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Journal : Jurnal Kesehatan

IDENTIFIKASI DRUG RELATED PROBLEM (DRP) PADA PASIEN INFEKSI SALURAN KEMIH DI RUMAH SAKIT BHAYANGKARA KENDARI Musdalipah Musdalipah
Jurnal Kesehatan Vol 11 No 1 (2018): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v11i1.4908

Abstract

Urinary tract infection (UTI) is a disease in which the formation of microorganisms in large quantities in the urinary tract. In order to increase rational use of drugs, pharmacists have an important role in identifying and solving problems related to Drug Related Problem (DRP), both potential and actual. The purpose of this research is to identify Drug Related Problem (DRP) of Urinary Tract Infection (ISK) patient at Bhayangkara Kendari Hospital. This research used descriptive method with retroprospective-prospective data collection technique based on inclusion and exclusion criteria by recipe and patient medical record data. The data is analyzed descriptively and described in narrative form. The results showed that 34 patients were found Drug Related Problem (DRP) category of potential drug interactions as many as 15 patients (44.11%), Polypharmacy, dose interval and Drug side effects not foundABSTRAKInfeksi saluran kemih (ISK) adalah suatu penyakit yang dimana terbentuknya mikroorganisme dalam jumlah banyak di saluran kemih. Dalam rangka meningkatkan penggunaan obat yang rasional, farmasis memiliki peran penting terutama dalam mengidentifikasi serta memecahkan masalah yang berkaitan dengan penggunaan obat atau Drug Related Problem (DRP) baik yang bersifat potensial maupun aktual. Tujuan penelitian ialah mengidentifikasi Drug Related Problem (DRP) pasien Infeksi Saluran Kemih (ISK) di Rumah Sakit Bhayangkara Kendari. Jenis penelitian menggunakan metode deskriptif dengan teknik pengumpulan data secara retroprospektif–prospektif berdasarkan kriteria inklusi dan eksklusi dengan melihat resep dan data rekam medik pasien. Data dianalis secara deskriptif dan dijabarkan dalam bentuk narasi. Hasil penelitian menunjukkan dari 34 pasien ditemukan Drug Related Problem (DRP) kategori adanya potensi Interaksi obat sebanyak 15 pasien (44,11%), Polifarmasi, Interval dosis dan Efek samping obat tidak ditemukan
PERBANDINGAN AKTIVITAS PENGHAMBATAN ENZIM TIROSINASE OLEH FRAKSI ETIL ASETAT DAUN PATIKALA (Etlingera elatior) DAN HIDROKUINON SECARA In Vitro Selfyana Austin Tee; Apriyanto Apriyanto; Musdalipah Musdalipah; Elfirah Elfirah
Jurnal Kesehatan Vol 13 No 1 (2020): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v13i1.10309

Abstract

Etlingera is one of the genus Zingiberacea which consists of 150 - 200 species in the world, and there are 48 species that grow in Sulawesi and 14 species of which are scattered in Sulawesi. Patikala (Etlingera elatior) has a bioactive compound in the form of flavonoids. Withdrawal of flavonoid compounds in plants is carried out using ethyl acetate solvents. One of the enzymes in the body is the tyrosinase enzyme. The tyrosinase enzyme is the main pathway in the pigmentation process, causing melanin pigment. This study aims to compare the inhibitory activity of the tyrosinase enzyme in the paticala fraction of ethyl acetate (Etlingera elatior) and hydroquinone in vitro. The research method used was a quasi experimental consisting of the treatment group and the control group with measurements made after the treatment was given (posttest only design with non equivalent group). Concentration of ethyl acetate fraction of patikala leaves used were 7.8125 µg / mL, 15,625 µg / mL, 31.25 µg / mL, 62.5 and 125 µg / mL with positive control of hydroquinone, respectively. Based on the results obtained, Inhibitory activity of the tyrosinase enzyme by the paticala leaf ethyl acetate fraction with a concentration of 125 μg. The inhibitory activity of the tyrosinase enzyme by both samples increased with increasing concentration