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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana ARSHI Veterinary Letters Jurnal Plastik Rekonstruksi Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JP2M (Jurnal Pendidikan dan Pembelajaran Matematika) Prosiding Seminar Nasional Program Pengabdian Masyarakat Jurnal MathEducation Nusantara Journal of Nursing Science Update Women, Education, and Social Welfare
Rismala Dewi
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : The Indonesian Biomedical Journal

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Citrullinated Histone H3 Level as a Novel Biomarker in Pediatric Clinical Sepsis Ronald Chandra; Antonius Hocky Pudjiadi; Rismala Dewi
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1597

Abstract

BACKGROUND: Sepsis is still leading cause of death in critically ill children. Early recognition of sepsis and treatments are needed to reduce its mortality. The use of citrullinated Histone H3 (Cit-H3) as an early sepsis marker and outcome predictor has been validated in previous studies among adults. However, only one study in pediatric meningococcal sepsis was reported with contradictory results. This study aims to determine Cit-H3 levels in pediatric clinical sepsis and analyze its association with sepsis severity and survival rate.METHODS: A prospective observational cohort study involving 67 pediatric subjects clinically diagnosed with sepsis was conducted. Cit-H3 levels, Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score, and Pediatric Sequential Organ Failure Assessment (pSOFA) score were assessed at the time of diagnosis (0-hour) and 48 hours later. Pearson Correlation test was used to determine the correlation between Cit-H3 levels with PELOD-2 and pSOFA scores and receiver operating curve to find the cut-off of Cit-H3 levels on clinical sepsis patients.RESULTS: Among clinically sepsis patients, the median Cit-H3 level was 1,210 (800-32,160) ng/mL, with optimal cut-off point ≥1200 ng/mL (sensitivity 83.3% and specificity 75.7%) to discriminate sepsis. The median Cit-H3 levels at 0-hour were lower in survivor compared to non-survivor group (p=0.016). Cit-H3 level was able to predict mortality with optimal cut-off point ≥1,200 ng/mL, sensitivity 72.2% and specificity 57.1% (AUC of 69.2%; p=0.017). Using survival analysis, Cit-H3 was significantly associated with the mortality rate (p=0.023; hazard ratio of 3.45).CONCLUSION: Cit-H3 level could be potential to predict pediatric sepsis events and its outcome.KEYWORDS: citrullinated histone H3, neutrophil extracellular traps, pediatric sepsis, PELOD-2 score, pSOFA score, survival
Co-Authors Abdul Latief Abdul Latief Abriyanto, Abriyanto Adam Adam Aditya Wardhana Afif, Ahmad Ainul Alan Roland Tumbelaka Amir S. Madjid, Amir S. Andina Judith Andriani, Adinda Viviana Antonius H. Pudjiadi Antonius Pudjiadi Arie Dian Fatmawati Arvina Novianti Arwin A.P Akib Ashfahani Imanadhia Badriul Hegar Bambang Supriyatno Cahyani Gita Ambarsari Cindy D. Christie Corry Wawolumaya Damayanti Rusli Sjarif Darmawan B Setyanto Darmawan B. Setyanto Dina Nurpita Suprawoto Dwi Utari Rahmiati Ega Iftahul Rizky Eka Laksmi Hidayati, Eka Laksmi Endah Sulistiawati Evita Kariani B. Ifran Fatimatuzzuhroh Fatimatuzzuhroh Freddy Guntur Mangapul Silitonga Gunanti . Hanifah Oswari Hartono Gunardi Hartono Gunardi Helen Dian Fridayani, Helen Dian Hermin Mardiana Hidayat, Nauval Edghina Hotber Pasaribu I Nyoman Budi Hartawan Ifran, Evita Kariani Imam D Imam N Iqbal Zein Assyidiqie Irawan Mangunatmadja Irawan Mangunatmadja Irene Yuniar, Irene Iskandar, Stephen Diah Jayanti, Reny Dwi Jeanne Laurensie Sihombing Jose M. Mandei Julianti Julianti, Julianti Kaltha, Karina Kusumaningrum, Alya Laila Laila Marissa Tania Stephanie Pudjiadi Misbah Muhammad Abhi Purnomosidi Mulya R. Karyanti Munar Lubis Nabilla Novella Riyanti Nathanne Septhiandi Niken Wahyu Puspaningtyas Novie Amelia Nycane Nycane oedjatmiko oedjatmiko Partini Pudjiastuti Trihono Piprim B Yanuarso Piprim B. Yanuarso, Piprim B. Purwasari, Lucy Asri Putri, Ruth Angelia Riki Siswandi Rina Amalia C. Saragih Rinawati Rohsiswatmo Rini Sekartini Risa Imanillah Risma Kerina Kaban, Risma Kerina Ronald Chandra Rosalina Dewi Roeslani, Rosalina Dewi Sita Febriani Sudung O Pardede, Sudung O Sudung O. Pardede Sukasno Sukasno Syafiqurosyid, M. Zufar Syamsidah Lubis, Syamsidah Teny Tjitra Teny Tjitra Sari, Teny Tjitra Tidi Maharani, Tidi Tjhin Wiguna Wahyuni Indawati Wardah, Nabila Amalya Wardhana, Aditya Widjaya, Malik Wisnu