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All Journal Jurnal Farmasi Indonesia Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal of Pharmascience
Eka Kumalasari
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL DAN FRAKSI ETANOL, FRAKSI KLOROFORM, FRAKSI N-HEKSANA, FRAKSI AIR, FRAKSI ETIL ASETAT DARI DAUN BAWANG DAYAK (Eleutherine palmifolia (L.) Merr.) Eka Kumalasari; Arini Septia; Dwi Rizki Febrianti; Noor Aisyah
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.678

Abstract

Dayak onion (Eleutherine palmifolia (L.) Merr.) is one of the typical Central Kalimantan plants that has been hereditary used by Dayak people as traditional medicine. Generally, only parts of dayak onion bulbs are used while the onion leaves are often discarded and rarely used. Dayak onion leaves contain secondary metabolites, one of them is flavonoids. Flavonoid compounds have many benefits, namely as an antioxidant, antibacterial, antiviral, anti-inflammatory, anti-allergic and anticancer. The purpose of this study was to determine the total flavonoid content contained in etahanol extraction, n-hexane fraction, chloroforom fraction, ethyl acetate fraction, 70% ethanol fraction and dayak onion leaf water fraction. Extraction of onion dayak leaves using maceration method with 70% ethanol as solvent. After extraction the fraction is carried out with a liquid-liquid extract method and different polarity of solvent. The product of extraction and fractionation were measured using UV-Vis spectrophotometry.The quantitative analysis of total flavonoid content from the highest level of onion dayak fraction chloroform fraction 85,478% ± 0,0019, then n-hexane fraction 60,171% ± 0,0010, water fraction 32,671% ± 0,0005, ethyl acetate fraction 27,934% ± 0, 0002, 70% ethanol extract 15,348% ± 0,0001, and the lowest ethanol 70% fraction 10,104% ± 0,0003.
FORMULASI DAN EVALUASI GEL HAND SANITIZER DARI MINYAK ATSIRI BUNGA LILI (Lilium auratum) Dwi Rizki Febrianti; Eka Kumalasari; Rakhmadhan Niah; Novia Ariani; Supomo Supomo; Dita Ayulia Dwi Sandi
Journal of Pharmascience Vol. 11 No. 1 (2024): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.13822

Abstract

Minyak atsiri bunga lili (lilium auratum) dapat berpotensi sebagai antibakteri dengan memformulasikan dalam bentuk sediaan gel hand sanitizer. Tujuan penelitian ini adalah untuk menentukan sediaan gel antiseptik (Hand sanitizer) minyak atsiri bunga lili dengan berbagai konsentrasi gelling agent carbopol 940 yang mempunyai sifat fisik yang baik dan memenuhi syarat. Carbopol 940 divariasikan dengan konsentrasi 0,667 % dan 1,334% dari total formula. Penelitian ini menggunakan metode eksperimental. Formula diuji sifat fisiknya, seperti uji organoleptis, pH, homogenitas, daya lekat dan daya sebar. Hasil penelitian menunjukkan dari kedua formula dengan variasi konsentrasi gelling agent carbopol 940 yaitu 0,667 % dan 1,334% memenuhi syarat uji sifat fisik. Didapatkan hasil formula yang mempunyai sifat fisik yang memenuhi standar uji sifat fisik adalah formula II dengan konsentrasi Carbopol 940 1,334%. Kata Kunci : Lilium Auratum, Hand Sanitizer, Carbopol 940, Uji Sifat Fisik, Antibakteri The essential oil of lili (Lilium auratum) can potentially be antibacterial by formulating in the form of hand sanitizer gel preparations. This study is to determine the preparation of antiseptic gel (Hand sanitizer) of lilies essential oil with various concentrations of gelling agent carbophol 940 which has good physical properties and qualifies. Carbophol 940 with a variation in concentration of 0.667% and 1.334% with experimental methods conducted trials on formulations so that a product of hand sanitizer gel preparations of lilies essential oil that has good physical properties and qualifies. The results of the research showed that from the two formulas with variations in the concentration of the gelling agent Carbopol 940, namely 0.667% and 1.334%, it met the requirements. The resulting formula which had good physical properties was formula II with the amount of Carbopol 1.334%.
Aktivitas Baccaurea motleyana Mull.Arg. terhadap Salmonella thypi Dwi Rizki Febrianti; Saftia Aryzki; Maulida Khadijah; Eka Kumalasari; Rakhmadhan Niah
Journal of Pharmascience Vol. 11 No. 2 (2024): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.16498

Abstract

Penyakit tifus adalah gangguan pada sistem pencernaan yang menyerang bagian usus halus dan terkadang dapat mempengaruhi aliran darah, kantong empedu, limfa, dan hati. Penyebab utama tifus adalah aktivitas bakteri Salmonella thypi, bakteri ini mampu mengontaminasi makanan ataupun minuman yang tidak terjaga sanitasinya. Baccaurea motleyana Mull.Arg memiliki kandungan senyawa antibakteri, diantaranya golongan flavonoid, saponin, dan tanin. Penelitian ini bertujuan untuk membuktikan aktivitas ekstrak daun rambai dalam menghambat S. thypi. Penelitian ini menggunakan metode ekstraksi maserasi dan uji antibakteri menggunakan metode difusi sumuran menggunakan nutrien agar (NA). Ekstraksi dengan maserasi dilakukan menggunakan pelarut etanol 70%. Kelompok perlakuan pada penelitian ini menggunakan seri  konsentrasi ekstrak 10%, 20%, 30%, dan kontrol negatif (water for injection) dengan tiga kali pengulangan. Ukuran diameter zona bening yang terbentuk diukur menggunakan jangka sorong digital. Hasil penelitian menunjukkan bahwa ekstrak daun rambai memiliki efek penghambatan terhadap pertumbuhan bakteri S. thypi. Rerata zona hambat dari ekstrak daun rambai dengan konsentrasi 10%, 20%, dan 30% masing-masing adalah 14,1 mm; 18,8 mm; dan 23,13 mm, sehingga dapat disimpulkan bahwa ekstrak daun B. motleyana memiliki aktivitas terhadap bakteri S. thypi. Kata Kunci: Antibakteri,  Zona Bening, Daun Rambai,  Difusi Padat, Salmonella thypi Typhoid disease is a disorder of the digestive system that attacks parts of the small intestine and can sometimes affect blood flow, gallbladder, lymph, and liver. The main cause of typhus is the activity of Salmonella thypi bacteria, this bacterium is able to contaminate food or drinks that are not maintained sanitation. Baccaurea motleyana Mull.Arg contains antibacterial compounds, including flavonoids, saponins, and tannins. This study aims to prove the activity of rambai leaf extract in inhibiting S. thypi. This study uses the maceration extraction method and antibacterial test using the well diffusion method using agar nutrients (NA). Extraction by maceration is carried out using a 70% ethanol solvent. The treatment group in this study used a series of 10%, 20%, 30% extract concentrations, and negative control (water for injection) with three repetitions. The size of the diameter of the formed clear zone is measured using a digital caliper. The results showed that rambai leaf extract had an inhibitory effect on the growth of S. thypi bacteria. The average inhibition zone of rambai leaf extract with concentrations of 10%, 20%, and 30% was 14.1 mm, respectively; 18.8 mm; and 23.13 mm, so it can be concluded that B. motleyana leaf extract has activity against S. thypi bacteria.
Co-Authors Aisyah Aisyah Arini Septia Ayu, Welinda Dyah Ayuchecaria, Noverda Dwi Rizki Febrianti Erna Prihandiwati Febrianti, Dwi Rizki Maulida Khadijah Merina Hariani Nazulla Mudjib Nararia Nida Munirah Noor Aisyah Novia Ariani Putra, Aditya Maulana Perdana Rakhmadhan Niah Rakhmadhan Niah Reksi Sundu Rianto, Leonov Rina Feteriyani Risa Supriningrum Riski, Akhmad Riza Alfian Saftia Aryzki Sandi, Dita Ayulia Dwi Sari, Ratih Pratiwi Siska Musiam Soraya Soraya Suci Renita Supomo Supomo Syifa Maharani Triswanto Sentat Wahyuni, Amaliyah Yumassik, Abdul Mahmud