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All Journal Jurnal Fitofarmaka Indonesia Journal of Pharmaceutical and Medicinal Sciences Fullerene Journal of Chemistry Jurnal farmasi UIN Alauddin Makassar Yumary: Jurnal Pengabdian kepada Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Kefarmasian Journal of Noncommunicable Diseases (JOND) Jurnal Sains dan Kesehatan
Astuti Amin
Sekolah Tinggi Ilmu Farmasi Makassar, Makassar, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Sains dan Kesehatan

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Aktivitas Antioksidan Ekstrak Etanol Batang, Daun, dan Akar Kopasanda (Chromolaena odorata L.) dengan Metode FRAP (Ferric Reducing Antioxidant Power): Antioxidant Activity of Ethanol Extract of Stems, Leaves, and Roots of Kopasanda (Chromolaena odorata L.) with FRAP (Ferric Reducing Antioxidant Power) Method Astuti Amin; Nur Khairi; Wahyu Hendrarti
Jurnal Sains dan Kesehatan Vol. 4 No. 5 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i5.1271

Abstract

Kopasanda (Chromolaena odorata L.) is a plant that contains flavonoid compounds that can act as antioxidants. This study aims to determine the antioxidant potential of the ethanol extract of the stems, leaves and roots of kopasanda by looking at the IC50 value. The stems, leaves and roots of Kopasanda were extracted by maceration using 70% ethanol as solvent. The results of the antioxidant activity test using the FRAP (Ferric Reducing Antioxidant Power) method showed very strong antioxidant activity with IC50 values ??of leaves 23.4 µg/ml, stems 37.556 g/ml and roots 36.860µg/ml with positive control of quarcetin, IC50 values ??were 2.724 g/ml . Based on these results, it can be said that the stems, leaves and roots have very strong antioxidant activity against the reduction of FRAP (Ferric Reducing Antioxidant Power).
Potensi Penghambatan Enzim Tirosinase dengan Ekstrak Etanol Daun Kopasanda (Chromolaena Odorata L.): Potential inhibition of Tyrosinase Enzyme by Ethanol Extracts Kopasanda Leaf (Chromolaena Odorata L.) Amin, Astuti; Hardianti, Besse; Lallo, Subehan; Hendrari, Wahyu
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2120

Abstract

The need for skin care is increasing. One indicator of skin health is the brightness of skin color. Tyrosinase enzyme can darken skin color due to its activity against melanin biosynthesis. Skin color will also change when exposed to UV rays, even at a more severe level can cause cancer. The purpose of this study was to determine the tyrosinase enzyme inhibitory activity of ethanol extract of copasanda leaves of Chromolaena odorata L. C. odorata leaves are weeds from the Asteraceae family which contain several compounds such as tannins, phenols, flavonoids, saponins, and steroids. In this study, the ethanol extract of C. odorata leaves was tested in inhibiting tyrosinase enzyme activity based on the percent inhibition. Determination of tyrosinase enzyme inhibitory activity using UV-Vis spectrometer at a wavelength of 495 nm, done by calculating the IC50 value with kojic acid as a positive control. The results showed that the IC50 value of the tyrosinase enzyme inhibition activity test, kojic acid as a positive control amounted to 27,472 mg L-1 (very strong), the sample of ethanol extract of C. odorata leaves amounted to 81,546 mg L-1 (very strong). The ethanol extract of C. odorata leaves has an inhibitory effect on tyrosinase enzyme which is used as a potential source material for natural antimelagenic compounds. Keywords:          Chromolaena odorata L., tyrosinase enzyme, Weeds   Abstrak Kebutuhan akan perawatan kulit semakin meningkat. Salah satu indikator kesehatan kulit adalah kecerahan kulit warna kulit. Enzim tirosinase dapat menggelapkan warna kulit karena aktivitasnya melawan biosintesis melanin. Warna kulit juga akan berubah ketika terpapar sinar UV, bahkan pada tingkat yang lebih parah dapat menyebabkan kanker. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas penghambatan enzim tirosinase dari ekstrak etanol daun kopasanda Chromolaena odorata L. Daun C. odorata merupakan tumbuhan gulma dari family Asteraceae yang mengandung beberapa senyawa seperti tannin, fenol, flavonoid, saponin, dan steroid. Pada penelitian ini dilakukan pengujian terhadap ekstrak etanol daun C. odorata dalam menghambat aktivitas enzim tirosinase berdasarkan persen penghambatannya. Penentuan aktivitas penghambatan enzim tirosinase menggunakan alat Spektrometer UV-Vis pada panjang gelombang 495 nm, dilakukan dengan menghitung nilai IC50 dengan asam kojic sebagai kontrol positif. Hasil penelitian menunjukkan bahwa nilai IC50 dari uji aktivitas penghambatan enzim tirosinase, asam kojic sebagai kontrol positif sebesar 27,472 mg L-1 (sangat kuat), sampel ekstrak etanol daun C.odorata  sebesar  81,546 mg L-1 (sangat kuat). Ekstrak etanol daun C. odorata memiliki efek penghambatan terhadap enzim tirosinase yang digunakan sebagai bahan sumber potensial senyawa antimelagenik alami. Kata Kunci:         Chromolaena odorata L, enzim tirosinase, Gulma
Co-Authors Abdul Halim Umar Abidin, Hamdayani Lance Agustina Ma'tang Parinding Alimuddin Ali Andi Nur Aisyah Andi Paluseri Andi puanguce Paluseri Arianty Kurniastuty asnita asnita Bela Chintya Besse Hardianti Besse Hardianti, Besse Djamaluddin, Suci F Eko Allo Fadel Ahmad Haris Fhahri Mubarak Fitriyanti Sami Hapiwaty, Saldi Hendrari, Wahyu Imrawati Imrawati Imrawati Imrawati Irwana, Rina Jeanny Wunas Jeni Anti Barrang Khairi, Nur Lallo, Subehan Maria Ulfah Mar’atun Jannah, Imrawati, Muzakkir Baitz, Maulita Indrisari, Maulita Megawati - Megawati Megawati Michrun Nisa Mus, Suwahyuni Muslimin, Lukman Ningsih, Ririn Iriani Noer Rahman Nuning Rindam Sutamanggala Nur Khairi Nursamsiar Nursamsiar paluseri, Andi Radhia Riski Rahmat Priyandi Linggotu Rosyid, Sujud Z Sami, Fitriyanti Solly Aryza Sri Reski Ananda Subehan Lallo Syamsu Nur Syamsu Nur, Syamsu Tandiarrang, Lira Tengker, Soenandar Millian Tompunu Utami, Yuri Pratiwi Wahyu Hendrari Wahyu Hendrarti Wahyu Hendrarti Wahyu Hendrarti Yuniven Merina Anin