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All Journal Jurnal Kedokteran Brawijaya Jurnal Teknologi Informasi dan Ilmu Komputer MNJ (Malang Neurology Journal) Indonesian Journal of Rheumatology International Journal of Retina Pediatric Sciences Journal IJRETINA - International Journal of Retina Ophthalmologica Indonesiana
Nadia Artha Dewi
Department Of Ophthalmology, Faculty Of Medicine Universitas Brawijaya, Saiful Anwar General Hospital, Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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DIAGNOSING VON HIPPEL LINDAU DISEASE BY RETINAL CAPILLARY HAEMANGIOBLASTOMAS Yurike Mandrasari; Wino Vrieda Vierlia; Andhika Yudistira; Nadia Artha Dewi
International Journal of Retina Vol 5 No 2 (2022): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2022.vol005.iss002.194

Abstract

Introduction: Von Hippel-Lindau (VHL) syndrome is a disease characterized by the formation of tumors or cysts in many different parts of the body caused by germline. The prevalence of this autosomal dominant condition is very rare. Understanding of clinical manifestasion and diagnostic criteria is needed. Case Report: Female, 22-year-old was reffered from orthopaedic department suffered from blurred and misalignment of the left eye since 3 months ago . Based on indirect funduscopy examination, we found disc swelling with exudative retinal detachment on her left eye and orange-reddish retinal mass concluded as Retinal Capillary Hemangioblastoma (RCH) with tortuosity and dilatation of blood vessel on her right eye. The MRI showed multiple masses in cervical to lumbar vertebrae and multiple cyst on pancreatic gland. Discussion: This patient had 1 ocular RCH, multiple spinal tumor and multiple pancreatic cysts with no confirmed family history, therefore almost fulfilling the diagnostic criteria of VHL. To further confirm the diagnosis, it was necessary to find other common comorbids of VHL such as gene testing of VHL heterozygous germline mutation. Interdisciplinary approach consists of not only diagnostic and treatment plans from one speciality department, but also the ones from other related divisions and departments. Conclusion: Screening and interdiciplinary approach in managing Von Hippel-Lindau syndrome are required to be performed promptly.
PROLIFERATIVE LEUKEMIC RETINOPATHY WITH BILATERAL EXUDATIVE RETINAL DETACHMENTS AND OPTIC DISC SWELLING IN A PATIENT WITH ACUTE LYMPHOBLASTIC LEUKEMIA Linda Susanti; Safaruddin Refa; Mirza Metita; Nadia Artha Dewi
International Journal of Retina Vol 2 No 2 (2019): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2019.vol002.iss002.95

Abstract

Introduction: To report a patient with acute lymphoblastic leukemia (ALL) who developed proliferative leukemic retinopathy with bilateral exudative retinal detachments and optic disc swelling. Case Report: A 11-year-old girl diagnosed with ALL-L2 on maintenance chemotherapy presented with severe blurred vision in both eyes for the past 1 year. Her visual acuity was 0,5/60 for both eyes. Slit-lamp examination of the anterior segment was found normal. Dilated fundus examination revealed tortuous retinal vessels, retinal haemorrhage, retinal and optic disc neovascularizations, optic disc with indistinct margins, and total retinal detachments in both eyes, as well as vitreous haemorrhage in the left eye. The ultrasonography examination revealed bilateral subretinal fluid. Discussion: The patient was diagnosed with bilateral proliferative leukemic retinopathy with exudative retinal detachments and infiltrative optic neuropathy, and left eye vitreous haemorrhage due to ALL. Conservative treatment was given. She continued the maintenance chemotherapy from pediatric department. After 2 months follow up, the visual acuity did not improve although retinal detachments were reduced. There were atrophic changes at the retina of her both eyes. Conclusion: It was reported a rare case of proliferative leukemic retinopathy with bilateral exudative retinal detachments and optic disc swelling. Early recognition and treatment is crucial to improve prognosis.
Usher Syndrome with Posterior Subcapsular Cataract Bramantya Surya Pratama; Nadia Artha Dewi
Majalah Oftalmologi Indonesia Vol 48 No 1 (2022): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v48i1.100122

Abstract

Introduction: Usher Syndrome (USH) is an autosomal recessive disorder characterized by congenital sensorineural deafness and progressive loss of vision due to retinitis pigmentosa. The aim of this report is to report rare cases of USH by perform diagnostic steps based on clinical examination and family history with expectations that if a similar case is found, an earlier diagnosis and rehabilitation can be done. Methods: Diagnosis is based on history, ophthalmology examination and ear, nose, and ear (ENT) examination. Results: A 23-year-old man came to the Ophthalmology Outpatient Department with complaints of bilateral blurred vision especially at night and visual field constriction starting 12 years ago. The patient experienced gradual vision deterioration followed by appearance of white spot in his left eye. Patient is deaf and mute since birth. Three family members of the paternal line exhibit the same symptoms. The best corrected visual acuity was right eye 6/15 and left eye hand movement. Bilateral cataract was found during eye examination. Posterior segment examination revealed peripheral bone spiculae appearance and waxy pallor optic disc in both eyes. Loss of neurosensory layer, worse in the left eye, was discovered through Optical Coherence Tomography (OCT). Humphrey perimetry of the right eye indicated tunnel vision. Examination by otorhinolaryngologist revealed a sensorineural hearing loss. In this patient, there is no management for the disorders due to the poor prognosis of visual acuity. What can be done to improve the patient's quality of life is supportive therapy. It is important to screen and educate families suffering from the same disorder for early diagnosis & rehabilitation. Conclusion: Clinical examination and family history confirm the diagnosis of USH. Early diagnosis and early rehabilitation are essential to improve patient's quality of life. In this case, no management was carried out for the cataracts because the visual acuity of both eyes did not match the cloudiness of the lens so there are possibility the visual acuity could not improve. Rehabilitations that can be done for the patients are visual and social rehabilitation to improve quality of life.
The correlation between body mass index and intraocular pressure in children without Down syndrome and children with Down syndrome Rizqillah, Aliyah Faiza; Wulandari, Lely Retno; Dewi, Nadia Artha; Anandita, Nanda Wahyu
Pediatric Sciences Journal Vol. 5 No. 1 (2024): (Available online: 1 June 2024)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v5i1.75

Abstract

Background: Intraocular Pressure (IOP) is the fluid pressure in the eye. Primarily, IOP is influenced by the production and drainage of aqueous humor. The IOP value is in the normal range if the production and drainage of aqueous humor are balanced so that IOP homeostasis must be maintained. Eye dysfunction can occur if the production and drainage of aqueous humour are not balanced. IOP can be influenced by factors such as Body Mass Index (BMI). This study aims to find out whether there is a correlation between BMI and IOP in children without Down syndrome and children with Down syndrome, where children with Down syndrome have one of the eye manifestations in the form of steep and thin corneas which could be one of the factors causing affect the results of IOP measurements. Methods: The research method used is quantitative-observational with a cross-sectional approach. The total research sample used in this study was 101 children aged 0 to 18 years, with details of 79 children without Down syndrome and 22 children with Down syndrome. Data were processed using the Mann-Whitney hypothesis test and T-test, as well as the Spearman correlation test. Results: The results of the study showed that there was a difference in IOP between children without Down syndrome and children with Down syndrome (p < 0.1), there was a difference in BMI results on IOP in children without Down syndrome and children with Down syndrome (p < 0.1), and there was no correlation between BMI and IOP in children without Down syndrome (p > 0.1). It was found that there was a correlation between BMI and IOP in children with Down syndrome (p < 0.1). It was stated that BMI contributed 91.7% to the increase in IOP. Conclusion: there was a significant difference in IOP and BMI results on IOP between children with and without Down syndrome. There was no correlation between BMI and IOP in children without Down syndrome, but there was a correlation between BMI and IOP in children with Down syndrome.
NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY Dewi, Nadia Artha; Arfan, Muhammad; Rahmasari, Herisa; Putri, Mutiara Kristiani; Rosandi, Rulli; Kurniawan, Shahdevi Nandar
MNJ (Malang Neurology Journal) Vol. 8 No. 1 (2022): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.01.12

Abstract

Diabetic retinopathy is major cause of visual impairment and blindness in diabetic patients worldwide. The concept of diabetic retinopathy as vascular disease has established into not only microvascular complication but also neurodegeneration problems. Neurodegeneration plays an important role in pathogenesis of diabetic retinopathy. In fact, neuroretinal changes in diabetes can take place even before vasculopathy can be clinically detected.  This condition is marked by accelerated loss of neurons due to apoptosis, particularly in the inner retinal layer. The characteristic of neurodegeneration can be detected through retinal imaging and electrodiagnostics. This review is very crucial, because identifying the pathophysiology of diabetic neurodegeneration better, we may be able to provide interventions using the appropriate therapy. We may also be able to utilize these diagnostic tools  for early detections of diabetic retinopathy, thus preventing blindness due to diabetes.
DIFFERENCES IN THE AMPLITUDE OF ACCOMMODATION BETWEEN CHILDREN WITHOUT DEVELOPMENTAL DISABILITIES AND CHILDREN WITH DEVELOPMENTAL DISABILITIES Karim, Muhammad Rico Abdul; Wulandari, Lely Retno; Dewi, Nadia Artha; Anandita, Nanda Wahyu
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.11

Abstract

Background: Accommodation is the eye's ability to change the refractive power of the lens, allowing objects to focus on the retina at different distances. The Amplitude of Accommodation (AoA) is the closest point at which the eye can focus and the distance between the far point and near point on the diopter scale. Children with developmental disabilities (CDD) are at a higher risk of encountering vision problems, including accommodation issues. Objective: This study aims to ascertain the disparity in Amplitude of Accommodation (AoA) results between children with developmental disabilities (CDD) and those without developmental disabilities (CWDD) Methods: This research constitutes an observational study with cross-sectional data, involving 44 subjects with developmental disabilities (CDD) and 44 subjects without developmental disabilities (CWDD). The participants were further categorized into 33 deaf children (DC) and 11 children with intellectual disabilities (CID). The data were obtained from eye examinations conducted at several special schools and orphanages in the city of Malang. The examinations covered the right eye (OD), left eye (OS), and binocular vision (ODS). Results: Significant differences were identified among groups in OD (P<0.001), OS (P<0.001), and ODS (P<0.001). To assess the specific variations between groups, a Bonferroni post-hoc test was conducted. The results indicated significant differences between CWDD and DC in both OD (P<0.001), OS (P<0.001), and ODS (P<0.001). Additionally, significant differences were observed between CWDD and CID in OD (P=0.002), OS (P=0.005), and ODS (P<0.001). Conclusion: It can be concluded that there is a significant difference in the average AoA value between CWDD and CDD, both CWDD-DC and CWDD-CID.
RETINAL NERVE FIBER LAYER THICKNESS ASSOCIATED WITH SEVERITY OF DIABETIC PERIPHERAL NEUROPATHY IN DIABETES MELLITUS TYPE 2 Putri, Mutiara Kristiani; Arfan, Muhammad; Rahmasari, Herisa; Dewi, Nadia Artha; Rosandi, Rulli; Kurniawan, Shahdevi Nandar
International Journal of Retina Vol 8 No 1 (2025): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2025.vol008.iss001.320

Abstract

Purpose: To identify whether the Retinal Nerve Fiber Layer is useful in detecting severity of peripheral neurodegeneration in diabetic patients Methods: A cross-sectional study was conducted. 36 people were enrolled in this study which is divided into two groups. 18 people with type 2 diabetes mellitus (DM) with Diabetic Peripheral Neuropathy (DPN) and 18 people with type 2 DM non-DPN. All subjects were 40-60 years old, and the best corrected visual acuity was better than 0,2 logMAR. An Optical Coherence Tomography (OCT) examination was carried out to determine the Retinal Nerve Fiber Layer (RNFL) thickness, and an Electroneuromyography examination was applied to establish a diagnosis of DPN. Data were analyzed with independent T-test and Spearman correlation analysis. Results: The average RNFL thickness in the DM with DPN was thinner than the RNFL thickness in the DM non-DPN group (100.22 ± 38; vs 102.61±9.11; p 0.444). At temporal quadrant and nasal quadrant, RNFL was also thinner in DM DPN group than DM non-DPN group (71.78±12.21, vs 76.33 ± 8.53, p 0.203; and 75.11±11.38 vs 77.39 ± 14, p 0.596). Sural and tibial amplitude (14.44±2.87 and 6.85± 4.98) , were the most significant predictor values in determining the severity of DPN (p=0.000). Average, temporal, and nasal RNFL thinning has an inverse association with DPN severity (r=-0,285; -0,258;and -0,126) Conclusion: RNFL was thinner at average, temporal, nasal quadrant in the DM group with DPN compared to DM non-DPN group. RNFL thickness has an inverse association with the severity of the DPN although they were not statistically significant. Keywords: Diabetes Mellitus, Diabetic Peripheral Neuropathy, Retinal Nerve Fiber Layer
GUIDELINES FOR THE DIAGNOSIS AND MANAGEMENT OF DIABETIC RETINOPATHY AND DIABETIC MACULAR EDEMA IN INDONESIA Harley, Ohisa; Hertanto, Martin; Sembiring, Sindy Boru; Yustiarini, Ima; Susilo, Teguh; Dharma, Andhika Guna; Sjahreza, Emil; Firmansyah, M; Iskandar, Erwin; Agustiawan, Referano; Andayani, Ari; Dewi, Nadia Artha; Andayani, Gitalisa; Djatikusumo, Ari; Elvioza, Elvioza; Ichsan, Andi M; Kartasasmita, Arief S
International Journal of Retina Vol 7 No 2 (2024): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2024.vol007.iss002.300

Abstract

Diabetic retinopathy (DR) and diabetic macular edema (DME) are among the microvascular complications in individuals with diabetes mellitus (DM) that can lead to blindness if not diagnosed early and managed appropriately. Both disorders can be diagnosed and treated using a variety of techniques. Treatment modalities include laser photocoagulation therapy, vitrectomy surgery, intraocular steroid injections, and anti-vascular endothelial growth factor (anti-VEGF) injections. These methods can help avoid blindness when used in conjunction with metabolic control. These recommendations were created with the use of evidence-based medicine principles to help medical professionals—particularly ophthalmologists—identify and treat cases of DR and DME.The primary objective is to provide consensus recommendations and hopefully reduce the incidence of blindness caused by DR and DME in Indonesia.
DIAGNOSTIC AND THERAPEUTIC CHALLENGES OF POSTERIOR SCLERITIS MIMICKING CHOROIDAL MELANOMA yuniasih, kristina; Dewi, Nadia Artha; Sofia, Ovi
International Journal of Retina Vol 7 No 1 (2024): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2024.vol007.iss001.256

Abstract

DIAGNOSTIC APPROACHES FOR MACULAR DYSTROPHY BY USING OCT AND VEP : A CASE SERIES Saldianovitta, Rahajeng Anugrahing; Dewi, Nadia Artha
International Journal of Retina Vol 7 No 2 (2024): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2024.vol007.iss002.259

Abstract

Introduction: Macular dystrophies (MDs) consist of a heterogeneous group of disorders that are characterized by bilateral symmetrical central visual loss. Clinical manifestation including atrophy in macula. This cases series provides clinical manifestation and characteristics in ancillary testing for better approach to macular disease Case report: Case 1 is 13-year-old girl with decrease visual acuity, uncorrected visual acuity (UCVA) was 2/60 on both eyes. The ophthalmologic examination showed an area of atrophy at macula accompanied with yellowish flecks on both eyes. Optical coherence tomography (OCT) shows thinning in all areas of macula and loss of outer nuclear layer (ONL) and photoreceptor. From VEP, there were low amplitude N75, P100, and N145 waves without any latency. Case 2 is 39-year-old woman with decrease of visual acuity, UCVA was 6/60 on both eyes, accompanied with partial colour blindness and red-green deficiencies. From ophthalmology examination showed large atrophy area at macula. OCT examination shows thinning in most of macula area and decrease of ONL thickness and photoreceptor. VEP showed normal wave without any latency. Discussion: There were a gradual central vision loss, at a more advanced stage, color blindness can occur due to photoreceptor damage in the macular area. From the posterior segment there was a yellowish spot on the macula which suggested lipofuscin deposition on the retinal pigment epithelium (RPE). From OCT, there ware loss of ONL and VEP showed low amplitude or normal waves. This findings suggested macular dystrophy due to Stargardt disease. Conclusion: OCT and VEP can be used to detect anatomical and physiological abnormalities that can aid in the diagnosis of macular dystrophy in the case of incomplete ancillary testing tools.
Co-Authors Agustiawan, Referano Andayani, Gitalisa Andhika Yudistira Arbawa, Yoke Kusuma Ari Andayani Arief S. Kartasasmita Athaya Febriantyo Purnomo Bramantya Surya Pratama Bramantya Surya Pratama Candra Dewi Cesarius Singgih Wahono Dharma, Andhika Guna Djatikusumo, Ari Elvioza Elvioza, Elvioza Fenti Kusumawardhani Hidayah Firmansyah, M Harahap, Vicia Belladona Carolina Harley, Ohisa Herman Bagus Trianto, Herman Bagus Hidayat Suyuti Ichsan, Andi M Indha Dwi Kartikasari Indriati Indriati Iskandar, Erwin Karim, Muhammad Rico Abdul Kartikasari, Indha Dwi Lely Retno W Linda Susanti Martin Hertanto Metita, Mirza Metita, Mirza Mirza Metita Mirza Metita Nasution, Ali Napiah Ovi Sofia Putri, Mutiara Kristiani Rahmasari, Herisa Rizqillah, Aliyah Faiza Rofa Husnul Khuluqi Rulli Rosandi Safaruddin Refa Safaruddin Refa Safaruddin Refa Saldianovitta, Rahajeng Anugrahing Santoso, Andri Sembiring, Sindy Boru Seravina Adila Izzati Seskoati Prayitnaningsih Shahdevi Nandar Kurniawan, Shahdevi Nandar Sjahreza, Emil Sofia, Ovi Susanto Nugroho Susilo, Teguh Taufiq Nur Budaya Teddy Kristiyan Wahono, Cesarius Singgih Wahyu Anandita, Nanda Wino Vrieda Vierlia Yuniasih, Kristina Yurike Mandrasari Yustiarini, Ima