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All Journal HAYATI Journal of Biosciences Jurnal Sains dan Seni ITS IPTEK Journal of Proceedings Series Matematika dan Sains Widyariset Jurnal Riset Industri Hasil Hutan PENA SAINS Indonesian Journal of Chemistry Akta Kimia Indonesia Indonesian Journal of Electrical Engineering and Computer Science Widyariset Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Sewagati Jurnal Kefarmasian Indonesia Journal of Tropical Pharmacy and Chemistry

Taslim Ersam

Departemen Kimia, Institut Teknologi Sepuluh Nopember

Author-ID : 260754

Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Isolasi Senyawa Antioksidan dari Kulit Batang Sonneratia ovata Backer Fatati Nurmalasari; Taslim Ersam; Sri Fatmawati
Jurnal Sains dan Seni ITS Vol 5, No 2 (2016)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM), ITS

Campuran Senyawa β-sitosterol (1a) dan stigmasterol (1b) telah diisolasi dari ekstrak metanol kulit batang Sonneratia ovata Backer dengan titik leleh 127-128 oC. Sonneratia ovata Backer merupakan tumbuhan mangrove yang berasal dari Pulau Dobo, Kepulauan Aru, Maluku yang telah banyak digunakan sebagai obat tradisional untuk berbagai penyakit. Isolasi dilakukan dengan ekstraksi (maserasi) dan kromatografi cair vakum (KCV). Senyawa hasil isolasi dikarakterisasi dengan IR dan 13C-NMR. Fraksi dan senyawa hasil isolasi menunjukkan aktivitas antioksidan dengan uji radikal DPPH. Fraksi dan senyawa hasil isolasi menunjukkan aktivitas antioksidan yang lebih rendah dibandingkan dengan asam galat sebagai kontrol positif dengan persentase penghambatan sebesar 43,652 ± 0,013 % dan 27,159 ± 0,014% pada konsentrasi 319,458 µg/mL.

Isolasi Senyawa 3β-asetoksi-lup-20(29)-en-2-ol dan Uji Antioksidan dari Tumbuhan Kepulauan Aru (Sonneratia ovata Backer) Fatmawati Inneke Putri; Taslim Ersam; Sri Fatmawati
Jurnal Sains dan Seni ITS Vol 5, No 2 (2016)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM), ITS

Sonneratia ovata Backer merupakan salah satu tanaman yang berasal dari Kota Dobo, Kepulauan Aru. Senyawa 3β-asetoksi-lup-20(29)-en-2α-ol (1) berupa serbuk putih dengan titik leleh 200-201oC berhasil diisolasi dari ekstrak metanol kulit batang Sonneratia ovata Backer. Senyawa tersebut difraksinasi menggunakan metode kromatografi cair vakum (KCV) dan kromatografi kolom gravitasi (KKG). Senyawa murni diidentifikasi menggunakan spektroskopi IR, 1H-NMR, dan 13C-NMR. Uji bioaktivitas antioksidan dilakukan dengan metode DPPH. Fraksi dari senyawa (1) menunjukan prosentase penghambatan sebesar 20,91 ± 0,006 %.

2, 4, 6-Trihidroksi Benzofenon dari Kulit Batang Garcinia balica Miq Retno Purbowati; Taslim Ersam
Jurnal Sains dan Seni ITS Vol 6, No 1 (2017)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM), ITS

Penelitian ini bertujuan untuk mengisolasi senyawa metabolit sekunder dari ekstrak etil asetat kulit batang Garcinia balica Miq. Proses ekstraksi dengan pelarut etil asetat didapatkan fraksi kering, kemudian difraksinasi menggunakan metode Kromatografi Kolom Gravitasi (KKG) dan dilanjutkan dengan metode Kromatografi Eksklusi Ukuran. Senyawa yang diisolasi berupa padatan amorf berwarna kuning kecoklatan dengan titik leleh sebesar 215-2160C. Penentuan struktur senyawa dilakukan dengan analisis UV, IR, 1H dan13C NMR. Senyawa yang diisolasi diketahui merupakan senyawa 2, 4, 6-trihidroksi benzofenon

Digeranilasi Santon pada Ekstrak Diklorometana Kulit Batang Wadung (Garcinia tetranda Pierre) Hesti Selfiana Dwi Jayanti; Taslim Ersam
Jurnal Sains dan Seni ITS Vol 7, No 1 (2018)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM), ITS

Penelitian ini melanjutkan penelitian terdahulu tentang spesies Garcinia tetrandra Pierre yang termasuk dalam genus Garcinia dan keluarga besar Cluciaceae yang mengandung turunan senyawa santon terprenilasi, didapatkan dari Koleksi Taman Nasional Meru Betiri, Jember, Jawa Timur. Senyawa 1 yang merupakan mangostanasanton I telah berhasil diisolasi dari ekstrak diklorometana kulit batang G. tetrandra Pierre menggunakan metode ekstraksi secara maserasi yang dielusi dengan berbagai pelarut dengan menaikkan kepolarannya, fraksinasi menggunakan berbagai metode kromatografi (kromatografi cair vakum dan kromatografi kolom grafitasi), dan pemurnian menggunakan rekristalisasi dua pelarut. Penentuan struktur senyawa didasarkan pada analisa spektroskopi IR, UV, 1H-NMR, dan 13C-NMR.

Isolasi Senyawa Rubrasanton dan Parvifolisanton C dari Ekstrak Kulit Batang Garcinia Tetrandra Pierre Rizaldy Nizzah Kurniawan; Taslim Ersam
Jurnal Sains dan Seni ITS Vol 7, No 1 (2018)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM), ITS

Spesies Garcinia tetrandra Pierre adalah salah satu spesies dari keluarga besar Cluciaceae yang telah dikenal mengandung turunan senyawa santon terprenilasi. Dua senyawa turunan santon berhasil didapatkan dari ekstrak diklorometana kulit batang Garcinia tetrandra yaitu rubrasanton (1) dan parvifolisanton C (2). Isolasi dua senyawa tersebut menggunakan metode ekstraksi secara maserasi, fraksinasi menggunakan berbagai metode kromatografi (kromatografi cair vakum dan kromatografi radial) dan pemurnian menggunakan rekristalisasi dua pelarut. Penentuan struktur senyawa tersebut berdasarkan analisis spektroskopi IR, UV, 1H-NMR dan 13C-NMR.

Exploration of Phenolic Compound from The Stem Bark of Garcinia latissima Miq. Retno Purbowati; Taslim Ersam
Jurnal Sains dan Seni ITS Vol 8, No 2 (2019)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM), ITS

Genus Garcinia, which well known as mangosteen family. It is belonging Cluciaceae family, consists of over 100 species. It is widely distributed in Southeast Asia. There are 77 species of this genus grows throughout Indonesia. Genus Garcinia have been identified to be a rich source of phenolic compounds, including xanthones, biflavonoids, benzophenones, depsidones, and triterpenoids. Some of those have been reported to have several biological activities, such as antioxidant, antidiabetic, and anticancer. Garcinia latissima Miq. is an endemic plant growing in Indonesia, especially in Papua Island, and its neighbouring country, Papua New Guinea. It is called Dolomagata by local people in Maluku. The plant usually grows with the straight and cylindrical stem. It has short buttresses and it has 50-80 cm diameter. Previous reports have revealed antimicrobial and antioxidant activites of the leaves, fruits, and stem bark extracts of the plant. Phytochemical investigation of the stem bark of G. latissima Miq. led to the isolation of new pyranoxanthones, latisxanthones-A-D. In this work, the isolation and structural elucidation of secondary metabolites from the stem bark of G. latissima Miq. will be conducted. Three known compounds such as kaempferol (1,2), 1,3,6,7-Tetrahydroxy-2-(3-methyl-but-2-enyl)-xanthen-9-one (3), 1,3,7 trihydroxy xanthone (4) were isolated from the ethyl acetat fraction.

ISOLATION, STRUCTURE ANALYSIS, AND ANTIBACTERIAL ACTIVITY OF BIFLAVONOID GB-1 FROM Garcinia tetranda Pierre Novi Sulistyaningrum; Taslim Ersam
Widyariset Vol 15, No 3 (2012): Widyariset
Publisher : Pusbindiklat - LIPI

Garcinia tetranda Pierre (Clusiaceae) was reported as source of flavonoid which has various bioactivities forhealth. Pure compound has been isolated by repeat chromatography techniques (Vacuum Column Chromatography,preparative TLC and TLC). UV, IR, 1H-NMR and 13C-NMR spectroscopic data of isolated compound (isolate)compared with the compound which was found before, and showed same as biflavonoid GB-1 data. Antibacterialassay against Salmonella typhi showed lower activity than chloramphenicol. Biflavonoid GB-1 compound foundin this study is different to the previous study, which all of compounds were classified as xanthones. Therefore,result of this study improves compound variability of Garcinia tetranda. However GB-1 is not potentially used asGram-negative antibacterial agent, especially against Salmonella typhi.

PHYTOCHEMICAL SCREENING OF ETHANOLIC EXTRACT: a Preliminary Test on Five Medicinal Plants on Bangkalan Laila Khamsatul Muharrami; Fatimatul Munawaroh; Taslim Ersam; Mardi Santoso
JURNAL PENA SAINS Vol 7, No 2 (2020): Jurnal Pena Sains
Publisher : Program Studi Pendidikan IPA, Fakultas Ilmu Pendidikan, Universitas Trunojoyo Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21107/jps.v7i2.8722

This study is preliminary research of secondary metabolite potential from medicinal Herb Madura. This study aims to know the medicinal plants used in the medicinal herb Madura and the phytochemical content contained in these medicinal plants. The method used in this study is a survey to know the kinds of medicinal plants used in Madura Herb. Then a phytochemical screening test for the medicinal plant was performed. The phytochemical screening test used are alkaloids, steroids, saponins, and flavonoids. Based on the research, it is found that 66 medicinal plants are widely used for "Ramuan Madura” in Bangkalan. Of the 66 plants selected, Madura five medicinal plants widely used by the Madurense; Parameria laevigata, Kaempferia galanga L., Curcuma domestica, Curcuma xanthorrhiza, dan Punica granatum. Then the preliminary phytochemical test to determine the secondary metabolite compounds. Secondary metabolite content obtained include alkaloids, saponins, steroids, and flavonoids.

HERB PLANT: INVENTORY AND PHYTOCHEMICAL SCREENING IN SAMPANG, MADURA Laila Khamsatul Muharrami; Fatimatul Munawaroh; Taslim Ersam; Mardi Santoso
JURNAL PENA SAINS Vol 4, No 2 (2017): JURNAL PENA SAINS
Publisher : Program Studi Pendidikan IPA, Fakultas Ilmu Pendidikan, Universitas Trunojoyo Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21107/jps.v4i2.3232

Currently, modern medicine has advanced rapidly but habits of drinking herbal medicine are still survived in Madurese society. The local wisdom of drinking herbal medicine in Madurese society, especially in Sampang Regency has been believed to be efficacious for generations. Average medicinal ingredients used are derived from natural ingredients taken from root organs, bark, leaves, fruit or seeds of herbs. This research aims to perform an inventory of herbs that have potential in improving the welfare of Madurese, especially in Sampang Regency. Type of research used is descriptive qualitative research method used is by conducting interviews to the community, IKOT owners, and herbalist. Madurese herbs in Sampang. Based on the results of research, 46 herbs are obtained. Of 46 plants found there are 16 different types of herbs. Herbal plants that many people use (have a percentage of more than 50%) are jahe (Indonesian name), kunyit (Indonesian name), kencur (Indonesian name), kayu rapet (Indonesian name) and delima (Indonesian name). The results of phytochemical screening of fifth herbs showed that positive herbal plants containing saponins were jahe (Indonesian name), kencur (Indonesian name), kayu rapet (Indonesian name) and delima (Indonesian name). And of the five samples, all positively contain secondary metabolites of flavonoids, tannins, and steroids.

3,6-dimethyl ester-α-mangostin Compound Modified from Isolate α-mangostin Garcinia Mangostana Linn Khoiriyah Umami; Arif Fadlan; Taslim Ersam
IPTEK Journal of Proceedings Series No 6 (2020): 6th International Seminar on Science and Technology 2020 (ISST 2020)
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2020i6.9184

Isolate α-mangostin (1) is a phenolic compound derived from oxygenated and prenylated xanthones and major compounds obtained from the fruit peel of G. mangostana Linn., Which is stated to have inhibitory activity against α-glucosidase enzymes, serves to determine the antidiabetic activity resulting in IC50 value of 29,92 µM, is of the nature moderate to positive control (acarbose) with an IC50 value of 4.55 µM. A modified compound of α-mangostin (1) with acetic anhydride obtained by 3,6-di-methyl ester-α-mangostin (2) derivative showed the inhibitory value of α-glucosidase (IC50 13,89 μM), this value is better than the activity inhibition of α-mangostin (1), but not as active as the positive control value of the acarbose compound. The separation process to obtain α-mangostin isolates from the fruit peel of G. mangostana Linn was obtained by maceration method with ethyl acetate solvent, followed by refraction using a vacuum liquid chromatography (KCV) method over silica gel (Merck 60 G) and eluted using eluent (n-hexane: ethyl acetate) with increasing polarity, to produce as much pure crystal (21.66 g), yield (24%). While the structural characterization of the two compounds was carried out using UV-Vis, IR, HRESIMS, 1H-NMR and 13C-NMR spectroscopic methods, the antidiabetic testing was carried out using the α-glucosidase enzyme inhibition method.

Co-Authors Adi Setyo Purnomo Adityo Pratomo Putro Ahmad Ubaidillah Ihsany Amalia Zafitri Amelinda Pratiwi Ananda Krisna Aldianita Anisa Rahma Maharani Ardi Lukman Hakim Aty Widyawaruyanti Aunurohim Aunurohim Cicilia Puspa Rini Dahlena Ariyani Dheva Noveilya Dini Nur Fauzia Fadlan, Arif Fatati Nurmalasari Fatimatul Munawaroh Fatimatul Munawaroh Fatmawati Inneke Putri Fiqey Indriati Eka Sari Fitria Fitria Fredy Kurniawan Fuji Ridha Kharomah Hadi Kuncoro Healthy Kainama Herdayanto Sulistyo Putro Hesti Selfiana Dwi Jayanti Ika Febriana Syafitri Imelda Priskila Simanjuntak Kamilia Mustikasari Karneg, Syahdam Khoiriyah Umami Kholifatu Rosyidah Kuniyoshi Shimizu Kuniyoshi Shimizu Laila Khamsatul Muharrami, Laila Khamsatul Lita Amalia Lukman Atmaja M Daffa Aditya Mardi Santoso Maria Dewi Astuti Mutia Devi Hidayati Nabilah Dita Anaqah Nadia Sasanti Ni Kadek Githa Kartika Gunadyani Noer Komari Nor Farida Novi Sulistyaningrum Novi Sulistyaningrum Novi Sulistyaningrum Nurbariyah Nurlatifah Nurlatifah Pieter Kakisina Prima Lukis Putri, Devi Anggraini Rafsanjani, Ega Rocky Maulana Rahma Rahayu Dinarlita Retno Purbowati Retno Purbowati Rizaldy Nizzah Kurniawan Ruzain Rafie Sukma Putra Sri Banun Titi Istiqomah Sri Fatmawati Suprapto Suprapto Susi Agustina Wilujeng Susy Budi Astuti Vanuella Tresnaning Budi Wiwit Denny Fitriana Yaqdhan Nufal Rafi Yatim Lailun Ni’mah Zulkarnain Zulkarnain

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