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All Journal Psikologika : Jurnal Pemikiran dan Penelitian Psikologi Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences METAMORFOSA Journal of Biological Sciences Jurnal Momentum JURNAL TEKNIK SIPIL ITP ISSN 2354-8452 Journal of Family Science Jurnal Ilmiah Mahasiswa Pendidikan Biologi Majalah Kedokteran Sriwijaya Jurnal Analisa JURNAL TEKNIK INFORMATIKA DAN SISTEM INFORMASI JMM UNRAM (Jurnal Magister Manajemen Universitas Mataram) Faktor Jurnal Ilmiah Kependidikan Logat: Jurnal Bahasa Indonesia dan Pembelajaran Avant Garde Jantra ICIT (Innovative Creative and Information Technology) Journal Jurnal Pendidikan Agroteksos Jurnal Pendidikan dan Perhotelan Jurnal Pengabdian Masyarakat Sains dan Teknologi Jurnal Nakula: Pusat Ilmu Pendidikan, Bahasa Dan Ilmu Sosial Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan
mulyati mulyati
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Level of mRNA Insulin Gene and Blood Glucose STZ-Induced Diabetic Rat are Improved by Glucomannan of Amorphophallus muelleri Blume from East Java Forest Indonesia Fatchiyah Fatchiyah; Damai Aulia Nurmasari; Nuri Masruro; Rista Nikmatu Rohmah; Lidwina Faraline Triprisila; Mulyati Mulyati; Takahisa Yamada; Takashi Ohta
Journal of Tropical Life Science Vol. 9 No. 2 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.09.02.05

Abstract

Diabetes mellitus is one of metabolic disorder with high level of blood sugar glucose and reduces pancreatic-insulin levels that are altered by unhealthy food and lifestyle. To manage the blood glucose and insulin level, we need the diabetes dietary management related with insulin gene cascade. The purpose of this study was to investigate the influence glucomannan fiber to mRNA level of the insulin gene and genes cascade expression of target cells of type 1 diabetic rat. Three-month-old male (Rattus norvegicus strain Wistar) were fed with fiber of glucomannan of Amorphophallus muelleri Blume with dosage 0,06g/kg BW and 0.12g/kg BW every day during one month. RNA dot blotting with specific cDNA probe was performed mRNA level of insulin gene. The result of this study showed that glucomannan could reduce of body weight and blood glucose level significantly. The mRNA level of insulin gene of diabetic rats-treated 0.12g/kg BW glucomannan fiber dosage was the highest significance level among of all groups. In histopathological analysis, glucomannan was increasing significantly in IRS-1 level expression proliferate properly and consistently increasing of the PI3-K expression level in treated diabetic rats. This study indicates that the 0.12g/kg BW glucomannan was optimum dosage that effectively as role for alternative high-fiber therapy of type 1 diabetic through insulin receptor tyrosine kinase pathway. 
Co-Authors Ami Aulia Angga Panugali Annisa Nur Islahi Astri Wulan Sari Bintarto Wicaksono Budi Santoso Damai Aulia Nurmasari Desty Endrawati Subroto Djufri Djufri Ega Dwisaputra Nurmawan Endah - Herlina Endry Setiawan Evy Hanifah Fatchiyah Fatchiyah Husna Nabilah Inggit Eka Wahyuni Kenty Martiastuti Lailan Sawiyah Siagian Lidwina Faraline Triprisila Marella Marella Melly Damayanti Noryani Noryani Nur Khayati Nuri Masruro Nurlaila Mashabi Ramzi Amin, Ramzi Rasyid Tarmizi Regina Rini Lestari Risna Herjayanti Rista Nikmatu Rohmah Saputri, Nurul Aini Suria Siti Ika Danti Supriatno Supriatno Suwardji Takahisa Yamada Takashi Ohta Widyatmike Gedhe Mulawarman Ziga Arkis