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Mediastinal T-Cell Lymphoblastic Lymphoma: A Rare Case in a Limited Resources Setting Sutrisno, Sutrisno; Kusumastuti, Etty Hary; Ridholia, Ridholia; Hasan, Hasan
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.251-258

Abstract

Background: Lymphoblastic Lymphoma (LBL) is a rare neoplasm which represents 1-2% of all Non-Hodgkin’s Lymphomas (NHLs).Objectives: To present challenges in diagnostic of a rare case in limited resources settingCase Presentation: A 36-year-old male came to Dr. Soetomo hospital with shortness of breath, facial edema and chest pain. Physical examination revealed a decreased breath sound and dull percussion in the right chest. CT scan showed solid mass 10.4 x 5.9 x 14.6 cm in the anterior - medius of mediastinum. Fine needle aspiration biopsy guided by CT scan showed the spread of lymphoid cells, big in size, anaplastic, rounded and hyperchromatic nuclei. Core biopsy showed diffuse and monotonous pattern of pleomorphic cells, round to oval and hyperchromatic nuclei. Immunostaining were positive for CD3 and Tdt, high Ki67 proliferation index 98%, and negative for CD20.Conclusion: T-LBL is a rare neoplasm, that generally occurs in adolescents and young adults, and is most common in males. It is an aggressive neoplasm, which can involve mediastinal mass and cause superior vena cava syndrome. Immunostaining would be positive for Tdt, and variably express CD1a, CD2, CD3, CD4, CD5, CD7, and CD8. The prognosis was poor due to the aggressiveness and the relapse.
Clinicopathological profile of nasopharyngeal carcinoma in 2016-2019 at Dr. Soetomo General Hospital Susetiyo, Karindra Amadea; Kusumastuti, Etty Hary; Yusuf, Muhtarum; Falerina, Rosa
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i1.474

Abstract

ABSTRACTBackground:.The number of nasopharyngeal carcinoma (NPC) cases is increasing and causing death, placing this cancer in fifth place as the cause of death in Indonesia. The initial clinical symptoms that are less specific often cause patients coming with advanced stage conditions. Therefore, the study of clinical and pathological profiles of NPC patients are required. Objective: To find out the clinicopathological profile of  NPC patients in Dr. Soetomo General Hospital in 2016-2019. Methods: This study was descriptive research with a retrospective study using medical records of NPC patients in Dr. Soetomo General Hospital from 2016 to 2019. Results:  192 NPC patients that meet the criteria were divided according to their age, gender, histopathological classification, stage, and post-therapy response. Out of 192 patients, 22 patients had post-therapy response based on histopathological data. Conclusion: NPC patients in Dr. Soetomo General Hospital in 2016-2019 were found in the range of 14-77 years old, most patients were in the age group 41-≤50 years old (66 patients, 34%). There were more male than female patients (73%). The most common clinical symptoms experienced by patients were a lump on the neck (82%), local ear complaints (79%), and local nasal complaints (75%). The most common histopathological subtype was non-keratinizing squamous cell carcinoma undifferentiated in 181 patients (94%). The highest stage of patients was IV A in 122 patients (64%). In 18 (82%) from 22 patients, based on histopathology examination had good criteria on therapy response. ABSTRAKLatar belakang: Angka kasus karsinoma nasofaring yang (KNF) kian meningkat dan dapat menyebabkan kematian, menempatkan kanker ini pada urutan ke lima di Indonesia. Gejala klinis awalnya yang kurang spesifik seringkali menyebabkan penderita datang dengan kondisi stadium lanjut. Oleh karena itu, profil penderita KNF secara klinis dan gambaran histopatologinya perlu diteliti lebih lanjut. Tujuan: Mengetahui profil klinikopatologi penderita KNF di RSUD Dr. Soetomo tahun 2016-2019. Metode: Penelitian secara deskriptif dengan studi retrospektif menggunakan rekam medis penderita KNF di RSUD Dr. Soetomo tahun 2016-2019. Hasil:  Sebanyak 192 penderita KNF yang memenuhi kriteria dibagi berdasarkan kategori usia, jenis kelamin, klasifikasi histopatologi, stadium, dan respon pasca terapi. Dari 192 penderita ditemukan sebanyak 22 penderita memiliki data respon pasca terapi berdasarkan histopatologi. Kesimpulan: Penderita KNF di RSUD Dr.Soetomo tahun 2016-2019 ditemukan pada rentang usia 14-77 tahun dengan penderita terbanyak pada rentang usia 41- 50 yaitu 66 (34%) serta lebih banyak terjadi jenis kelamin laki-laki yaitu 140 (73%). Gejala klinis yang paling banyak dialami penderita adalah benjolan pada leher 158 (82%), keluhan lokal telinga 151 (79%), dan lokal hidung 144 (75%). Subtipe histopatologi terbanyak adalah nonkeratinizing squamous cell carcinoma undifferentiated yaitu 181 (94%) penderita. Stadium terbanyak penderita adalah IV A yaitu 122 (64%) penderita. Sebanyak 18 (82%) dari 22 penderita berkriteria baik pada respon terapi berdasarkan histopatologi.
Profile of Endometrial Cancer Patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia Alim, Kenny Dion; Tjokroprawiro, Brahmana Askandar; Kusumastuti, Etty Hary
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.83-88

Abstract

Highlights:1. Endometrial cancer is one of the most common cancers that affect the female genitalia.2. Endometrial cancer patients are mostly women in the age group of 51-60 years old, nullipara, with normal BMI, had type 1 endometrial cancer, and on stage II. AbstractIntroduction: Endometrial cancer is one of the most common cancers that affect the female genitalia. This study aimed to find the profile of endometrial cancer patients in Dr. Soetomo General Academic Hospital, Surabaya, from January 2019 to December 2020. Methods: Data were collected from medical records of endometrial cancer patients in Dr. Soetomo General Academic Hospital, Surabaya, from January 2019 to December 2020. There were 154 endometrial cancer patients, and 66 met the inclusion and exclusion criteria. Forty-one of those patients also had curettage grades. Data were extracted from the medical records of those patients.Results: There were 66 samples used in this study. The most common age group of patients was the age group of 51-60 years old (40.91%). The highest parity rate was nullipara (28.79%). The highest body mass index (BMI) group was the normal BMI group (42.42%). The most common type of endometrial cancer was type 1, with endometrioid adenocarcinoma (93.94%). The most common stage of endometrial cancer was stage II (36.36%). The similarity between curettage and post-operative grade was 70.73%. Patients with a history of diabetes mellitus were 6.06%, and patients with a history of hypertension were 12.12%.Conclusion: Most of the endometrial cancer patients in Dr. Soetomo General Academic Hospital, Surabaya, were women in the age group of 51-60 years old, nullipara, with normal BMI, had type 1 endometrial cancer, and on stage II. Most patients had similar curettage and post-operative grades, and only a minority had diabetes mellitus and hypertension histories.
Pengukuran Adekuasi Sediaan Papsmear dan Deteksi Dini Kanker Serviks di Ngoro Kabupaten Mojokerto Rahaju, Anny Setijo; Rahniayu, Alphania; Mastutik, Gondo; Kurniasari, Nila; Fauziah, Dyah; Kusumastuti, Etty Hary; Sandhika, Willy; Wiratama, Priangga Adi; Ariani, Grace; Heriyawati, Heriyawati; Sari, Aditya Sita; Ilmiah, Khafidhotul; Qonitatillah, Ana; Ridholia, Ridholia; Sudiana, I Ketut; Susilo, Imam
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 1 (2025): Maret
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i1.2127

Abstract

Penelitian ini bertujuan untuk meningkatkan pemahaman masyarakat tentang deteksi dini kanker serviks dan evaluasi Pap smear, serta meningkatkan keterampilan pengambilan sampel Pap smear pada penyedia layanan kesehatan di Kecamatan Mawaddah, Kabupaten Mojokerto. Studi deskriptif observasional dengan desain cross sectional dilakukan pada 100 wanita berusia 20-70 tahun dari Rumah Sakit Mawaddah. Penilaian dilakukan sebelum dan sesudah pemaparan materi. 100 sampel Pap smear yang dikumpulkan oleh bidan setempat dievaluasi untuk menilai kecukupan spesimen menggunakan sistem Papanicolaou dan Bethesda. Kegiatan ini secara signifikan meningkatkan pemahaman tentang kanker serviks (8,05% menjadi 82,26%), sementara kegiatan pelatihan tenaga medis meningkatkan pengetahuan mengenai pengambilan sampel Pap smear (51,62% menjadi 100%). 99% dari sampel Pap smear yang dikumpulkan oleh tenaga medis di Kecamatan Mawaddah dinilai memadai dan memuaskan. Program pengabdian masyarakat yang berfokus pada deteksi dini kanker serviks melalui Pap smear, secara efektif meningkatkan pemahaman masyarakat, meningkatkan pengetahuan dan keterampilan pengambilan sampel oleh tenaga medis, yang dapat meningkatkan pula efektifitas layanan Pap smear di Rumah Sakit Mawaddah pada masyarakat.
Role of Chest CT Scan to Predict Malignancy on Mediastinal Mass Widyaningrum, Saraswati; Widyoningroem, Anita; Sensusiati, Anggraini Dwi; Kusumastuti, Etty Hary
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14218

Abstract

Mediastinal mass is becoming a global health problem due to high mortality. The heterogeneous mediastinal components make the symptoms of mediastinal mass diverse. CT scans are still the imaging modality for examining mediastinal mass before surgery or other therapies. In this study, we evaluate whether a CT scan could predict the malignancy of mediastinal mass, which is expected to help establish a pre-surgical or pre-biopsy diagnosis. Sixty-two samples were taken consecutively from mediastinal mass patients who came to Dr. Soetomo General Academic Hospital to undergo a CT scan of the thorax with contrast and histopathology examination (core biopsy or open biopsy), which was carried out in the period from December 2019 to March 2024. The results of the CT scan imaging used in this study variable include mass location, mass shape, mass size, infiltration with surrounding organs, attenuation values before contrast administration, after contrast administration, and additional attenuation before and after contrast administration. The CT scan and histopathology results were compared, and multivariate analysis was performed to obtain predictor factors. The location of the mediastinal mass (anterior, medius, posterior), the solid heterogeny component, cystic, calcification, mass shape, organ infiltration, and contrast enhancement value could significantly predict the mediastinal mass's malignancy. If obtained simultaneously, the organ infiltration and contrast enhancement value >20 HU can indicate whether a mediastinal mass is malignant with a specificity of up to 100%.
Program Pengabdian Masyarakat: Edukasi dan Deteksi Dini Kanker Serviks melalui Pemeriksaan Pap Smear di Kecamatan Bangkalan Sari, Aditya Sita; Kurniasari, Nila; Rahaju, Anny Setijo; Rahniayu, Alphania; Mastutik, Gondo; Fauziah, Dyah; Kusumastuti, Etty Hary; Sandhika, Willy; Wiratama, Priangga Adi; Ariani, Grace; Ridholia, Ridholia; Heriyawati, Heriyawati; Sudiana, I Ketut; Ilmiah, Khafidhotul; Qonitatillah, Ana
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 3 (2025): Mei
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i3.2310

Abstract

Kegiatan pengabdia masyarakat ini bertujuan untuk meningkatkan pemahaman tenaga kesehatan dan masyarakat mengenai deteksi dini serta pencegahan kanker serviks. Pelatihan tenaga kesehatan dilakukan agar mereka dapat melakukan prosedur Pap smear dengan benar dan sesuai standar, sementara penyuluhan masyarakat bertujuan untuk meningkatkan kesadaran akan pentingnya deteksi dini dan pencegahan kanker serviks. Studi ini menggunakan metode deskriptif observasional dengan pendekatan cross-sectional, mencakup dua kegiatan utama: pelatihan tenaga medis secara daring dan penyuluhan masyarakat secara langsung. Pelatihan Pap smear diikuti oleh 51 peserta yang terdiri dari perawat, bidan, dan dokter. Evaluasi sebelum dan sesudah pelatihan menunjukkan peningkatan pemahaman yang signifikan, di mana peserta dengan skor 80-100 meningkat dari 58,82% menjadi 82,35%. Penyuluhan kanker serviks diikuti oleh 74 peserta. Sebelum penyuluhan, hanya 12,16% peserta yang memperoleh nilai 80-100, namun setelahnya meningkat menjadi 100%. Sebanyak 62,2% peserta telah menikah, 8,1% memiliki riwayat hubungan seksual sebelum usia 17 tahun, dan 9,5% memiliki lebih dari satu pasangan. Selain itu, 98,6% belum pernah menerima vaksin HPV, dan 78,4% jarang melakukan Pap smear, menunjukkan rendahnya kesadaran pencegahan kanker serviks. Setelah penyuluhan, 60 peserta menjalani skrining kanker serviks. Mayoritas (41,7%) berusia 31-40 tahun. Hasil skrining dengan sistem Bethesda menunjukkan 100% NILM. Berdasarkan klasifikasi Papanicolaou, 88,1% termasuk kelas II (96,2% inflamasi, 1,9% bacterial vaginosis, 1,9% atrofi), dan 11,1% kelas I. Program ini terbukti efektif dalam meningkatkan pemahaman tenaga kesehatan dan masyarakat, serta keterampilan tenaga kesehatan dalam prosedur Pap smear, yang berkontribusi pada peningkatan kualitas layanan deteksi dini kanker serviks di RSIA Hikmah Sawi Bangkalan.
PROFIL KLINIKOPATOLOGI KARSINOMA LARING DI RSUD DR SOETOMO, SURABAYA 2018-2021 Djuanda, Stephanie Natasha; Kusumastuti, Etty Hary; Ariani, Grace
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.614

Abstract

Introduction Laryngeal carcinoma is the second most common malignancy of the respiratory tract1. Based on 2020 Global Cancer Observatory data, the incidence rate of laryngeal carcinoma is 184,615 cases with a mortality rate > 50%2. There are some prognostic factors that predict the prognosis and 5 year survival rate of the patients. Study of this factor is very important because it will affect the patient's management 1,3.The clinicopathological profile is very important in laryngeal carcinoma because the majority of specimen are received in the small biopsies. Methods This research is observational descriptive study with a retrospective approach. Population of this study are paraffin blocks obtained from biopsy and surgical that had been diagnosed histopathologically as laryngeal carcinoma in the Dr. Soetomo General Academic Hospital from January 2018 - December 2021. Demographic, radiologic and histopathology data were taken from the patient's medical records. Results The majority patients were males (93%). The average age of patients was 59 (±5.91) years, with age range is 27 – 84 years, peak incidence were in 61-70 years (34.1%). The tumor located mostly in glottic (60.2%). Based on the T and N staging, most patient came at T4 and N2 stage. All the tumor were conventional squamous cell carcinoma. Conclusion Clinicopathology profile is very important in determine the prognostic factor in laryngeal carcinoma. Most of patient were males, in age group 61-70 years, located in glottis. Most patient came at advanced stadium. Most tumor were conventional squamous cell carcinoma, and the majority was well differentiated grade.  
Histopathological Grading based on BI-RADS Mammography Category 4 and 5 in Breast Cancer Ramadhan, Farhan Ubaidillah; Mardiyana, Lies; Kusumastuti, Etty Hary; Ghaib, Husnul
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 2 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I22025.109-114

Abstract

Highlights: Most breast cancer patients were in the 45-49 years old age group. There was no difference in the age interval between BI-RADS C-4 and C-5 in breast cancer patients. There was no difference in histopathological grading between BI-RADS C-4 and C-5 in breast cancer patients.   Abstract Introduction: Breast cancer is the most common cancer worldwide. The diagnosis of breast cancer is established by a triple diagnostic, such as clinical examination, radiology (mammography), and histopathology. This study aimed to compare mammography breast imaging-reporting and data system (BI-RADS) category 4 and 5 with histopathological grading of breast cancer at Dr. Soetomo General Academic Hospital, Surabaya. Methods: This was an observational, descriptive study with a comparative approach, utilizing secondary data from medical records of breast cancer patients at Dr. Soetomo General Hospital, Surabaya, from January 2017 to December 2021. There were 234 samples of patients who met the inclusion criteria. All statistical data were analyzed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26, with a p<0.05 regarded as statistically significant. Results: The breast cancer patients were most prevalent in the 45-49 years old age group (20.9%). The highest distribution of the BI-RADS category was C-5 (85.9). The highest distribution of histopathological grading was grade III (53%). There was no difference in age intervals between BI-RADS C-4 and BI-RADS C-5 in breast cancer patients (p=0.499). There was no difference in histopathological grading between BI-RADS C-4 and C-5 in breast cancer patients (p=0.592). Conclusion: There was no difference either in age interval or histopathological grading between BI-RADS category 4 and 5 in breast cancer patients.
Role of Chest CT Scan to Predict Malignancy on Mediastinal Mass Widyaningrum, Saraswati; Widyoningroem, Anita; Sensusiati, Anggraini Dwi; Kusumastuti, Etty Hary
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14137

Abstract

Mediastinal mass is becoming a global health problem due to high mortality. The heterogeneous mediastinal components make the symptoms of mediastinal mass diverse. CT scans are still the imaging modality for examining mediastinal mass before surgery or other therapies. In this study, we evaluate whether a CT scan could predict the malignancy of mediastinal mass, which is expected to help establish a pre-surgical or pre-biopsy diagnosis. Sixty-two samples were taken consecutively from mediastinal mass patients who came to Dr. Soetomo General Academic Hospital to undergo a CT scan of the thorax with contrast and histopathology examination (core biopsy or open biopsy), which was carried out in the period from December 2019 to March 2024. The results of the CT scan imaging used in this study variable include mass location, mass shape, mass size, infiltration with surrounding organs, attenuation values before contrast administration, after contrast administration, and additional attenuation before and after contrast administration. The CT scan and histopathology results were compared, and multivariate analysis was performed to obtain predictor factors. The location of the mediastinal mass (anterior, medius, posterior), the solid heterogeny component, cystic, calcification, mass shape, organ infiltration, and contrast enhancement value could significantly predict the mediastinal mass's malignancy. If obtained simultaneously, the organ infiltration and contrast enhancement value >20 HU can indicate whether a mediastinal mass is malignant with a specificity of up to 100%.
Diagnosis of Kaposi’s sarcoma Alvian Arifin Saiboo; Dwi Murtiastutik; Etty Hary Kusumastuti; Putri Halla Shavira
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 2 (December 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/9hqvm129

Abstract

Kaposi’s sarcoma has a picture reminiscent of several skin conditions, so further testing is needed to show the diagnosis of Kaposi’s sarcoma. Lymphatic endothelium cells infected with KSHV or human herpesvirus 8 form the basis of Kaposi’s sarcoma (KS), a multicentric tumor (HHV-8). These macules and plaques might be purple, reddish-blue or dark brown-black in color. KS is distinguished by this look.” Inflamed, ulcerated nodular lesions are common. They are neither unpleasant or uncomfortable, and the overlying skin or underlying tissues seldom die as a result of them. The gold standard examination in establishing the diagnosis of KS is histopathology. Several techniques that can be used for histopathological tissue retrieval are punch biopsy, shave biopsy, excision biopsy and incision biopsy. Immunohistochemical examination can also be performed to rule out the differential diagnosis. Immunohistochemical examination that we can do is with LANA-1, CD 34, CD 31, D2-40. Diagnosis of Kaposi’s sarcoma is difficult to diagnose only from a clinical picture, so similar diagnoses, i.e. histopathological and immunohistochemical examinations, are required.