efektif dari beberapa spesies Syzygium sp. dengan perbandingan komposisi etanol-air, sebagai obat herbal antidiabetik melalui penghambatan enzim alfa-glikosidase. Kelima spesies Syzygium diekstraksi menggunakan metode maserasi dengan pelarut 96% dengan rendemen rata-rata 30%. Ekstrak kental lima spesies Syzygium diuji antioksidannya dengan nilai rata-rata IC-50 pada Ekstrak Daun Pucuk Merah tercatat sebesar 14,7. Nilai rata-rata IC-50 Ekstrak Daun Salam tercatat sebesar 8,46, Nilai rata-rata IC-50 Ekstrak Daun Jambu Biji Bol sebesar 9,42, Nilai rata-rata IC-50 Ekstrak Daun Jambu Biji yang dihitung dari ketiga pengukuran tersebut adalah 10,51. Nilai rata-rata IC-50 ekstrak daun jambu biji yang dihitung dari ketiga pengukuran tersebut adalah 9,88. Aktivitas penghambatan enzim a-glukosidase daun jambu biji pekat 96% diuji pada berbagai konsentrasi dan diperoleh hasil yang signifikan. Pada konsentrasi 50 ppm, % penghambatan yang diamati sebesar 97,74 dengan nilai IC-50 sebesar 6,42, yang menunjukkan bahwa kemampuan penghambatan terhadap enzim tersebut sangat tinggi. Ketika konsentrasi diturunkan menjadi 25 ppm, % penghambatan yang diamati adalah 89,35, menunjukkan penurunan potensi, meskipun penghambatan tetap signifikan.
EFFECT OF STORAGE TIME VARIATION OF ANDALIMAN FRUIT ON FREE RADICAL SCAVENGING AND PROLIFERATION INHIBITION ON MCF-7 CELLS Rosidah, Idah; Kusumastuti, Siska Andrina; Simanungkalit, Grace Sophiwati; Rahayu, Maya Damayanti; Nuralih, Nuralih; Martgrita, Merry Meryam; Kembaren, Roga Florida; Chaidir, Chaidir; Sunaryanto, Rofiq; Wibowo, Agung Eru
Berita Biologi Vol 23 No 2 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2024.3334

Abstract

Andaliman (Zanthoxylum acanthopodium D.C) is a plant widely used by the Batak people in North Sumatera. Several studies demonstrated that Andaliman fruit exhibits antioxidant activities and cytotoxic effects on cancer cells. Quality of Andaliman fruit could affected by post-harvest process including storage time. This research aims to analyze the compound, antioxidant activity and proliferation inhibition on MCF-7 cells of Andaliman fruit extracts (AFE) stored at varying storage time. A series of fresh 250 g Andaliman fruit sealed in a closed container and stored in the oven at 30ºC. After storage at 0, 24, 48, 72, 96, 120 and 144 hours, Andaliman fruit macerated using methanol and obtained successive extract yields of 4.12; 3.70; 12.79; 8.17; 8.15; 3.7 and 2.21. These extracts were analyzed for total phenolic, total flavonoids, free radical scavenging activity and proliferation inhibition on MCF-7 cells. The chemical compound analysis of AFE was performed by ultra performance liquid chromatography (UPLC). Results showed that the AFE stored at zero hours had higher total phenol content (47.32 mg gallic acid equivalent (GAE)/g of extract) and free radical scavenging activity (50.38%) at 500 µg/mL significantly compared to other extracts. The total flavonoid content of all extracts showed no difference level except for the extract at 120 hours of storage. The proliferation inhibition test on MCF-7 cells at 100 µg/mL showed that AFE stored at 72, 96 and 144 hours could inhibit MCF-7 cells above 50%. The storage time variation of Andaliman fruit may affect the total phenolic and flavonoid content, and also activity of free radical scavenging and proliferation inhibition on MCF-7. The UPLC analysis founded the major compound of AFE was predicted as α-sanshool. Analysis of chemicals substance in Andaliman fruit with varying of storage time need to be conducted to evaluated alteration of secondary metabolites contained in Andaliman fruit.
Co-Authors Adek Zamrud Adnan Agung Eru Wibowo Amelia Amelia Chaniago, Mutia Desi Fajrianti Djamil, Ratna Effionora Anwar Fairus, Fairus Idah Rosidah Imma Fretisari Kawuryan, Shanti Lintang Lotulung, Puspa Dewi N M.Hanafi Martgrita, Merry Meryam Minarti Minarti Muhammad Fuad Nabilla, Ulya Nuralih Nuralih, Nuralih Nurviana, Nurviana Pitriana, Mira Rahayu, Maya Damayanti RAHMAT, DENI Rangga Pradana, Rangga Rofiq Sunaryanto ROGA FLORIDA KEMBAREN Sari, Riezky Purnama Silaban, Christianly Yery Simanungkalit, Grace Sophiwati Siska Andrina Kusumastuti Tuharea, Natasha Dewanti Ulfa, Dina Amalia Witono Basuki, Witono Yolandari, Febby Ola