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All Journal KOMUNITAS: INTERNATIONAL JOURNAL OF INDONESIAN SOCIETY AND CULTURE Media Ilmu Keolahragaan Indonesia International Journal of Education Jurnal Keolahragaan Jurnal SPORTIF : Jurnal Penelitian Pembelajaran Wellness And Healthy Magazine SMART SPORT Narra J Journal of Multidisciplinary Applied Natural Science Indonesian Journal of Physical Education and Sport Science (IJPESS) Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Physical Therapy Journal of Indonesia Journal of Social Work and Science Education Jurnal Info Kesehatan
Muchsin Doewes
Faculty of Medicine, Sebelas Maret University
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Caesalpinia bonduc (L) Roxb Seed Extract Dosage and Sex Effects on Pathobiological Changes in A Rat Model of Diabetes Mellitus Sopianti, Densi Selpia; Doewes, Muchsin; Sumandjar, Tatar; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita; Nurwati, Ida
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.349

Abstract

Caesalpinia bonduc (L) Roxb is a medicinal plant commonly utilized in traditional Indonesian medicine, particularly for the treatment of diabetes mellitus (DM). This study examined the effects of varying doses C. bonduc extract on fasting blood sugar (FBS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), and pancreatic histology in male and female wistar rats with diabetes. The study design included six groups of 18 male and female rats (Wistar strain) each. To develop diabetes, nicotinamide (NA) (110 mg/kg) and streptozotocin (STZ) (45 mg/kg) were supplied, followed by oral administration of C. bonduc extract at dosages of 200, 400, and 600 mg/kg for 21 days. We utilized ELISA to analyze biochemical parameters and employed H&E staining to evaluate histological changes. A factorial design was employed for the statistical analysis to examine the effects of both dosage and sex. This study offers a unique comparative examination of the antidiabetic efficacy of C. bonduc across genders, a dimension seldom explored in experimental diabetes research. The findings indicated that C. bonduc markedly reduced levels of FBS, MDA, TNF-α, and TGF-β (p < 0.05) enhanced the structural integrity of the pancreas. There were no significant differences between males and female (p > 0.05). The dosage and sex influenced MDA and TGF-β. The extract of C. bonduc shown the ability to lower blood sugar, fight free radicals, and reduce inflammation; however, the intensity of these benefits depended on the dosage given. This means that it might assist persons with diabetes minimize oxidative stress and damage to the pancreas.
Pengaruh Ice Massage terhadap Delayed Onset Muscle Soreness pada Otot Gastrocnemius Ditinjau dari Jenis Kelamin Akbar, Muhammad Thoriq Hadad; Doewes, Muchsin; Syaifullah, Rony
Smart Sport Vol 25, No 2 (2024): Jurnal Smart Sport
Publisher : Smart Sport

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/smsp.v25i2.99818

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh delayed onset musclesoreness pada mahasiswa pencak silat UTP Surakarta ditinjau dari jenis kelamin. Jenis penelitian yang digunakan adalah metode eksperimen. Populasi dalam penelitian ini adalah mahasiswa (laki-laki dan perempuan) Pencak Silat UTP Surakarta. Sampel yang digunakan dalam penelitian ini adalah 100, yang terdiri dari mahasiswa dan mahasiswi UTP Surakarta yang diperoleh dengan tehnik purposive random sampling. Analisis statistik yang dilakukan pada hasil awal DOMS setelah latihan dan hasil akhir DOMS setelah diberikan treatment ice massage pada mahasiswa laki-laki dan perempuan. Hasil analisis statistik dilakukan dengan menggunakan progam SPSS versi 25. Dari hasil penelitian menunjukkan ada perbedaan pengaruh jenis kelamin ( laki-laki dan perempuan terhadap penurunan DOMS pada otot Gastrocnemius dibuktikan dari nilai Signifikansi .019<0,05 (p<0,05). Jadi dapat disimpulkan bahwa mahasiswa yang berjenis kelamin laki-laki memiliki penurunan DOMS yang berbeda dengan mahasiswa yang berjenis kelamin perempuan dapat diterima kebenarannya. Pemberian ice massage lebih baik menurunkan DOMS pada mahasiswa laki- laki daripada mahasiswa perempuan. Kata Kunci: DOM, Pencak Silat, Jenis Kelamin
Co-Authors . Fadityo . Kisrini . Samigun Abdurrachman, Abdurachman Agus Kristiyanto Akbar, Muhammad Thoriq Hadad Alifiyanti Muharramah ANAS KHOLIKUL AMIN, ANAS KHOLIKUL Annisa Marsha Evanti Aprilia, Khalida Nawa Aulia Ramadhani Bambang Purwanto Bhisma Murti Didik Gunawan Tamtomo Dono Indarto Duta Putra Utama, Dimas Ekawati, Febriani Fajar Eti Poncorini Pamungkasari Fajar Ekawati, Febriani Hari Hanggoro, Hari Hartono Hartono Hidayatullah, Muhammad A'raaf Ida Nurwati Jatmiko Susilo Khoirul Huda Kisrini . M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Muh. Furqon Hidayatullah Németh, Zsolt NINGRUM, TYAS SARI RATNA Nugroho, Kristanto Adi Nur Zahratul Jannah Pamungkasari, Eti P. Paramasari Dirgahayu pasa, chusairil Purnama, Siswanta Jaka Ratih Puspita Febrinasari Restian Gigih sejati, Restian Gigih Risya Cilmiaty, Risya Riza Setya Agrensa Rohma, Noer Rony Syaifullah, Rony Sapta Kunta Purnama Savira, Intan Shanti Listyawati Sinu Andhi Jusup, Sinu Andhi Slamet Riyadi Soetrisno Soetrisno Sopianti, Densi Selpia SUGIYANTO Sumandjar, Tatar Syahmirza Indra Lesmana Syetiawinanda, Amriansyah Utama, Dimas Duta Putra Vitri Widyaningsih Wahyuni, Ardianti