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All Journal Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Veteriner BIOTROPIA - The Southeast Asian Journal of Tropical Biology JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Berkala Penelitian Hayati Jurnal Kedokteran Hewan Jurnal Farmasi Indonesia Current Biomedicine Policy Brief Pertanian, Kelautan, dan Biosains Tropika
Okti Nadia Poetri
IPB University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Electrical & Electronics Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : Current Biomedicine

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Evaluation of influenza-specific immunoglobulin Y stability in liquid, solid, and cream-based body care formulations Poetri, Okti Nadia; Setyawati, Yusefin Marcelina; Kal Alfin, Zabrino Wahid; Kalsum, Salsabila; Fathurrahman, Fathurrahman; Rong, Chin Xiao; Nugraheni, Indi Amalia; Kuswanti, Andrea Septiandra
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.98

Abstract

Background Specific immunoglobulin Y (IgY) is widely used in immunotherapy, with expanding applications in body care products. Topically applied influenza-specific antibodies may provide an alternative strategy for preventing respiratory infections. Objective This study aimed to evaluate the stability and biological activity of influenza-specific IgY in various body care products. Methods The biological activity of influenza-specific IgY was evaluated in various body care products at different concentrations. Commercial face mists contained 5% and 10% w/v IgY, face mists and nasal sprays contained 0.5% w/v IgY, lip balm, sunscreen, and hand cream contained 0.1% and 0.25% w/v IgY. The products were stored at room temperature for four weeks, and organoleptic changes were monitored weekly. IgY activity was assessed by enzyme-linked-immunosorbent-assay (ELISA). Results In both face mist products, the aroma gradually became fishy, the color remained stable, and turbidity increased. The biological activity of IgY was still detectable by ELISA at concentrations of 0.5%, 5%, and 10%. In nasal spray, no changes in aroma, color, or turbidity were observed, but IgY activity was not detectable. In lip balm, sunscreen, and hand cream, only slight color changes occurred without any change in aroma, and IgY activity was not detected. Conclusion Influenza-specific IgY retained biological activity in face mist formulations at higher concentrations (≥0.5%) despite observable changes in aroma and turbidity. In contrast, IgY activity was not detected in nasal sprays, lip balm, sunscreen, or hand cream, suggesting that the formulation type and IgY concentration significantly influence its stability and detectability in body-care products.
Preparation of avian influenza H5N1 and Newcastle disease antigens for hemagglutination inhibition assay applications Poetri, Okti Nadia; Salsabila, Syaharani; Pebriana, Nada Adinda
Current Biomedicine Vol. 4 No. 1 (2026): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.4.1.8

Abstract

Background Avian influenza (AI) and Newcastle disease (ND) are major poultry diseases in Indonesia, where monitoring of vaccination efficacy commonly relies on the hemagglutination inhibition (HI) assay. The HI assay requires viral antigens, which are generally obtained commercially from PUSVETMA. However, independent antigen preparation would be beneficial for private laboratories. Objective This study aimed to prepare and validate in-house AI and ND antigens as HI assay reagents. Methods Viruses were propagated in embryonated chicken eggs (ECE), inactivated using buffered neutral formalin (BNF), precipitated with polyethylene glycol (PEG-6000), and preserved with glycerol. Validation was conducted by parallel HI testing of 24 chicken sera for AI and 22 chicken sera for ND using both in-house and PUSVETMA’s antigens. Antibody titers were analyzed using analysis of variance (ANOVA), with sensitivity (Se), specificity (Sp), and kappa (κ) tests performed for agreement.   Results ANOVA revealed no significant differences in geometric mean titers between in-house and PUSVETMA’s antigens (P<0.05). Both the AI and ND in-house antigens demonstrated Se and Sp values of 100% and κ values of 1, indicating perfect agreement. Conclusion These findings confirm that in-house AI and ND antigens are comparable to their commercial counterparts and can serve as reliable and cost-effective reagents for HI testing in private laboratories.
Co-Authors Agustin Indrawati Aldo Yanuar Wuriyantara Anindita Sista Widyadhari Anindita Sista Widyadhari Annisa, Syifa Apriana, Cut Desna Ari Rumekso Cece Sumantri Chaerul Basri Dilas Pradana Dinda Reisinta Dwi Desmiyeni Putri Dwi Utari Rahmiati Eko Sugeng Pribadi Ekowati Handharyani Etih Sudarnika Fachriyan Hasmi Pasaribu Fachriyan Hasmi Pasaribu Fathurrahman Fathurrahman Ferry Ardiawan Hadri Latif Hanandi, Sharon I Wayan T. Wibawan I wayan Teguh Wibawan Kal Alfin, Zabrino Wahid Kalsum, Salsabila koekoeh santoso Kris Damar Sasi Kurnia Sari Setio Putri Kurnia Sari Setio Putri, Kurnia Sari Setio Kuswanti, Andrea Septiandra La Jumadin La Jumadin Melani Wahyu Adiningsih Mokhamad Fakhrul Ulum, Mokhamad Ni Luh Putu Ika Mayasari Novera Nirmalasanti Nugraheni, Indi Amalia Nur Khusni Hidayanto Nurjumaatun Nurjumaatun Pebriana, Nada Adinda Pramuwidyatama, M. Gumilang Putra, Raditya Pradana R. Dikky Indrawan Rahayu WoroWiranti Rahmasari, Ratika Rahmat Setya Adji Rakhmat, Asep Reisinta, Dinda Retno D Soejoedono Retno D Soejoedono Retno D. Soejoedono Retno Damajanti Soejoedono Retno Damajanti Soejoedono Retno Damayanti Soejoedono Retno Setyaningsih Rifky Rizkiantino Rizkiantino, Rifky Rong, Chin Xiao Salsabila, Syaharani Sasi, Kris Damar Setyawati, Yusefin Marcelina sri murtini . Surachmi Setiyaningsih Sutriyo Suwarny Ruhi Tan, Zhi Yien Trioso Purnawarman Widyadhari, Atsmarina Wilbert Wylie Wyanda Arnafia Wyanda Arnafia, Wyanda